NR1H2 | ENSG00000131408 | NCBI 7376

Details for: NR1H2

Gene ID: 7376

Symbol: NR1H2

Ensembl ID: ENSG00000131408

Description: nuclear receptor subfamily 1 group H member 2

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Nr1h2 & nr1h3 regulate gene expression linked to lipogenesis
(R-HSA-9029558)
Nr1h2 & nr1h3 regulate gene expression linked to triglyceride lipolysis in adipose
(R-HSA-9031528)
Nr1h2 & nr1h3 regulate gene expression to control bile acid homeostasis
(R-HSA-9623433)
Nr1h2 & nr1h3 regulate gene expression to limit cholesterol uptake
(R-HSA-9031525)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Nuclear receptor transcription pathway
(R-HSA-383280)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein clearance
(R-HSA-8964043)
Post-translational protein modification
(R-HSA-597592)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of intracellular receptors
(R-HSA-4090294)
Transport of small molecules
(R-HSA-382551)
Vldlr internalisation and degradation
(R-HSA-8866427)
Apolipoprotein a-i receptor binding
(GO:0034191)
Atpase binding
(GO:0051117)
Cell differentiation
(GO:0030154)
Cholesterol homeostasis
(GO:0042632)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Hormone-mediated signaling pathway
(GO:0009755)
Intracellular receptor signaling pathway
(GO:0030522)
Mrna transcription by rna polymerase ii
(GO:0042789)
Negative regulation of cholesterol storage
(GO:0010887)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of lipid transport
(GO:0032369)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Negative regulation of pinocytosis
(GO:0048550)
Negative regulation of proteolysis
(GO:0045861)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of type ii interferon-mediated signaling pathway
(GO:0060336)
Nuclear receptor activity
(GO:0004879)
Nuclear retinoid x receptor binding
(GO:0046965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidylcholine acyl-chain remodeling
(GO:0036151)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of cholesterol transport
(GO:0032376)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fatty acid biosynthetic process
(GO:0045723)
Positive regulation of high-density lipoprotein particle assembly
(GO:0090108)
Positive regulation of lipid storage
(GO:0010884)
Positive regulation of lipoprotein lipase activity
(GO:0051006)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of pancreatic juice secretion
(GO:0090187)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of secretion of lysosomal enzymes
(GO:0090340)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of triglyceride biosynthetic process
(GO:0010867)
Protein binding
(GO:0005515)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 148.2527
Cell Significance Index: -23.0600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 104.7534
Cell Significance Index: -26.5700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 69.2665
Cell Significance Index: -28.1400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 68.0120
Cell Significance Index: -32.1100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 62.9295
Cell Significance Index: -32.3700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 29.9871
Cell Significance Index: -28.6300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 24.2182
Cell Significance Index: -29.8600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.9926
Cell Significance Index: -24.0900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.3451
Cell Significance Index: -32.9300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.2995
Cell Significance Index: -22.4200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.9758
Cell Significance Index: -10.8900
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 4.6130
Cell Significance Index: 76.0200
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 3.1477
Cell Significance Index: 26.4400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.4135
Cell Significance Index: 281.2700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.2698
Cell Significance Index: 66.1400
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.2271
Cell Significance Index: 21.6900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2072
Cell Significance Index: 16.4700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.0448
Cell Significance Index: 103.3600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.9078
Cell Significance Index: 24.7100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7399
Cell Significance Index: 47.7400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7361
Cell Significance Index: 34.6000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6484
Cell Significance Index: 33.6800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6087
Cell Significance Index: 74.8500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.5730
Cell Significance Index: 74.0300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5723
Cell Significance Index: 78.5900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5672
Cell Significance Index: 66.8900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.5611
Cell Significance Index: 10.3700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5492
Cell Significance Index: 16.1300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5365
Cell Significance Index: 96.7200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5022
Cell Significance Index: 13.4100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4885
Cell Significance Index: 36.4100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4835
Cell Significance Index: 33.4400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.4675
Cell Significance Index: 13.4000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4575
Cell Significance Index: 24.0200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4538
Cell Significance Index: 247.8200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4310
Cell Significance Index: 55.2500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4210
Cell Significance Index: 9.1200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4182
Cell Significance Index: 19.5000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3358
Cell Significance Index: 148.4700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3102
Cell Significance Index: 14.0600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2943
Cell Significance Index: 56.0000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2711
Cell Significance Index: 7.2600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.2641
Cell Significance Index: 3.0000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2436
Cell Significance Index: 48.3500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1866
Cell Significance Index: 37.4400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1753
Cell Significance Index: 5.0500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1589
Cell Significance Index: 57.0000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1261
Cell Significance Index: 8.9200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0902
Cell Significance Index: 3.1700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0321
Cell Significance Index: 49.4000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0309
Cell Significance Index: 23.4000
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0295
Cell Significance Index: 54.3500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0090
Cell Significance Index: 12.2000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0071
Cell Significance Index: 13.4300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0079
Cell Significance Index: -0.8100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0120
Cell Significance Index: -8.8100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0163
Cell Significance Index: -2.7800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0245
Cell Significance Index: -15.5800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0301
Cell Significance Index: -1.9000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0388
Cell Significance Index: -4.4500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0420
Cell Significance Index: -31.1300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0470
Cell Significance Index: -21.3100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0505
Cell Significance Index: -1.0800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0536
Cell Significance Index: -30.2400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0631
Cell Significance Index: -39.3900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0647
Cell Significance Index: -18.6100
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0652
Cell Significance Index: -0.6000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0770
Cell Significance Index: -2.4700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0873
Cell Significance Index: -5.3700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0882
Cell Significance Index: -2.3600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1298
Cell Significance Index: -9.9600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1300
Cell Significance Index: -3.3200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1338
Cell Significance Index: -3.7400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1496
Cell Significance Index: -21.7400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1718
Cell Significance Index: -36.1900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1936
Cell Significance Index: -5.0900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2005
Cell Significance Index: -4.1600
Cell Name: peg cell (CL4033014)
Fold Change: -0.2134
Cell Significance Index: -4.9300
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.2191
Cell Significance Index: -3.1400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2241
Cell Significance Index: -3.7500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2475
Cell Significance Index: -13.8900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2823
Cell Significance Index: -4.2300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2900
Cell Significance Index: -4.9700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3059
Cell Significance Index: -24.2300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3059
Cell Significance Index: -31.8500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3296
Cell Significance Index: -8.2400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3376
Cell Significance Index: -11.7300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3444
Cell Significance Index: -23.1600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3691
Cell Significance Index: -4.4000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4210
Cell Significance Index: -21.2800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4316
Cell Significance Index: -26.4600
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.5468
Cell Significance Index: -7.8300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5480
Cell Significance Index: -11.4700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5831
Cell Significance Index: -17.1800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6068
Cell Significance Index: -26.8400
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.6214
Cell Significance Index: -4.2100
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.6557
Cell Significance Index: -26.8700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6936
Cell Significance Index: -17.8300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.7215
Cell Significance Index: -27.3200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7321
Cell Significance Index: -26.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Nuclear Receptor Structure:** NR1H2 is a transcription factor that belongs to the nuclear receptor superfamily. It consists of an ligand-binding domain, a DNA-binding domain, and a transcription activation domain. 2. **Ligand-Binding:** NR1H2 binds to oxysterols, which are oxidized derivatives of cholesterol, and other ligands, such as bile acids and fatty acids. 3. **Gene Regulation:** NR1H2 regulates the expression of genes involved in lipid metabolism, including those involved in cholesterol uptake, efflux, and storage. 4. **Tissue Expression:** NR1H2 is highly expressed in the liver, kidney, and adipose tissue, and is also found in other tissues, including the pancreas, immune cells, and blood cells. **Pathways and Functions:** 1. **Cholesterol Homeostasis:** NR1H2 regulates the expression of genes involved in cholesterol uptake, efflux, and storage, ensuring that cholesterol levels are maintained within a narrow range. 2. **Lipid Metabolism:** NR1H2 regulates the expression of genes involved in lipid synthesis, storage, and breakdown, including those involved in triglyceride lipolysis and fatty acid biosynthesis. 3. **Energy Homeostasis:** NR1H2 regulates the expression of genes involved in energy metabolism, including those involved in glucose and lipid metabolism. 4. **Inflammation:** NR1H2 regulates the expression of genes involved in inflammation, including those involved in the regulation of immune responses and the production of pro-inflammatory cytokines. 5. **Cell Differentiation:** NR1H2 regulates the expression of genes involved in cell differentiation, including those involved in the development of adipocytes and hepatocytes. **Clinical Significance:** 1. **Atherosclerosis:** Aberrant expression or function of NR1H2 has been implicated in the development of atherosclerosis, a condition characterized by the buildup of cholesterol-rich plaques in the arteries. 2. **Metabolic Syndrome:** NR1H2 dysregulation has been implicated in the development of metabolic syndrome, a condition characterized by insulin resistance, hypertension, and dyslipidemia. 3. **Cancer:** NR1H2 dysregulation has been implicated in the development and progression of certain cancers, including breast, lung, and colon cancer. 4. **Neurodegenerative Diseases:** NR1H2 dysregulation has been implicated in the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, the NR1H2 gene plays a critical role in regulating cholesterol homeostasis and lipid metabolism, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which NR1H2 regulates lipid metabolism and to develop therapeutic strategies to target NR1H2 for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Oxysterols receptor LXR-beta
F1D8P7_HUMAN

Genular Protein ID: 1373822690

Symbol: NR1H2_HUMAN

Name: Oxysterols receptor LXR-beta

UniProtKB Accession Codes:

P55055 A8K490 B4DNM6 E7EWA6 Q12970 Q5I0Y1

Database IDs:

Citations:

PubMed ID: 7926814

Title: NER, a new member of the gene family encoding the human steroid hormone nuclear receptor.

PubMed ID: 7926814

DOI: 10.1016/0378-1119(94)90080-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20159957

Title: GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.

PubMed ID: 20159957

DOI: 10.1101/gad.545110

PubMed ID: 23931754

Title: ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis.

PubMed ID: 23931754

DOI: 10.1016/j.cmet.2013.07.003

PubMed ID: 25661920

Title: CCAR2 negatively regulates nuclear receptor LXRalpha by competing with SIRT1 deacetylase.

PubMed ID: 25661920

DOI: 10.1016/j.jsbmb.2015.02.001

PubMed ID: 12819202

Title: The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.

PubMed ID: 12819202

DOI: 10.1074/jbc.m304842200

Sequence Information:

Length: 460
Mass: 50974
Checksum: 9465A6FFB7FCFD2F
Sequence:

MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD EASSACSTDW 
VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN VLSCEGCKGF FRRSVVRGGA 
RRYACRGGGT CQMDAFMRRK CQQCRLRKCK EAGMREQCVL SEEQIRKKKI RKQQQESQSQ 
SQSPVGPQGS SSSASGPGAS PGGSEAGSQG SGEGEGVQLT AAQELMIQQL VAAQLQCNKR 
SFSDQPKVTP WPLGADPQSR DARQQRFAHF TELAIISVQE IVDFAKQVPG FLQLGREDQI 
ALLKASTIEI MLLETARRYN HETECITFLK DFTYSKDDFH RAGLQVEFIN PIFEFSRAMR 
RLGLDDAEYA LLIAINIFSA DRPNVQEPGR VEALQQPYVE ALLSYTRIKR PQDQLRFPRM 
LMKLVSLRTL SSVHSEQVFA LRLQDKKLPP LLSEIWDVHE

Genular Protein ID: 1613500213

Symbol: F1D8P7_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1D8P7

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 461
Mass: 51102
Checksum: 68CE3D9F9BC5C0BE
Sequence:

MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD EASSACSTDW 
VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN VLSCEGCKGF FRRSVVRGGA 
RRYACRGGGT CQMDAFMRRK CQQCRLRKCK EAGMREQCVL SEEQIRKKKI RKQQQQESQS 
QSQSPVGPQG SSSSASGPGA SPGGSEAGSQ GSGEGEGVQL TAAQELMIQQ LVAAQLQCNK 
RSFSDQPKVT PWPLGADPQS RDARQQRFAH FTELAIISVQ EIVDFAKQVP GFLQLGREDQ 
IALLKASTIE IMLLETARRY NHETECITFL KDFTYSKDDF HRAGLQVEFI NPIFEFSRAM 
RRLGLDDAEY ALLIAINIFS ADRPNVQEPG RVEALQQPYV EALLSYTRIK RPQDQLRFPR 
MLMKLVSLRT LSSVHSEQVF ALRLQDKKLP PLLSEIWDVH E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NR1H2

Associated with

Cells (max top 100)

Other Information

NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. PubMed ID: 7926814

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response. PubMed ID: 20159957

ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. PubMed ID: 23931754

CCAR2 negatively regulates nuclear receptor LXRalpha by competing with SIRT1 deacetylase. PubMed ID: 25661920

The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. PubMed ID: 12819202

The sequence of the human genome. PubMed ID: 11181995