Details for: VCAM1

Gene ID: 7412

Symbol: VCAM1

Ensembl ID: ENSG00000162692

Description: vascular cell adhesion molecule 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.0206
    Cell Significance Index: -14.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.7169
    Cell Significance Index: -14.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.4611
    Cell Significance Index: -10.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9875
    Cell Significance Index: -14.7800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.1702
    Cell Significance Index: 24.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.5075
    Cell Significance Index: 93.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4047
    Cell Significance Index: -13.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.8892
    Cell Significance Index: 44.7000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.8787
    Cell Significance Index: 17.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.4585
    Cell Significance Index: 43.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.3924
    Cell Significance Index: 68.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.6814
    Cell Significance Index: 28.2800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7262
    Cell Significance Index: 6.1000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.5546
    Cell Significance Index: 4.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5484
    Cell Significance Index: 6.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4333
    Cell Significance Index: 85.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4272
    Cell Significance Index: 22.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2963
    Cell Significance Index: 37.9900
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.2866
    Cell Significance Index: 1.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2131
    Cell Significance Index: 5.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2016
    Cell Significance Index: 4.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1261
    Cell Significance Index: 2.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0983
    Cell Significance Index: 13.5000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.0648
    Cell Significance Index: 0.3100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0543
    Cell Significance Index: 0.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0499
    Cell Significance Index: 31.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0420
    Cell Significance Index: 18.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0376
    Cell Significance Index: 4.3100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0355
    Cell Significance Index: 0.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0030
    Cell Significance Index: 5.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0065
    Cell Significance Index: -4.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0099
    Cell Significance Index: -5.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0139
    Cell Significance Index: -10.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0169
    Cell Significance Index: -10.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0187
    Cell Significance Index: -14.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0212
    Cell Significance Index: -3.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0222
    Cell Significance Index: -4.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0264
    Cell Significance Index: -11.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0280
    Cell Significance Index: -5.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0283
    Cell Significance Index: -15.4800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0350
    Cell Significance Index: -0.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0386
    Cell Significance Index: -3.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0454
    Cell Significance Index: -13.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0503
    Cell Significance Index: -6.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0712
    Cell Significance Index: -9.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0720
    Cell Significance Index: -10.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0762
    Cell Significance Index: -15.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0986
    Cell Significance Index: -11.2500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1073
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1103
    Cell Significance Index: -12.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1109
    Cell Significance Index: -13.0800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1156
    Cell Significance Index: -0.8300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1214
    Cell Significance Index: -2.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1271
    Cell Significance Index: -13.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1343
    Cell Significance Index: -6.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1470
    Cell Significance Index: -11.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1481
    Cell Significance Index: -11.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1517
    Cell Significance Index: -7.6600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1618
    Cell Significance Index: -0.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1840
    Cell Significance Index: -11.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1989
    Cell Significance Index: -12.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2089
    Cell Significance Index: -16.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2244
    Cell Significance Index: -15.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2258
    Cell Significance Index: -6.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2331
    Cell Significance Index: -14.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2393
    Cell Significance Index: -14.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2455
    Cell Significance Index: -10.0600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2578
    Cell Significance Index: -4.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2579
    Cell Significance Index: -6.6300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2668
    Cell Significance Index: -2.6400
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.3013
    Cell Significance Index: -2.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3042
    Cell Significance Index: -13.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3079
    Cell Significance Index: -6.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3108
    Cell Significance Index: -14.4900
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3213
    Cell Significance Index: -2.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3246
    Cell Significance Index: -9.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3278
    Cell Significance Index: -8.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3291
    Cell Significance Index: -18.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3461
    Cell Significance Index: -18.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3499
    Cell Significance Index: -18.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3616
    Cell Significance Index: -5.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3623
    Cell Significance Index: -13.3000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.3755
    Cell Significance Index: -3.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3866
    Cell Significance Index: -5.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4042
    Cell Significance Index: -17.8800
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: -0.4208
    Cell Significance Index: -3.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4413
    Cell Significance Index: -12.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4436
    Cell Significance Index: -15.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4785
    Cell Significance Index: -12.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4798
    Cell Significance Index: -15.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4814
    Cell Significance Index: -18.2300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.4885
    Cell Significance Index: -4.0400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.5003
    Cell Significance Index: -2.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5018
    Cell Significance Index: -13.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5071
    Cell Significance Index: -16.1500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5229
    Cell Significance Index: -10.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5298
    Cell Significance Index: -15.1200
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.5386
    Cell Significance Index: -6.0400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5501
    Cell Significance Index: -5.9800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5622
    Cell Significance Index: -14.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression**: VCAM-1 is primarily expressed on the surface of endothelial cells, particularly in the context of inflammation. 2. **Function**: VCAM-1 facilitates the interaction between leukocytes and endothelial cells, promoting the rolling and migration of leukocytes across the endothelial layer. 3. **Structure**: VCAM-1 is a transmembrane glycoprotein composed of two extracellular domains and one intracellular domain. 4. **Regulation**: VCAM-1 expression is induced by inflammatory cytokines, such as TNF-α and IL-1β, which are released in response to tissue injury or infection. **Pathways and Functions** 1. **Adaptive Immune Response**: VCAM-1 plays a critical role in the recruitment and migration of leukocytes to sites of infection or injury, facilitating the adaptive immune response. 2. **Inflammatory Response**: VCAM-1 is involved in the regulation of leukocyte recruitment and migration during inflammation, promoting the inflammatory response. 3. **Cell-Cell Adhesion**: VCAM-1 facilitates the interaction between leukocytes and endothelial cells, promoting cell-cell adhesion and migration. 4. **Cytokine Signaling**: VCAM-1 is involved in the signaling of inflammatory cytokines, such as TNF-α and IL-1β, which regulate VCAM-1 expression and function. **Clinical Significance** 1. **Inflammatory Disorders**: VCAM-1 is associated with various inflammatory disorders, including atherosclerosis, rheumatoid arthritis, and inflammatory bowel disease. 2. **Cardiovascular Disease**: Elevated VCAM-1 levels have been linked to an increased risk of cardiovascular disease, including myocardial infarction and stroke. 3. **Cancer**: VCAM-1 has been implicated in the metastasis of certain cancers, including breast and lung cancer. 4. **Neurodegenerative Diseases**: VCAM-1 has been linked to neurodegenerative diseases, including Alzheimer's disease and multiple sclerosis. In conclusion, VCAM-1 plays a critical role in the regulation of leukocyte recruitment, migration, and adhesion to endothelial cells during inflammation. Its dysregulation has been implicated in various inflammatory disorders, cardiovascular disease, cancer, and neurodegenerative diseases, highlighting the importance of VCAM-1 in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 1308269249

Symbol: VCAM1_HUMAN

Name: Vascular cell adhesion protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2688898

Title: Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes.

PubMed ID: 2688898

DOI: 10.1016/0092-8674(89)90775-7

PubMed ID: 1699207

Title: Full length vascular cell adhesion molecule 1 (VCAM-1).

PubMed ID: 1699207

DOI: 10.1093/nar/18.19.5901

PubMed ID: 1707873

Title: Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1).

PubMed ID: 1707873

DOI: 10.1016/s0021-9258(20)89551-9

PubMed ID: 1715583

Title: Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene.

PubMed ID: 1715583

DOI: 10.1073/pnas.88.17.7859

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1379595

Title: Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1).

PubMed ID: 1379595

DOI: 10.1016/s0021-9258(18)42004-2

PubMed ID: 1707234

Title: Alternative splicing of human VCAM-1 in activated vascular endothelium.

PubMed ID: 1707234

PubMed ID: 1377228

Title: Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1.

PubMed ID: 1377228

DOI: 10.1084/jem.176.1.99

PubMed ID: 10209034

Title: The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1.

PubMed ID: 10209034

DOI: 10.1083/jcb.145.2.413

PubMed ID: 12878595

Title: Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17).

PubMed ID: 12878595

DOI: 10.1074/jbc.m305877200

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 22970700

Title: Distinct sites within the vascular cell adhesion molecule-1 (VCAM-1) cytoplasmic domain regulate VCAM-1 activation of calcium fluxes versus Rac1 during leukocyte transendothelial migration.

PubMed ID: 22970700

DOI: 10.1021/bi300925r

PubMed ID: 31310649

Title: TRIM65 E3 ligase targets VCAM-1 degradation to limit LPS-induced lung inflammation.

PubMed ID: 31310649

DOI: 10.1093/jmcb/mjz077

PubMed ID: 36127634

Title: The soluble VCAM-1 level is a potential biomarker predicting severe acute graft versus host disease after allogeneic hematopoietic cell transplantation.

PubMed ID: 36127634

DOI: 10.1186/s12885-022-10096-3

PubMed ID: 35210567

Title: VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells.

PubMed ID: 35210567

DOI: 10.1038/s41556-022-00849-4

PubMed ID: 7531291

Title: Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8-A resolution.

PubMed ID: 7531291

DOI: 10.1038/373539a0

PubMed ID: 7539925

Title: The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction.

PubMed ID: 7539925

DOI: 10.1073/pnas.92.12.5714

PubMed ID: 15299708

Title: Structure of a functional fragment of VCAM-1 refined at 1.9-A resolution.

PubMed ID: 15299708

DOI: 10.1107/s0907444995012352

Sequence Information:

  • Length: 739
  • Mass: 81276
  • Checksum: 050E2EBD39AC2FF4
  • Sequence:
  • MPGKMVVILG ASNILWIMFA ASQAFKIETT PESRYLAQIG DSVSLTCSTT GCESPFFSWR 
    TQIDSPLNGK VTNEGTTSTL TMNPVSFGNE HSYLCTATCE SRKLEKGIQV EIYSFPKDPE 
    IHLSGPLEAG KPITVKCSVA DVYPFDRLEI DLLKGDHLMK SQEFLEDADR KSLETKSLEV 
    TFTPVIEDIG KVLVCRAKLH IDEMDSVPTV RQAVKELQVY ISPKNTVISV NPSTKLQEGG 
    SVTMTCSSEG LPAPEIFWSK KLDNGNLQHL SGNATLTLIA MRMEDSGIYV CEGVNLIGKN 
    RKEVELIVQE KPFTVEISPG PRIAAQIGDS VMLTCSVMGC ESPSFSWRTQ IDSPLSGKVR 
    SEGTNSTLTL SPVSFENEHS YLCTVTCGHK KLEKGIQVEL YSFPRDPEIE MSGGLVNGSS 
    VTVSCKVPSV YPLDRLEIEL LKGETILENI EFLEDTDMKS LENKSLEMTF IPTIEDTGKA 
    LVCQAKLHID DMEFEPKQRQ STQTLYVNVA PRDTTVLVSP SSILEEGSSV NMTCLSQGFP 
    APKILWSRQL PNGELQPLSE NATLTLISTK MEDSGVYLCE GINQAGRSRK EVELIIQVTP 
    KDIKLTAFPS ESVKEGDTVI ISCTCGNVPE TWIILKKKAE TGDTVLKSID GAYTIRKAQL 
    KDAGVYECES KNKVGSQLRS LTLDVQGREN NKDYFSPELL VLYFASSLII PAIGMIIYFA 
    RKANMKGSYS LVEAQKSKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.