Details for: VCAM1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 95.0206
Cell Significance Index: -14.7800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 29.7169
Cell Significance Index: -14.0300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 26.4611
Cell Significance Index: -10.7500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.9875
Cell Significance Index: -14.7800 - Cell Name: theca cell (CL0000503)
Fold Change: 4.1702
Cell Significance Index: 24.5000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.5075
Cell Significance Index: 93.9900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.4047
Cell Significance Index: -13.4400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 2.8892
Cell Significance Index: 44.7000 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 2.8787
Cell Significance Index: 17.8100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.4585
Cell Significance Index: 43.4500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.3924
Cell Significance Index: 68.5800 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.6814
Cell Significance Index: 28.2800 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.7262
Cell Significance Index: 6.1000 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.5546
Cell Significance Index: 4.2400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.5484
Cell Significance Index: 6.2300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4333
Cell Significance Index: 85.9900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4272
Cell Significance Index: 22.2500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2963
Cell Significance Index: 37.9900 - Cell Name: glioblast (CL0000030)
Fold Change: 0.2866
Cell Significance Index: 1.8000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2131
Cell Significance Index: 5.7000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.2016
Cell Significance Index: 4.2200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1261
Cell Significance Index: 2.1100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0983
Cell Significance Index: 13.5000 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.0648
Cell Significance Index: 0.3100 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.0543
Cell Significance Index: 0.3400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0499
Cell Significance Index: 31.1500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0420
Cell Significance Index: 18.5800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0376
Cell Significance Index: 4.3100 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.0355
Cell Significance Index: 0.8600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0030
Cell Significance Index: 5.6700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0065
Cell Significance Index: -4.8400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0099
Cell Significance Index: -5.5700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0139
Cell Significance Index: -10.2200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0169
Cell Significance Index: -10.7100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0187
Cell Significance Index: -14.1400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0212
Cell Significance Index: -3.6200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0222
Cell Significance Index: -4.0000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0264
Cell Significance Index: -11.9800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0280
Cell Significance Index: -5.9000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0283
Cell Significance Index: -15.4800 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: -0.0350
Cell Significance Index: -0.2200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0386
Cell Significance Index: -3.9400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0454
Cell Significance Index: -13.0700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0503
Cell Significance Index: -6.1800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0712
Cell Significance Index: -9.2000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0720
Cell Significance Index: -10.4600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0762
Cell Significance Index: -15.2900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0986
Cell Significance Index: -11.2500 - Cell Name: chondroblast (CL0000058)
Fold Change: -0.1073
Cell Significance Index: -0.6300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1103
Cell Significance Index: -12.8500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1109
Cell Significance Index: -13.0800 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.1156
Cell Significance Index: -0.8300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1214
Cell Significance Index: -2.6000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1271
Cell Significance Index: -13.2300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1343
Cell Significance Index: -6.3100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1470
Cell Significance Index: -11.6400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1481
Cell Significance Index: -11.0400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1517
Cell Significance Index: -7.6600 - Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1618
Cell Significance Index: -0.9600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1840
Cell Significance Index: -11.3100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1989
Cell Significance Index: -12.8400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2089
Cell Significance Index: -16.0300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2244
Cell Significance Index: -15.0900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2258
Cell Significance Index: -6.3100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2331
Cell Significance Index: -14.6900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2393
Cell Significance Index: -14.6700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2455
Cell Significance Index: -10.0600 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.2578
Cell Significance Index: -4.0900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2579
Cell Significance Index: -6.6300 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.2668
Cell Significance Index: -2.6400 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: -0.3013
Cell Significance Index: -2.5500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3042
Cell Significance Index: -13.7900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3079
Cell Significance Index: -6.0100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3108
Cell Significance Index: -14.4900 - Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.3213
Cell Significance Index: -2.9400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3246
Cell Significance Index: -9.5600 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3278
Cell Significance Index: -8.1800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3291
Cell Significance Index: -18.4700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3461
Cell Significance Index: -18.1700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3499
Cell Significance Index: -18.1800 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.3616
Cell Significance Index: -5.2500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3623
Cell Significance Index: -13.3000 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.3755
Cell Significance Index: -3.5700 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.3866
Cell Significance Index: -5.5600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4042
Cell Significance Index: -17.8800 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: -0.4208
Cell Significance Index: -3.0900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4413
Cell Significance Index: -12.9600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4436
Cell Significance Index: -15.5400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4785
Cell Significance Index: -12.7800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4798
Cell Significance Index: -15.7100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4814
Cell Significance Index: -18.2300 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: -0.4885
Cell Significance Index: -4.0400 - Cell Name: perivascular cell (CL4033054)
Fold Change: -0.5003
Cell Significance Index: -2.3100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5018
Cell Significance Index: -13.2000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5071
Cell Significance Index: -16.1500 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.5229
Cell Significance Index: -10.6400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5298
Cell Significance Index: -15.1200 - Cell Name: endothelial stalk cell (CL0002671)
Fold Change: -0.5386
Cell Significance Index: -6.0400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.5501
Cell Significance Index: -5.9800 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.5622
Cell Significance Index: -14.3200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1308269249
Symbol: VCAM1_HUMAN
Name: Vascular cell adhesion protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2688898
Title: Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes.
PubMed ID: 2688898
PubMed ID: 1699207
Title: Full length vascular cell adhesion molecule 1 (VCAM-1).
PubMed ID: 1699207
PubMed ID: 1707873
Title: Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1).
PubMed ID: 1707873
PubMed ID: 1715583
Title: Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene.
PubMed ID: 1715583
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1379595
Title: Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1).
PubMed ID: 1379595
PubMed ID: 1707234
Title: Alternative splicing of human VCAM-1 in activated vascular endothelium.
PubMed ID: 1707234
PubMed ID: 1377228
Title: Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1.
PubMed ID: 1377228
DOI: 10.1084/jem.176.1.99
PubMed ID: 10209034
Title: The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1.
PubMed ID: 10209034
PubMed ID: 12878595
Title: Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17).
PubMed ID: 12878595
PubMed ID: 15340161
Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.
PubMed ID: 15340161
DOI: 10.1110/ps.04682504
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 22970700
Title: Distinct sites within the vascular cell adhesion molecule-1 (VCAM-1) cytoplasmic domain regulate VCAM-1 activation of calcium fluxes versus Rac1 during leukocyte transendothelial migration.
PubMed ID: 22970700
DOI: 10.1021/bi300925r
PubMed ID: 31310649
Title: TRIM65 E3 ligase targets VCAM-1 degradation to limit LPS-induced lung inflammation.
PubMed ID: 31310649
DOI: 10.1093/jmcb/mjz077
PubMed ID: 36127634
Title: The soluble VCAM-1 level is a potential biomarker predicting severe acute graft versus host disease after allogeneic hematopoietic cell transplantation.
PubMed ID: 36127634
PubMed ID: 35210567
Title: VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells.
PubMed ID: 35210567
PubMed ID: 7531291
Title: Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8-A resolution.
PubMed ID: 7531291
DOI: 10.1038/373539a0
PubMed ID: 7539925
Title: The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction.
PubMed ID: 7539925
PubMed ID: 15299708
Title: Structure of a functional fragment of VCAM-1 refined at 1.9-A resolution.
PubMed ID: 15299708
Sequence Information:
- Length: 739
- Mass: 81276
- Checksum: 050E2EBD39AC2FF4
- Sequence:
MPGKMVVILG ASNILWIMFA ASQAFKIETT PESRYLAQIG DSVSLTCSTT GCESPFFSWR TQIDSPLNGK VTNEGTTSTL TMNPVSFGNE HSYLCTATCE SRKLEKGIQV EIYSFPKDPE IHLSGPLEAG KPITVKCSVA DVYPFDRLEI DLLKGDHLMK SQEFLEDADR KSLETKSLEV TFTPVIEDIG KVLVCRAKLH IDEMDSVPTV RQAVKELQVY ISPKNTVISV NPSTKLQEGG SVTMTCSSEG LPAPEIFWSK KLDNGNLQHL SGNATLTLIA MRMEDSGIYV CEGVNLIGKN RKEVELIVQE KPFTVEISPG PRIAAQIGDS VMLTCSVMGC ESPSFSWRTQ IDSPLSGKVR SEGTNSTLTL SPVSFENEHS YLCTVTCGHK KLEKGIQVEL YSFPRDPEIE MSGGLVNGSS VTVSCKVPSV YPLDRLEIEL LKGETILENI EFLEDTDMKS LENKSLEMTF IPTIEDTGKA LVCQAKLHID DMEFEPKQRQ STQTLYVNVA PRDTTVLVSP SSILEEGSSV NMTCLSQGFP APKILWSRQL PNGELQPLSE NATLTLISTK MEDSGVYLCE GINQAGRSRK EVELIIQVTP KDIKLTAFPS ESVKEGDTVI ISCTCGNVPE TWIILKKKAE TGDTVLKSID GAYTIRKAQL KDAGVYECES KNKVGSQLRS LTLDVQGREN NKDYFSPELL VLYFASSLII PAIGMIIYFA RKANMKGSYS LVEAQKSKV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.