Details for: TRPV1

Gene ID: 7442

Symbol: TRPV1

Ensembl ID: ENSG00000196689

Description: transient receptor potential cation channel subfamily V member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 69.6903
    Cell Significance Index: -10.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.2103
    Cell Significance Index: -10.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.8324
    Cell Significance Index: -10.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8129
    Cell Significance Index: -11.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0431
    Cell Significance Index: 65.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6617
    Cell Significance Index: 19.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6284
    Cell Significance Index: 126.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5796
    Cell Significance Index: 44.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4880
    Cell Significance Index: 24.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4631
    Cell Significance Index: 45.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4537
    Cell Significance Index: 90.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4385
    Cell Significance Index: 157.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3902
    Cell Significance Index: 352.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3560
    Cell Significance Index: 5.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2805
    Cell Significance Index: 16.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2407
    Cell Significance Index: 39.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1975
    Cell Significance Index: 11.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1752
    Cell Significance Index: 7.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1302
    Cell Significance Index: 23.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1196
    Cell Significance Index: 2.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1143
    Cell Significance Index: 1.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1129
    Cell Significance Index: 7.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1094
    Cell Significance Index: 20.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1016
    Cell Significance Index: 5.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0813
    Cell Significance Index: 56.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0687
    Cell Significance Index: 3.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0573
    Cell Significance Index: 1.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0475
    Cell Significance Index: 1.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0388
    Cell Significance Index: 4.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0342
    Cell Significance Index: 2.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0144
    Cell Significance Index: 2.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0120
    Cell Significance Index: 6.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0117
    Cell Significance Index: 22.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0080
    Cell Significance Index: 0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0064
    Cell Significance Index: 11.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0057
    Cell Significance Index: 8.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0026
    Cell Significance Index: 3.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0024
    Cell Significance Index: 1.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0013
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0047
    Cell Significance Index: -0.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0078
    Cell Significance Index: -4.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0122
    Cell Significance Index: -8.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0135
    Cell Significance Index: -6.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0155
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0162
    Cell Significance Index: -9.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0162
    Cell Significance Index: -12.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0188
    Cell Significance Index: -5.4100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0207
    Cell Significance Index: -0.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0388
    Cell Significance Index: -4.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0488
    Cell Significance Index: -5.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0513
    Cell Significance Index: -6.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0515
    Cell Significance Index: -0.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0525
    Cell Significance Index: -5.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0545
    Cell Significance Index: -11.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0563
    Cell Significance Index: -3.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0622
    Cell Significance Index: -2.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0629
    Cell Significance Index: -0.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0797
    Cell Significance Index: -5.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0812
    Cell Significance Index: -10.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0823
    Cell Significance Index: -9.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0844
    Cell Significance Index: -2.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0973
    Cell Significance Index: -6.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0974
    Cell Significance Index: -3.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0987
    Cell Significance Index: -10.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1004
    Cell Significance Index: -1.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1011
    Cell Significance Index: -4.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1032
    Cell Significance Index: -5.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1116
    Cell Significance Index: -1.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1120
    Cell Significance Index: -7.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1160
    Cell Significance Index: -1.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1217
    Cell Significance Index: -3.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1232
    Cell Significance Index: -2.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1272
    Cell Significance Index: -2.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1295
    Cell Significance Index: -10.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1337
    Cell Significance Index: -2.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1375
    Cell Significance Index: -4.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1411
    Cell Significance Index: -4.6200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1419
    Cell Significance Index: -2.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1440
    Cell Significance Index: -10.7300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1443
    Cell Significance Index: -1.8000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1568
    Cell Significance Index: -1.9500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1619
    Cell Significance Index: -1.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1626
    Cell Significance Index: -7.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1664
    Cell Significance Index: -4.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1787
    Cell Significance Index: -9.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1833
    Cell Significance Index: -3.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1851
    Cell Significance Index: -4.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1861
    Cell Significance Index: -3.6800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1901
    Cell Significance Index: -1.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1935
    Cell Significance Index: -4.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1958
    Cell Significance Index: -6.8600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2004
    Cell Significance Index: -2.5700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2036
    Cell Significance Index: -2.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2049
    Cell Significance Index: -5.1100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2243
    Cell Significance Index: -3.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2307
    Cell Significance Index: -6.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2398
    Cell Significance Index: -6.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2567
    Cell Significance Index: -8.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2591
    Cell Significance Index: -9.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ion Channel Function**: TRPV1 is a cation channel that allows the influx of cations, such as calcium and sodium, into the cell upon activation. 2. **Temperature Sensitivity**: TRPV1 is activated by temperature changes, with a bell-shaped curve of activation at temperatures between 30°C and 50°C. 3. **Pain Sensitivity**: TRPV1 is also activated by chemical stimuli, such as capsaicin, and plays a crucial role in the detection of pain. 4. **Wide Expression**: TRPV1 is expressed in various tissues, including the nervous system, immune cells, and epithelial tissues. 5. **Regulatory Mechanisms**: TRPV1 is regulated by multiple mechanisms, including calcium-mediated signaling, calmodulin binding, and interactions with other proteins. **Pathways and Functions** 1. **Calcium-Mediated Signaling**: TRPV1 activation leads to the influx of calcium ions into the cell, which activates various signaling pathways, including the NF-κB and MAPK pathways. 2. **Neurotransmission**: TRPV1 is involved in the regulation of neurotransmitter release, including glutamate and substance P. 3. **Immune Response**: TRPV1 is expressed on immune cells, such as microglia and macrophages, and plays a role in the detection of pathogens and the regulation of immune responses. 4. **Pain Modulation**: TRPV1 is involved in the regulation of pain perception, with activation of the receptor leading to the release of pain-relieving neurotransmitters, such as endorphins. 5. **Regulation of Blood Pressure**: TRPV1 is also involved in the regulation of blood pressure, with activation of the receptor leading to the release of vasoconstrictors, such as endothelin-1. **Clinical Significance** 1. **Pain Management**: TRPV1 is a target for pain management, with the development of TRPV1 antagonists, such as capsaicin, as a potential treatment for chronic pain. 2. **Neurological Disorders**: TRPV1 is involved in various neurological disorders, including multiple sclerosis, Parkinson's disease, and Alzheimer's disease. 3. **Immune-Mediated Diseases**: TRPV1 is involved in the regulation of immune responses, with aberrant expression of the receptor contributing to autoimmune diseases, such as rheumatoid arthritis. 4. **Cancer**: TRPV1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is involved in the regulation of tumor growth and metastasis. 5. **Therapeutic Applications**: TRPV1 is a potential target for the development of novel therapeutic agents, including analgesics, immunomodulators, and anti-cancer therapies. In conclusion, the TRPV1 gene plays a crucial role in the detection of various stimuli, including temperature, pain, and chemical substances, and is involved in various physiological and pathological processes. Understanding the mechanisms of TRPV1 activation and regulation is essential for the development of novel therapeutic agents for the treatment of various diseases, including pain management, neurological disorders, and cancer.

Genular Protein ID: 2438404325

Symbol: TRPV1_HUMAN

Name: Transient receptor potential cation channel subfamily V member 1

UniProtKB Accession Codes:

Q8NER1 A2RUA9 Q3LU47 Q9H0G9 Q9H303 Q9H304 Q9NQ74 Q9NY22

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 18 DrugCentral 1 EMBL 11 EMDB 3 Ensembl 4 ExpressionAtlas 1 GO 55 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11050376

Title: Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.

PubMed ID: 11050376

DOI: 10.1016/s0304-3959(00)00353-5

PubMed ID: 11243859

Title: The tissue distribution and functional characterization of human VR1.

PubMed ID: 11243859

DOI: 10.1006/bbrc.2001.4482

PubMed ID: 11226139

Title: Pharmacological differences between human and rat vanilloid receptor 1 (VR1).

PubMed ID: 11226139

DOI: 10.1038/sj.bjp.0703918

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12077606

Title: TRPV3 is a temperature-sensitive vanilloid receptor-like protein.

PubMed ID: 12077606

DOI: 10.1038/nature00894

PubMed ID: 14987252

Title: Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures.

PubMed ID: 14987252

DOI: 10.1111/j.0906-6705.2004.0178.x

PubMed ID: 14996838

Title: Molecular determinants of vanilloid sensitivity in TRPV1.

PubMed ID: 14996838

DOI: 10.1074/jbc.m312577200

PubMed ID: 29656858

Title: A recurrent de novo PACS2 heterozygous missense variant causes neonatal-onset developmental epileptic encephalopathy, facial dysmorphism, and cerebellar dysgenesis.

PubMed ID: 29656858

DOI: 10.1016/j.ajhg.2018.03.005

Sequence Information:

  • Length: 839
  • Mass: 94956
  • Checksum: 7142F59D428827FB
  • Sequence:
    • MKKWSSTDLG AAADPLQKDT CPDPLDGDPN SRPPPAKPQL STAKSRTRLF GKGDSEEAFP 
VDCPHEEGEL DSCPTITVSP VITIQRPGDG PTGARLLSQD SVAASTEKTL RLYDRRSIFE 
AVAQNNCQDL ESLLLFLQKS KKHLTDNEFK DPETGKTCLL KAMLNLHDGQ NTTIPLLLEI 
ARQTDSLKEL VNASYTDSYY KGQTALHIAI ERRNMALVTL LVENGADVQA AAHGDFFKKT 
KGRPGFYFGE LPLSLAACTN QLGIVKFLLQ NSWQTADISA RDSVGNTVLH ALVEVADNTA 
DNTKFVTSMY NEILMLGAKL HPTLKLEELT NKKGMTPLAL AAGTGKIGVL AYILQREIQE 
PECRHLSRKF TEWAYGPVHS SLYDLSCIDT CEKNSVLEVI AYSSSETPNR HDMLLVEPLN 
RLLQDKWDRF VKRIFYFNFL VYCLYMIIFT MAAYYRPVDG LPPFKMEKTG DYFRVTGEIL 
SVLGGVYFFF RGIQYFLQRR PSMKTLFVDS YSEMLFFLQS LFMLATVVLY FSHLKEYVAS 
MVFSLALGWT NMLYYTRGFQ QMGIYAVMIE KMILRDLCRF MFVYIVFLFG FSTAVVTLIE 
DGKNDSLPSE STSHRWRGPA CRPPDSSYNS LYSTCLELFK FTIGMGDLEF TENYDFKAVF 
IILLLAYVIL TYILLLNMLI ALMGETVNKI AQESKNIWKL QRAITILDTE KSFLKCMRKA 
FRSGKLLQVG YTPDGKDDYR WCFRVDEVNW TTWNTNVGII NEDPGNCEGV KRTLSFSLRS 
SRVSGRHWKN FALVPLLREA SARDRQSAQP EEVYLRQFSG SLKPEDAEVF KSPAASGEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.