Details for: WARS1

Gene ID: 7453

Symbol: WARS1

Ensembl ID: ENSG00000140105

Description: tryptophanyl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 173.1651
    Cell Significance Index: -26.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.9074
    Cell Significance Index: -27.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 67.9698
    Cell Significance Index: -28.0000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.5460
    Cell Significance Index: -31.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.2040
    Cell Significance Index: -33.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.8029
    Cell Significance Index: -28.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2516
    Cell Significance Index: -28.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.4836
    Cell Significance Index: -14.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.2430
    Cell Significance Index: 36.4600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.9284
    Cell Significance Index: 56.5000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.9552
    Cell Significance Index: 54.6200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.7933
    Cell Significance Index: 44.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1087
    Cell Significance Index: 32.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6882
    Cell Significance Index: 138.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6446
    Cell Significance Index: 104.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6433
    Cell Significance Index: 69.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5703
    Cell Significance Index: 34.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4750
    Cell Significance Index: 259.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3862
    Cell Significance Index: 5.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3689
    Cell Significance Index: 333.1000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3641
    Cell Significance Index: 2.2000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.3481
    Cell Significance Index: 2.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2808
    Cell Significance Index: 100.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2506
    Cell Significance Index: 49.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2273
    Cell Significance Index: 157.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2136
    Cell Significance Index: 5.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1974
    Cell Significance Index: 24.2700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1947
    Cell Significance Index: 3.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1943
    Cell Significance Index: 35.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1727
    Cell Significance Index: 32.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1486
    Cell Significance Index: 14.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1204
    Cell Significance Index: 3.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1164
    Cell Significance Index: 51.4700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1073
    Cell Significance Index: 1.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1072
    Cell Significance Index: 14.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1066
    Cell Significance Index: 13.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0644
    Cell Significance Index: 2.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0628
    Cell Significance Index: 47.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0469
    Cell Significance Index: 5.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0457
    Cell Significance Index: 3.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0415
    Cell Significance Index: 1.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0397
    Cell Significance Index: 1.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0082
    Cell Significance Index: 15.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0050
    Cell Significance Index: 0.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0006
    Cell Significance Index: 0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0092
    Cell Significance Index: -14.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0119
    Cell Significance Index: -16.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0123
    Cell Significance Index: -7.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0309
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0324
    Cell Significance Index: -23.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0339
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0355
    Cell Significance Index: -26.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0403
    Cell Significance Index: -1.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0454
    Cell Significance Index: -20.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0483
    Cell Significance Index: -8.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0498
    Cell Significance Index: -28.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0525
    Cell Significance Index: -32.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0530
    Cell Significance Index: -1.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0603
    Cell Significance Index: -1.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0658
    Cell Significance Index: -4.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0735
    Cell Significance Index: -9.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0815
    Cell Significance Index: -23.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0872
    Cell Significance Index: -12.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0885
    Cell Significance Index: -6.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1118
    Cell Significance Index: -3.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1136
    Cell Significance Index: -5.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1153
    Cell Significance Index: -7.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1155
    Cell Significance Index: -6.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1180
    Cell Significance Index: -5.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1204
    Cell Significance Index: -3.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1406
    Cell Significance Index: -9.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1524
    Cell Significance Index: -17.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1567
    Cell Significance Index: -33.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1633
    Cell Significance Index: -10.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1825
    Cell Significance Index: -9.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1919
    Cell Significance Index: -14.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2186
    Cell Significance Index: -11.0500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2410
    Cell Significance Index: -3.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2631
    Cell Significance Index: -27.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2732
    Cell Significance Index: -15.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3104
    Cell Significance Index: -5.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3296
    Cell Significance Index: -6.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3468
    Cell Significance Index: -3.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3569
    Cell Significance Index: -11.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3789
    Cell Significance Index: -30.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4056
    Cell Significance Index: -4.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4587
    Cell Significance Index: -9.7700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4653
    Cell Significance Index: -6.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4670
    Cell Significance Index: -11.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4980
    Cell Significance Index: -12.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4993
    Cell Significance Index: -13.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5261
    Cell Significance Index: -14.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5412
    Cell Significance Index: -22.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5818
    Cell Significance Index: -18.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5872
    Cell Significance Index: -20.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5892
    Cell Significance Index: -19.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6117
    Cell Significance Index: -21.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6355
    Cell Significance Index: -10.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6384
    Cell Significance Index: -13.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The WARS1 gene encodes a protein that is involved in the aminoacylation of tryptophan-tRNA, a crucial step in protein synthesis. This protein has been shown to have a high degree of specificity for tryptophan, with a low affinity for other amino acids. The WARS1 protein is also known to interact with various proteins, including interferon-induced protein 53 (SYWC_HUMAN), which is a key player in the regulation of immune responses. The protein has a high degree of homology with other tryptophanyl-tRNA synthetases, suggesting that it plays a conserved role in protein synthesis. **Pathways and Functions** The WARS1 gene is involved in multiple signaling pathways, including: 1. **Angiogenesis**: The WARS1 protein has been shown to regulate angiogenesis, a process critical for tumor growth and metastasis. The protein interacts with vascular endothelial growth factor (VEGF) and other angiogenic factors to promote tube formation and endothelial cell migration. 2. **Protein Kinase Activity**: The WARS1 protein has been shown to interact with various protein kinases, including those involved in the regulation of cell proliferation and survival. The protein can inhibit the activity of certain protein kinases, while also regulating the activity of others. 3. **Gene Expression**: The WARS1 protein has been shown to regulate gene expression by interacting with transcription factors and other regulatory proteins. The protein can either stimulate or inhibit the expression of specific genes, depending on the context. 4. **Translation**: The WARS1 protein is involved in the regulation of protein synthesis, including the aminoacylation of tryptophan-tRNA. The protein can also regulate the translation of specific mRNAs, including those involved in angiogenesis and cell proliferation. **Clinical Significance** The dysregulation of WARS1 has been implicated in several diseases, including: 1. **Cancer**: The WARS1 protein has been shown to promote tumor growth and metastasis by regulating angiogenesis and protein kinase activity. 2. **Cardiovascular Disorders**: The WARS1 protein has been implicated in the regulation of endothelial cell function and angiogenesis, which is critical for the development of cardiovascular disorders. 3. **Autoimmune Diseases**: The WARS1 protein has been shown to interact with various immune regulatory proteins, including those involved in the regulation of immune responses and inflammation. In conclusion, the WARS1 gene plays a critical role in the regulation of various cellular processes, including protein synthesis, cell proliferation, and angiogenesis. The dysregulation of WARS1 has been implicated in several diseases, including cancer and cardiovascular disorders. Further research is needed to fully understand the clinical significance of WARS1 and its role in human disease.

Genular Protein ID: 2975180354

Symbol: SYWC_HUMAN

Name: Interferon-induced protein 53

UniProtKB Accession Codes:

P23381 A6NGN1 A6NID3 P78535 Q502Y0 Q53XB6 Q9UDI5 Q9UDL3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 7 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 21 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 12 Rhea 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1761529

Title: Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts.

PubMed ID: 1761529

DOI: 10.1016/s0021-9258(18)54219-8

PubMed ID: 1763065

Title: Human interferon gamma potently induces the synthesis of a 55-kDa protein (gamma 2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase.

PubMed ID: 1763065

DOI: 10.1073/pnas.88.24.11520

PubMed ID: 1765274

Title: Cloning and nucleotide sequence of the structural gene encoding for human tryptophanyl-tRNA synthetase.

PubMed ID: 1765274

DOI: 10.1016/0378-1119(91)90624-k

PubMed ID: 1537332

Title: Molecular cloning and characterization of an interferon induced human cDNA with sequence homology to a mammalian peptide chain release factor.

PubMed ID: 1537332

DOI: 10.1002/j.1460-2075.1992.tb05079.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8724762

Title: Alternative splicing of 5'-terminal exons of the human tryptophanyl-tRNA synthetase gene.

PubMed ID: 8724762

PubMed ID: 7685728

Title: The human gene encoding tryptophanyl-tRNA synthetase: interferon-response elements and exon-intron organization.

PubMed ID: 7685728

DOI: 10.1016/0378-1119(93)90568-n

PubMed ID: 8496617

Title: Gamma interferon potently induces tryptophanyl-tRNA synthetase expression in human keratinocytes.

PubMed ID: 8496617

DOI: 10.1111/1523-1747.ep12476463

PubMed ID: 11773626

Title: A human aminoacyl-tRNA synthetase as a regulator of angiogenesis.

PubMed ID: 11773626

DOI: 10.1073/pnas.012602099

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 1373391

Title: An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase.

PubMed ID: 1373391

DOI: 10.1016/0014-5793(92)80187-l

PubMed ID: 7814400

Title: Transcriptional regulation of the interferon-gamma-inducible tryptophanyl-tRNA synthetase includes alternative splicing.

PubMed ID: 7814400

DOI: 10.1074/jbc.270.1.397

PubMed ID: 11773625

Title: A fragment of human TrpRS as a potent antagonist of ocular angiogenesis.

PubMed ID: 11773625

DOI: 10.1073/pnas.012601899

PubMed ID: 14630953

Title: Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells.

PubMed ID: 14630953

DOI: 10.1073/pnas.2436330100

PubMed ID: 15628863

Title: Oxidative stress-responsive intracellular regulation specific for the angiostatic form of human tryptophanyl-tRNA synthetase.

PubMed ID: 15628863

DOI: 10.1021/bi048313k

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28369220

Title: A recurrent WARS mutation is a novel cause of autosomal dominant distal hereditary motor neuropathy.

PubMed ID: 28369220

DOI: 10.1093/brain/awx058

PubMed ID: 14671330

Title: Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains.

PubMed ID: 14671330

DOI: 10.1073/pnas.2136794100

PubMed ID: 14660560

Title: Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity.

PubMed ID: 14660560

DOI: 10.1074/jbc.m311284200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 34585293

Title: Four pedigrees with aminoacyl-tRNA synthetase abnormalities.

PubMed ID: 34585293

DOI: 10.1007/s10072-021-05626-z

PubMed ID: 31321409

Title: A novel WARS mutation causes distal hereditary motor neuropathy in a Chinese family.

PubMed ID: 31321409

DOI: 10.1093/brain/awz218

PubMed ID: 31069783

Title: A novel WARS mutation (p.Asp314Gly) identified in a Chinese distal hereditary motor neuropathy family.

PubMed ID: 31069783

DOI: 10.1111/cge.13563

PubMed ID: 35790048

Title: WARS1 and SARS1: Two tRNA synthetases implicated in autosomal recessive microcephaly.

PubMed ID: 35790048

DOI: 10.1002/humu.24430

PubMed ID: 35815345

Title: Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function.

PubMed ID: 35815345

DOI: 10.1002/humu.24435

Sequence Information:

  • Length: 471
  • Mass: 53165
  • Checksum: E96344449053A0D0
  • Sequence:
    • MPNSEPASLL ELFNSIATQG ELVRSLKAGN ASKDEIDSAV KMLVSLKMSY KAAAGEDYKA 
DCPPGNPAPT SNHGPDATEA EEDFVDPWTV QTSSAKGIDY DKLIVRFGSS KIDKELINRI 
ERATGQRPHH FLRRGIFFSH RDMNQVLDAY ENKKPFYLYT GRGPSSEAMH VGHLIPFIFT 
KWLQDVFNVP LVIQMTDDEK YLWKDLTLDQ AYSYAVENAK DIIACGFDIN KTFIFSDLDY 
MGMSSGFYKN VVKIQKHVTF NQVKGIFGFT DSDCIGKISF PAIQAAPSFS NSFPQIFRDR 
TDIQCLIPCA IDQDPYFRMT RDVAPRIGYP KPALLHSTFF PALQGAQTKM SASDPNSSIF 
LTDTAKQIKT KVNKHAFSGG RDTIEEHRQF GGNCDVDVSF MYLTFFLEDD DKLEQIRKDY 
TSGAMLTGEL KKALIEVLQP LIAEHQARRK EVTDEIVKEF MTPRKLSFDF Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.