Details for: WNT2B

Gene ID: 7482

Symbol: WNT2B

Ensembl ID: ENSG00000134245

Description: Wnt family member 2B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.35
    Marker Score: 6407
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169071
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.46
    Marker Score: 14653
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.42
    Marker Score: 455
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.14
    Marker Score: 1434
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.14
    Marker Score: 567
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.12
    Marker Score: 667
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.05
    Marker Score: 1529
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.03
    Marker Score: 2094
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.03
    Marker Score: 371
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48031
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15139
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.96
    Marker Score: 4038
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.94
    Marker Score: 455
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5169
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.9
    Marker Score: 959.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.86
    Marker Score: 292
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.8
    Marker Score: 852
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1251
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.75
    Marker Score: 1151
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3069
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 234
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 651
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.71
    Marker Score: 6119
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.68
    Marker Score: 7031
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.67
    Marker Score: 2724
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.66
    Marker Score: 753
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.66
    Marker Score: 713
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.65
    Marker Score: 206
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.65
    Marker Score: 178
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.63
    Marker Score: 583
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.63
    Marker Score: 369
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.61
    Marker Score: 744
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.61
    Marker Score: 3653
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.6
    Marker Score: 22200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.59
    Marker Score: 36273
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 182
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.57
    Marker Score: 1336
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.57
    Marker Score: 706
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.56
    Marker Score: 223
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 351
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.54
    Marker Score: 132
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.52
    Marker Score: 1462
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.51
    Marker Score: 2106
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.51
    Marker Score: 495.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.5
    Marker Score: 9957
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5
    Marker Score: 551
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.49
    Marker Score: 1750.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.49
    Marker Score: 662
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.48
    Marker Score: 4559
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.48
    Marker Score: 201
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.47
    Marker Score: 7094
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.47
    Marker Score: 134
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.46
    Marker Score: 664
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.46
    Marker Score: 190
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.45
    Marker Score: 528
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.45
    Marker Score: 198
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.44
    Marker Score: 566
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.44
    Marker Score: 128
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.44
    Marker Score: 1107
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.43
    Marker Score: 1089
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.42
    Marker Score: 3152
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.42
    Marker Score: 95
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.42
    Marker Score: 3985
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 111
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.42
    Marker Score: 114
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.41
    Marker Score: 3125
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.41
    Marker Score: 784
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.41
    Marker Score: 268
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 244
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.41
    Marker Score: 501
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4
    Marker Score: 1562
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.4
    Marker Score: 431
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.39
    Marker Score: 170
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.39
    Marker Score: 401
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.39
    Marker Score: 1372
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.38
    Marker Score: 142
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.38
    Marker Score: 14496
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.38
    Marker Score: 97
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.37
    Marker Score: 236
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.37
    Marker Score: 319
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.37
    Marker Score: 205
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 174
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.36
    Marker Score: 324
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.36
    Marker Score: 606
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.35
    Marker Score: 183

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Other Information

**Key Characteristics:** WNT2B is a ligand of the Wnt family, which is a group of signaling molecules involved in various cellular processes. WNT2B is specifically expressed in several cell types, including ovarian surface epithelial cells, mural cells, granulosa cells, and primordial germ cells. Its expression is also detected in immune cells, such as central nervous system macrophages, cerebral cortex endothelial cells, and mature microglial cells. WNT2B's expression is often regulated by various transcription factors, including β-catenin and TCF/LEF transcription factors. **Pathways and Functions:** WNT2B's signaling pathway is closely associated with the canonical Wnt signaling pathway, which is a key regulator of cell fate commitment, differentiation, and proliferation. WNT2B interacts with Frizzled receptors and co-receptors, such as LRP5/6, to activate the canonical Wnt signaling pathway. This pathway is involved in various cellular processes, including: 1. **Cell fate commitment**: WNT2B regulates the differentiation of stem cells into specific cell types, such as neuronal cells and chondrocytes. 2. **Cellular response to starvation**: WNT2B is involved in the regulation of cellular metabolism and energy homeostasis in response to nutrient deprivation. 3. **Hematopoietic stem cell proliferation**: WNT2B regulates the proliferation and differentiation of hematopoietic stem cells. 4. **Cytokine activity**: WNT2B modulates the production of cytokines, which are essential for immune responses. **Clinical Significance:** WNT2B's dysregulation has been implicated in various diseases, including: 1. **Cancer**: WNT2B's overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Autoimmune diseases**: WNT2B's dysregulation has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurodegenerative diseases**: WNT2B's dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Developmental disorders**: WNT2B's dysregulation has been linked to developmental disorders, such as Down syndrome and congenital heart defects. In conclusion, WNT2B is a multifunctional gene that plays a critical role in various cellular processes, including cell fate commitment, differentiation, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying WNT2B's function and its clinical implications. **Recommendations:** 1. **Further research**: Investigate the mechanisms underlying WNT2B's function and its clinical implications in different diseases. 2. **Therapeutic targeting**: Explore the potential of targeting WNT2B as a therapeutic strategy for treating various diseases. 3. **Immunological applications**: Investigate the potential of WNT2B as a biomarker for immune-related diseases and develop immunotherapeutic strategies. By unraveling the mysteries of WNT2B, we can gain a deeper understanding of its immunological significance and clinical implications, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1186558414

Symbol: WNT2B_HUMAN

Name: Protein Wnt-2b

UniProtKB Accession Codes:

Q93097 O14903 Q5TEH9 Q5TEI2 Q9HDC1 Q9HDC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8761309

Title: Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family.

PubMed ID: 8761309

PubMed ID: 10944466

Title: Alternative splicing of the WNT-2B/WNT-13 gene.

PubMed ID: 10944466

DOI: 10.1006/bbrc.2000.3252

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9441749

Title: Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.

PubMed ID: 9441749

DOI: 10.1006/geno.1997.5041

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

PubMed ID: 29909964

Title: Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations.

PubMed ID: 29909964

DOI: 10.1016/j.ajhg.2018.05.007

Sequence Information:

  • Length: 391
  • Mass: 43770
  • Checksum: BD7BB7F795FB33B1
  • Sequence:
    • MLRPGGAEEA AQLPLRRASA PVPVPSPAAP DGSRASARLG LACLLLLLLL TLPARVDTSW 
WYIGALGARV ICDNIPGLVS RQRQLCQRYP DIMRSVGEGA REWIRECQHQ FRHHRWNCTT 
LDRDHTVFGR VMLRSSREAA FVYAISSAGV VHAITRACSQ GELSVCSCDP YTRGRHHDQR 
GDFDWGGCSD NIHYGVRFAK AFVDAKEKRL KDARALMNLH NNRCGRTAVR RFLKLECKCH 
GVSGSCTLRT CWRALSDFRR TGDYLRRRYD GAVQVMATQD GANFTAARQG YRRATRTDLV 
YFDNSPDYCV LDKAAGSLGT AGRVCSKTSK GTDGCEIMCC GRGYDTTRVT RVTQCECKFH 
WCCAVRCKEC RNTVDVHTCK APKKAEWLDQ T

Genular Protein ID: 2520410377

Symbol: Q5TEH8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5TEH8

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMART 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 299
  • Mass: 33945
  • Checksum: D6540DC48F592C09
  • Sequence:
    • MRSVGEGARE WIRECQHQFR HHRWNCTTLD RDHTVFGRVM LRSSREAAFV YAISSAGVVH 
AITRACSQGE LSVCSCDPYT RGRHHDQRGD FDWGGCSDNI HYGVRFAKAF VDAKEKRLKD 
ARALMNLHNN RCGRTAVRRF LKLECKCHGV SGSCTLRTCW RALSDFRRTG DYLRRRYDGA 
VQVMATQDGA NFTAARQGYR RATRTDLVYF DNSPDYCVLD KAAGSLGTAG RVCSKTSKGT 
DGCEIMCCGR GYDTTRVTRV TQCECKFHWC CAVRCKECRN TVDVHTCKAP KKAEWLDQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.