Details for: WNT2B

Gene ID: 7482

Symbol: WNT2B

Ensembl ID: ENSG00000134245

Description: Wnt family member 2B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 110.0002
    Cell Significance Index: -17.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.6935
    Cell Significance Index: -17.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 36.9184
    Cell Significance Index: -17.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.0110
    Cell Significance Index: -17.2800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 6.6783
    Cell Significance Index: 32.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0770
    Cell Significance Index: -13.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4221
    Cell Significance Index: -17.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2879
    Cell Significance Index: -13.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1706
    Cell Significance Index: 29.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9247
    Cell Significance Index: 13.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7193
    Cell Significance Index: 71.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6807
    Cell Significance Index: 614.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6797
    Cell Significance Index: 42.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.6045
    Cell Significance Index: 9.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5687
    Cell Significance Index: 11.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5403
    Cell Significance Index: 15.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5136
    Cell Significance Index: 7.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5045
    Cell Significance Index: 10.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3893
    Cell Significance Index: 63.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3668
    Cell Significance Index: 39.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3666
    Cell Significance Index: 69.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2807
    Cell Significance Index: 16.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2759
    Cell Significance Index: 55.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2547
    Cell Significance Index: 50.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2352
    Cell Significance Index: 5.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1969
    Cell Significance Index: 13.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1900
    Cell Significance Index: 8.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1761
    Cell Significance Index: 5.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1679
    Cell Significance Index: 60.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1505
    Cell Significance Index: 5.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1476
    Cell Significance Index: 102.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1331
    Cell Significance Index: 16.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1212
    Cell Significance Index: 5.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1115
    Cell Significance Index: 20.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1114
    Cell Significance Index: 6.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0844
    Cell Significance Index: 6.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0792
    Cell Significance Index: 149.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0771
    Cell Significance Index: 8.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0462
    Cell Significance Index: 1.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0421
    Cell Significance Index: 1.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0344
    Cell Significance Index: 18.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0339
    Cell Significance Index: 4.6500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0331
    Cell Significance Index: 0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0329
    Cell Significance Index: 50.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0259
    Cell Significance Index: 16.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0215
    Cell Significance Index: 9.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0199
    Cell Significance Index: 36.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0120
    Cell Significance Index: 16.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0101
    Cell Significance Index: 0.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0030
    Cell Significance Index: -0.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0099
    Cell Significance Index: -0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0107
    Cell Significance Index: -0.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0173
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0176
    Cell Significance Index: -13.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0179
    Cell Significance Index: -8.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0215
    Cell Significance Index: -15.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0232
    Cell Significance Index: -17.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0276
    Cell Significance Index: -7.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0293
    Cell Significance Index: -16.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0304
    Cell Significance Index: -18.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0525
    Cell Significance Index: -7.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0612
    Cell Significance Index: -1.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0638
    Cell Significance Index: -8.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0661
    Cell Significance Index: -11.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0725
    Cell Significance Index: -8.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0837
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0839
    Cell Significance Index: -17.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1212
    Cell Significance Index: -15.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1316
    Cell Significance Index: -8.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1335
    Cell Significance Index: -15.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1349
    Cell Significance Index: -13.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1354
    Cell Significance Index: -3.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1363
    Cell Significance Index: -14.1900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1422
    Cell Significance Index: -1.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1436
    Cell Significance Index: -7.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1479
    Cell Significance Index: -6.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1660
    Cell Significance Index: -3.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1936
    Cell Significance Index: -13.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1976
    Cell Significance Index: -4.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2084
    Cell Significance Index: -10.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2225
    Cell Significance Index: -10.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2229
    Cell Significance Index: -16.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2243
    Cell Significance Index: -14.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2251
    Cell Significance Index: -11.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2276
    Cell Significance Index: -3.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2529
    Cell Significance Index: -8.1000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2587
    Cell Significance Index: -3.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2680
    Cell Significance Index: -5.5600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2958
    Cell Significance Index: -4.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2976
    Cell Significance Index: -7.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3012
    Cell Significance Index: -15.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3017
    Cell Significance Index: -6.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3603
    Cell Significance Index: -5.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3790
    Cell Significance Index: -12.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3842
    Cell Significance Index: -10.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3939
    Cell Significance Index: -13.8000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.4045
    Cell Significance Index: -4.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4091
    Cell Significance Index: -13.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4101
    Cell Significance Index: -14.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4122
    Cell Significance Index: -15.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** WNT2B is a ligand of the Wnt family, which is a group of signaling molecules involved in various cellular processes. WNT2B is specifically expressed in several cell types, including ovarian surface epithelial cells, mural cells, granulosa cells, and primordial germ cells. Its expression is also detected in immune cells, such as central nervous system macrophages, cerebral cortex endothelial cells, and mature microglial cells. WNT2B's expression is often regulated by various transcription factors, including β-catenin and TCF/LEF transcription factors. **Pathways and Functions:** WNT2B's signaling pathway is closely associated with the canonical Wnt signaling pathway, which is a key regulator of cell fate commitment, differentiation, and proliferation. WNT2B interacts with Frizzled receptors and co-receptors, such as LRP5/6, to activate the canonical Wnt signaling pathway. This pathway is involved in various cellular processes, including: 1. **Cell fate commitment**: WNT2B regulates the differentiation of stem cells into specific cell types, such as neuronal cells and chondrocytes. 2. **Cellular response to starvation**: WNT2B is involved in the regulation of cellular metabolism and energy homeostasis in response to nutrient deprivation. 3. **Hematopoietic stem cell proliferation**: WNT2B regulates the proliferation and differentiation of hematopoietic stem cells. 4. **Cytokine activity**: WNT2B modulates the production of cytokines, which are essential for immune responses. **Clinical Significance:** WNT2B's dysregulation has been implicated in various diseases, including: 1. **Cancer**: WNT2B's overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Autoimmune diseases**: WNT2B's dysregulation has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurodegenerative diseases**: WNT2B's dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Developmental disorders**: WNT2B's dysregulation has been linked to developmental disorders, such as Down syndrome and congenital heart defects. In conclusion, WNT2B is a multifunctional gene that plays a critical role in various cellular processes, including cell fate commitment, differentiation, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying WNT2B's function and its clinical implications. **Recommendations:** 1. **Further research**: Investigate the mechanisms underlying WNT2B's function and its clinical implications in different diseases. 2. **Therapeutic targeting**: Explore the potential of targeting WNT2B as a therapeutic strategy for treating various diseases. 3. **Immunological applications**: Investigate the potential of WNT2B as a biomarker for immune-related diseases and develop immunotherapeutic strategies. By unraveling the mysteries of WNT2B, we can gain a deeper understanding of its immunological significance and clinical implications, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1186558414

Symbol: WNT2B_HUMAN

Name: Protein Wnt-2b

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8761309

Title: Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family.

PubMed ID: 8761309

PubMed ID: 10944466

Title: Alternative splicing of the WNT-2B/WNT-13 gene.

PubMed ID: 10944466

DOI: 10.1006/bbrc.2000.3252

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9441749

Title: Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.

PubMed ID: 9441749

DOI: 10.1006/geno.1997.5041

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

PubMed ID: 29909964

Title: Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations.

PubMed ID: 29909964

DOI: 10.1016/j.ajhg.2018.05.007

Sequence Information:

  • Length: 391
  • Mass: 43770
  • Checksum: BD7BB7F795FB33B1
  • Sequence:
  • MLRPGGAEEA AQLPLRRASA PVPVPSPAAP DGSRASARLG LACLLLLLLL TLPARVDTSW 
    WYIGALGARV ICDNIPGLVS RQRQLCQRYP DIMRSVGEGA REWIRECQHQ FRHHRWNCTT 
    LDRDHTVFGR VMLRSSREAA FVYAISSAGV VHAITRACSQ GELSVCSCDP YTRGRHHDQR 
    GDFDWGGCSD NIHYGVRFAK AFVDAKEKRL KDARALMNLH NNRCGRTAVR RFLKLECKCH 
    GVSGSCTLRT CWRALSDFRR TGDYLRRRYD GAVQVMATQD GANFTAARQG YRRATRTDLV 
    YFDNSPDYCV LDKAAGSLGT AGRVCSKTSK GTDGCEIMCC GRGYDTTRVT RVTQCECKFH 
    WCCAVRCKEC RNTVDVHTCK APKKAEWLDQ T

Genular Protein ID: 2520410377

Symbol: Q5TEH8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 299
  • Mass: 33945
  • Checksum: D6540DC48F592C09
  • Sequence:
  • MRSVGEGARE WIRECQHQFR HHRWNCTTLD RDHTVFGRVM LRSSREAAFV YAISSAGVVH 
    AITRACSQGE LSVCSCDPYT RGRHHDQRGD FDWGGCSDNI HYGVRFAKAF VDAKEKRLKD 
    ARALMNLHNN RCGRTAVRRF LKLECKCHGV SGSCTLRTCW RALSDFRRTG DYLRRRYDGA 
    VQVMATQDGA NFTAARQGYR RATRTDLVYF DNSPDYCVLD KAAGSLGTAG RVCSKTSKGT 
    DGCEIMCCGR GYDTTRVTRV TQCECKFHWC CAVRCKECRN TVDVHTCKAP KKAEWLDQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.