Details for: XPNPEP1

Gene ID: 7511

Symbol: XPNPEP1

Ensembl ID: ENSG00000108039

Description: X-prolyl aminopeptidase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 157.4462
    Cell Significance Index: -24.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.2986
    Cell Significance Index: -22.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 70.9313
    Cell Significance Index: -29.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.2598
    Cell Significance Index: -28.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.2205
    Cell Significance Index: -24.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.0925
    Cell Significance Index: -27.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.3831
    Cell Significance Index: -28.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.6980
    Cell Significance Index: -24.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.4931
    Cell Significance Index: -26.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9497
    Cell Significance Index: -23.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8119
    Cell Significance Index: -26.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6639
    Cell Significance Index: 1502.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5664
    Cell Significance Index: 94.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3579
    Cell Significance Index: 147.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9459
    Cell Significance Index: 19.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8898
    Cell Significance Index: 178.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7468
    Cell Significance Index: 16.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7205
    Cell Significance Index: 49.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5908
    Cell Significance Index: 211.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5626
    Cell Significance Index: 96.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5324
    Cell Significance Index: 62.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.5217
    Cell Significance Index: 75.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4859
    Cell Significance Index: 22.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4143
    Cell Significance Index: 56.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3859
    Cell Significance Index: 210.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3518
    Cell Significance Index: 4.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3301
    Cell Significance Index: 65.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2973
    Cell Significance Index: 15.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2840
    Cell Significance Index: 54.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2780
    Cell Significance Index: 7.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2533
    Cell Significance Index: 11.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2409
    Cell Significance Index: 12.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2153
    Cell Significance Index: 38.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2038
    Cell Significance Index: 15.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1996
    Cell Significance Index: 138.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1981
    Cell Significance Index: 13.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1705
    Cell Significance Index: 8.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1645
    Cell Significance Index: 10.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1598
    Cell Significance Index: 19.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1562
    Cell Significance Index: 7.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1487
    Cell Significance Index: 14.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1449
    Cell Significance Index: 18.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1405
    Cell Significance Index: 5.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1345
    Cell Significance Index: 4.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1324
    Cell Significance Index: 58.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1318
    Cell Significance Index: 5.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1168
    Cell Significance Index: 14.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1043
    Cell Significance Index: 2.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1009
    Cell Significance Index: 189.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0798
    Cell Significance Index: 9.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0790
    Cell Significance Index: 2.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0681
    Cell Significance Index: 1.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0339
    Cell Significance Index: 21.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0243
    Cell Significance Index: 37.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0183
    Cell Significance Index: 33.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0125
    Cell Significance Index: 17.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0082
    Cell Significance Index: 0.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0075
    Cell Significance Index: 0.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0017
    Cell Significance Index: 0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0018
    Cell Significance Index: -0.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0084
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0170
    Cell Significance Index: -9.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0188
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0190
    Cell Significance Index: -13.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0190
    Cell Significance Index: -11.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0226
    Cell Significance Index: -17.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0523
    Cell Significance Index: -5.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0591
    Cell Significance Index: -1.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0605
    Cell Significance Index: -3.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0705
    Cell Significance Index: -14.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0772
    Cell Significance Index: -22.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0887
    Cell Significance Index: -10.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0988
    Cell Significance Index: -16.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1018
    Cell Significance Index: -11.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1050
    Cell Significance Index: -6.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1087
    Cell Significance Index: -7.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1142
    Cell Significance Index: -0.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1145
    Cell Significance Index: -8.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1208
    Cell Significance Index: -6.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1280
    Cell Significance Index: -3.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1284
    Cell Significance Index: -3.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1476
    Cell Significance Index: -2.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1487
    Cell Significance Index: -3.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1791
    Cell Significance Index: -9.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1912
    Cell Significance Index: -2.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2182
    Cell Significance Index: -22.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2450
    Cell Significance Index: -6.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2548
    Cell Significance Index: -6.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2679
    Cell Significance Index: -5.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2737
    Cell Significance Index: -7.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2910
    Cell Significance Index: -6.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3048
    Cell Significance Index: -24.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3194
    Cell Significance Index: -19.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3204
    Cell Significance Index: -11.2600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3532
    Cell Significance Index: -5.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3558
    Cell Significance Index: -8.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3898
    Cell Significance Index: -6.6800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4037
    Cell Significance Index: -5.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4665
    Cell Significance Index: -11.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** XPNPEP1 is a member of the aminopeptidase family, characterized by its ability to remove amino acids from the N-terminus of peptides and proteins. Its unique structure, featuring a manganese ion cofactor, enables it to catalyze the hydrolysis of peptide bonds. This enzyme is also notable for its homodimerization activity, allowing it to form dimers with other XPNPEP1 molecules. Furthermore, XPNPEP1 has been implicated in various cellular processes, including negative regulation of programmed cell death, suggesting its potential role in maintaining tissue homeostasis. **Pathways and Functions:** XPNPEP1 is involved in several key pathways, including: 1. **Aminopeptidase activity**: XPNPEP1's primary function is to remove amino acids from the N-terminus of peptides and proteins, which is essential for regulating protein degradation and signaling pathways. 2. **Bradykinin catabolic process**: XPNPEP1 has been shown to degrade bradykinin, a peptide involved in inflammation and blood pressure regulation. 3. **Cytoplasm and cytosol**: XPNPEP1 is localized to the cytoplasm and cytosol, where it can interact with other proteins and regulate signaling pathways. 4. **Extracellular exosome**: XPNPEP1 has been detected in extracellular exosomes, suggesting its role in regulating communication between cells. 5. **Manganese ion binding**: The manganese ion cofactor is essential for XPNPEP1's enzymatic activity, highlighting the importance of metal ions in regulating enzyme function. 6. **Metalloaminopeptidase activity**: XPNPEP1's metalloaminopeptidase activity allows it to degrade metalloproteins and regulate metal ion homeostasis. 7. **Proteolysis**: XPNPEP1's proteolytic activity is involved in regulating protein degradation and signaling pathways. 8. **Negative regulation of programmed cell death**: XPNPEP1 has been shown to inhibit programmed cell death, suggesting its potential role in maintaining tissue homeostasis. 9. **Protein homodimerization activity**: XPNPEP1's homodimerization activity allows it to form dimers with other XPNPEP1 molecules, regulating its activity and interactions with other proteins. **Clinical Significance:** XPNPEP1's involvement in various cellular processes and pathways highlights its potential role in regulating human disease. Dysregulation of XPNPEP1 has been implicated in several diseases, including: 1. **Neurological disorders**: XPNPEP1's role in regulating neuronal function and survival suggests its potential involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: XPNPEP1's involvement in regulating protein degradation and signaling pathways suggests its potential role in cancer development and progression. 3. **Cardiovascular disease**: XPNPEP1's role in regulating blood pressure and inflammation suggests its potential involvement in cardiovascular disease. 4. **Neurodevelopmental disorders**: XPNPEP1's role in regulating neuronal development and function suggests its potential involvement in neurodevelopmental disorders, such as autism and schizophrenia. In conclusion, XPNPEP1 is a multifaceted enzyme involved in various cellular processes, including protein degradation, signaling pathways, and regulation of programmed cell death. Its significant expression in diverse cell types and its involvement in various disease processes highlight its potential as a therapeutic target for the treatment of human diseases.

Genular Protein ID: 4139068521

Symbol: XPP1_HUMAN

Name: Aminoacylproline aminopeptidase

UniProtKB Accession Codes:

Q9NQW7 A8K071 G5E9Y2 G8JLB2 O15250 Q53EX6 Q8N3Q0 Q96D23

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9465902

Title: Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P).

PubMed ID: 9465902

DOI: 10.1159/000134671

PubMed ID: 10871044

Title: Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2.

PubMed ID: 10871044

DOI: 10.1006/abbi.2000.1792

PubMed ID: 11106490

Title: Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme.

PubMed ID: 11106490

DOI: 10.1021/bi001585c

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 35165443

Title: M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.

PubMed ID: 35165443

DOI: 10.1038/s41589-021-00964-7

PubMed ID: 18515364

Title: Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit.

PubMed ID: 18515364

DOI: 10.1074/jbc.m710274200

Sequence Information:

  • Length: 623
  • Mass: 69918
  • Checksum: DF4F5AF41E2F3876
  • Sequence:
    • MPPKVTSELL RQLRQAMRNS EYVTEPIQAY IIPSGDAHQS EYIAPCDCRR AFVSGFDGSA 
GTAIITEEHA AMWTDGRYFL QAAKQMDSNW TLMKMGLKDT PTQEDWLVSV LPEGSRVGVD 
PLIIPTDYWK KMAKVLRSAG HHLIPVKENL VDKIWTDRPE RPCKPLLTLG LDYTGISWKD 
KVADLRLKMA ERNVMWFVVT ALDEIAWLFN LRGSDVEHNP VFFSYAIIGL ETIMLFIDGD 
RIDAPSVKEH LLLDLGLEAE YRIQVHPYKS ILSELKALCA DLSPREKVWV SDKASYAVSE 
TIPKDHRCCM PYTPICIAKA VKNSAESEGM RRAHIKDAVA LCELFNWLEK EVPKGGVTEI 
SAADKAEEFR RQQADFVDLS FPTISSTGPN GAIIHYAPVP ETNRTLSLDE VYLIDSGAQY 
KDGTTDVTRT MHFGTPTAYE KECFTYVLKG HIAVSAAVFP TGTKGHLLDS FARSALWDSG 
LDYLHGTGHG VGSFLNVHEG PCGISYKTFS DEPLEAGMIV TDEPGYYEDG AFGIRIENVV 
LVVPVKTKYN FNNRGSLTFE PLTLVPIQTK MIDVDSLTDK ECDWLNNYHL TCRDVIGKEL 
QKQGRQEALE WLIRETQPIS KQH

Genular Protein ID: 988429433

Symbol: Q5T6H7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5T6H7

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 2 RefSeq 3 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 552
  • Mass: 62139
  • Checksum: 627539255505E5CE
  • Sequence:
    • MWTDGRYFLQ AAKQMDSNWT LMKMGLKDTP TQEDWLVSVL PEGSRVGVDP LIIPTDYWKK 
MAKVLRSAGH HLIPVKENLV DKIWTDRPER PCKPLLTLGL DYTGISWKDK VADLRLKMAE 
RNVMWFVVTA LDEIAWLFNL RGSDVEHNPV FFSYAIIGLE TIMLFIDGDR IDAPSVKEHL 
LLDLGLEAEY RIQVHPYKSI LSELKALCAD LSPREKVWVS DKASYAVSET IPKDHRCCMP 
YTPICIAKAV KNSAESEGMR RAHIKDAVAL CELFNWLEKE VPKGGVTEIS AADKAEEFRR 
QQADFVDLSF PTISSTGPNG AIIHYAPVPE TNRTLSLDEV YLIDSGAQYK DGTTDVTRTM 
HFGTPTAYEK ECFTYVLKGH IAVSAAVFPT GTKGHLLDSF ARSALWDSGL DYLHGTGHGV 
GSFLNVHEGP CGISYKTFSD EPLEAGMIVT DEPGYYEDGA FGIRIENVVL VVPVKTKYNF 
NNRGSLTFEP LTLVPIQTKM IDVDSLTDKE CDWLNNYHLT CRDVIGKELQ KQGRQEALEW 
LIRETQPISK QH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.