Details for: XPNPEP1
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 10.58rCSI 8.32%PRS 61.93
-
CSI 9.12rCSI 13.35%PRS 52.35
-
CSI 7.13rCSI 30.92%PRS 69.3
-
CSI 5.36rCSI 4.84%PRS 51.97
-
CSI 4.66rCSI 4.96%PRS 67.16
-
CSI 4.66rCSI 18.8%PRS 53.74
-
CSI 3.6rCSI 3.12%PRS 59.84
-
CSI 3.59rCSI 3.52%PRS 71.03
-
CSI 3.5rCSI 9.99%PRS 68.36
-
CSI 3.47rCSI 2.64%PRS 67.81
-
CSI 3.36rCSI 2.34%PRS 65.6
-
CSI 3.35rCSI 4.49%PRS 64.25
-
CSI 3.25rCSI 5.27%PRS 52.46
-
CSI 3.17rCSI 8.04%PRS 49.92
-
CSI 3.13rCSI 6.29%PRS 44.35
-
CSI 3.07rCSI 4.37%PRS 57.68
-
CSI 3.05rCSI 3.89%PRS 61.51
-
CSI 2.99rCSI 6.54%PRS 63.79
-
CSI 2.93rCSI 7.44%PRS 44.88
-
CSI 2.83rCSI 6.35%PRS 73.49
-
CSI 2.78rCSI 2.3%PRS 56.86
-
CSI 2.71rCSI 3.96%PRS 59.07
-
CSI 2.68rCSI 2.79%PRS 55.61
-
CSI 2.67rCSI 1.98%PRS 47.88
-
CSI 2.63rCSI 4.04%PRS 63.66
-
CSI 2.62rCSI 1.83%PRS 57.85
-
CSI 2.61rCSI 2.3%PRS 60.38
-
CSI 2.6rCSI 4.68%PRS 48.22
-
CSI 2.59rCSI 3.11%PRS 53.42
-
CSI 2.55rCSI 9.55%PRS 47.45
-
CSI 2.53rCSI 2.39%PRS 55.04
-
CSI 2.47rCSI 2.3%PRS 55.11
-
CSI 2.43rCSI 1.8%PRS 69.01
-
CSI 2.25rCSI 1.82%PRS 56.38
-
CSI 2.25rCSI 5.14%PRS 54.66
-
CSI 2.24rCSI 3.42%PRS 51.51
-
CSI 2.22rCSI 1.97%PRS 53.42
-
CSI 2.21rCSI 2.37%PRS 53.88
-
CSI 2.15rCSI 3.28%PRS 55.8
-
CSI 2.13rCSI 6.64%PRS 39.17
-
CSI 2.09rCSI 1.61%PRS 54.86
-
CSI 2.09rCSI 2.08%PRS 48.75
-
CSI 2.07rCSI 3.7%PRS 54.01
-
CSI 2.06rCSI 3.56%PRS 45.32
-
CSI 2.02rCSI 4.54%PRS 38.47
-
CSI 2.02rCSI 4.19%PRS 52.45
-
CSI 2.01rCSI 1.59%PRS 42.19
-
CSI 2rCSI 2.38%PRS 37.55
-
CSI 1.99rCSI 1.32%PRS 58.67
-
CSI 1.97rCSI 1.9%PRS 45.63
-
CSI 1.96rCSI 4.47%PRS 47.44
-
CSI 1.92rCSI 1.99%PRS 60.82
-
CSI 1.91rCSI 1.77%PRS 56.29
-
CSI 1.83rCSI 2.06%PRS 71.74
-
CSI 1.82rCSI 1.6%PRS 43.43
-
CSI 1.82rCSI 1.9%PRS 51.95
-
CSI 1.82rCSI 3.18%PRS 47.37
-
CSI 1.8rCSI 1.88%PRS 53.65
-
CSI 1.79rCSI 6.46%PRS 36.36
-
CSI 1.78rCSI 3.14%PRS 52.59
-
CSI 1.77rCSI 1.33%PRS 59.92
-
CSI 1.77rCSI 2.05%PRS 45.05
-
CSI 1.76rCSI 2.65%PRS 58.36
-
CSI 1.73rCSI 2.16%PRS 35.98
-
CSI 1.72rCSI 2.73%PRS 47.61
-
CSI 1.71rCSI 2.12%PRS 57.18
-
CSI 1.7rCSI 2.45%PRS 64.99
-
CSI 1.7rCSI 2.25%PRS 60.76
-
CSI 1.58rCSI 2.27%PRS 60.17
-
CSI 1.57rCSI 1.06%PRS 67.61
-
CSI 1.56rCSI 2.49%PRS 48.1
-
CSI 1.54rCSI 2.88%PRS 43.9
-
CSI 1.53rCSI 2.01%PRS 68.72
-
CSI 1.52rCSI 2.68%PRS 36.74
-
CSI 1.5rCSI 4.87%PRS 56.63
-
CSI 1.5rCSI 2.05%PRS 63.33
-
CSI 1.4rCSI 2.26%PRS 60.41
-
CSI 1.4rCSI 2.16%PRS 53.21
-
CSI 1.39rCSI 1.9%PRS 47.51
-
CSI 1.39rCSI 2.05%PRS 71.67
-
CSI 1.39rCSI 7.94%PRS 65.34
-
CSI 1.36rCSI 3.35%PRS 53.16
-
CSI 1.34rCSI 2.25%PRS 37.72
-
CSI 1.3rCSI 6.41%PRS 66.7
-
CSI 1.24rCSI 4.74%PRS 46.74
-
CSI 1.23rCSI 2.72%PRS 52.94
-
CSI 1.22rCSI 1.58%PRS 38.84
-
CSI 1.18rCSI 3.38%PRS 74.57
-
CSI 1.12rCSI 1.84%PRS 44.87
-
CSI 1.05rCSI 1.69%PRS 45.1
-
CSI 1.03rCSI 1.66%PRS 39.85
-
CSI 1.02rCSI 2.74%PRS 62.92
-
CSI 1.01rCSI 4.18%PRS 61.02
-
CSI 0.97rCSI 1.88%PRS 57.68
-
CSI 0.91rCSI 2.56%PRS 67.84
-
CSI 0.88rCSI 3.87%PRS 46.75
-
CSI 0.84rCSI 3.19%PRS 38.56
-
CSI 0.84rCSI 2.44%PRS 45.35
-
CSI 0.76rCSI 1.84%PRS 36.5
-
CSI 0.63rCSI 1.96%PRS 41.58
-
CSI 0.3rCSI 1.7%PRS 39.2%
-
CSI 0.3rCSI 7.6%PRS 38.0%
-
CSI 0.5rCSI 2.6%PRS 67.7%
-
CSI 0.5rCSI 0.6%PRS 63.6%
-
CSI 0.6rCSI 13.5%PRS 37.1%
-
CSI 0.6rCSI 3.4%PRS 40.7%
-
CSI 0.6rCSI 2.0%PRS 41.6%
-
CSI 0.8rCSI 1.8%PRS 36.5%
-
CSI 0.8rCSI 2.4%PRS 45.4%
-
CSI 0.8rCSI 3.2%PRS 38.6%
-
CSI 0.9rCSI 3.9%PRS 46.8%
-
CSI 0.9rCSI 2.6%PRS 67.8%
-
CSI 1.0rCSI 1.9%PRS 57.7%
-
CSI 1.0rCSI 4.2%PRS 61.0%
-
CSI 1.0rCSI 2.7%PRS 62.9%
-
CSI 1.0rCSI 1.7%PRS 39.9%
-
CSI 1.1rCSI 1.7%PRS 45.1%
-
CSI 1.1rCSI 1.8%PRS 44.9%
-
CSI 1.2rCSI 3.4%PRS 74.6%
-
CSI 1.2rCSI 1.6%PRS 38.8%
-
CSI 1.2rCSI 2.7%PRS 52.9%
-
CSI 1.2rCSI 4.7%PRS 46.7%
-
CSI 1.3rCSI 6.4%PRS 66.7%
-
CSI 1.3rCSI 2.3%PRS 37.7%
-
CSI 1.4rCSI 3.4%PRS 53.2%
-
CSI 1.4rCSI 7.9%PRS 65.3%
-
CSI 1.4rCSI 2.1%PRS 71.7%
-
CSI 1.4rCSI 1.9%PRS 47.5%
-
CSI 1.4rCSI 2.2%PRS 53.2%
-
CSI 1.4rCSI 2.3%PRS 60.4%
-
CSI 1.5rCSI 2.1%PRS 63.3%
-
CSI 1.5rCSI 4.9%PRS 56.6%
-
CSI 1.5rCSI 2.7%PRS 36.7%
-
CSI 1.5rCSI 2.0%PRS 68.7%
-
CSI 1.5rCSI 2.9%PRS 43.9%
-
CSI 1.6rCSI 2.5%PRS 48.1%
-
CSI 1.6rCSI 1.1%PRS 67.6%
-
CSI 1.6rCSI 2.3%PRS 60.2%
-
CSI 1.7rCSI 2.3%PRS 60.8%
-
CSI 1.7rCSI 2.5%PRS 65.0%
-
CSI 1.7rCSI 2.1%PRS 57.2%
-
CSI 1.7rCSI 2.7%PRS 47.6%
-
CSI 1.7rCSI 2.2%PRS 36.0%
-
CSI 1.8rCSI 2.7%PRS 58.4%
-
CSI 1.8rCSI 2.1%PRS 45.1%
-
CSI 1.8rCSI 1.3%PRS 59.9%
-
CSI 1.8rCSI 3.1%PRS 52.6%
-
CSI 1.8rCSI 6.5%PRS 36.4%
-
CSI 1.8rCSI 1.9%PRS 53.7%
-
CSI 1.8rCSI 3.2%PRS 47.4%
-
CSI 1.8rCSI 1.9%PRS 52.0%
-
CSI 1.8rCSI 1.6%PRS 43.4%
-
CSI 1.8rCSI 2.1%PRS 71.7%
-
CSI 1.9rCSI 1.8%PRS 56.3%
-
CSI 1.9rCSI 2.0%PRS 60.8%
-
CSI 2.0rCSI 4.5%PRS 47.4%
-
CSI 2.0rCSI 1.9%PRS 45.6%
-
CSI 2.0rCSI 1.3%PRS 58.7%
-
CSI 2.0rCSI 2.4%PRS 37.6%
-
CSI 2.0rCSI 1.6%PRS 42.2%
-
CSI 2.0rCSI 4.2%PRS 52.5%
-
CSI 2.0rCSI 4.5%PRS 38.5%
-
CSI 2.1rCSI 3.6%PRS 45.3%
-
CSI 2.1rCSI 3.7%PRS 54.0%
-
CSI 2.1rCSI 2.1%PRS 48.8%
-
CSI 2.1rCSI 1.6%PRS 54.9%
-
CSI 2.1rCSI 6.6%PRS 39.2%
-
CSI 2.2rCSI 3.3%PRS 55.8%
-
CSI 2.2rCSI 2.4%PRS 53.9%
-
CSI 2.2rCSI 2.0%PRS 53.4%
-
CSI 2.2rCSI 3.4%PRS 51.5%
-
CSI 2.3rCSI 5.1%PRS 54.7%
-
CSI 2.3rCSI 1.8%PRS 56.4%
-
CSI 2.4rCSI 1.8%PRS 69.0%
-
CSI 2.5rCSI 2.3%PRS 55.1%
-
CSI 2.5rCSI 2.4%PRS 55.0%
-
CSI 2.6rCSI 9.6%PRS 47.5%
-
CSI 2.6rCSI 3.1%PRS 53.4%
-
CSI 2.6rCSI 4.7%PRS 48.2%
-
CSI 2.6rCSI 2.3%PRS 60.4%
-
CSI 2.6rCSI 1.8%PRS 57.9%
-
CSI 2.6rCSI 4.0%PRS 63.7%
-
CSI 2.7rCSI 2.0%PRS 47.9%
-
CSI 2.7rCSI 2.8%PRS 55.6%
-
CSI 2.7rCSI 4.0%PRS 59.1%
-
CSI 2.8rCSI 2.3%PRS 56.9%
-
CSI 2.8rCSI 6.4%PRS 73.5%
-
CSI 2.9rCSI 7.4%PRS 44.9%
-
CSI 3.0rCSI 6.5%PRS 63.8%
-
CSI 3.1rCSI 3.9%PRS 61.5%
-
CSI 3.1rCSI 4.4%PRS 57.7%
-
CSI 3.1rCSI 6.3%PRS 44.4%
-
CSI 3.2rCSI 8.0%PRS 49.9%
-
CSI 3.3rCSI 5.3%PRS 52.5%
-
CSI 3.4rCSI 4.5%PRS 64.3%
-
CSI 3.4rCSI 2.3%PRS 65.6%
-
CSI 3.5rCSI 2.6%PRS 67.8%
-
CSI 3.5rCSI 10.0%PRS 68.4%
-
CSI 3.6rCSI 3.5%PRS 71.0%
-
CSI 3.6rCSI 3.1%PRS 59.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4139068521
Symbol: XPP1_HUMAN
Name: Aminoacylproline aminopeptidase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9465902
Title: Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P).
PubMed ID: 9465902
DOI: 10.1159/000134671
PubMed ID: 10871044
Title: Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2.
PubMed ID: 10871044
PubMed ID: 11106490
Title: Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme.
PubMed ID: 11106490
DOI: 10.1021/bi001585c
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 35165443
Title: M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.
PubMed ID: 35165443
PubMed ID: 18515364
Title: Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit.
PubMed ID: 18515364
Sequence Information:
- Length: 623
- Mass: 69918
- Checksum: DF4F5AF41E2F3876
- Sequence:
MPPKVTSELL RQLRQAMRNS EYVTEPIQAY IIPSGDAHQS EYIAPCDCRR AFVSGFDGSA GTAIITEEHA AMWTDGRYFL QAAKQMDSNW TLMKMGLKDT PTQEDWLVSV LPEGSRVGVD PLIIPTDYWK KMAKVLRSAG HHLIPVKENL VDKIWTDRPE RPCKPLLTLG LDYTGISWKD KVADLRLKMA ERNVMWFVVT ALDEIAWLFN LRGSDVEHNP VFFSYAIIGL ETIMLFIDGD RIDAPSVKEH LLLDLGLEAE YRIQVHPYKS ILSELKALCA DLSPREKVWV SDKASYAVSE TIPKDHRCCM PYTPICIAKA VKNSAESEGM RRAHIKDAVA LCELFNWLEK EVPKGGVTEI SAADKAEEFR RQQADFVDLS FPTISSTGPN GAIIHYAPVP ETNRTLSLDE VYLIDSGAQY KDGTTDVTRT MHFGTPTAYE KECFTYVLKG HIAVSAAVFP TGTKGHLLDS FARSALWDSG LDYLHGTGHG VGSFLNVHEG PCGISYKTFS DEPLEAGMIV TDEPGYYEDG AFGIRIENVV LVVPVKTKYN FNNRGSLTFE PLTLVPIQTK MIDVDSLTDK ECDWLNNYHL TCRDVIGKEL QKQGRQEALE WLIRETQPIS KQH
Genular Protein ID: 988429433
Symbol: Q5T6H7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 552
- Mass: 62139
- Checksum: 627539255505E5CE
- Sequence:
MWTDGRYFLQ AAKQMDSNWT LMKMGLKDTP TQEDWLVSVL PEGSRVGVDP LIIPTDYWKK MAKVLRSAGH HLIPVKENLV DKIWTDRPER PCKPLLTLGL DYTGISWKDK VADLRLKMAE RNVMWFVVTA LDEIAWLFNL RGSDVEHNPV FFSYAIIGLE TIMLFIDGDR IDAPSVKEHL LLDLGLEAEY RIQVHPYKSI LSELKALCAD LSPREKVWVS DKASYAVSET IPKDHRCCMP YTPICIAKAV KNSAESEGMR RAHIKDAVAL CELFNWLEKE VPKGGVTEIS AADKAEEFRR QQADFVDLSF PTISSTGPNG AIIHYAPVPE TNRTLSLDEV YLIDSGAQYK DGTTDVTRTM HFGTPTAYEK ECFTYVLKGH IAVSAAVFPT GTKGHLLDSF ARSALWDSGL DYLHGTGHGV GSFLNVHEGP CGISYKTFSD EPLEAGMIVT DEPGYYEDGA FGIRIENVVL VVPVKTKYNF NNRGSLTFEP LTLVPIQTKM IDVDSLTDKE CDWLNNYHLT CRDVIGKELQ KQGRQEALEW LIRETQPISK QH