Details for: XRCC1

Gene ID: 7515

Symbol: XRCC1

Ensembl ID: ENSG00000073050

Description: X-ray repair cross complementing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 111.9932
    Cell Significance Index: -17.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.5752
    Cell Significance Index: -17.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 47.1662
    Cell Significance Index: -19.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.8189
    Cell Significance Index: -21.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.9439
    Cell Significance Index: -17.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.2896
    Cell Significance Index: -20.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.0363
    Cell Significance Index: -17.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.0022
    Cell Significance Index: -19.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6596
    Cell Significance Index: -17.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1089
    Cell Significance Index: -20.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5996
    Cell Significance Index: 304.4200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7129
    Cell Significance Index: 7.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6979
    Cell Significance Index: 482.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6677
    Cell Significance Index: 108.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6625
    Cell Significance Index: 72.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5724
    Cell Significance Index: 4.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5597
    Cell Significance Index: 112.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5121
    Cell Significance Index: 10.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5017
    Cell Significance Index: 30.1200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4045
    Cell Significance Index: 5.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3934
    Cell Significance Index: 10.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3818
    Cell Significance Index: 45.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3325
    Cell Significance Index: 17.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3191
    Cell Significance Index: 57.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2923
    Cell Significance Index: 40.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2909
    Cell Significance Index: 158.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2859
    Cell Significance Index: 102.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2813
    Cell Significance Index: 28.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2806
    Cell Significance Index: 19.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2780
    Cell Significance Index: 17.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2649
    Cell Significance Index: 13.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1947
    Cell Significance Index: 5.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1898
    Cell Significance Index: 4.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1766
    Cell Significance Index: 2.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1737
    Cell Significance Index: 11.2100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1652
    Cell Significance Index: 1.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1588
    Cell Significance Index: 3.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1549
    Cell Significance Index: 68.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1542
    Cell Significance Index: 18.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1511
    Cell Significance Index: 14.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1447
    Cell Significance Index: 6.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1412
    Cell Significance Index: 3.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1401
    Cell Significance Index: 27.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1297
    Cell Significance Index: 7.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1234
    Cell Significance Index: 6.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1111
    Cell Significance Index: 14.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0788
    Cell Significance Index: 3.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0595
    Cell Significance Index: 2.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0590
    Cell Significance Index: 7.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0291
    Cell Significance Index: 1.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0111
    Cell Significance Index: 0.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0033
    Cell Significance Index: 6.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0103
    Cell Significance Index: -6.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0110
    Cell Significance Index: -14.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0123
    Cell Significance Index: -0.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0137
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0150
    Cell Significance Index: -11.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0173
    Cell Significance Index: -13.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0193
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0249
    Cell Significance Index: -18.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0288
    Cell Significance Index: -13.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0307
    Cell Significance Index: -17.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0312
    Cell Significance Index: -1.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0335
    Cell Significance Index: -1.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0342
    Cell Significance Index: -2.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0351
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0373
    Cell Significance Index: -23.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0417
    Cell Significance Index: -3.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0440
    Cell Significance Index: -6.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0456
    Cell Significance Index: -7.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0479
    Cell Significance Index: -1.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0573
    Cell Significance Index: -1.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0581
    Cell Significance Index: -16.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0658
    Cell Significance Index: -7.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0887
    Cell Significance Index: -2.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1047
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1075
    Cell Significance Index: -22.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1183
    Cell Significance Index: -13.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1451
    Cell Significance Index: -3.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1820
    Cell Significance Index: -2.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1838
    Cell Significance Index: -19.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1936
    Cell Significance Index: -4.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2111
    Cell Significance Index: -16.7200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2193
    Cell Significance Index: -1.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2223
    Cell Significance Index: -13.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2265
    Cell Significance Index: -15.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2322
    Cell Significance Index: -6.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2647
    Cell Significance Index: -3.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2770
    Cell Significance Index: -8.1600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3401
    Cell Significance Index: -7.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3571
    Cell Significance Index: -8.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3640
    Cell Significance Index: -8.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3908
    Cell Significance Index: -19.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4035
    Cell Significance Index: -13.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4134
    Cell Significance Index: -7.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4207
    Cell Significance Index: -13.4000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4361
    Cell Significance Index: -2.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** XRCC1 is a phosphoprotein with a molecular weight of approximately 110 kDa. It is composed of three domains: a C-terminal domain that interacts with DNA, a central domain that interacts with other proteins, and an N-terminal domain that interacts with the ERCC1 protein. XRCC1 is highly conserved across species, with high sequence identity to its murine and rat counterparts. It is also highly expressed in various tissues, including the brain, heart, and kidneys. **Pathways and Functions** XRCC1 plays a critical role in several DNA repair pathways: 1. **Non-Homologous End Joining (NHEJ)**: XRCC1 interacts with the Ku protein to facilitate the repair of DSBs through NHEJ. This pathway is essential for maintaining genomic stability and preventing mutations. 2. **Homology-Directed Repair (HDR)**: XRCC1 interacts with the ERCC1 protein to facilitate the repair of DSBs through HDR. This pathway is essential for maintaining genomic stability and preventing mutations. 3. **Base Excision Repair (BER)**: XRCC1 interacts with the PARP1 protein to facilitate the repair of SSBs through BER. This pathway is essential for maintaining genomic stability and preventing mutations. 4. **Resolution of Abasic Sites (AP Sites)**: XRCC1 interacts with the APE1 protein to facilitate the repair of AP sites, which are caused by the removal of a uracil base from DNA. 5. **Single-Strand Break Repair**: XRCC1 interacts with the APE1 protein to facilitate the repair of SSBs through the single-strand break repair pathway. **Clinical Significance** Dysregulation of XRCC1 has been implicated in various diseases, including: 1. **Cancer**: XRCC1 mutations have been identified in several types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Diseases**: XRCC1 mutations have been identified in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Genetic Disorders**: XRCC1 mutations have been identified in several genetic disorders, including ataxia-telangiectasia and Fanconi anemia. 4. **Radiosensitivity**: XRCC1 mutations have been identified in individuals with radiosensitivity, which is a condition characterized by an increased risk of developing cancer after exposure to ionizing radiation. In conclusion, XRCC1 is a critical gene that plays a pivotal role in maintaining genomic stability and preventing mutations. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, genetic disorders, and radiosensitivity. Understanding the mechanisms of XRCC1 function and its role in disease will be essential for the development of novel therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 695793385

Symbol: XRCC1_HUMAN

Name: X-ray repair cross-complementing protein 1

UniProtKB Accession Codes:

P18887 Q6IBS4 Q9HCB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2247054

Title: Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.

PubMed ID: 2247054

DOI: 10.1128/mcb.10.12.6160-6171.1990

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11163244

Title: XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair.

PubMed ID: 11163244

DOI: 10.1016/s0092-8674(01)00195-7

PubMed ID: 14500814

Title: A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage.

PubMed ID: 14500814

DOI: 10.1093/nar/gkg761

PubMed ID: 14755728

Title: Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.

PubMed ID: 14755728

DOI: 10.1002/ana.10808

PubMed ID: 15066279

Title: The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.

PubMed ID: 15066279

DOI: 10.1016/s0092-8674(04)00206-5

PubMed ID: 15380105

Title: The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.

PubMed ID: 15380105

DOI: 10.1016/j.dnarep.2004.06.017

PubMed ID: 15044383

Title: Aprataxin, a novel protein that protects against genotoxic stress.

PubMed ID: 15044383

DOI: 10.1093/hmg/ddh122

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16397295

Title: XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage.

PubMed ID: 16397295

DOI: 10.1093/nar/gkj409

PubMed ID: 17507382

Title: Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks.

PubMed ID: 17507382

DOI: 10.1074/jbc.c700060200

PubMed ID: 17353262

Title: APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks.

PubMed ID: 17353262

DOI: 10.1128/mcb.02269-06

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19336415

Title: Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.

PubMed ID: 19336415

DOI: 10.1093/nar/gkp201

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19934257

Title: SIRT1 deacetylates APE1 and regulates cellular base excision repair.

PubMed ID: 19934257

DOI: 10.1093/nar/gkp1039

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34102106

Title: XRCC1 prevents toxic PARP1 trapping during DNA base excision repair.

PubMed ID: 34102106

DOI: 10.1016/j.molcel.2021.05.009

PubMed ID: 34811483

Title: XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair.

PubMed ID: 34811483

DOI: 10.1038/s41556-021-00792-w

PubMed ID: 19155274

Title: Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK.

PubMed ID: 19155274

DOI: 10.1093/nar/gkn1086

PubMed ID: 9485007

Title: Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.

PubMed ID: 9485007

PubMed ID: 10783319

Title: Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells.

PubMed ID: 10783319

DOI: 10.1093/carcin/21.5.965

PubMed ID: 11782372

Title: The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction.

PubMed ID: 11782372

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 28002403

Title: XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.

PubMed ID: 28002403

DOI: 10.1038/nature20790

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 633
  • Mass: 69498
  • Checksum: 76174967D034F89F
  • Sequence:
    • MPEIRLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE KEEQIHSVDI 
GNDGSAFVEV LVGSSAGGAG EQDYEVLLVT SSFMSPSESR SGSNPNRVRM FGPDKLVRAA 
AEKRWDRVKI VCSQPYSKDS PFGLSFVRFH SPPDKDEAEA PSQKVTVTKL GQFRVKEEDE 
SANSLRPGAL FFSRINKTSP VTASDPAGPS YAAATLQASS AASSASPVSR AIGSTSKPQE 
SPKGKRKLDL NQEEKKTPSK PPAQLSPSVP KRPKLPAPTR TPATAPVPAR AQGAVTGKPR 
GEGTEPRRPR AGPEELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR PDWTRDSTHL 
ICAFANTPKY SQVLGLGGRI VRKEWVLDCH RMRRRLPSQR YLMAGPGSSS EEDEASHSGG 
SGDEAPKLPQ KQPQTKTKPT QAAGPSSPQK PPTPEETKAA SPVLQEDIDI EGVQSEGQDN 
GAEDSGDTED ELRRVAEQKE HRLPPGQEEN GEDPYAGSTD ENTDSEEHQE PPDLPVPELP 
DFFQGKHFFL YGEFPGDERR KLIRYVTAFN GELEDYMSDR VQFVITAQEW DPSFEEALMD 
NPSLAFVRPR WIYSCNEKQK LLPHQLYGVV PQA

Genular Protein ID: 861197974

Symbol: B2RCY5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RCY5

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 633
  • Mass: 69537
  • Checksum: 123BEA5277A3ACF0
  • Sequence:
    • MPEIRLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE KEEQIHSVDI 
GNDGSAFVEV LVGSSAGGAG EQDYEVLLVT SSFMSPSESR SGSNPNRVRM FGPDKLVRAA 
AEKRWDRVKI VCSQPYSKDS PFGLSFVRFH SPPDKDEAEA PSQKVTVTKL GQFRVKEEDE 
SANSLRPGAL FFSRINKTSP VTASDPAGPS YAAATLQASS AASSASPVSR AIGSTSKPQE 
SPKGKRKLDL NQEEKKTPSK PPAQLSPSVP KRPKLPAPTH TPATAPVPAR AQGAVTGKPR 
GEGTEPRRPR AGPEELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR PDWTRDSTHL 
ICAFANTPKY SQVLGLGSRI VRKEWVLDCH RMRRRLPSRR YLMAGPGSSS EEDEASHSGG 
SGDEAPKLPQ KQPQTKTKPT QAAGPSSPQK PPTPEETKAA SPVLQEDIDI EGVQSEGQDN 
GAEDSGDTED ELRRVAEQKE HRLPPGQEEN GEDPYAGSTD ENTDSEEHQE PPDLPVPELP 
DFFQGKHFFL YGEFPGDERR KLIRYVTAFN GELEDYMSDR VQFVITAQEW DPSFEEALMD 
NPSLAFVRPR WIYSCNEKQK LLPHQLYGVV PQA

Genular Protein ID: 3028745205

Symbol: Q59HH7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59HH7

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 IntAct 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 647
  • Mass: 71014
  • Checksum: 881FBDB515E9926E
  • Sequence:
    • STSSFWPGEA HDVDMPEIRL RHVVSCSSQD STHCAENLLK ADTYRKWRAA KAGEKTISVV 
LQLEKEEQIH SVDIGNDGSA FVEVLVGSSA GGAGEQDYEV LLVTSSFMSP SESRSGSNPN 
RVRMFGPDKL VRAAAEKRWD RVKIVCSQPY SKDSPFGLSF VRFHSPPDKD EAEAPSQKVT 
VTKLGQFRVK EEDESANSLR PGALFFSRIN KTSPVTASDP AGPSYAAATL QASSAASSAS 
PVSRAIGSTS KPQESPKGKR KLDLNQEEKK TPSKPPAQLS PSVPKRPKLP APTRTPATAP 
VPARAQGAVT GKPRGEGTEP RRPRAGPEEL GKILQGVVVV LSGFQNPFRS ELRDKALELG 
AKYRPDWTRD STHLICAFAN TPKYSQVLGL GGRIVRKEWV LDCHRMRRRL PSQRYLMAGP 
GSSSEEDEAS HSGGSGDEAP KLPQKQPQTK TKPTQAAGPS SPQKPPTPEE TKAASPVLQE 
DIDIEGVQSE GQDNGAEDSG DTEDELRRVA EQKEHRLPPG QEENGEDPYA GSTDENTDSE 
EHQEPPDLPV PELPDFFQGK HFFLYGEFPG DERRKLIRYV TAFNGELEDY MSDRVQFVIT 
AQEWDPSFEE ALMDNPSLAF VRPRWIYSCN EKQKLLPHQL YGVVPQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.