Details for: YWHAH

Gene ID: 7533

Symbol: YWHAH

Ensembl ID: ENSG00000128245

Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 335.7866
    Cell Significance Index: -52.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 287.2143
    Cell Significance Index: -72.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 175.8233
    Cell Significance Index: -72.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 161.6317
    Cell Significance Index: -76.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 144.5804
    Cell Significance Index: -74.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 114.3628
    Cell Significance Index: -76.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.5432
    Cell Significance Index: -75.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.8556
    Cell Significance Index: -70.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.5834
    Cell Significance Index: -55.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.0961
    Cell Significance Index: -79.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.3671
    Cell Significance Index: -29.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.6057
    Cell Significance Index: 294.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.6348
    Cell Significance Index: 469.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 3.3822
    Cell Significance Index: 973.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6930
    Cell Significance Index: 126.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4158
    Cell Significance Index: 484.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.4086
    Cell Significance Index: 179.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7178
    Cell Significance Index: 186.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6352
    Cell Significance Index: 98.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4515
    Cell Significance Index: 93.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.4062
    Cell Significance Index: 24.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1312
    Cell Significance Index: 617.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0297
    Cell Significance Index: 141.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9555
    Cell Significance Index: 43.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9107
    Cell Significance Index: 55.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8067
    Cell Significance Index: 95.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7804
    Cell Significance Index: 279.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7535
    Cell Significance Index: 21.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7418
    Cell Significance Index: 16.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7357
    Cell Significance Index: 15.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7189
    Cell Significance Index: 24.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6329
    Cell Significance Index: 279.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4508
    Cell Significance Index: 21.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4380
    Cell Significance Index: 53.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4375
    Cell Significance Index: 83.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3039
    Cell Significance Index: 30.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2884
    Cell Significance Index: 19.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2847
    Cell Significance Index: 46.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2031
    Cell Significance Index: 36.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1308
    Cell Significance Index: 1.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1078
    Cell Significance Index: 18.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0788
    Cell Significance Index: 0.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0488
    Cell Significance Index: 6.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0176
    Cell Significance Index: 0.4800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0066
    Cell Significance Index: 0.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0137
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0238
    Cell Significance Index: -14.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0264
    Cell Significance Index: -19.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0268
    Cell Significance Index: -36.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0282
    Cell Significance Index: -21.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0364
    Cell Significance Index: -68.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0492
    Cell Significance Index: -90.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0513
    Cell Significance Index: -5.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0549
    Cell Significance Index: -84.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0739
    Cell Significance Index: -5.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0817
    Cell Significance Index: -1.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0956
    Cell Significance Index: -2.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1037
    Cell Significance Index: -58.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1049
    Cell Significance Index: -66.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1192
    Cell Significance Index: -2.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1466
    Cell Significance Index: -29.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1543
    Cell Significance Index: -4.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1587
    Cell Significance Index: -3.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1636
    Cell Significance Index: -74.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2118
    Cell Significance Index: -44.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2714
    Cell Significance Index: -30.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2891
    Cell Significance Index: -33.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4381
    Cell Significance Index: -51.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4888
    Cell Significance Index: -30.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5047
    Cell Significance Index: -13.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5137
    Cell Significance Index: -74.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5549
    Cell Significance Index: -12.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5918
    Cell Significance Index: -30.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6600
    Cell Significance Index: -37.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6717
    Cell Significance Index: -16.1100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7442
    Cell Significance Index: -4.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7494
    Cell Significance Index: -59.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7570
    Cell Significance Index: -78.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8478
    Cell Significance Index: -15.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9295
    Cell Significance Index: -29.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9415
    Cell Significance Index: -72.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9488
    Cell Significance Index: -24.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.9944
    Cell Significance Index: -27.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1407
    Cell Significance Index: -50.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1838
    Cell Significance Index: -72.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2925
    Cell Significance Index: -38.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.3318
    Cell Significance Index: -50.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3587
    Cell Significance Index: -33.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.4363
    Cell Significance Index: -50.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.4975
    Cell Significance Index: -16.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.5133
    Cell Significance Index: -40.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5208
    Cell Significance Index: -49.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.5373
    Cell Significance Index: -48.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6285
    Cell Significance Index: -57.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.6421
    Cell Significance Index: -19.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6443
    Cell Significance Index: -60.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.6535
    Cell Significance Index: -48.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.6861
    Cell Significance Index: -36.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.9963
    Cell Significance Index: -42.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** YWHAH is a member of the 14-3-3 family of proteins, which are known for their ability to bind to and regulate the activity of a wide range of proteins. YWHAH's unique structure, which includes a PH domain, a SH2 domain, and a J domain, enables it to interact with various signaling molecules, including protein kinases, phosphatases, and transcription factors. This versatility allows YWHAH to modulate multiple signaling pathways, including those involved in apoptosis, cell cycle regulation, and synaptic plasticity. **Pathways and Functions:** YWHAH's involvement in various signaling pathways is a testament to its multifaceted role in cellular processes. Some of the key pathways and functions of YWHAH include: * **Apoptosis:** YWHAH regulates the activity of pro-apoptotic proteins, such as BAD, and modulates the mitochondrial pathway of apoptosis. * **Cell Cycle Regulation:** YWHAH interacts with cyclin-dependent kinases (CDKs) and regulates the cell cycle checkpoint, ensuring proper DNA replication and repair. * **Neurotransmission:** YWHAH is involved in the regulation of synaptic plasticity and neurotransmission, particularly in the cerebellum, where it interacts with glutamate receptors and modulates the activity of GABAergic neurons. * **Immune Response:** YWHAH is expressed in immune cells, including macrophages and dendritic cells, and regulates the activity of immune receptors, such as CD1c, and modulates the production of cytokines and chemokines. **Clinical Significance:** YWHAH's involvement in various disease states highlights its potential as a therapeutic target. Some of the clinical significance of YWHAH includes: * **Neurodegenerative Diseases:** YWHAH's role in regulating synaptic plasticity and neurotransmission makes it a potential target for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's. * **Cancer:** YWHAH's involvement in cell cycle regulation and apoptosis makes it a potential target for cancer therapy. * **Infectious Diseases:** YWHAH's role in regulating the immune response and modulating the activity of immune receptors makes it a potential target for the treatment of infectious diseases, such as COVID-19. In conclusion, YWHAH is a multifunctional protein that plays a significant role in various cellular and immunological processes. Its involvement in apoptosis, cell cycle regulation, neurotransmission, and immune response highlights its potential as a therapeutic target for a range of disease states. Further research is needed to fully elucidate the mechanisms by which YWHAH regulates these processes and to explore its therapeutic potential.

Genular Protein ID: 2896252319

Symbol: 1433F_HUMAN

Name: 14-3-3 protein eta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8218406

Title: The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions.

PubMed ID: 8218406

DOI: 10.1016/0167-4781(93)90053-g

PubMed ID: 1578511

Title: cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain.

PubMed ID: 1578511

DOI: 10.1002/jnr.490310403

PubMed ID: 8561965

Title: The effect on methamphetamine on the mRNA level for 14.3.3 eta chain in the human cultured cells.

PubMed ID: 8561965

DOI: 10.1007/bf02740697

PubMed ID: 8812417

Title: Structural organization and chromosomal assignment of the human 14-3-3 eta chain gene (YWHAH).

PubMed ID: 8812417

DOI: 10.1006/geno.1996.0426

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8515476

Title: Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.

PubMed ID: 8515476

DOI: 10.1006/jmbi.1993.1346

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 23572552

Title: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.

PubMed ID: 23572552

DOI: 10.1128/mbio.00098-13

PubMed ID: 11266503

Title: Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140.

PubMed ID: 11266503

DOI: 10.1210/mend.15.4.0624

PubMed ID: 12177059

Title: Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3.

PubMed ID: 12177059

DOI: 10.1074/jbc.m205141200

PubMed ID: 14504289

Title: Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization.

PubMed ID: 14504289

DOI: 10.1074/jbc.m306614200

PubMed ID: 15696159

Title: JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.

PubMed ID: 15696159

DOI: 10.1038/ncb1228

PubMed ID: 19172738

Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

PubMed ID: 19172738

DOI: 10.1038/emboj.2008.159

PubMed ID: 19640509

Title: SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner.

PubMed ID: 19640509

DOI: 10.1016/j.biopsych.2009.05.033

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26047703

Title: Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.

PubMed ID: 26047703

DOI: 10.1016/j.bbrc.2015.05.105

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27030597

Title: Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.

PubMed ID: 27030597

DOI: 10.1126/scitranslmed.aaf1471

PubMed ID: 17085597

Title: Structural basis for protein-protein interactions in the 14-3-3 protein family.

PubMed ID: 17085597

DOI: 10.1073/pnas.0605779103

Sequence Information:

  • Length: 246
  • Mass: 28219
  • Checksum: D70FBC100C45D6E5
  • Sequence:
  • MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK NVVGARRSSW 
    RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV LSLLDKFLIK NCNDFQYESK 
    VFYLKMKGDY YRYLAEVASG EKKNSVVEAS EAAYKEAFEI SKEQMQPTHP IRLGLALNFS 
    VFYYEIQNAP EQACLLAKQA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE 
    EAGEGN

Genular Protein ID: 2517904027

Symbol: Q9H4N8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

  • Length: 176
  • Mass: 20240
  • Checksum: CC0A4F2C20D1816F
  • Sequence:
  • MADGNEKKLE KVKAYREKIE KELETVCNDV LSLLDKFLIK NCNDFQYESK VFYLKMKGDY 
    YRYLAEVASG EKKNSVVEAS EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP 
    EQACLLAKQA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.