Details for: ZNF20

Gene ID: 7568

Symbol: ZNF20

Ensembl ID: ENSG00000132010

Description: zinc finger protein 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 36.4524
    Cell Significance Index: -5.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.8811
    Cell Significance Index: -5.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.6230
    Cell Significance Index: -5.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2702
    Cell Significance Index: -2.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.2307
    Cell Significance Index: -3.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7830
    Cell Significance Index: 16.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6197
    Cell Significance Index: 61.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5217
    Cell Significance Index: 31.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5178
    Cell Significance Index: 467.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4556
    Cell Significance Index: 49.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4231
    Cell Significance Index: 23.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3679
    Cell Significance Index: 6.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3470
    Cell Significance Index: 56.4300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2854
    Cell Significance Index: 3.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2731
    Cell Significance Index: 7.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2580
    Cell Significance Index: 3.5200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.2528
    Cell Significance Index: 1.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2282
    Cell Significance Index: 15.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2189
    Cell Significance Index: 11.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2151
    Cell Significance Index: 9.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1963
    Cell Significance Index: 5.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1925
    Cell Significance Index: 55.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1744
    Cell Significance Index: 13.3900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1416
    Cell Significance Index: 4.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1297
    Cell Significance Index: 15.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1280
    Cell Significance Index: 7.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1236
    Cell Significance Index: 22.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1192
    Cell Significance Index: 23.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1190
    Cell Significance Index: 23.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1130
    Cell Significance Index: 61.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1028
    Cell Significance Index: 12.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0947
    Cell Significance Index: 18.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0889
    Cell Significance Index: 2.5600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0570
    Cell Significance Index: 0.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0542
    Cell Significance Index: 19.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0540
    Cell Significance Index: 1.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0455
    Cell Significance Index: 0.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0375
    Cell Significance Index: 5.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0279
    Cell Significance Index: 0.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0216
    Cell Significance Index: 0.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0163
    Cell Significance Index: 22.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0157
    Cell Significance Index: 0.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0154
    Cell Significance Index: 23.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0146
    Cell Significance Index: 1.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0127
    Cell Significance Index: 23.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0121
    Cell Significance Index: 0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0096
    Cell Significance Index: 17.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0030
    Cell Significance Index: 0.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0014
    Cell Significance Index: 0.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0003
    Cell Significance Index: 0.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0012
    Cell Significance Index: -0.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0048
    Cell Significance Index: -0.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0060
    Cell Significance Index: -4.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0069
    Cell Significance Index: -0.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0102
    Cell Significance Index: -1.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0103
    Cell Significance Index: -1.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0109
    Cell Significance Index: -0.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0161
    Cell Significance Index: -1.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0161
    Cell Significance Index: -0.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0186
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0256
    Cell Significance Index: -2.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0262
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0278
    Cell Significance Index: -5.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0311
    Cell Significance Index: -0.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0339
    Cell Significance Index: -4.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0362
    Cell Significance Index: -1.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0376
    Cell Significance Index: -3.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0384
    Cell Significance Index: -2.5800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0404
    Cell Significance Index: -0.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0411
    Cell Significance Index: -2.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0424
    Cell Significance Index: -0.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0434
    Cell Significance Index: -3.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0438
    Cell Significance Index: -4.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0631
    Cell Significance Index: -4.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0648
    Cell Significance Index: -5.1300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0669
    Cell Significance Index: -0.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0737
    Cell Significance Index: -3.8700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0779
    Cell Significance Index: -1.1500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0790
    Cell Significance Index: -1.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0815
    Cell Significance Index: -1.5900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0858
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0865
    Cell Significance Index: -1.8100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0935
    Cell Significance Index: -0.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1015
    Cell Significance Index: -2.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1095
    Cell Significance Index: -2.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1108
    Cell Significance Index: -5.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1125
    Cell Significance Index: -3.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1129
    Cell Significance Index: -3.0200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1133
    Cell Significance Index: -1.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1135
    Cell Significance Index: -1.9000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1139
    Cell Significance Index: -1.9700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1143
    Cell Significance Index: -2.8500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1158
    Cell Significance Index: -1.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1177
    Cell Significance Index: -3.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1198
    Cell Significance Index: -3.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1198
    Cell Significance Index: -3.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF20 is a member of the zinc finger protein family, characterized by its distinctive zinc finger motifs, which enable it to bind to specific DNA sequences. This protein is highly expressed in various cell types, including those involved in the development and maintenance of the nervous system and the epithelial lining of the gut. ZNF20 exhibits a unique expression pattern, with a high level of expression in GABAergic interneurons and radial glial cells, suggesting a crucial role in neuronal development and function. **Pathways and Functions:** ZNF20's primary function is to regulate gene expression through its interaction with RNA polymerase II, a key enzyme responsible for transcribing genes into mRNA. By binding to specific DNA sequences, ZNF20 recruits RNA polymerase II to regulate the transcription of target genes involved in cellular differentiation, proliferation, and survival. This process is mediated through several pathways, including: 1. **DNA-binding transcription factor activity**: ZNF20's ability to bind to specific DNA sequences enables it to regulate gene expression by recruiting or inhibiting RNA polymerase II. 2. **Regulation of transcription by RNA polymerase II**: ZNF20 modulates the transcription of target genes by interacting with RNA polymerase II, thereby influencing the expression of genes involved in cellular differentiation and proliferation. 3. **Metal ion binding**: ZNF20's zinc finger motifs allow it to bind to metal ions, which are essential for its DNA-binding activity. **Clinical Significance:** ZNF20's role in regulating gene expression in various cell types has significant implications for our understanding of developmental and epithelial disorders. Abnormal expression of ZNF20 has been linked to various diseases, including: 1. **Neurological disorders**: Altered expression of ZNF20 has been observed in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Gastrointestinal diseases**: ZNF20's role in regulating gene expression in intestinal epithelial cells makes it a potential target for the treatment of gastrointestinal diseases, such as inflammatory bowel disease. 3. **Cancer**: Abnormal expression of ZNF20 has been observed in various types of cancer, suggesting its potential as a therapeutic target. In conclusion, ZNF20 is a transcription factor that plays a crucial role in regulating gene expression in developmental and epithelial tissues. Its unique expression pattern and ability to interact with RNA polymerase II make it a key player in regulating cellular differentiation, proliferation, and survival. Further research is needed to fully elucidate ZNF20's role in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 559275364

Symbol: ZNF20_HUMAN

Name: Zinc finger protein 20

UniProtKB Accession Codes:

P17024 Q8N457 Q9UG41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

Sequence Information:

  • Length: 532
  • Mass: 61567
  • Checksum: C92473E875FCAA42
  • Sequence:
    • MMFQDSVAFE DVAVSFTQEE WALLDPSQKN LYRDVMQETF KNLTSVGKTW KVQNIEDEYK 
NPRRNLSLMR EKLCESKESH HCGESFNQIA DDMLNRKTLP GITPCESSVC GEVGTGHSSL 
NTHIRADTGH KSSEYQEYGE NPYRNKECKK AFSYLDSFQS HDKACTKEKP YDGKECTETF 
ISHSCIQRHR VMHSGDGPYK CKFCGKAFYF LNLCLIHERI HTGVKPYKCK QCGKAFTRST 
TLPVHERTHT GVNADECKEC GNAFSFPSEI RRHKRSHTGE KPYECKQCGK VFISFSSIQY 
HKMTHTGEKP YECKQCGKAF RCGSHLQKHG RTHTGEKPYE CRQCGKAFRC TSDLQRHEKT 
HTEDKPYGCK QCGKGFRCAS QLQIHERTHS GEKPHECKEC GKVFKYFSSL RIHERTHTGE 
KPHECKQCGK AFRYFSSLHI HERTHTGDKP YECKVCGKAF TCSSSIRYHE RTHTGEKPYE 
CKHCGKAFIS NYIRYHERTH TGEKPYQCKQ CGKAFIRASS CREHERTHTI NR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.