Details for: ZNF28

Gene ID: 7576

Symbol: ZNF28

Ensembl ID: ENSG00000198538

Description: zinc finger protein 28

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 56.7038
    Cell Significance Index: -8.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.7786
    Cell Significance Index: -9.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 19.4865
    Cell Significance Index: -9.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.4458
    Cell Significance Index: -7.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.2640
    Cell Significance Index: -7.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.5347
    Cell Significance Index: -9.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0871
    Cell Significance Index: -8.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4024
    Cell Significance Index: -9.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.3474
    Cell Significance Index: -7.2100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.9795
    Cell Significance Index: 32.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7637
    Cell Significance Index: -3.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1670
    Cell Significance Index: 115.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1569
    Cell Significance Index: 188.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0979
    Cell Significance Index: 14.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9725
    Cell Significance Index: 878.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8575
    Cell Significance Index: 51.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8041
    Cell Significance Index: 87.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5348
    Cell Significance Index: 27.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5179
    Cell Significance Index: 60.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5106
    Cell Significance Index: 13.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4334
    Cell Significance Index: 29.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3614
    Cell Significance Index: 9.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3065
    Cell Significance Index: 6.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2398
    Cell Significance Index: 47.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2164
    Cell Significance Index: 39.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2082
    Cell Significance Index: 6.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1781
    Cell Significance Index: 33.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1518
    Cell Significance Index: 30.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1271
    Cell Significance Index: 5.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1198
    Cell Significance Index: 3.2600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1120
    Cell Significance Index: 0.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1084
    Cell Significance Index: 2.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0901
    Cell Significance Index: 0.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0888
    Cell Significance Index: 48.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0719
    Cell Significance Index: 25.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0648
    Cell Significance Index: 28.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0629
    Cell Significance Index: 7.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0595
    Cell Significance Index: 7.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0487
    Cell Significance Index: 2.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0470
    Cell Significance Index: 1.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0386
    Cell Significance Index: 5.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0327
    Cell Significance Index: 0.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0198
    Cell Significance Index: 1.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0147
    Cell Significance Index: 0.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0067
    Cell Significance Index: 0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0062
    Cell Significance Index: 11.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0055
    Cell Significance Index: 10.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0042
    Cell Significance Index: 0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0038
    Cell Significance Index: 0.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0024
    Cell Significance Index: 3.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0017
    Cell Significance Index: 2.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0003
    Cell Significance Index: 0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0001
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0014
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0037
    Cell Significance Index: -0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0047
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0127
    Cell Significance Index: -1.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0137
    Cell Significance Index: -0.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0142
    Cell Significance Index: -7.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0162
    Cell Significance Index: -0.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0171
    Cell Significance Index: -1.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0183
    Cell Significance Index: -0.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0205
    Cell Significance Index: -1.5300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0235
    Cell Significance Index: -0.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0266
    Cell Significance Index: -0.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0267
    Cell Significance Index: -7.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0353
    Cell Significance Index: -0.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0363
    Cell Significance Index: -4.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0373
    Cell Significance Index: -1.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0373
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0402
    Cell Significance Index: -4.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0408
    Cell Significance Index: -2.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0482
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0483
    Cell Significance Index: -10.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0531
    Cell Significance Index: -3.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0540
    Cell Significance Index: -3.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0641
    Cell Significance Index: -1.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0660
    Cell Significance Index: -3.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0792
    Cell Significance Index: -8.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0835
    Cell Significance Index: -1.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0893
    Cell Significance Index: -3.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0910
    Cell Significance Index: -7.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0967
    Cell Significance Index: -3.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1000
    Cell Significance Index: -2.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1207
    Cell Significance Index: -2.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1342
    Cell Significance Index: -1.9100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1478
    Cell Significance Index: -2.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1517
    Cell Significance Index: -9.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1685
    Cell Significance Index: -2.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1686
    Cell Significance Index: -8.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1784
    Cell Significance Index: -6.2000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1850
    Cell Significance Index: -5.8500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1957
    Cell Significance Index: -3.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1992
    Cell Significance Index: -5.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2019
    Cell Significance Index: -5.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2032
    Cell Significance Index: -7.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2107
    Cell Significance Index: -6.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc finger motif:** ZNF28 possesses a characteristic zinc finger motif that enables it to bind to specific DNA sequences, thereby regulating gene expression. 2. **DNA-binding activity:** ZNF28 exhibits DNA-binding activity, which is essential for its function as a transcriptional regulator. 3. **RNA polymerase II specificity:** ZNF28 is specifically activated by RNA polymerase II, a key enzyme involved in the transcription of protein-coding genes. 4. **Transcriptional regulation:** ZNF28 regulates gene expression by modulating the activity of RNA polymerase II and other transcription factors. **Pathways and Functions:** 1. **Transcriptional regulation:** ZNF28 regulates the expression of target genes by binding to specific DNA sequences and recruiting RNA polymerase II. 2. **Gene expression:** ZNF28 is involved in the regulation of gene expression in various cell types, including GABAergic interneurons, radial glial cells, and intestinal epithelial cells. 3. **Developmental processes:** ZNF28 is expressed in neural stem cells and plays a role in the development of the cerebral cortex and forebrain. 4. **Cancer development:** ZNF28 is overexpressed in neoplastic cells, suggesting its involvement in cancer development and progression. **Clinical Significance:** 1. **Cancer diagnosis:** ZNF28 expression levels could serve as a potential biomarker for the diagnosis of various cancers, including colorectal and lung cancers. 2. **Neurological disorders:** ZNF28 is involved in the regulation of gene expression in the cerebral cortex, and alterations in its expression may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Stem cell biology:** ZNF28 plays a role in the regulation of stem cell proliferation and differentiation, making it a potential target for the development of regenerative therapies. 4. **Gene therapy:** ZNF28 could be a potential target for gene therapy interventions aimed at regulating gene expression in specific tissues or cells. In conclusion, ZNF28 is a multifunctional transcriptional regulator that plays a crucial role in the regulation of gene expression in various cell types. Its involvement in developmental processes, cancer development, and neurological disorders highlights the importance of further research into its molecular mechanisms and clinical significance.

Genular Protein ID: 2699390085

Symbol: ZNF28_HUMAN

Name: Zinc finger protein 28

UniProtKB Accession Codes:

P17035 A8KAK9 B4E3G0 B9EIK7 Q5H9V1 Q5HYM9 Q6ZML9 Q6ZN56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 718
  • Mass: 83658
  • Checksum: CF602657CFEC8633
  • Sequence:
    • MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMKTFFS 
TGQGNTEAFH TGTLQRQASH HIGDFCFQKI EKDIHGFQFQ WKEDETNDHA APMTEIKELT 
GSTGQHDQRH AGNKHIKDQL GLSFHSHLPE LHIFQPEGKI GNQVEKSINN ASSVSTSQRI 
CCRPKTHISN KYGNNSLHSS LLTQKRNVHM REKSFQCIES GKSFNCSSLL KKHQITHLEE 
KQCKCDVYGK VFNQKRYLAC HRRSHIDEKP YKCNECGKIF GHNTSLFLHK ALHTADKPYE 
CEECDKVFSR KSHLETHKII YTGGKPYKCK VCDKAFTCNS YLAKHTIIHT GEKPYKCNEC 
GKVFNRLSTL ARHRRLHTGE KPYECEECEK VFSRKSHLER HKRIHTGEKP YKCKVCDKAF 
AYNSYLAKHS IIHTGEKPYK CNECGKVFNQ QSTLARHHRL HTAEKPYKCE ECDKVFRCKS 
HLERHRRIHT GEKPYKCKVC DKAFRSDSCL TEHQRVHTGE KPYMCNECGK VFSTKANLAC 
HHKLHTAEKP YKCEECEKVF SRKSHMERHR RIHTGEKPYK CKVCDKAFRR DSHLAQHQRV 
HTGEKPYKCN ECGKTFRQTS SLIIHRRLHT GEKPYKCNEC GKTFSQMSSL VYHHRLHSGE 
KPYKCNECGK VFNQQAHLAQ HQRVHTGEKP YKCNECGKTF SQMSNLVYHH RLHSGEKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.