Details for: ZNF70

Gene ID: 7621

Symbol: ZNF70

Ensembl ID: ENSG00000187792

Description: zinc finger protein 70

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.6885
    Cell Significance Index: -6.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.1140
    Cell Significance Index: -6.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.4746
    Cell Significance Index: -6.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.7283
    Cell Significance Index: -6.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8131
    Cell Significance Index: 154.7300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3253
    Cell Significance Index: 5.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3122
    Cell Significance Index: 19.6800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2754
    Cell Significance Index: 3.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2648
    Cell Significance Index: 15.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2607
    Cell Significance Index: 7.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2379
    Cell Significance Index: 23.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2138
    Cell Significance Index: 193.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2100
    Cell Significance Index: 9.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1995
    Cell Significance Index: 12.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1923
    Cell Significance Index: 20.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1844
    Cell Significance Index: 4.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1432
    Cell Significance Index: 7.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1331
    Cell Significance Index: 21.6500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1034
    Cell Significance Index: 1.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1020
    Cell Significance Index: 20.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0950
    Cell Significance Index: 18.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0887
    Cell Significance Index: 4.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0883
    Cell Significance Index: 31.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0873
    Cell Significance Index: 2.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0822
    Cell Significance Index: 5.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0698
    Cell Significance Index: 9.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0515
    Cell Significance Index: 1.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0478
    Cell Significance Index: 2.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0388
    Cell Significance Index: 4.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0335
    Cell Significance Index: 1.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0306
    Cell Significance Index: 1.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0249
    Cell Significance Index: 4.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0173
    Cell Significance Index: 0.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0162
    Cell Significance Index: 2.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0134
    Cell Significance Index: 1.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0127
    Cell Significance Index: 8.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0060
    Cell Significance Index: 0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0054
    Cell Significance Index: 8.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0052
    Cell Significance Index: 9.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0050
    Cell Significance Index: 2.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0041
    Cell Significance Index: 1.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0025
    Cell Significance Index: 3.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0018
    Cell Significance Index: 3.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0032
    Cell Significance Index: -2.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0072
    Cell Significance Index: -1.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0072
    Cell Significance Index: -0.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0099
    Cell Significance Index: -7.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0108
    Cell Significance Index: -3.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0127
    Cell Significance Index: -7.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0146
    Cell Significance Index: -1.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0225
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0262
    Cell Significance Index: -4.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0270
    Cell Significance Index: -3.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0300
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0367
    Cell Significance Index: -7.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0381
    Cell Significance Index: -4.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0413
    Cell Significance Index: -2.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0436
    Cell Significance Index: -0.8500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0461
    Cell Significance Index: -0.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0477
    Cell Significance Index: -6.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0491
    Cell Significance Index: -3.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0584
    Cell Significance Index: -1.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0602
    Cell Significance Index: -6.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0621
    Cell Significance Index: -0.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0657
    Cell Significance Index: -1.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0706
    Cell Significance Index: -4.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0777
    Cell Significance Index: -4.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0796
    Cell Significance Index: -5.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0811
    Cell Significance Index: -6.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0849
    Cell Significance Index: -1.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0859
    Cell Significance Index: -2.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0942
    Cell Significance Index: -2.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1009
    Cell Significance Index: -2.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1037
    Cell Significance Index: -2.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1048
    Cell Significance Index: -5.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1062
    Cell Significance Index: -4.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1065
    Cell Significance Index: -2.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1260
    Cell Significance Index: -3.4300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1354
    Cell Significance Index: -1.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1387
    Cell Significance Index: -4.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1404
    Cell Significance Index: -4.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1420
    Cell Significance Index: -6.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1497
    Cell Significance Index: -2.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1509
    Cell Significance Index: -2.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1530
    Cell Significance Index: -5.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1540
    Cell Significance Index: -4.9100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1545
    Cell Significance Index: -3.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1591
    Cell Significance Index: -4.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1601
    Cell Significance Index: -4.7200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1612
    Cell Significance Index: -4.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1624
    Cell Significance Index: -6.1500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1718
    Cell Significance Index: -2.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1757
    Cell Significance Index: -4.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1779
    Cell Significance Index: -6.5300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1784
    Cell Significance Index: -3.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1805
    Cell Significance Index: -3.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF70 is a member of the zinc finger protein family, characterized by the presence of zinc finger motifs that allow it to bind to specific DNA sequences. The protein is composed of 7 zinc fingers, which are responsible for its DNA-binding activity. ZNF70 is a transcription factor that regulates gene expression by interacting with RNAP II and other transcriptional co-regulators. It is also known to bind to metal ions, which stabilizes its structure and enhances its DNA-binding affinity. **Pathways and Functions:** ZNF70 is involved in several signaling pathways, including: 1. **RNA polymerase II-specific transcription**: ZNF70 regulates RNAP II-dependent transcription, which is essential for the expression of genes involved in cellular development, differentiation, and survival. 2. **Generic transcription pathway**: ZNF70 is also involved in the regulation of generic transcription, which is important for the expression of housekeeping genes that are required for cellular maintenance. 3. **Metal ion binding**: ZNF70 binds to metal ions, which stabilizes its structure and enhances its DNA-binding affinity. ZNF70's functions include: 1. **Regulation of transcription**: ZNF70 regulates transcription by interacting with RNAP II and other transcriptional co-regulators. 2. **Gene expression**: ZNF70 is involved in the regulation of gene expression, particularly in the context of RNAP II-dependent transcription. 3. **Cellular development**: ZNF70 is required for cellular development, particularly in the context of neural development and intestinal epithelial cell differentiation. **Clinical Significance:** Dysregulation of ZNF70 has been implicated in various diseases, including: 1. **Neurological disorders**: ZNF70's role in regulating gene expression in the brain makes it an important target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: ZNF70's involvement in regulating gene expression and cellular development makes it an important target for the treatment of cancer. 3. **Intestinal disorders**: ZNF70's role in regulating gene expression in the intestinal epithelium makes it an important target for the treatment of intestinal disorders, such as inflammatory bowel disease. In conclusion, ZNF70 is a critical transcription factor that regulates gene expression in various cell types. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in maintaining cellular homeostasis and development.

Genular Protein ID: 1878594548

Symbol: ZNF70_HUMAN

Name: Zinc finger protein 70

UniProtKB Accession Codes:

Q9UC06

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1639391

Title: Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2).

PubMed ID: 1639391

DOI: 10.1016/0888-7543(92)90135-f

Sequence Information:

  • Length: 446
  • Mass: 50802
  • Checksum: E79A25ED2BD816D9
  • Sequence:
    • MEVPPATKFG ETFAFENRLE SQQGLFPGED LGDPFLQERG LEQMAVIYKE IPLGEQDEEN 
DDYEGNFSLC SSPVQHQSIP PGTRPQDDEL FGQTFLQKSD LSMCQIIHSE EPSPCDCAET 
DRGDSGPNAP HRTPQPAKPY ACRECGKAFS QSSHLLRHLV IHTGEKPYEC CECGKAFSQS 
SHLLRHQIIH TGEKPYECRE CGKAFRQSSA LTQHQKIHTG KRPYECRECG KDFSRSSSLR 
KHERIHTGER PYQCKECGKS FNQSSGLSQH RKIHTLKKPH ECDLCGKAFC HRSHLIRHQR 
IHTGKKPYKC DECGKAFSQS SNLIEHRKTH TGEKPYKCQK CGKAFSQSSS LIEHQRIHTG 
EKPYECCQCG KAFCHSSALI QHQRIHTGKK PYTCECGKAF RHRSALIEHY KTHTREKPYV 
CNLCGKSFRG SSHLIRHQKI HSGEKL

Genular Protein ID: 3456818353

Symbol: B3KV76_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KV76

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 446
  • Mass: 50742
  • Checksum: 2ED3FB880F26E40F
  • Sequence:
    • MEVPPATKFG ETFAFENRLE SQQGLFPGED LGDPFLQERG LEQMAVICKE IPLGEQDEEN 
DDYEGNFSLC SSPVQHQSIP PGTRPQDDEL FGQTFLQKSD LSMCQIIHSE EPSPCDCAET 
DRGDSGPNAP HRTPQPAKPY ACRECGKAFS QSSHLLRHLV IHTGEKPYEC CECGKAFSQS 
SHLLRHQIIH TGEKPYECRE CGKAFRQSSA LTQHQKIHTG KRPYECRECG KDFSRSSSLR 
KHERIHTGER PYQCKECGKS FNQSSGLSQH RKIHTLKKPH ECDLCGKAFC HRSHLIRHQR 
IHTGKKPYKC DECGKAFSQS SNLIEHRKTH TGEKPYKCQK CGKAFSQSSS LIEHQRIHTG 
EKPYECCQCG KAFCHSSALI QHQRIHTGKK PYTCECGKAF RHRSALIEHY KTHTREKPYV 
CNLCGKSFRG SSHLIRHQKI HSGEKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.