Details for: ZNF80

Gene ID: 7634

Symbol: ZNF80

Ensembl ID: ENSG00000174255

Description: zinc finger protein 80

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2546
    Cell Significance Index: 2.6400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1227
    Cell Significance Index: 1.2300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.0572
    Cell Significance Index: 0.9200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0089
    Cell Significance Index: 0.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0003
    Cell Significance Index: 0.0400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0022
    Cell Significance Index: -3.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0025
    Cell Significance Index: -1.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0030
    Cell Significance Index: -0.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0035
    Cell Significance Index: -1.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0037
    Cell Significance Index: -2.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0040
    Cell Significance Index: -0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0047
    Cell Significance Index: -2.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0056
    Cell Significance Index: -0.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0095
    Cell Significance Index: -1.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0100
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0103
    Cell Significance Index: -1.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0113
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0118
    Cell Significance Index: -2.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0126
    Cell Significance Index: -1.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0134
    Cell Significance Index: -1.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0135
    Cell Significance Index: -1.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0144
    Cell Significance Index: -1.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0145
    Cell Significance Index: -1.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0177
    Cell Significance Index: -0.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0195
    Cell Significance Index: -0.9100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0205
    Cell Significance Index: -0.2000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0218
    Cell Significance Index: -0.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0225
    Cell Significance Index: -2.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0237
    Cell Significance Index: -1.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0248
    Cell Significance Index: -0.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0290
    Cell Significance Index: -0.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0291
    Cell Significance Index: -2.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0293
    Cell Significance Index: -0.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0300
    Cell Significance Index: -1.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0303
    Cell Significance Index: -2.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0343
    Cell Significance Index: -2.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0353
    Cell Significance Index: -0.8800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0362
    Cell Significance Index: -0.4400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0365
    Cell Significance Index: -0.6200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0367
    Cell Significance Index: -0.3900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0397
    Cell Significance Index: -0.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0446
    Cell Significance Index: -2.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0468
    Cell Significance Index: -2.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0469
    Cell Significance Index: -2.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0485
    Cell Significance Index: -0.5500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0514
    Cell Significance Index: -0.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0536
    Cell Significance Index: -2.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0545
    Cell Significance Index: -1.4600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0547
    Cell Significance Index: -1.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0555
    Cell Significance Index: -1.9300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0558
    Cell Significance Index: -0.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0572
    Cell Significance Index: -2.5300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0583
    Cell Significance Index: -0.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0614
    Cell Significance Index: -2.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0644
    Cell Significance Index: -2.0500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0651
    Cell Significance Index: -0.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0654
    Cell Significance Index: -1.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0660
    Cell Significance Index: -2.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0665
    Cell Significance Index: -1.9600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0674
    Cell Significance Index: -0.8500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0690
    Cell Significance Index: -0.9200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0733
    Cell Significance Index: -0.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0739
    Cell Significance Index: -2.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0745
    Cell Significance Index: -1.9900
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0757
    Cell Significance Index: -0.7700
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0767
    Cell Significance Index: -0.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0778
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0842
    Cell Significance Index: -0.7800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0848
    Cell Significance Index: -2.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0871
    Cell Significance Index: -2.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0872
    Cell Significance Index: -2.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0873
    Cell Significance Index: -2.2300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0876
    Cell Significance Index: -0.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0881
    Cell Significance Index: -1.9300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0888
    Cell Significance Index: -1.5300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0920
    Cell Significance Index: -1.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0921
    Cell Significance Index: -1.9600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0933
    Cell Significance Index: -1.2900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0933
    Cell Significance Index: -0.6700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0938
    Cell Significance Index: -1.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0948
    Cell Significance Index: -2.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0964
    Cell Significance Index: -1.3800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0987
    Cell Significance Index: -1.9300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0999
    Cell Significance Index: -1.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1022
    Cell Significance Index: -2.0200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1025
    Cell Significance Index: -1.1800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1025
    Cell Significance Index: -2.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1036
    Cell Significance Index: -2.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1055
    Cell Significance Index: -1.9500
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: -0.1069
    Cell Significance Index: -0.6200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1086
    Cell Significance Index: -2.5100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1094
    Cell Significance Index: -1.8700
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1095
    Cell Significance Index: -0.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** ZNF80 is a transcriptional regulator that interacts with RNA polymerase II to control the expression of specific genes. 2. **DNA binding:** ZNF80 exhibits a high degree of specificity in binding to DNA sequences, indicating its ability to target specific gene promoters or enhancers. 3. **Metal ion binding:** The presence of a metal ion-binding motif in ZNF80 suggests that it may interact with metal ions, which could influence its DNA-binding activity. 4. **Cell-type specific expression:** ZNF80 is expressed in a diverse range of cell types, including immune cells, epithelial cells, and endothelial cells, underscoring its importance in maintaining cellular homeostasis. **Pathways and Functions:** 1. **RNA polymerase II-specific transcription regulation:** ZNF80 binds to RNA polymerase II and modulates its activity, influencing the transcription of specific genes. 2. **DNA-binding transcription factor activity:** ZNF80 exhibits DNA-binding activity, allowing it to regulate gene expression by interacting with specific DNA sequences. 3. **Metal ion-dependent regulation:** The metal ion-binding motif in ZNF80 may influence its DNA-binding activity, potentially modulating its transcriptional regulatory function. 4. **Cellular differentiation and proliferation:** ZNF80's expression in specific cell types, such as intestinal crypt stem cells and cerebral cortex GABAergic interneurons, suggests its role in maintaining cellular homeostasis and regulating cellular differentiation and proliferation. **Clinical Significance:** 1. **Immune system disorders:** Dysregulation of ZNF80's transcriptional regulatory function may contribute to immune system disorders, such as autoimmune diseases or immunodeficiency syndromes. 2. **Cancer:** Aberrant expression of ZNF80 has been implicated in various types of cancer, including leukemia and lymphoma, suggesting its potential as a diagnostic biomarker or therapeutic target. 3. **Neurological disorders:** ZNF80's expression in GABAergic interneurons and forebrain radial glial cells highlights its role in maintaining neural homeostasis, which may be disrupted in neurological disorders such as epilepsy or schizophrenia. 4. **Epithelial disorders:** ZNF80's expression in epithelial cells, including goblet cells and absorptive cells, suggests its role in maintaining epithelial homeostasis, which may be disrupted in epithelial disorders such as inflammatory bowel disease or cancer. In conclusion, ZNF80 is a critical transcriptional regulator that plays a pivotal role in regulating gene expression in various cell types. Its unique expression pattern and interaction with RNA polymerase II highlight its importance in maintaining cellular homeostasis and regulating cellular responses to environmental cues. Further research is needed to fully elucidate the role of ZNF80 in immune and non-immune cells, as well as its potential as a diagnostic biomarker or therapeutic target for various diseases.

Genular Protein ID: 3524235617

Symbol: ZNF80_HUMAN

Name: Zinc finger protein 80

UniProtKB Accession Codes:

P51504 Q6NSW4 Q6NT14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8478004

Title: Chromosomal localization of four human zinc finger cDNAs.

PubMed ID: 8478004

DOI: 10.1007/bf00218259

PubMed ID: 7659503

Title: Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family.

PubMed ID: 7659503

DOI: 10.1093/nar/23.15.2823

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 273
  • Mass: 31224
  • Checksum: 16A1CA82DCE2F579
  • Sequence:
    • MSPKRDGLGT GDGLHSQVLQ EQVSTGDNLH ECDSQGPSKD TLVREGKTYK CKECGSVFNK 
NSLLVRHQQI HTGVKPYECQ ECGKAFPEKV DFVRPMRIHT GEKPCKCVEC GKVFNRRSHL 
LCYRQIHTGE KPYECSECGK TFSYHSVFIQ HRVTHTGEKL FGCKECGKTF YYNSSLTRHM 
KIHTGEKPCK CSECGKTFTY RSVFFRHSMT HTAGKPYECK ECGKGFYYSY SLTRHTRSHT 
GEKPYECLEH RKDFGYHSAF AQQSKIHSGG KNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.