Details for: ZNF80

Gene ID: 7634

Symbol: ZNF80

Ensembl ID: ENSG00000174255

Description: zinc finger protein 80

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.49
    Marker Score: 2503
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.17
    Marker Score: 706
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7694
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.11
    Marker Score: 2821
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251819
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.03
    Marker Score: 1376
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1315
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 491
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.59
    Marker Score: 1126
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.48
    Marker Score: 316
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.42
    Marker Score: 858
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.29
    Marker Score: 4505
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.27
    Marker Score: 88
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.19
    Marker Score: 95
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.13
    Marker Score: 76
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.12
    Marker Score: 781
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.11
    Marker Score: 320
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.1
    Marker Score: 78
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.1
    Marker Score: 128
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.1
    Marker Score: 87
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.09
    Marker Score: 904
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.08
    Marker Score: 71
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.07
    Marker Score: 62
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.06
    Marker Score: 67
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.06
    Marker Score: 92
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.05
    Marker Score: 157
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.04
    Marker Score: 85
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 67
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.04
    Marker Score: 55
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.04
    Marker Score: 67
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.03
    Marker Score: 81
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.03
    Marker Score: 61
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.03
    Marker Score: 83
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 13

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Other Information

**Key Characteristics:** 1. **Transcription Factor Activity:** ZNF80 exhibits DNA-binding transcription factor activity, specifically targeting RNA polymerase II-specific sequences, which are crucial for the regulation of gene expression. 2. **Metal Ion Binding:** The zinc finger motif in ZNF80 allows it to bind metal ions, which are essential for the protein's function and stability. 3. **Cell Type-Specific Expression:** ZNF80 is significantly expressed in various cell types, including blood vessel endothelial cells, lymphoid lineage restricted progenitor cells, goblet cells, and intestinal crypt stem cells, suggesting its role in maintaining tissue homeostasis. 4. **Regulation of Transcription by RNA Polymerase II:** ZNF80's interaction with RNA polymerase II-specific sequences enables it to regulate transcriptional activity, influencing the expression of target genes. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** ZNF80's interaction with specific DNA sequences modulates transcriptional activity, regulating the expression of target genes. 2. **Regulation of Transcription by RNA Polymerase II:** ZNF80's binding to RNA polymerase II-specific sequences enables it to regulate transcriptional activity, influencing the expression of target genes. 3. **Cell Differentiation and Proliferation:** ZNF80's expression in various cell types suggests its involvement in maintaining tissue homeostasis and regulating cell differentiation and proliferation. 4. **Metal Ion Binding and Protein Stability:** ZNF80's metal ion-binding motif is essential for its function and stability, ensuring proper protein folding and activity. **Clinical Significance:** 1. **Disease Association:** ZNF80's involvement in transcriptional regulation and cell differentiation makes it a potential therapeutic target for diseases characterized by abnormal gene expression, such as cancer, autoimmune disorders, and neurodegenerative diseases. 2. **Cancer Therapy:** Modulating ZNF80's activity or expression could potentially inhibit tumor growth and progression by disrupting the transcriptional regulation of target genes. 3. **Neurological Disorders:** ZNF80's expression in GABAergic interneurons and forebrain radial glial cells suggests its involvement in neurological disorders, such as epilepsy and schizophrenia, where transcriptional dysregulation plays a key role. 4. **Diagnostic Biomarkers:** ZNF80's expression in specific cell types could serve as diagnostic biomarkers for various diseases, enabling early detection and treatment. In conclusion, ZNF80 is a zinc finger protein that plays a crucial role in regulating transcriptional activity and cell differentiation. Its widespread expression across different tissues and cell types highlights its potential as a therapeutic target for diseases characterized by abnormal gene expression. Further research is necessary to fully understand ZNF80's functions and clinical significance, but its identification as a key player in transcriptional regulation and cell differentiation makes it an exciting area of investigation.

Genular Protein ID: 3524235617

Symbol: ZNF80_HUMAN

Name: Zinc finger protein 80

UniProtKB Accession Codes:

P51504 Q6NSW4 Q6NT14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8478004

Title: Chromosomal localization of four human zinc finger cDNAs.

PubMed ID: 8478004

DOI: 10.1007/bf00218259

PubMed ID: 7659503

Title: Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family.

PubMed ID: 7659503

DOI: 10.1093/nar/23.15.2823

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 273
  • Mass: 31224
  • Checksum: 16A1CA82DCE2F579
  • Sequence:
    • MSPKRDGLGT GDGLHSQVLQ EQVSTGDNLH ECDSQGPSKD TLVREGKTYK CKECGSVFNK 
NSLLVRHQQI HTGVKPYECQ ECGKAFPEKV DFVRPMRIHT GEKPCKCVEC GKVFNRRSHL 
LCYRQIHTGE KPYECSECGK TFSYHSVFIQ HRVTHTGEKL FGCKECGKTF YYNSSLTRHM 
KIHTGEKPCK CSECGKTFTY RSVFFRHSMT HTAGKPYECK ECGKGFYYSY SLTRHTRSHT 
GEKPYECLEH RKDFGYHSAF AQQSKIHSGG KNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.