Details for: ZNF131

Gene ID: 7690

Symbol: ZNF131

Ensembl ID: ENSG00000172262

Description: zinc finger protein 131

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 329.8076
    Cell Significance Index: -51.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 188.4930
    Cell Significance Index: -47.8100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 142.7366
    Cell Significance Index: -58.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 119.2699
    Cell Significance Index: -56.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.3673
    Cell Significance Index: -45.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.0854
    Cell Significance Index: -53.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.1700
    Cell Significance Index: -45.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.2595
    Cell Significance Index: -54.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.1906
    Cell Significance Index: -48.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.5073
    Cell Significance Index: -47.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.0318
    Cell Significance Index: -55.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.6987
    Cell Significance Index: -23.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1467
    Cell Significance Index: 120.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7001
    Cell Significance Index: 609.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5297
    Cell Significance Index: 303.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4366
    Cell Significance Index: 19.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3331
    Cell Significance Index: 267.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2681
    Cell Significance Index: 24.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2399
    Cell Significance Index: 95.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0774
    Cell Significance Index: 30.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0691
    Cell Significance Index: 65.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0687
    Cell Significance Index: 68.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0671
    Cell Significance Index: 963.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0123
    Cell Significance Index: 29.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9842
    Cell Significance Index: 121.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9743
    Cell Significance Index: 43.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8598
    Cell Significance Index: 32.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8265
    Cell Significance Index: 22.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7564
    Cell Significance Index: 34.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7181
    Cell Significance Index: 78.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6959
    Cell Significance Index: 16.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6484
    Cell Significance Index: 116.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6133
    Cell Significance Index: 84.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6068
    Cell Significance Index: 36.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5999
    Cell Significance Index: 414.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5855
    Cell Significance Index: 15.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5485
    Cell Significance Index: 13.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4907
    Cell Significance Index: 216.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4783
    Cell Significance Index: 32.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4703
    Cell Significance Index: 46.5200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.4659
    Cell Significance Index: 5.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3714
    Cell Significance Index: 19.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3488
    Cell Significance Index: 190.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3351
    Cell Significance Index: 9.1200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3076
    Cell Significance Index: 3.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2220
    Cell Significance Index: 7.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2046
    Cell Significance Index: 14.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1843
    Cell Significance Index: 347.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1826
    Cell Significance Index: 9.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1598
    Cell Significance Index: 11.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1426
    Cell Significance Index: 90.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0823
    Cell Significance Index: 15.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0771
    Cell Significance Index: 118.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0770
    Cell Significance Index: 1.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0583
    Cell Significance Index: 2.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0545
    Cell Significance Index: 100.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0544
    Cell Significance Index: 24.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0230
    Cell Significance Index: 31.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0057
    Cell Significance Index: 0.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0056
    Cell Significance Index: 0.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0337
    Cell Significance Index: -3.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0410
    Cell Significance Index: -30.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0525
    Cell Significance Index: -38.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0637
    Cell Significance Index: -48.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0933
    Cell Significance Index: -52.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0971
    Cell Significance Index: -60.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1190
    Cell Significance Index: -12.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1373
    Cell Significance Index: -7.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1598
    Cell Significance Index: -27.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1689
    Cell Significance Index: -48.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1793
    Cell Significance Index: -26.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1894
    Cell Significance Index: -6.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1971
    Cell Significance Index: -9.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2044
    Cell Significance Index: -12.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2571
    Cell Significance Index: -19.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2763
    Cell Significance Index: -58.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2770
    Cell Significance Index: -32.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2887
    Cell Significance Index: -46.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2894
    Cell Significance Index: -8.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2964
    Cell Significance Index: -6.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3274
    Cell Significance Index: -5.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3781
    Cell Significance Index: -5.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3865
    Cell Significance Index: -44.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4127
    Cell Significance Index: -4.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4203
    Cell Significance Index: -13.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4243
    Cell Significance Index: -44.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4686
    Cell Significance Index: -9.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4951
    Cell Significance Index: -12.0800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5642
    Cell Significance Index: -8.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5770
    Cell Significance Index: -16.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6040
    Cell Significance Index: -47.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6417
    Cell Significance Index: -39.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6417
    Cell Significance Index: -17.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6781
    Cell Significance Index: -17.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6942
    Cell Significance Index: -14.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8091
    Cell Significance Index: -20.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8520
    Cell Significance Index: -22.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8623
    Cell Significance Index: -5.2100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8691
    Cell Significance Index: -12.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9204
    Cell Significance Index: -19.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** ZNF131 exhibits dual functional properties, acting as both a transcription activator and repressor, mediated by its RNA polymerase II-specific activity. 2. **Cell specificity:** ZNF131 is significantly expressed in specific cell types, including astrocytes, GABAergic cortical interneurons, and neurons in the cerebral cortex. 3. **Metal ion binding:** The protein ZNF131 binds to metal ions, suggesting its involvement in protein metabolism and redox regulation. 4. **Post-translational modifications:** ZNF131 is subject to post-translational modifications, including sumoylation, which may regulate its activity and interactions with other proteins. **Pathways and Functions:** 1. **Immune regulation:** ZNF131 is involved in the regulation of cytokine production and immune system processes, highlighting its role in modulating immune responses. 2. **Neuronal function:** The protein ZNF131 is expressed in specific neuronal populations, including GABAergic cortical interneurons, suggesting its involvement in neuronal development and function. 3. **Protein metabolism:** ZNF131 regulates protein metabolism, including the metabolism of proteins, intermediate filament cytoskeleton formation, and regulation of protein modifications. 4. **Transcriptional regulation:** ZNF131 modulates transcriptional activity by regulating RNA polymerase II-specific activity, influencing the expression of target genes. **Clinical Significance:** 1. **Neurological disorders:** Alterations in ZNF131 expression or function may contribute to neurological disorders, such as epilepsy, schizophrenia, and autism spectrum disorder. 2. **Immune-related diseases:** Dysregulation of ZNF131 may contribute to immune-related diseases, including autoimmune disorders and cancer. 3. **Cancer therapy:** ZNF131 may serve as a potential therapeutic target in cancer treatment, particularly in cancers with altered immune responses. 4. **Neurodegenerative diseases:** The protein ZNF131 may play a role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where immune system dysregulation and neuronal dysfunction are prominent features. In conclusion, ZNF131 is a complex transcription factor that plays a crucial role in regulating immune response, protein metabolism, and neuronal function. Further studies are needed to fully elucidate its mechanisms of action and its clinical significance in various diseases.

Genular Protein ID: 476077736

Symbol: ZN131_HUMAN

Name: Zinc finger protein 131

UniProtKB Accession Codes:

P52739 B4DRL3 Q6PIF0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 5 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 15 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7557990

Title: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

PubMed ID: 7557990

DOI: 10.1006/geno.1995.1040

PubMed ID: 12163020

Title: The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus.

PubMed ID: 12163020

DOI: 10.1016/s0006-291x(02)00850-1

PubMed ID: 17306895

Title: Nuclear trafficking of the POZ-ZF protein Znf131.

PubMed ID: 17306895

DOI: 10.1016/j.bbamcr.2006.12.005

PubMed ID: 18847501

Title: High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling.

PubMed ID: 18847501

DOI: 10.1186/1471-2164-9-476

PubMed ID: 22467880

Title: Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling.

PubMed ID: 22467880

DOI: 10.1074/jbc.m111.336354

PubMed ID: 23404503

Title: UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.

PubMed ID: 23404503

DOI: 10.1074/jbc.m112.438234

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 623
  • Mass: 71422
  • Checksum: E2720D922A39572C
  • Sequence:
    • MEAEETMECL QEFPEHHKMI LDRLNEQREQ DRFTDITLIV DGHHFKAHKA VLAACSKFFY 
KFFQEFTQEP LVEIEGVSKM AFRHLIEFTY TAKLMIQGEE EANDVWKAAE FLQMLEAIKA 
LEVRNKENSA PLEENTTGKN EAKKRKIAET SNVITESLPS AESEPVEIEV EIAEGTIEVE 
DEGIETLEEV ASAKQSVKYI QSTGSSDDSA LALLADITSK YRQGDRKGQI KEDGCPSDPT 
SKQVEGIEIV ELQLSHVKDL FHCEKCNRSF KLFYHFKEHM KSHSTESFKC EICNKRYLRE 
SAWKQHLNCY HLEEGGVSKK QRTGKKIHVC QYCEKQFDHF GHFKEHLRKH TGEKPFECPN 
CHERFARNST LKCHLTACQT GVGAKKGRKK LYECQVCNSV FNSWDQFKDH LVIHTGDKPN 
HCTLCDLWFM QGNELRRHLS DAHNISERLV TEEVLSVETR VQTEPVTSMT IIEQVGKVHV 
LPLLQVQVDS AQVTVEQVHP DLLQDSQVHD SHMSELPEQV QVSYLEVGRI QTEEGTEVHV 
EELHVERVNQ MPVEVQTELL EADLDHVTPE IMNQEERESS QADAAEAARE DHEDAEDLET 
KPTVDSEAEK AENEDRTALP VLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.