Details for: ZNF146

Gene ID: 7705

Symbol: ZNF146

Ensembl ID: ENSG00000167635

Description: zinc finger protein 146

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 224.6935
    Cell Significance Index: -34.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 132.1935
    Cell Significance Index: -33.5300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 100.1341
    Cell Significance Index: -41.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.4105
    Cell Significance Index: -39.3800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 78.0540
    Cell Significance Index: -31.7100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.6086
    Cell Significance Index: -36.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.9995
    Cell Significance Index: -39.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.3702
    Cell Significance Index: -31.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.4796
    Cell Significance Index: -37.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6542
    Cell Significance Index: -31.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6869
    Cell Significance Index: -38.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1390
    Cell Significance Index: -28.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5802
    Cell Significance Index: -16.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.1202
    Cell Significance Index: 146.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8929
    Cell Significance Index: 187.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1857
    Cell Significance Index: 71.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0582
    Cell Significance Index: 212.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0086
    Cell Significance Index: 200.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9405
    Cell Significance Index: 72.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6829
    Cell Significance Index: 472.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6768
    Cell Significance Index: 242.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6506
    Cell Significance Index: 17.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6321
    Cell Significance Index: 35.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5992
    Cell Significance Index: 16.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5988
    Cell Significance Index: 8.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5619
    Cell Significance Index: 77.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5589
    Cell Significance Index: 34.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5120
    Cell Significance Index: 92.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4910
    Cell Significance Index: 60.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4702
    Cell Significance Index: 256.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4196
    Cell Significance Index: 14.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4076
    Cell Significance Index: 11.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3769
    Cell Significance Index: 7.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3465
    Cell Significance Index: 18.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3264
    Cell Significance Index: 62.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2924
    Cell Significance Index: 129.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2251
    Cell Significance Index: 6.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1881
    Cell Significance Index: 4.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1543
    Cell Significance Index: 7.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1537
    Cell Significance Index: 9.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1454
    Cell Significance Index: 18.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1382
    Cell Significance Index: 7.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1340
    Cell Significance Index: 9.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1238
    Cell Significance Index: 5.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1111
    Cell Significance Index: 2.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1108
    Cell Significance Index: 208.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0960
    Cell Significance Index: 11.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0902
    Cell Significance Index: 15.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0811
    Cell Significance Index: 6.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0630
    Cell Significance Index: 8.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0605
    Cell Significance Index: 1.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0578
    Cell Significance Index: 2.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0463
    Cell Significance Index: 71.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0401
    Cell Significance Index: 74.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0341
    Cell Significance Index: 15.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0331
    Cell Significance Index: 21.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0165
    Cell Significance Index: 22.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0018
    Cell Significance Index: 1.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0060
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0130
    Cell Significance Index: -8.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0203
    Cell Significance Index: -0.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0217
    Cell Significance Index: -15.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0263
    Cell Significance Index: -19.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0312
    Cell Significance Index: -17.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0325
    Cell Significance Index: -4.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0338
    Cell Significance Index: -0.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0570
    Cell Significance Index: -3.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0713
    Cell Significance Index: -4.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0922
    Cell Significance Index: -9.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1025
    Cell Significance Index: -3.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1044
    Cell Significance Index: -21.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1084
    Cell Significance Index: -2.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1152
    Cell Significance Index: -33.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1208
    Cell Significance Index: -14.0800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1210
    Cell Significance Index: -2.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1389
    Cell Significance Index: -2.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1548
    Cell Significance Index: -7.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1785
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1810
    Cell Significance Index: -20.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1871
    Cell Significance Index: -5.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2231
    Cell Significance Index: -2.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2530
    Cell Significance Index: -3.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2562
    Cell Significance Index: -29.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2735
    Cell Significance Index: -28.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2938
    Cell Significance Index: -5.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3026
    Cell Significance Index: -6.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3157
    Cell Significance Index: -9.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3367
    Cell Significance Index: -17.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4040
    Cell Significance Index: -32.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4040
    Cell Significance Index: -12.9400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4174
    Cell Significance Index: -5.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4740
    Cell Significance Index: -10.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4919
    Cell Significance Index: -10.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5050
    Cell Significance Index: -12.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5104
    Cell Significance Index: -14.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5218
    Cell Significance Index: -31.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6836
    Cell Significance Index: -4.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7184
    Cell Significance Index: -22.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7261
    Cell Significance Index: -18.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Zinc Finger Domain**: The ZNF146 protein contains a zinc finger domain, a conserved structural motif found in many transcription factors, which enables it to bind to specific DNA sequences. 2. **Transcriptional Regulation**: ZNF146 is involved in regulating transcription by binding to RNA polymerase II cis-regulatory regions, modulating the activity of the RNA polymerase II complex. 3. **Cell Type-Specific Expression**: ZNF146 is expressed in various cell types, including neurons, oligodendrocytes, and skeletal muscle fibers, suggesting its role in the development and maintenance of these tissues. 4. **Heparin-Binding Properties**: ZNF146 has been shown to bind to heparin, a polysaccharide found in the extracellular matrix, which may influence its cellular localization and function. **Pathways and Functions** 1. **DNA-Binding Transcription Factor Activity**: ZNF146 acts as a transcription factor, binding to specific DNA sequences and regulating transcriptional activity. 2. **Regulation of DNA-Templated Transcription**: ZNF146 modulates the activity of RNA polymerase II, a key enzyme involved in transcriptional regulation. 3. **Regulation of Transcription by RNA Polymerase II**: ZNF146 regulates the expression of genes involved in various cellular processes, including neuronal development and muscle function. 4. **Cytosol and Nucleus**: ZNF146 is found in both the cytosol and nucleus, suggesting its role in regulating transcriptional activity in different cellular compartments. **Clinical Significance** 1. **Neurological Disorders**: Aberrant expression of ZNF146 has been implicated in various neurological disorders, including autism spectrum disorder and schizophrenia, suggesting its potential role in neurodevelopmental processes. 2. **Muscular Dystrophy**: ZNF146 has been shown to be involved in the regulation of muscle function, and its dysregulation may contribute to muscular dystrophy. 3. **Cancer**: The role of ZNF146 in cancer development and progression is still unclear, but its involvement in transcriptional regulation suggests its potential as a therapeutic target. 4. **Gene Therapy**: Understanding the mechanisms of ZNF146 regulation may provide insights into the development of gene therapies for neurological and muscular disorders. In conclusion, ZNF146 is a transcription factor that plays a crucial role in regulating gene expression in various cell types, particularly in the nervous system and skeletal muscle. Further research is needed to fully understand its mechanisms of action and clinical significance, but its involvement in neurodevelopmental processes and muscle function makes it an interesting target for therapeutic intervention.

Genular Protein ID: 181877835

Symbol: OZF_HUMAN

Name: Zinc finger protein OZF

UniProtKB Accession Codes:

Q15072 Q2TB94

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 8 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8107129

Title: The OZF gene encodes a protein consisting essentially of zinc finger motifs.

PubMed ID: 8107129

DOI: 10.1006/jmbi.1994.1151

PubMed ID: 11306801

Title: Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains.

PubMed ID: 11306801

DOI: 10.1159/000056873

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8665923

Title: Identification, nuclear localization, and binding activities of OZF, a human protein solely composed of zinc-finger motifs.

PubMed ID: 8665923

DOI: 10.1111/j.1432-1033.1996.00991.x

PubMed ID: 9935176

Title: Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas.

PubMed ID: 9935176

DOI: 10.1002/(sici)1097-0215(19990129)80:3<369::aid-ijc6>3.0.co;2-y

PubMed ID: 12754738

Title: The zinc finger protein OZF (ZNF146) is overexpressed in colorectal cancer.

PubMed ID: 12754738

DOI: 10.1002/path.1337

PubMed ID: 15838871

Title: Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1.

PubMed ID: 15838871

DOI: 10.1002/jcb.20487

PubMed ID: 15881673

Title: A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo.

PubMed ID: 15881673

DOI: 10.1007/s11010-005-6417-2

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 292
  • Mass: 33308
  • Checksum: D5062375D261B971
  • Sequence:
    • MSHLSQQRIY SGENPFACKV CGKVFSHKSN LTEHEHFHTR EKPFECNECG KAFSQKQYVI 
KHQNTHTGEK LFECNECGKS FSQKENLLTH QKIHTGEKPF ECKDCGKAFI QKSNLIRHQR 
THTGEKPFVC KECGKTFSGK SNLTEHEKIH IGEKPFKCSE CGTAFGQKKY LIKHQNIHTG 
EKPYECNECG KAFSQRTSLI VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY 
GCNECGKAFS QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.