Details for: ZNF225

Gene ID: 7768

Symbol: ZNF225

Ensembl ID: ENSG00000256294

Description: zinc finger protein 225

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 32.6593
    Cell Significance Index: -5.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.7719
    Cell Significance Index: -5.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 12.7201
    Cell Significance Index: -5.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.2337
    Cell Significance Index: -5.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.7619
    Cell Significance Index: -4.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7745
    Cell Significance Index: 147.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4350
    Cell Significance Index: 43.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3786
    Cell Significance Index: 341.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3285
    Cell Significance Index: 19.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2968
    Cell Significance Index: 32.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2435
    Cell Significance Index: 39.6100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2266
    Cell Significance Index: 3.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2053
    Cell Significance Index: 5.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1983
    Cell Significance Index: 12.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1604
    Cell Significance Index: 11.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1598
    Cell Significance Index: 2.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1382
    Cell Significance Index: 27.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1103
    Cell Significance Index: 2.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0978
    Cell Significance Index: 28.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0977
    Cell Significance Index: 4.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0814
    Cell Significance Index: 16.1500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0776
    Cell Significance Index: 1.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0592
    Cell Significance Index: 21.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0495
    Cell Significance Index: 8.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0445
    Cell Significance Index: 5.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0442
    Cell Significance Index: 2.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0411
    Cell Significance Index: 0.9000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0398
    Cell Significance Index: 0.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0291
    Cell Significance Index: 3.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0283
    Cell Significance Index: 1.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0274
    Cell Significance Index: 2.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0212
    Cell Significance Index: 11.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0201
    Cell Significance Index: 0.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0171
    Cell Significance Index: 0.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0159
    Cell Significance Index: 0.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0150
    Cell Significance Index: 6.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0129
    Cell Significance Index: 0.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0120
    Cell Significance Index: 0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0018
    Cell Significance Index: 3.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0015
    Cell Significance Index: 0.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -2.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0028
    Cell Significance Index: -2.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -3.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0052
    Cell Significance Index: -0.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0052
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -4.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0060
    Cell Significance Index: -4.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0069
    Cell Significance Index: -1.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0082
    Cell Significance Index: -4.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0103
    Cell Significance Index: -0.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0104
    Cell Significance Index: -0.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0169
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0178
    Cell Significance Index: -3.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0199
    Cell Significance Index: -2.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0232
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0243
    Cell Significance Index: -2.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0251
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0273
    Cell Significance Index: -5.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0297
    Cell Significance Index: -2.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0301
    Cell Significance Index: -1.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0309
    Cell Significance Index: -0.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0334
    Cell Significance Index: -2.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0337
    Cell Significance Index: -4.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0404
    Cell Significance Index: -1.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0419
    Cell Significance Index: -1.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0432
    Cell Significance Index: -0.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0497
    Cell Significance Index: -5.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0505
    Cell Significance Index: -3.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0515
    Cell Significance Index: -1.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0551
    Cell Significance Index: -1.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0568
    Cell Significance Index: -1.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0593
    Cell Significance Index: -4.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0640
    Cell Significance Index: -3.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0688
    Cell Significance Index: -0.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0702
    Cell Significance Index: -1.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0705
    Cell Significance Index: -1.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0764
    Cell Significance Index: -2.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0817
    Cell Significance Index: -1.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0832
    Cell Significance Index: -2.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0856
    Cell Significance Index: -2.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0890
    Cell Significance Index: -1.4900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0992
    Cell Significance Index: -1.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1041
    Cell Significance Index: -2.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1044
    Cell Significance Index: -2.9800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1082
    Cell Significance Index: -1.5400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1116
    Cell Significance Index: -1.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1120
    Cell Significance Index: -2.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1178
    Cell Significance Index: -5.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1181
    Cell Significance Index: -3.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1225
    Cell Significance Index: -3.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1247
    Cell Significance Index: -4.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1261
    Cell Significance Index: -4.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1292
    Cell Significance Index: -1.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1311
    Cell Significance Index: -3.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1321
    Cell Significance Index: -1.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1365
    Cell Significance Index: -4.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1373
    Cell Significance Index: -5.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZN225 is a member of the zinc finger protein family, characterized by its high degree of sequence specificity and ability to bind to specific DNA sequences. Its unique structure, comprising a zinc finger domain, allows it to interact with RNA polymerase II and other transcription factors, thereby modulating gene expression. ZNF225 is also known to exhibit metal ion-binding properties, which may contribute to its stability and activity. **Pathways and Functions:** ZN225's primary function is to regulate gene expression by interacting with RNA polymerase II and other transcription factors. Its ability to bind to RNA polymerase II-specific sequences enables it to activate transcription, influencing the expression of genes involved in cellular development, differentiation, and homeostasis. Specifically, ZNF225 is implicated in the regulation of transcription by RNA polymerase II, a crucial process in the expression of protein-coding genes. ZN225's involvement in various cellular processes can be attributed to its expression in multiple cell types, including: 1. **GABAergic interneurons**: ZNF225 is expressed in cerebral cortex GABAergic interneurons, suggesting its potential role in regulating neuronal development and function. 2. **Intestinal epithelial cells**: Its expression in BEST4+ intestinal epithelial cells and goblet cells implies a role in maintaining intestinal homeostasis and barrier function. 3. **Radial glial cells**: ZNF225's presence in forebrain radial glial cells indicates its involvement in neural development and differentiation. **Clinical Significance:** ZN225's role in regulating gene expression and its involvement in various cellular processes make it a potential candidate for therapeutic intervention in diseases characterized by dysregulated gene expression. Some potential applications of ZNF225 include: 1. **Neurological disorders**: ZNF225's involvement in neuronal development and function suggests its potential role in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, or autism spectrum disorder. 2. **Gastrointestinal disorders**: Its expression in intestinal epithelial cells and goblet cells implies a potential role in the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease or irritable bowel syndrome. 3. **Cancer**: ZNF225's ability to regulate gene expression may also be exploited in cancer therapy, where its expression is often dysregulated. In conclusion, ZNF225 is a zinc finger protein that plays a critical role in regulating gene expression, with implications for various cellular processes, including neuronal development, intestinal homeostasis, and cancer. Further research is necessary to fully elucidate the mechanisms by which ZNF225 regulates gene expression and to explore its therapeutic potential in diseases characterized by dysregulated gene expression.

Genular Protein ID: 2739014485

Symbol: ZN225_HUMAN

Name: Zinc finger protein 225

UniProtKB Accession Codes:

Q9UK10 A8K8S2 Q53F12 Q9NS46 Q9UID8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12743021

Title: Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

PubMed ID: 12743021

DOI: 10.1101/gr.963903

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 706
  • Mass: 82471
  • Checksum: 4C357A3AB1E32FB2
  • Sequence:
    • MTTLKEAVTF KDVAVVFTEE ELRLLDLAQR KLYREVMLEN FRNLLSVGHQ SLHRDTFHFL 
KEEKFWMMET ATQREGNLGG KIQMEMETVS ESGTHEGLFS HQTWEQISSD LTRFQDSMVN 
SFQFSKQDDM PCQVDAGLSI IHVRQKPSEG RTCKKSFSDV SVLDLHQQLQ SREKSHTCDE 
CGKSFCYSSA LRIHQRVHMG EKLYNCDVCG KEFNQSSHLQ IHQRIHTGEK PFKCEQCGKG 
FSRRSGLYVH RKLHTGVKPH ICEKCGKAFI HDSQLQEHQR IHTGEKPFKC DICCKSFRSR 
ANLNRHSMVH MREKPFRCDT CGKSFGLKSA LNSHRMVHTG EKRYKCEECG KRFIYRQDLY 
KHQIDHTGEK PYNCKECGKS FRWASGLSRH VRVHSGETTF KCEECGKGFY TNSQRYSHQR 
AHSGEKPYRC EECGKGYKRR LDLDFHQRVH RGEKPYNCKE CGKSFGWASC LLNHQRIHSG 
EKPFKCEECG KRFTQNSQLY THRRVHSGEK PFKCEECGKR FTQNSQLYSH RRVHTGVKPY 
KCEECGKGFN SKFNLDMHQR VHTGERPYNC KECGKSFSRA SSILNHKRLH GDEKPFKCEE 
CGKRFTENSQ LHSHQRVHTG EKPYKCEKCG KSFRWASTHL THQRLHSREK LLQCEDCGKS 
IVHSSCLKDQ QRDQSGEKTS KCEDCGKRYK RRLNLDTLLS LFLNDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.