Details for: DAP3

Gene ID: 7818

Symbol: DAP3

Ensembl ID: ENSG00000132676

Description: death associated protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 277.8613
    Cell Significance Index: -43.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 158.8056
    Cell Significance Index: -40.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 115.3514
    Cell Significance Index: -54.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.8103
    Cell Significance Index: -45.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 112.3444
    Cell Significance Index: -46.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 100.6444
    Cell Significance Index: -51.7700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 81.4131
    Cell Significance Index: -54.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.1700
    Cell Significance Index: -45.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.3826
    Cell Significance Index: -49.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.6447
    Cell Significance Index: -41.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.2799
    Cell Significance Index: -43.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.1929
    Cell Significance Index: -52.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.5724
    Cell Significance Index: -20.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1022
    Cell Significance Index: 214.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1568
    Cell Significance Index: 57.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7933
    Cell Significance Index: 107.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7686
    Cell Significance Index: 350.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7533
    Cell Significance Index: 351.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4344
    Cell Significance Index: 19.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2287
    Cell Significance Index: 94.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1175
    Cell Significance Index: 31.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9995
    Cell Significance Index: 180.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9583
    Cell Significance Index: 45.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9528
    Cell Significance Index: 860.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9239
    Cell Significance Index: 331.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8841
    Cell Significance Index: 23.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8533
    Cell Significance Index: 25.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8410
    Cell Significance Index: 103.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7198
    Cell Significance Index: 46.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6709
    Cell Significance Index: 79.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6111
    Cell Significance Index: 270.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6066
    Cell Significance Index: 45.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5970
    Cell Significance Index: 31.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5818
    Cell Significance Index: 75.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5815
    Cell Significance Index: 317.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5598
    Cell Significance Index: 39.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5323
    Cell Significance Index: 24.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4976
    Cell Significance Index: 68.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4606
    Cell Significance Index: 11.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4189
    Cell Significance Index: 26.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3979
    Cell Significance Index: 275.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3476
    Cell Significance Index: 59.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2770
    Cell Significance Index: 7.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2051
    Cell Significance Index: 13.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1877
    Cell Significance Index: 35.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1655
    Cell Significance Index: 7.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1315
    Cell Significance Index: 4.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1149
    Cell Significance Index: 3.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1079
    Cell Significance Index: 13.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0638
    Cell Significance Index: 10.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0524
    Cell Significance Index: 98.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0456
    Cell Significance Index: 84.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0303
    Cell Significance Index: 46.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0218
    Cell Significance Index: 13.8700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0174
    Cell Significance Index: 0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0042
    Cell Significance Index: 1.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0016
    Cell Significance Index: 2.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0023
    Cell Significance Index: -0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0060
    Cell Significance Index: -4.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0158
    Cell Significance Index: -9.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0296
    Cell Significance Index: -21.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0304
    Cell Significance Index: -1.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0351
    Cell Significance Index: -25.7100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0362
    Cell Significance Index: -0.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0453
    Cell Significance Index: -2.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0492
    Cell Significance Index: -5.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0578
    Cell Significance Index: -32.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1120
    Cell Significance Index: -2.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1272
    Cell Significance Index: -12.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1273
    Cell Significance Index: -4.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1297
    Cell Significance Index: -27.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1380
    Cell Significance Index: -8.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1475
    Cell Significance Index: -4.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1477
    Cell Significance Index: -2.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1615
    Cell Significance Index: -46.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1699
    Cell Significance Index: -8.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1754
    Cell Significance Index: -25.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1799
    Cell Significance Index: -20.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2337
    Cell Significance Index: -5.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2375
    Cell Significance Index: -4.0700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2575
    Cell Significance Index: -2.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2628
    Cell Significance Index: -2.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2724
    Cell Significance Index: -31.7500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3072
    Cell Significance Index: -35.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3313
    Cell Significance Index: -5.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3452
    Cell Significance Index: -17.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3457
    Cell Significance Index: -7.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3551
    Cell Significance Index: -10.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4446
    Cell Significance Index: -46.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4457
    Cell Significance Index: -11.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4463
    Cell Significance Index: -10.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4464
    Cell Significance Index: -11.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5252
    Cell Significance Index: -16.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5436
    Cell Significance Index: -43.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6526
    Cell Significance Index: -40.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7296
    Cell Significance Index: -12.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7564
    Cell Significance Index: -4.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7813
    Cell Significance Index: -14.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7978
    Cell Significance Index: -17.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8267
    Cell Significance Index: -19.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization:** DAP3 is primarily localized to the mitochondrial inner membrane, where it interacts with ribosomal proteins and plays a role in mitochondrial translation. 2. **Apoptotic signaling:** DAP3 has been implicated in the regulation of apoptosis, a process essential for eliminating damaged or unwanted cells. Its absence or dysfunction has been linked to various diseases, including cancer and neurodegenerative disorders. 3. **Ribosomal protein:** DAP3 is a component of the 28S ribosomal subunit, which is responsible for protein synthesis and translation. 4. **GTP binding:** DAP3 possesses GTP-binding capabilities, which are essential for its function in mitochondrial translation and apoptosis. **Pathways and Functions:** 1. **Apoptotic signaling pathway:** DAP3 interacts with pro-apoptotic and anti-apoptotic proteins, influencing the regulation of apoptosis. 2. **Mitochondrial translation:** DAP3 plays a crucial role in mitochondrial translation, which is essential for the production of mitochondrial proteins and the maintenance of mitochondrial function. 3. **Protein synthesis:** As a ribosomal protein, DAP3 is involved in the synthesis of proteins, including those involved in energy metabolism and cell signaling. 4. **GTP-dependent regulation:** DAP3's GTP-binding capabilities allow it to regulate various cellular processes, including protein synthesis and apoptosis. **Clinical Significance:** 1. **Cancer:** DAP3 has been implicated in cancer development and progression, where its dysregulation can contribute to tumorigenesis and metastasis. 2. **Neurodegenerative diseases:** DAP3's involvement in mitochondrial translation and apoptosis has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Cardiovascular disease:** DAP3's expression in cardiac myocytes has been linked to cardiac function and disease, highlighting its potential as a therapeutic target. 4. **Regenerative medicine:** Understanding DAP3's functions and significance has implications for regenerative medicine, where its dysregulation can be targeted to promote tissue repair and regeneration. In conclusion, DAP3 is a multifunctional protein that plays a critical role in regulating cellular processes, including apoptosis, protein synthesis, and translation. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the functions and significance of DAP3, but its importance in maintaining cellular homeostasis and regulating cell death pathways is clear.

Genular Protein ID: 1068849714

Symbol: RT29_HUMAN

Name: 28S ribosomal protein S29, mitochondrial

UniProtKB Accession Codes:

P51398 B4DP59 B4DY62 E7EM60 Q13044 Q68CT7 Q96Q20

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EMDB 41 Ensembl 5 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 10 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7499268

Title: Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death.

PubMed ID: 7499268

DOI: 10.1074/jbc.270.46.27932

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 11162496

Title: A conserved N-terminal sequence targets human DAP3 to mitochondria.

PubMed ID: 11162496

DOI: 10.1006/bbrc.2000.4119

PubMed ID: 11279123

Title: The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present.

PubMed ID: 11279123

DOI: 10.1074/jbc.m100727200

PubMed ID: 19103604

Title: hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis.

PubMed ID: 19103604

DOI: 10.1074/jbc.m807797200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20563667

Title: Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction.

PubMed ID: 20563667

DOI: 10.1007/s10495-010-0519-3

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

Sequence Information:

  • Length: 398
  • Mass: 45566
  • Checksum: 778AF183FA04DEC8
  • Sequence:
    • MMLKGITRLI SRIHKLDPGR FLHMGTQARQ SIAAHLDNQV PVESPRAISR TNENDPAKHG 
DQHEGQHYNI SPQDLETVFP HGLPPRFVMQ VKTFSEACLM VRKPALELLH YLKNTSFAYP 
AIRYLLYGEK GTGKTLSLCH VIHFCAKQDW LILHIPDAHL WVKNCRDLLQ SSYNKQRFDQ 
PLEASTWLKN FKTTNERFLN QIKVQEKYVW NKRESTEKGS PLGEVVEQGI TRVRNATDAV 
GIVLKELKRQ SSLGMFHLLV AVDGINALWG RTTLKREDKS PIAPEELALV HNLRKMMKND 
WHGGAIVSAL SQTGSLFKPR KAYLPQELLG KEGFDALDPF IPILVSNYNP KEFESCIQYY 
LENNWLQHEK APTEEGKKEL LFLSNANPSL LERHCAYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.