Details for: IL1R2

Gene ID: 7850

Symbol: IL1R2

Ensembl ID: ENSG00000115590

Description: interleukin 1 receptor type 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.3391
    Cell Significance Index: -7.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 26.4840
    Cell Significance Index: -10.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.7197
    Cell Significance Index: -7.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 11.9221
    Cell Significance Index: -8.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.9812
    Cell Significance Index: -7.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 5.9154
    Cell Significance Index: 147.8700
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 4.5763
    Cell Significance Index: 13.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.5475
    Cell Significance Index: 321.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.9482
    Cell Significance Index: 110.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2477
    Cell Significance Index: -8.7000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.5646
    Cell Significance Index: 16.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.2074
    Cell Significance Index: -6.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0293
    Cell Significance Index: 386.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9868
    Cell Significance Index: -7.8400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.6159
    Cell Significance Index: 25.9300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.4147
    Cell Significance Index: 8.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3054
    Cell Significance Index: 19.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2443
    Cell Significance Index: 26.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0292
    Cell Significance Index: 46.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8156
    Cell Significance Index: 95.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7399
    Cell Significance Index: 44.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6979
    Cell Significance Index: 630.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6494
    Cell Significance Index: 70.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5245
    Cell Significance Index: 85.3100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.4517
    Cell Significance Index: 7.7600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.4452
    Cell Significance Index: 4.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3290
    Cell Significance Index: 145.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3183
    Cell Significance Index: 22.0100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.2503
    Cell Significance Index: 1.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1786
    Cell Significance Index: 17.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0947
    Cell Significance Index: 51.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0939
    Cell Significance Index: 1.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0896
    Cell Significance Index: 2.4000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0691
    Cell Significance Index: 1.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0553
    Cell Significance Index: 1.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0552
    Cell Significance Index: 10.9600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0123
    Cell Significance Index: 0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0094
    Cell Significance Index: 6.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0021
    Cell Significance Index: -0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0031
    Cell Significance Index: -0.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0037
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0045
    Cell Significance Index: -0.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0085
    Cell Significance Index: -13.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0098
    Cell Significance Index: -13.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0120
    Cell Significance Index: -7.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0165
    Cell Significance Index: -0.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0170
    Cell Significance Index: -3.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0177
    Cell Significance Index: -10.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0205
    Cell Significance Index: -9.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0213
    Cell Significance Index: -1.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0213
    Cell Significance Index: -7.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0217
    Cell Significance Index: -13.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0228
    Cell Significance Index: -2.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0232
    Cell Significance Index: -6.6700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0296
    Cell Significance Index: -0.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0297
    Cell Significance Index: -3.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0338
    Cell Significance Index: -1.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0357
    Cell Significance Index: -7.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0379
    Cell Significance Index: -1.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0413
    Cell Significance Index: -5.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0434
    Cell Significance Index: -6.3100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0483
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0494
    Cell Significance Index: -10.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0513
    Cell Significance Index: -8.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0524
    Cell Significance Index: -3.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0542
    Cell Significance Index: -7.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0563
    Cell Significance Index: -2.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0688
    Cell Significance Index: -8.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0708
    Cell Significance Index: -8.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0710
    Cell Significance Index: -1.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0913
    Cell Significance Index: -5.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0943
    Cell Significance Index: -7.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1081
    Cell Significance Index: -8.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1168
    Cell Significance Index: -3.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1200
    Cell Significance Index: -9.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1231
    Cell Significance Index: -8.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1425
    Cell Significance Index: -8.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1472
    Cell Significance Index: -9.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1490
    Cell Significance Index: -7.7400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1499
    Cell Significance Index: -3.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1561
    Cell Significance Index: -4.1800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1567
    Cell Significance Index: -1.0400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1585
    Cell Significance Index: -2.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1639
    Cell Significance Index: -3.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1912
    Cell Significance Index: -7.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1933
    Cell Significance Index: -1.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1935
    Cell Significance Index: -10.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1978
    Cell Significance Index: -8.7500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2017
    Cell Significance Index: -5.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2077
    Cell Significance Index: -2.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2121
    Cell Significance Index: -7.4300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2153
    Cell Significance Index: -4.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2168
    Cell Significance Index: -8.2100
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.2256
    Cell Significance Index: -2.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2279
    Cell Significance Index: -7.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2337
    Cell Significance Index: -10.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL1R2 is a type II transmembrane receptor that consists of an extracellular domain, a transmembrane domain, and an intracellular domain. Unlike IL-1R, which is a type I transmembrane receptor, IL1R2 lacks the intracellular kinase domain, making it a non-functional receptor. However, IL1R2 is capable of binding to IL-1 dimers and recruiting signaling molecules to the receptor, thereby initiating a negative regulatory feedback loop that inhibits IL-1 mediated signaling. **Pathways and Functions:** IL1R2 is involved in several signaling pathways, including: 1. **Negative regulation of cytokine production**: IL1R2 competes with IL-1R for binding to IL-1 dimers, thereby reducing the production of pro-inflammatory cytokines. 2. **Negative regulation of interleukin-1 alpha production**: IL1R2 inhibits the production of IL-1α, a potent pro-inflammatory cytokine. 3. **Negative regulation of interleukin-1-mediated signaling pathway**: IL1R2 blocks the activation of downstream signaling pathways, including the JAK/STAT and MAPK pathways. 4. **Interleukin-10 signaling**: IL1R2 interacts with IL-10, a anti-inflammatory cytokine, to regulate its signaling pathway. **Clinical Significance:** Dysregulation of IL1R2 has been implicated in various inflammatory and autoimmune diseases, including: 1. **Rheumatoid arthritis**: IL1R2 has been shown to be overexpressed in the synovial fluid of patients with rheumatoid arthritis, leading to an imbalance in cytokine production. 2. **Inflammatory bowel disease**: IL1R2 has been implicated in the pathogenesis of inflammatory bowel disease, where it contributes to the production of pro-inflammatory cytokines. 3. **Autoimmune diseases**: IL1R2 has been shown to be overexpressed in autoimmune diseases, such as lupus and multiple sclerosis, where it contributes to the dysregulation of cytokine production. In conclusion, IL1R2 plays a crucial role in regulating cytokine-mediated signaling pathways, and its dysregulation has significant implications for the development of inflammatory and autoimmune diseases. Further research is needed to fully understand the mechanisms by which IL1R2 regulates cytokine production and to explore its therapeutic potential in treating these diseases.

Genular Protein ID: 3211879412

Symbol: IL1R2_HUMAN

Name: Interleukin-1 receptor type 2

UniProtKB Accession Codes:

P27930 D3DVJ5 Q6LCE6 Q9UE68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 4 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1833184

Title: A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

PubMed ID: 1833184

DOI: 10.1002/j.1460-2075.1991.tb07831.x

PubMed ID: 8702856

Title: Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA.

PubMed ID: 8702856

DOI: 10.1074/jbc.271.34.20965

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7989776

Title: Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.

PubMed ID: 7989776

PubMed ID: 7878046

Title: Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist.

PubMed ID: 7878046

DOI: 10.1073/pnas.92.5.1714

PubMed ID: 9395521

Title: Role of metalloproteases in the release of the IL-1 type II decoy receptor.

PubMed ID: 9395521

DOI: 10.1074/jbc.272.50.31764

PubMed ID: 9862719

Title: The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.

PubMed ID: 9862719

PubMed ID: 10975853

Title: The membrane form of the type II IL-1 receptor accounts for inhibitory function.

PubMed ID: 10975853

DOI: 10.4049/jimmunol.165.6.3350

PubMed ID: 12530978

Title: The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.

PubMed ID: 12530978

DOI: 10.1016/s1074-7613(02)00514-9

PubMed ID: 20802483

Title: Structural insights into the assembly and activation of IL-1beta with its receptors.

PubMed ID: 20802483

DOI: 10.1038/ni.1925

Sequence Information:

  • Length: 398
  • Mass: 45421
  • Checksum: 2C2A03ADA6F3AC5B
  • Sequence:
    • MLRLYVLVMG VSAFTLQPAA HTGAARSCRF RGRHYKREFR LEGEPVALRC PQVPYWLWAS 
VSPRINLTWH KNDSARTVPG EEETRMWAQD GALWLLPALQ EDSGTYVCTT RNASYCDKMS 
IELRVFENTD AFLPFISYPQ ILTLSTSGVL VCPDLSEFTR DKTDVKIQWY KDSLLLDKDN 
EKFLSVRGTT HLLVHDVALE DAGYYRCVLT FAHEGQQYNI TRSIELRIKK KKEETIPVII 
SPLKTISASL GSRLTIPCKV FLGTGTPLTT MLWWTANDTH IESAYPGGRV TEGPRQEYSE 
NNENYIEVPL IFDPVTREDL HMDFKCVVHN TLSFQTLRTT VKEASSTFSW GIVLAPLSLA 
FLVLGGIWMH RRCKHRTGKA DGLTVLWPHH QDFQSYPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.