Details for: IFRD2

Gene ID: 7866

Symbol: IFRD2

Ensembl ID: ENSG00000214706

Description: interferon related developmental regulator 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.9224
    Cell Significance Index: -10.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.0593
    Cell Significance Index: -14.9800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 54.7157
    Cell Significance Index: -22.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.0946
    Cell Significance Index: -18.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.8718
    Cell Significance Index: -21.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.4084
    Cell Significance Index: -18.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.6461
    Cell Significance Index: -16.8300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 5.8712
    Cell Significance Index: 94.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.5733
    Cell Significance Index: -14.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2787
    Cell Significance Index: -20.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.0139
    Cell Significance Index: -15.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0456
    Cell Significance Index: 122.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7191
    Cell Significance Index: 1552.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6701
    Cell Significance Index: 194.6300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.4227
    Cell Significance Index: 11.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3134
    Cell Significance Index: 35.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2270
    Cell Significance Index: 57.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8594
    Cell Significance Index: 59.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8540
    Cell Significance Index: 40.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8361
    Cell Significance Index: 9.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8194
    Cell Significance Index: 11.1800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.8165
    Cell Significance Index: 5.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7949
    Cell Significance Index: 59.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7946
    Cell Significance Index: 22.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7483
    Cell Significance Index: 21.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7479
    Cell Significance Index: 96.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6375
    Cell Significance Index: 11.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6210
    Cell Significance Index: 43.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5622
    Cell Significance Index: 12.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5582
    Cell Significance Index: 36.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5165
    Cell Significance Index: 26.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5153
    Cell Significance Index: 63.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4485
    Cell Significance Index: 244.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4293
    Cell Significance Index: 85.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4231
    Cell Significance Index: 58.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4216
    Cell Significance Index: 4.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3909
    Cell Significance Index: 70.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3876
    Cell Significance Index: 13.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3822
    Cell Significance Index: 10.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3808
    Cell Significance Index: 10.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3593
    Cell Significance Index: 158.8400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.3382
    Cell Significance Index: 2.2100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.3356
    Cell Significance Index: 2.4100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3045
    Cell Significance Index: 7.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2822
    Cell Significance Index: 7.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2273
    Cell Significance Index: 26.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2172
    Cell Significance Index: 2.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2143
    Cell Significance Index: 40.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2092
    Cell Significance Index: 6.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1961
    Cell Significance Index: 8.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1843
    Cell Significance Index: 36.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1565
    Cell Significance Index: 1.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1460
    Cell Significance Index: 16.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1256
    Cell Significance Index: 12.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1011
    Cell Significance Index: 12.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0964
    Cell Significance Index: 16.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0710
    Cell Significance Index: 11.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0639
    Cell Significance Index: 22.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0592
    Cell Significance Index: 1.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0560
    Cell Significance Index: 2.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0467
    Cell Significance Index: 35.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0251
    Cell Significance Index: 0.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0238
    Cell Significance Index: 1.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0125
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0030
    Cell Significance Index: 5.6000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0082
    Cell Significance Index: -15.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0090
    Cell Significance Index: -5.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0093
    Cell Significance Index: -14.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0108
    Cell Significance Index: -7.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0121
    Cell Significance Index: -16.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0234
    Cell Significance Index: -17.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0238
    Cell Significance Index: -1.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0291
    Cell Significance Index: -0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0306
    Cell Significance Index: -3.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0315
    Cell Significance Index: -17.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0316
    Cell Significance Index: -14.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0335
    Cell Significance Index: -20.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0532
    Cell Significance Index: -3.3500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0754
    Cell Significance Index: -0.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0834
    Cell Significance Index: -12.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1069
    Cell Significance Index: -22.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1096
    Cell Significance Index: -2.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1435
    Cell Significance Index: -2.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1946
    Cell Significance Index: -20.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2035
    Cell Significance Index: -3.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2104
    Cell Significance Index: -12.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2153
    Cell Significance Index: -17.0500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2417
    Cell Significance Index: -3.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2438
    Cell Significance Index: -16.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2547
    Cell Significance Index: -14.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2583
    Cell Significance Index: -15.8800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2763
    Cell Significance Index: -1.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3306
    Cell Significance Index: -9.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3544
    Cell Significance Index: -10.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3626
    Cell Significance Index: -16.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3995
    Cell Significance Index: -10.2700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4064
    Cell Significance Index: -5.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4437
    Cell Significance Index: -16.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** IFRD2 acts as a transcriptional regulator, modulating the expression of target genes involved in cellular development, differentiation, and immune response. 2. **Negative regulation of translation:** IFRD2 binds to ribosomes, inhibiting translation and regulating protein synthesis in response to specific cellular signals. 3. **Cell-type specific expression:** IFRD2 is differentially expressed in various cell types, including extravillous trophoblast, pancreatic A and D cells, and cardiac muscle cells, highlighting its tissue-specific functions. 4. **Interactions with other proteins:** IFRD2 interacts with various proteins, including translation factors and transcriptional regulators, to modulate cellular processes. **Pathways and Functions:** 1. **Negative regulation of translation:** IFRD2 binds to ribosomes, inhibiting translation and regulating protein synthesis in response to specific cellular signals. 2. **Nucleus:** IFRD2 regulates nuclear processes, including transcriptional activation and repression, to modulate cellular development and differentiation. 3. **Protein binding:** IFRD2 interacts with various proteins, including translation factors and transcriptional regulators, to modulate cellular processes. 4. **Ribosome binding:** IFRD2 binds to ribosomes, regulating translation and protein synthesis in response to specific cellular signals. **Clinical Significance:** Dysregulation of IFRD2 expression has been implicated in various diseases, including: 1. **Cancer:** Aberrant IFRD2 expression has been observed in various types of cancer, including pancreatic and prostate cancer, suggesting its potential role in tumorigenesis. 2. **Autoimmune disorders:** IFRD2 may play a role in regulating immune responses and preventing autoimmune diseases, such as type 1 diabetes and multiple sclerosis. 3. **Cardiovascular diseases:** IFRD2 expression in cardiac muscle cells may influence cardiac function and disease progression in conditions such as heart failure. In conclusion, IFRD2 is a multifunctional gene that regulates cellular development, differentiation, and immune response. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 3111689728

Symbol: IFRD2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q12894 A0A0R4J2F6 Q9BVB4 Q9UJ88

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9050919

Title: The human homolog of the rodent immediate early response genes, PC4 and TIS7, resides in the lung cancer tumor suppressor gene region on chromosome 3p21.

PubMed ID: 9050919

DOI: 10.1007/s004390050368

PubMed ID: 30355441

Title: Structures of translationally inactive mammalian ribosomes.

PubMed ID: 30355441

DOI: 10.7554/elife.40486

Sequence Information:

  • Length: 442
  • Mass: 48048
  • Checksum: CB54F2118C0CBA74
  • Sequence:
    • MPRARKGNTL RKGGQRRGGG ARSSAQADSG SSDDEAASEA RSTASECPSL LSTTAEDSLG 
GDVVDEQGQQ EDLEEKLKEY VDCLTDKSAK TRQGALESLR LALASRLLPD FLLERRLTLA 
DALEKCLKKG KGEEQALAAA VLGLLCVQLG PGPKGEELFH SLQPLLVSVL SDSTASPAAR 
LHCASALGLG CYVAAADIQD LVSCLACLES VFSRFYGLGG SSTSPVVPAS LHGLLSAALQ 
AWALLLTICP STQISHILDR QLPRLPQLLS SESVNLRIAA GETIALLFEL ARDLEEEFVY 
EDMEALCSVL RTLATDSNKY RAKADRRRQR STFRAVLHSV EGGECEEEIV RFGFEVLYMD 
SWARHRIYAA FKEVLGSGMH HHLQNNELLR DIFGLGPVLL LDATALKACK VPRFEKHLYN 
AAAFKARTKA RSRVRDKRAD IL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.