Details for: ST8SIA4

Gene ID: 7903

Symbol: ST8SIA4

Ensembl ID: ENSG00000113532

Description: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 123.6296
    Cell Significance Index: -19.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.9945
    Cell Significance Index: -17.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.9130
    Cell Significance Index: -19.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.7306
    Cell Significance Index: -21.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6616
    Cell Significance Index: -19.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8742
    Cell Significance Index: -18.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7989
    Cell Significance Index: -14.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8213
    Cell Significance Index: -17.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9619
    Cell Significance Index: -19.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.5290
    Cell Significance Index: 88.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.1049
    Cell Significance Index: 50.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9585
    Cell Significance Index: 42.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.7641
    Cell Significance Index: 108.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8806
    Cell Significance Index: 609.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8728
    Cell Significance Index: 166.0900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.8516
    Cell Significance Index: 14.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7613
    Cell Significance Index: 14.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6057
    Cell Significance Index: 17.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5946
    Cell Significance Index: 13.0200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5020
    Cell Significance Index: 7.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4960
    Cell Significance Index: 11.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4686
    Cell Significance Index: 46.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4477
    Cell Significance Index: 404.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4228
    Cell Significance Index: 49.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4146
    Cell Significance Index: 83.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4069
    Cell Significance Index: 18.0000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.3974
    Cell Significance Index: 4.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3910
    Cell Significance Index: 10.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3753
    Cell Significance Index: 24.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2500
    Cell Significance Index: 4.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2481
    Cell Significance Index: 40.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2229
    Cell Significance Index: 8.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2164
    Cell Significance Index: 7.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2011
    Cell Significance Index: 5.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1874
    Cell Significance Index: 20.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1482
    Cell Significance Index: 29.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1367
    Cell Significance Index: 49.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0770
    Cell Significance Index: 4.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0465
    Cell Significance Index: 29.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0365
    Cell Significance Index: 19.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0325
    Cell Significance Index: 2.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0282
    Cell Significance Index: 1.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0132
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0091
    Cell Significance Index: -17.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0122
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0123
    Cell Significance Index: -22.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0140
    Cell Significance Index: -21.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0176
    Cell Significance Index: -9.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0178
    Cell Significance Index: -24.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0201
    Cell Significance Index: -0.5800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0206
    Cell Significance Index: -0.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0220
    Cell Significance Index: -16.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0279
    Cell Significance Index: -12.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0292
    Cell Significance Index: -21.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0309
    Cell Significance Index: -19.6300
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.0433
    Cell Significance Index: -0.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0444
    Cell Significance Index: -20.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0509
    Cell Significance Index: -10.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0601
    Cell Significance Index: -2.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0602
    Cell Significance Index: -17.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0729
    Cell Significance Index: -12.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0768
    Cell Significance Index: -1.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0814
    Cell Significance Index: -8.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0921
    Cell Significance Index: -16.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1008
    Cell Significance Index: -5.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1017
    Cell Significance Index: -2.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1115
    Cell Significance Index: -14.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1173
    Cell Significance Index: -17.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1263
    Cell Significance Index: -15.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1266
    Cell Significance Index: -17.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1441
    Cell Significance Index: -2.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1466
    Cell Significance Index: -2.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1523
    Cell Significance Index: -9.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1581
    Cell Significance Index: -18.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1670
    Cell Significance Index: -21.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1671
    Cell Significance Index: -12.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1747
    Cell Significance Index: -20.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1767
    Cell Significance Index: -11.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1773
    Cell Significance Index: -20.6600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1781
    Cell Significance Index: -2.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1873
    Cell Significance Index: -6.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1893
    Cell Significance Index: -19.7100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1952
    Cell Significance Index: -1.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2515
    Cell Significance Index: -3.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2550
    Cell Significance Index: -18.0400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2607
    Cell Significance Index: -1.6200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2665
    Cell Significance Index: -4.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2666
    Cell Significance Index: -12.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2722
    Cell Significance Index: -21.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2810
    Cell Significance Index: -5.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2910
    Cell Significance Index: -21.6900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3444
    Cell Significance Index: -4.3000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3550
    Cell Significance Index: -4.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3625
    Cell Significance Index: -9.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3666
    Cell Significance Index: -19.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3719
    Cell Significance Index: -19.3200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3746
    Cell Significance Index: -7.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3953
    Cell Significance Index: -8.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3955
    Cell Significance Index: -12.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ST8SIA4 is a member of the sialyltransferase family, which catalyzes the transfer of sialic acid residues to specific glycoproteins and lipids. This enzyme is characterized by its ability to synthesize gangliosides, sialylated glycoproteins, and other biomolecules, which are essential for maintaining immune homeostasis and neuronal function. ST8SIA4 is specifically expressed in cells involved in immune responses, such as macrophages and goblet cells, as well as in neurons, where it regulates axon guidance and neuronal development. **Pathways and Functions:** ST8SIA4 is involved in multiple signaling pathways that regulate immune responses and neuronal development. These pathways include: 1. **Ganglioside biosynthesis:** ST8SIA4 catalyzes the synthesis of gangliosides, which are complex lipids composed of sialic acid residues attached to ceramide. Gangliosides play a critical role in modulating immune responses and neuronal function. 2. **Asparagine n-linked glycosylation:** ST8SIA4 is involved in the glycosylation of proteins, which is essential for protein stability, folding, and function. 3. **Axon guidance:** ST8SIA4 regulates axon guidance by modulating the expression of sialylated glycoproteins, which are essential for neuronal development and axon outgrowth. 4. **Ncam1 interactions:** ST8SIA4 is involved in the regulation of Ncam1, a protein that plays a critical role in axon guidance and neuronal development. **Clinical Significance:** Dysregulation of ST8SIA4 has been implicated in various neurological and immunological disorders, including: 1. **Neurodegenerative diseases:** Alterations in ST8SIA4 expression have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Immune disorders:** Dysregulation of ST8SIA4 has been implicated in immune disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** ST8SIA4 has been shown to be overexpressed in certain types of cancer, including colon cancer and glioblastoma. In conclusion, ST8SIA4 is a crucial enzyme involved in regulating immune responses and neuronal development. Its dysregulation has significant clinical implications, and further research is needed to fully understand its role in disease pathogenesis and to develop novel therapeutic strategies.

Genular Protein ID: 387357175

Symbol: SIA8D_HUMAN

Name: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

UniProtKB Accession Codes:

Q92187 A8KA07 G3V104 Q8N1F4 Q92693

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7624364

Title: Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain.

PubMed ID: 7624364

DOI: 10.1073/pnas.92.15.7031

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9774483

Title: Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX.

PubMed ID: 9774483

DOI: 10.1074/jbc.273.43.28524

PubMed ID: 9852130

Title: In vivo autopolysialylation and localization of the polysialyltransferases PST and STX.

PubMed ID: 9852130

DOI: 10.1074/jbc.273.51.34586

PubMed ID: 10766765

Title: Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha2,8-Sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III.

PubMed ID: 10766765

DOI: 10.1074/jbc.m910204199

PubMed ID: 11279095

Title: Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity.

PubMed ID: 11279095

DOI: 10.1074/jbc.m100576200

PubMed ID: 28810663

Title: Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4.

PubMed ID: 28810663

DOI: 10.1093/glycob/cwx057

PubMed ID: 30569872

Title: The Inhibition of Polysialyltranseferase ST8SiaIV Through Heparin Binding to Polysialyltransferase Domain (PSTD).

PubMed ID: 30569872

DOI: 10.2174/1573406415666181218101623

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 359
  • Mass: 41295
  • Checksum: C53FFDF658926D61
  • Sequence:
    • MRSIRKRWTI CTISLLLIFY KTKEIARTEE HQETQLIGDG ELSLSRSLVN SSDKIIRKAG 
SSIFQHNVEG WKINSSLVLE IRKNILRFLD AERDVSVVKS SFKPGDVIHY VLDRRRTLNI 
SHDLHSLLPE VSPMKNRRFK TCAVVGNSGI LLDSECGKEI DSHNFVIRCN LAPVVEFAAD 
VGTKSDFITM NPSVVQRAFG GFRNESDREK FVHRLSMLND SVLWIPAFMV KGGEKHVEWV 
NALILKNKLK VRTAYPSLRL IHAVRGYWLT NKVPIKRPST GLLMYTLATR FCDEIHLYGF 
WPFPKDLNGK AVKYHYYDDL KYRYFSNASP HRMPLEFKTL NVLHNRGALK LTTGKCVKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.