Details for: BAG6

Gene ID: 7917

Symbol: BAG6

Ensembl ID: ENSG00000204463

Description: BAG cochaperone 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 172.7793
    Cell Significance Index: -26.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.3177
    Cell Significance Index: -28.2400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 86.4916
    Cell Significance Index: -35.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.1741
    Cell Significance Index: -30.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.8006
    Cell Significance Index: -35.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.3333
    Cell Significance Index: -30.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.6440
    Cell Significance Index: -30.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1652
    Cell Significance Index: -29.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3235
    Cell Significance Index: -32.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6057
    Cell Significance Index: -10.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9689
    Cell Significance Index: 118.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8038
    Cell Significance Index: 24.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6381
    Cell Significance Index: 266.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0528
    Cell Significance Index: 54.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8308
    Cell Significance Index: 17.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7775
    Cell Significance Index: 154.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7539
    Cell Significance Index: 20.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7506
    Cell Significance Index: 38.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7329
    Cell Significance Index: 21.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7199
    Cell Significance Index: 84.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6876
    Cell Significance Index: 43.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6811
    Cell Significance Index: 83.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6582
    Cell Significance Index: 125.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6494
    Cell Significance Index: 41.9000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6456
    Cell Significance Index: 4.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6164
    Cell Significance Index: 336.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6112
    Cell Significance Index: 110.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6014
    Cell Significance Index: 27.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5666
    Cell Significance Index: 19.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5661
    Cell Significance Index: 15.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5498
    Cell Significance Index: 4.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5346
    Cell Significance Index: 24.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5203
    Cell Significance Index: 71.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5180
    Cell Significance Index: 13.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5087
    Cell Significance Index: 23.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4415
    Cell Significance Index: 57.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4094
    Cell Significance Index: 4.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4083
    Cell Significance Index: 11.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3769
    Cell Significance Index: 340.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3616
    Cell Significance Index: 26.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3545
    Cell Significance Index: 45.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3446
    Cell Significance Index: 69.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3055
    Cell Significance Index: 135.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3030
    Cell Significance Index: 3.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2965
    Cell Significance Index: 5.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2946
    Cell Significance Index: 15.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2338
    Cell Significance Index: 39.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1834
    Cell Significance Index: 18.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1472
    Cell Significance Index: 1.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1459
    Cell Significance Index: 52.3400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1326
    Cell Significance Index: 1.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1015
    Cell Significance Index: 3.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0869
    Cell Significance Index: 1.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0796
    Cell Significance Index: 5.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0754
    Cell Significance Index: 8.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0075
    Cell Significance Index: 0.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0031
    Cell Significance Index: 2.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0102
    Cell Significance Index: -18.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0129
    Cell Significance Index: -9.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0139
    Cell Significance Index: -21.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0152
    Cell Significance Index: -0.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0154
    Cell Significance Index: -9.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0172
    Cell Significance Index: -12.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0225
    Cell Significance Index: -30.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0294
    Cell Significance Index: -18.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0344
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0406
    Cell Significance Index: -4.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0416
    Cell Significance Index: -23.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0429
    Cell Significance Index: -19.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0458
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0466
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0594
    Cell Significance Index: -6.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0931
    Cell Significance Index: -19.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0959
    Cell Significance Index: -2.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1077
    Cell Significance Index: -15.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1112
    Cell Significance Index: -8.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1189
    Cell Significance Index: -1.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1227
    Cell Significance Index: -35.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1518
    Cell Significance Index: -17.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1815
    Cell Significance Index: -2.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2179
    Cell Significance Index: -4.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2201
    Cell Significance Index: -7.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2242
    Cell Significance Index: -12.5800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2539
    Cell Significance Index: -2.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2612
    Cell Significance Index: -6.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3113
    Cell Significance Index: -32.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3190
    Cell Significance Index: -13.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3501
    Cell Significance Index: -27.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4271
    Cell Significance Index: -7.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4329
    Cell Significance Index: -7.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4806
    Cell Significance Index: -4.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4808
    Cell Significance Index: -29.4800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4996
    Cell Significance Index: -2.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5028
    Cell Significance Index: -14.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5863
    Cell Significance Index: -15.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5973
    Cell Significance Index: -26.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6674
    Cell Significance Index: -24.5000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6806
    Cell Significance Index: -4.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BAG6 is a 150-kDa protein that belongs to the BAG family, characterized by its ability to bind to HSP70, HSP90, and other proteins. It possesses a unique structure, consisting of a coiled-coil domain, a BAG domain, and a proline-rich domain. BAG6 is highly expressed in various cell types, including extravillous trophoblasts, myeloid dendritic cells, and peripheral nervous system neurons. Its expression is also regulated by post-translational modifications, such as phosphorylation and ubiquitination, which modulate its activity and interactions with other proteins. **Pathways and Functions** BAG6 is involved in multiple cellular pathways, including: 1. **Apoptotic Process**: BAG6 regulates apoptosis by interacting with pro-apoptotic proteins, such as BAX and BAK, and modulating the activity of caspases. 2. **Immune Response-Activating Cell Surface Receptor Signaling Pathway**: BAG6 interacts with signaling receptors, such as Toll-like receptors, to regulate immune responses and activate inflammatory pathways. 3. **Endoplasmic Reticulum Stress-Induced Pre-emptive Quality Control**: BAG6 regulates the unfolded protein response by interacting with HSP70 and modulating the activity of ubiquitin ligases. 4. **Intrinsic Apoptotic Signaling Pathway**: BAG6 regulates apoptosis in response to DNA damage by interacting with p53 class mediators and modulating the activity of caspases. 5. **Protein Stability and Localization**: BAG6 regulates protein stability and localization by interacting with HSP70 and other chaperones, and modulating the activity of ubiquitin ligases. **Clinical Significance** Dysregulation of BAG6 has been implicated in various diseases, including: 1. **Cancer**: BAG6 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, and has been associated with poor prognosis. 2. **Neurodegenerative Diseases**: BAG6 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, and has been associated with protein misfolding and aggregation. 3. **Inflammatory Disorders**: BAG6 has been implicated in inflammatory disorders, such as atherosclerosis and rheumatoid arthritis, and has been associated with immune responses and inflammation. 4. **Developmental Disorders**: BAG6 has been implicated in developmental disorders, such as autism and schizophrenia, and has been associated with protein misregulation and cellular dysfunction. In conclusion, BAG6 is a multifunctional molecular chaperone that plays a crucial role in maintaining protein homeostasis, regulating cellular processes, and modulating immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of BAG6 in maintaining cellular homeostasis and regulating cellular behavior.

Genular Protein ID: 2958832550

Symbol: BAG6_HUMAN

Name: BAG family molecular chaperone regulator 6

UniProtKB Accession Codes:

P46379 A2ADJ7 A3KQ42 A3KQ44 A6NGY6 A6PWF7 B0UX84 B4DZ12 B4E3V4 E7EMZ4 F8VXY4 O95874 Q5HYL9 Q5SQ35 Q5SQ36 Q5SQ37 Q5SQ41 Q5SRP8 Q5SRP9 Q5STC1 Q5STX1 Q5STX3 Q96SA6 Q9BCN4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 19 EMDB 3 Ensembl 23 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2156268

Title: A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain.

PubMed ID: 2156268

DOI: 10.1073/pnas.87.6.2374

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14960581

Title: Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3.

PubMed ID: 14960581

DOI: 10.1074/jbc.m307049200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17403783

Title: HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.

PubMed ID: 17403783

DOI: 10.1101/gad.1534107

PubMed ID: 18055229

Title: Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells.

PubMed ID: 18055229

DOI: 10.1016/j.immuni.2007.10.010

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18765639

Title: BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression.

PubMed ID: 18765639

DOI: 10.1128/mcb.00568-08

PubMed ID: 18852879

Title: Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function.

PubMed ID: 18852879

DOI: 10.1371/journal.pone.0003377

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20547746

Title: E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates.

PubMed ID: 20547746

DOI: 10.1128/iai.00344-10

PubMed ID: 20516149

Title: Bat3 promotes the membrane integration of tail-anchored proteins.

PubMed ID: 20516149

DOI: 10.1242/jcs.066738

PubMed ID: 20676083

Title: A ribosome-associating factor chaperones tail-anchored membrane proteins.

PubMed ID: 20676083

DOI: 10.1038/nature09296

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21636303

Title: A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.

PubMed ID: 21636303

DOI: 10.1016/j.molcel.2011.05.010

PubMed ID: 21743475

Title: Protein targeting and degradation are coupled for elimination of mislocalized proteins.

PubMed ID: 21743475

DOI: 10.1038/nature10181

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23129660

Title: SGTA antagonizes BAG6-mediated protein triage.

PubMed ID: 23129660

DOI: 10.1073/pnas.1209997109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24160817

Title: Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex.

PubMed ID: 24160817

DOI: 10.1042/bj20130710

PubMed ID: 24424410

Title: USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

PubMed ID: 24424410

DOI: 10.7554/elife.01369

PubMed ID: 25179605

Title: SGTA regulates the cytosolic quality control of hydrophobic substrates.

PubMed ID: 25179605

DOI: 10.1242/jcs.155648

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24981174

Title: Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.

PubMed ID: 24981174

DOI: 10.1016/j.molcel.2014.05.025

PubMed ID: 26565908

Title: Pre-emptive quality control protects the ER from protein overload via the proximity of ERAD components and SRP.

PubMed ID: 26565908

DOI: 10.1016/j.celrep.2015.09.047

PubMed ID: 26337389

Title: Proteasomal degradation of preemptive quality control (pQC) substrates is mediated by an AIRAPL-p97 complex.

PubMed ID: 26337389

DOI: 10.1091/mbc.e15-02-0085

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27113755

Title: UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation.

PubMed ID: 27113755

DOI: 10.15252/embr.201541402

PubMed ID: 26692333

Title: Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.

PubMed ID: 26692333

DOI: 10.1038/nm.4013

PubMed ID: 28104892

Title: Mechanistic basis for a molecular triage reaction.

PubMed ID: 28104892

DOI: 10.1126/science.aah6130

PubMed ID: 25713138

Title: Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis.

PubMed ID: 25713138

DOI: 10.1074/jbc.m114.631804

PubMed ID: 25535373

Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.

PubMed ID: 25535373

DOI: 10.1073/pnas.1402745112

PubMed ID: 27193484

Title: Structural and functional insights into the E3 ligase, RNF126.

PubMed ID: 27193484

DOI: 10.1038/srep26433

PubMed ID: 29042515

Title: Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35.

PubMed ID: 29042515

DOI: 10.1073/pnas.1702940114

Sequence Information:

  • Length: 1132
  • Mass: 119409
  • Checksum: 625B5F86321367ED
  • Sequence:
    • MEPNDSTSTA VEEPDSLEVL VKTLDSQTRT FIVGAQMNVK EFKEHIAASV SIPSEKQRLI 
YQGRVLQDDK KLQEYNVGGK VIHLVERAPP QTHLPSGASS GTGSASATHG GGSPPGTRGP 
GASVHDRNAN SYVMVGTFNL PSDGSAVDVH INMEQAPIQS EPRVRLVMAQ HMIRDIQTLL 
SRMETLPYLQ CRGGPQPQHS QPPPQPPAVT PEPVALSSQT SEPVESEAPP REPMEAEEVE 
ERAPAQNPEL TPGPAPAGPT PAPETNAPNH PSPAEYVEVL QELQRLESRL QPFLQRYYEV 
LGAAATTDYN NNHEGREEDQ RLINLVGESL RLLGNTFVAL SDLRCNLACT PPRHLHVVRP 
MSHYTTPMVL QQAAIPIQIN VGTTVTMTGN GTRPPPTPNA EAPPPGPGQA SSVAPSSTNV 
ESSAEGAPPP GPAPPPATSH PRVIRISHQS VEPVVMMHMN IQDSGTQPGG VPSAPTGPLG 
PPGHGQTLGQ QVPGFPTAPT RVVIARPTPP QARPSHPGGP PVSGTLQGAG LGTNASLAQM 
VSGLVGQLLM QPVLVAQGTP GMAPPPAPAT ASASAGTTNT ATTAGPAPGG PAQPPPTPQP 
SMADLQFSQL LGNLLGPAGP GAGGSGVASP TITVAMPGVP AFLQGMTDFL QATQTAPPPP 
PPPPPPPPAP EQQTMPPPGS PSGGAGSPGG LGLESLSPEF FTSVVQGVLS SLLGSLGARA 
GSSESIAAFI QRLSGSSNIF EPGADGALGF FGALLSLLCQ NFSMVDVVML LHGHFQPLQR 
LQPQLRSFFH QHYLGGQEPT PSNIRMATHT LITGLEEYVR ESFSLVQVQP GVDIIRTNLE 
FLQEQFNSIA AHVLHCTDSG FGARLLELCN QGLFECLALN LHCLGGQQME LAAVINGRIR 
RMSRGVNPSL VSWLTTMMGL RLQVVLEHMP VGPDAILRYV RRVGDPPQPL PEEPMEVQGA 
ERASPEPQRE NASPAPGTTA EEAMSRGPPP APEGGSRDEQ DGASAETEPW AAAVPPEWVP 
IIQQDIQSQR KVKPQPPLSD AYLSGMPAKR RKTMQGEGPQ LLLSEAVSRA AKAAGARPLT 
SPESLSRDLE APEVQESYRQ QLRSDIQKRL QEDPNYSPQR FPNAQRAFAD DP

Genular Protein ID: 2169542417

Symbol: A0A1U9X7A6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1U9X7A6

Database IDs:

ARBA 14 AlphaFoldDB 1 Antibodypedia 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 ExpressionAtlas 1 GO 9 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 3 RefSeq 3 SAM 1 SMART 1 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 1126
  • Mass: 118693
  • Checksum: 8A67290BC8176ABA
  • Sequence:
    • MEPNDSTSTA VEEPDSLEVL VKTLDSQTRT FIVGAQMNVK EFKEHIAASV SIPSEKQRLI 
YQGRVLQDDK KLQEYNVGGK VIHLVERAPP QTHLPSGASS GTGSASATHG GGSPPGTRGP 
GASVHDRNAN SYVMVGTFNL PSDGSAVDVH INMEQAPIQS EPRVRLVMAQ HMIRDIQTLL 
SRMECRGGPQ PQHSQPPPQP PAVTPEPVAL SSQTSEPVES EAPPREPMEA EEVEERAPAQ 
NPELTPGPAP AGPTPAPETN APNHPSPAEY VEVLQELQRL ESRLQPFLQR YYEVLGAAAT 
TDYNNNHEGR EEDQRLINLV GESLRLLGNT FVALSDLRCN LACTPPRHLH VVRPMSHYTT 
PMVLQQAAIP IQINVGTTVT MTGNGTRPPP TPNAEAPPPG PGQASSVAPS STNVESSAEG 
APPPGPAPPP ATSHPRVIRI SHQSVEPVVM MHMNIQDSGT QPGGVPSAPT GPLGPPGHGQ 
TLGQQVPGFP TAPTRVVIAR PTPPQARPSH PGGPPVSGTL QGAGLGTNAS LAQMVSGLVG 
QLLMQPVLVA QGTPGMAPPP APATASASAG TTNTATTAGP APGGPAQPPP TPQPSMADLQ 
FSQLLGNLLG PAGPGAGGSG VASPTITVAM PGVPAFLQGM TDFLQATQTA PPPPPPPPPP 
PPAPEQQTMP PPGSPSGGAG SPGGLGLESL SPEFFTSVVQ GVLSSLLGSL GARAGSSESI 
AAFIQRLSGS SNIFEPGADG ALGFFGALLS LLCQNFSMVD VVMLLHGHFQ PLQRLQPQLR 
SFFHQHYLGG QEPTPSNIRM ATHTLITGLE EYVRESFSLV QVQPGVDIIR TNLEFLQEQF 
NSIAAHVLHC TDSGFGARLL ELCNQGLFEC LALNLHCLGG QQMELAAVIN GRIRRMSRGV 
NPSLVSWLTT MMGLRLQVVL EHMPVGPDAI LRYVRRVGDP PQPLPEEPME VQGAERASPE 
PQRENASPAP GTTAEEAMSR GPPPAPEGGS RDEQDGASAE TEPWAAAVPP EWVPIIQQDI 
QSQRKVKPQP PLSDAYLSGM PAKRRKTMQG EGPQLLLSEA VSRAAKAAGA RPLTSPESLS 
RDLEAPEVQE SYRQQLRSDI QKRLQEDPNY SPQRFPNAQR AFADDP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.