AAAS | ENSG00000094914 | NCBI 8086

Details for: AAAS

Gene ID: 8086

Symbol: AAAS

Ensembl ID: ENSG00000094914

Description: aladin WD repeat nucleoporin

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective tpr may confer susceptibility towards thyroid papillary carcinoma (tpc)
(R-HSA-5619107)
Disease
(R-HSA-1643685)
Disorders of transmembrane transporters
(R-HSA-5619115)
Export of viral ribonucleoproteins from nucleus
(R-HSA-168274)
Gene expression (transcription)
(R-HSA-74160)
Gene silencing by rna
(R-HSA-211000)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Interactions of rev with host cellular proteins
(R-HSA-177243)
Interactions of vpr with host cellular proteins
(R-HSA-176033)
Interferon signaling
(R-HSA-913531)
Isg15 antiviral mechanism
(R-HSA-1169408)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of non-coding rna
(R-HSA-194441)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Nep/ns2 interacts with the cellular export machinery
(R-HSA-168333)
Ns1 mediated effects on host pathways
(R-HSA-168276)
Nuclear envelope breakdown
(R-HSA-2980766)
Nuclear import of rev protein
(R-HSA-180746)
Nuclear pore complex (npc) disassembly
(R-HSA-3301854)
Post-translational protein modification
(R-HSA-597592)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Regulation of glucokinase by glucokinase regulatory protein
(R-HSA-170822)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Rev-mediated nuclear export of hiv rna
(R-HSA-165054)
Rhoa gtpase cycle
(R-HSA-8980692)
Rho gtpase cycle
(R-HSA-9012999)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Slc transporter disorders
(R-HSA-5619102)
Snrnp assembly
(R-HSA-191859)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Sumoylation of dna replication proteins
(R-HSA-4615885)
Sumoylation of rna binding proteins
(R-HSA-4570464)
Sumoylation of sumoylation proteins
(R-HSA-4085377)
Sumoylation of ubiquitinylation proteins
(R-HSA-3232142)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transport of mature mrna derived from an intron-containing transcript
(R-HSA-159236)
Transport of mature mrna derived from an intronless transcript
(R-HSA-159231)
Transport of mature mrnas derived from intronless transcripts
(R-HSA-159234)
Transport of mature transcript to cytoplasm
(R-HSA-72202)
Transport of ribonucleoproteins into the host nucleus
(R-HSA-168271)
Transport of the slbp dependant mature mrna
(R-HSA-159230)
Transport of the slbp independent mature mrna
(R-HSA-159227)
Trna processing
(R-HSA-72306)
Trna processing in the nucleus
(R-HSA-6784531)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Vpr-mediated nuclear import of pics
(R-HSA-180910)
Centrosome
(GO:0005813)
Fertilization
(GO:0009566)
Learning
(GO:0007612)
Microtubule bundle formation
(GO:0001578)
Mitotic spindle assembly
(GO:0090307)
Molecular_function
(GO:0003674)
Mrna transport
(GO:0051028)
Nuclear envelope
(GO:0005635)
Nuclear pore
(GO:0005643)
Nucleocytoplasmic transport
(GO:0006913)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein transport
(GO:0015031)
Regulation of nucleocytoplasmic transport
(GO:0046822)
Spindle pole
(GO:0000922)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 74.2549
Cell Significance Index: -11.5500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 57.2556
Cell Significance Index: -14.5200
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 47.3604
Cell Significance Index: -19.5100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 38.5281
Cell Significance Index: -18.1900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 38.4486
Cell Significance Index: -15.6200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 16.4756
Cell Significance Index: -15.7300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 13.1635
Cell Significance Index: -16.2300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.1183
Cell Significance Index: -16.3900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.4703
Cell Significance Index: -17.6400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.9981
Cell Significance Index: -12.2800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.5183
Cell Significance Index: -7.7000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.5046
Cell Significance Index: 244.7200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.4359
Cell Significance Index: 15.6100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9975
Cell Significance Index: 108.5000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9731
Cell Significance Index: 58.4200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.7912
Cell Significance Index: 92.2000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.7324
Cell Significance Index: 25.4500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.7018
Cell Significance Index: 18.8100
Cell Name: kidney cell (CL1000497)
Fold Change: 0.6682
Cell Significance Index: 5.3400
Cell Name: germ cell (CL0000586)
Fold Change: 0.6470
Cell Significance Index: 4.8900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6468
Cell Significance Index: 8.8300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.6163
Cell Significance Index: 12.9000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.6016
Cell Significance Index: 7.7100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5066
Cell Significance Index: 35.0400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4748
Cell Significance Index: 94.2200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4389
Cell Significance Index: 27.6600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3280
Cell Significance Index: 9.4500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3270
Cell Significance Index: 44.9100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3144
Cell Significance Index: 14.2500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3076
Cell Significance Index: 61.7000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3038
Cell Significance Index: 8.4900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2894
Cell Significance Index: 15.0400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2874
Cell Significance Index: 7.8200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2767
Cell Significance Index: 32.6300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2589
Cell Significance Index: 5.6100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2520
Cell Significance Index: 11.7500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2258
Cell Significance Index: 28.9500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2205
Cell Significance Index: 16.9200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2177
Cell Significance Index: 118.9000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.2145
Cell Significance Index: 2.2200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2140
Cell Significance Index: 38.5800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1998
Cell Significance Index: 88.3600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1860
Cell Significance Index: 35.3900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.1551
Cell Significance Index: 2.2900
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1403
Cell Significance Index: 3.6900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1289
Cell Significance Index: 15.8500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1176
Cell Significance Index: 7.5900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1012
Cell Significance Index: 36.3100
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0814
Cell Significance Index: 10.5100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0720
Cell Significance Index: 2.5300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0667
Cell Significance Index: 60.2700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0601
Cell Significance Index: 5.9500
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0565
Cell Significance Index: 1.6600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0501
Cell Significance Index: 3.5400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0497
Cell Significance Index: 3.7100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0414
Cell Significance Index: 2.0900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0379
Cell Significance Index: 6.4800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0236
Cell Significance Index: 0.7500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0179
Cell Significance Index: 0.9400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0178
Cell Significance Index: 33.4900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0131
Cell Significance Index: 0.2800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0087
Cell Significance Index: 0.1500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0069
Cell Significance Index: 0.3600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0067
Cell Significance Index: 9.0700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0034
Cell Significance Index: 6.3100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0026
Cell Significance Index: 0.0700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0005
Cell Significance Index: 0.7900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0032
Cell Significance Index: -2.0100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0040
Cell Significance Index: -0.1900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0053
Cell Significance Index: -3.9900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0109
Cell Significance Index: -1.5800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0119
Cell Significance Index: -8.7400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0130
Cell Significance Index: -5.8900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0197
Cell Significance Index: -2.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0210
Cell Significance Index: -15.5400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0279
Cell Significance Index: -15.7100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0333
Cell Significance Index: -0.8500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0388
Cell Significance Index: -24.2400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0476
Cell Significance Index: -13.7100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0613
Cell Significance Index: -3.4400
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0649
Cell Significance Index: -0.9100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0927
Cell Significance Index: -10.6200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0968
Cell Significance Index: -20.3900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1007
Cell Significance Index: -1.7300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1166
Cell Significance Index: -1.3900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.1452
Cell Significance Index: -1.2200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1530
Cell Significance Index: -15.9300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1801
Cell Significance Index: -11.0400
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1850
Cell Significance Index: -2.8100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1992
Cell Significance Index: -15.7800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2085
Cell Significance Index: -5.3600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2105
Cell Significance Index: -5.6300
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.2503
Cell Significance Index: -3.2100
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.2652
Cell Significance Index: -6.4700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2677
Cell Significance Index: -11.8400
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.2732
Cell Significance Index: -1.7100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2826
Cell Significance Index: -8.1000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3144
Cell Significance Index: -9.2600
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.3168
Cell Significance Index: -1.8800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3169
Cell Significance Index: -12.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **WD Repeat Domain**: The AAAS protein contains a WD repeat domain, which is a conserved motif found in proteins involved in signal transduction and nuclear transport. 2. **Nuclear Pore Complex (NPC) Component**: AAAS is a component of the NPC, which is responsible for the transport of molecules between the nucleus and cytoplasm. 3. **Antiviral Mechanism**: AAAS is involved in the antiviral mechanism of interferon-stimulated genes, which helps to prevent viral infections. 4. **Cell Cycle Regulation**: AAAS plays a role in regulating the cell cycle, particularly during mitosis and meiosis. 5. **Immune Response**: AAAS is involved in the regulation of immune responses, including the activation of cytokine signaling pathways. **Pathways and Functions** 1. **Nuclear Import of Rev Protein**: AAAS is involved in the nuclear import of the Rev protein, which is essential for the replication of HIV-1. 2. **Regulation of Glucokinase**: AAAS regulates the expression of glucokinase, a key enzyme involved in glucose metabolism. 3. **Heat Shock Response**: AAAS is involved in the regulation of the heat shock response, which helps to protect cells against heat stress. 4. **Cytokine Signaling**: AAAS is involved in the regulation of cytokine signaling pathways, which are essential for the activation of immune responses. 5. **Viral Messenger RNA Synthesis**: AAAS is involved in the transport of viral messenger RNA into the host nucleus, where it can be translated into proteins. **Clinical Significance** 1. **Thyroid Papillary Carcinoma (TPC)**: Defects in the AAAS gene may confer susceptibility to TPC, a type of thyroid cancer. 2. **Viral Infections**: AAAS plays a critical role in the regulation of viral infections, including HIV-1, SARS-CoV-2, and influenza. 3. **Immune Response**: AAAS is involved in the regulation of immune responses, which are essential for the protection against viral and bacterial infections. 4. **Cancer Research**: AAAS may be involved in the regulation of cancer cell growth and survival, making it a potential target for cancer therapy. In conclusion, the AAAS gene is a critical component of the nuclear pore complex and plays a vital role in various cellular processes, including antiviral mechanisms, cell cycle regulation, and immune responses. Its dysregulation may contribute to the development of various diseases, including thyroid papillary carcinoma and viral infections. Further research is needed to fully understand the functions and clinical significance of the AAAS gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Aladin

Genular Protein ID: 1359976088

Symbol: AAAS_HUMAN

Name: Aladin

UniProtKB Accession Codes:

Q9NRG9 Q5JB47 Q9NWI6 Q9UG19

Database IDs:

Citations:

PubMed ID: 11062474

Title: Mutant WD-repeat protein in triple-A syndrome.

PubMed ID: 11062474

DOI: 10.1038/81642

PubMed ID: 11159947

Title: Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene.

PubMed ID: 11159947

DOI: 10.1093/hmg/10.3.283

PubMed ID: 16022285

Title: Molecular cloning and characterization of AAAS-V2, a novel splice variant of human AAAS.

PubMed ID: 16022285

DOI: 10.1007/s11033-004-6939-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19782045

Title: The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope.

PubMed ID: 19782045

DOI: 10.1016/j.bbrc.2009.09.080

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26246606

Title: The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation.

PubMed ID: 26246606

DOI: 10.1091/mbc.e15-02-0113

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27754849

Title: Identification of a novel putative interaction partner of the nucleoporin ALADIN.

PubMed ID: 27754849

DOI: 10.1242/bio.021162

Sequence Information:

Length: 546
Mass: 59574
Checksum: E0F4E7145D8C192E
Sequence:

MCSLGLFPPP PPRGQVTLYE HNNELVTGSS YESPPPDFRG QWINLPVLQL TKDPLKTPGR 
LDHGTRTAFI HHREQVWKRC INIWRDVGLF GVLNEIANSE EEVFEWVKTA SGWALALCRW 
ASSLHGSLFP HLSLRSEDLI AEFAQVTNWS SCCLRVFAWH PHTNKFAVAL LDDSVRVYNA 
SSTIVPSLKH RLQRNVASLA WKPLSASVLA VACQSCILIW TLDPTSLSTR PSSGCAQVLS 
HPGHTPVTSL AWAPSGGRLL SASPVDAAIR VWDVSTETCV PLPWFRGGGV TNLLWSPDGS 
KILATTPSAV FRVWEAQMWT CERWPTLSGR CQTGCWSPDG SRLLFTVLGE PLIYSLSFPE 
RCGEGKGCVG GAKSATIVAD LSETTIQTPD GEERLGGEAH SMVWDPSGER LAVLMKGKPR 
VQDGKPVILL FRTRNSPVFE LLPCGIIQGE PGAQPQLITF HPSFNKGALL SVGWSTGRIA 
HIPLYFVNAQ FPRFSPVLGR AQEPPAGGGG SIHDLPLFTE TSPTSAPWDP LPGPPPVLPH 
SPHSHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AAAS

Associated with

Cells (max top 100)

Other Information

Mutant WD-repeat protein in triple-A syndrome. PubMed ID: 11062474

Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene. PubMed ID: 11159947

Molecular cloning and characterization of AAAS-V2, a novel splice variant of human AAAS. PubMed ID: 16022285

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope. PubMed ID: 19782045

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation. PubMed ID: 26246606

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Identification of a novel putative interaction partner of the nucleoporin ALADIN. PubMed ID: 27754849