Details for: YEATS4

Gene ID: 8089

Symbol: YEATS4

Ensembl ID: ENSG00000127337

Description: YEATS domain containing 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.4122
    Cell Significance Index: -11.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.5070
    Cell Significance Index: -17.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.9179
    Cell Significance Index: -25.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.9116
    Cell Significance Index: -25.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.5529
    Cell Significance Index: -21.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.2129
    Cell Significance Index: -24.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.4249
    Cell Significance Index: -21.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.4330
    Cell Significance Index: -23.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3333
    Cell Significance Index: -19.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5509
    Cell Significance Index: -25.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8316
    Cell Significance Index: -14.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2453
    Cell Significance Index: 1124.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1135
    Cell Significance Index: 70.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8373
    Cell Significance Index: 22.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7393
    Cell Significance Index: 25.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7384
    Cell Significance Index: 38.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7315
    Cell Significance Index: 86.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5269
    Cell Significance Index: 94.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5169
    Cell Significance Index: 228.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5154
    Cell Significance Index: 63.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4588
    Cell Significance Index: 31.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4166
    Cell Significance Index: 227.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4126
    Cell Significance Index: 81.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3942
    Cell Significance Index: 20.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3482
    Cell Significance Index: 56.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3481
    Cell Significance Index: 16.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2943
    Cell Significance Index: 59.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2931
    Cell Significance Index: 20.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2791
    Cell Significance Index: 8.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2469
    Cell Significance Index: 18.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2385
    Cell Significance Index: 23.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2151
    Cell Significance Index: 10.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2072
    Cell Significance Index: 2.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2043
    Cell Significance Index: 26.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1955
    Cell Significance Index: 12.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1773
    Cell Significance Index: 5.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1772
    Cell Significance Index: 3.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1731
    Cell Significance Index: 62.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1668
    Cell Significance Index: 7.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1537
    Cell Significance Index: 29.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1207
    Cell Significance Index: 83.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1169
    Cell Significance Index: 6.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1130
    Cell Significance Index: 2.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1106
    Cell Significance Index: 14.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1015
    Cell Significance Index: 13.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0846
    Cell Significance Index: 0.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0262
    Cell Significance Index: 0.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0161
    Cell Significance Index: 0.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0159
    Cell Significance Index: 0.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0071
    Cell Significance Index: 1.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0044
    Cell Significance Index: 8.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0038
    Cell Significance Index: -2.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0096
    Cell Significance Index: -14.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0097
    Cell Significance Index: -7.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0106
    Cell Significance Index: -19.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0132
    Cell Significance Index: -17.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0156
    Cell Significance Index: -9.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0174
    Cell Significance Index: -0.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0192
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0247
    Cell Significance Index: -18.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0249
    Cell Significance Index: -0.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0328
    Cell Significance Index: -14.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0368
    Cell Significance Index: -3.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0374
    Cell Significance Index: -21.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0416
    Cell Significance Index: -2.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0453
    Cell Significance Index: -6.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0495
    Cell Significance Index: -30.9400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0536
    Cell Significance Index: -0.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0551
    Cell Significance Index: -1.5400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0610
    Cell Significance Index: -0.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0628
    Cell Significance Index: -0.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0675
    Cell Significance Index: -19.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0678
    Cell Significance Index: -1.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0869
    Cell Significance Index: -0.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1100
    Cell Significance Index: -2.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1111
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1149
    Cell Significance Index: -13.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1196
    Cell Significance Index: -13.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1353
    Cell Significance Index: -28.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1556
    Cell Significance Index: -4.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1681
    Cell Significance Index: -2.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1795
    Cell Significance Index: -13.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2131
    Cell Significance Index: -11.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2306
    Cell Significance Index: -2.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2347
    Cell Significance Index: -18.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2384
    Cell Significance Index: -24.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2683
    Cell Significance Index: -3.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2942
    Cell Significance Index: -18.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3059
    Cell Significance Index: -20.5700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3121
    Cell Significance Index: -1.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3334
    Cell Significance Index: -8.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3408
    Cell Significance Index: -9.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3448
    Cell Significance Index: -15.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3728
    Cell Significance Index: -10.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3731
    Cell Significance Index: -8.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4056
    Cell Significance Index: -15.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4664
    Cell Significance Index: -13.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5224
    Cell Significance Index: -4.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5247
    Cell Significance Index: -10.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5351
    Cell Significance Index: -17.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. ** YEATS domain**: YEATS4 contains a YEATS domain, a conserved protein-protein interaction domain that mediates interactions with histones and other chromatin-modifying enzymes. 2. **Histone binding**: YEATS4 binds to lysine-acetylated histones, influencing chromatin structure and transcription. 3. **Chromatin remodeling**: YEATS4 participates in chromatin remodeling complexes, facilitating changes in chromatin structure and gene expression. 4. **Transcriptional regulation**: YEATS4 regulates transcription by interacting with the AP-2 family of transcription factors and RNA polymerase II. 5. **Cell cycle regulation**: YEATS4 is involved in regulating the cell cycle, particularly in the progression of mitosis and double-strand break repair. **Pathways and Functions:** 1. **Activation of the AP-2 family of transcription factors**: YEATS4 interacts with the AP-2 family of transcription factors, activating their activity and influencing gene expression. 2. **Chromatin modifying enzymes**: YEATS4 interacts with chromatin-modifying enzymes, such as histone acetyltransferases, to regulate chromatin structure and transcription. 3. **Chromatin organization**: YEATS4 influences chromatin organization, particularly in the context of nuclear matrix and nuclear membrane formation. 4. **Gene expression (transcription)**: YEATS4 regulates transcription by interacting with RNA polymerase II and other transcriptional regulators. 5. **DNA-templated transcription**: YEATS4 participates in DNA-templated transcription, influencing the regulation of gene expression. 6. **Double-strand break repair**: YEATS4 is involved in the regulation of double-strand break repair via homologous recombination. 7. **Apoptotic process**: YEATS4 regulates the apoptotic process, influencing cell death and survival. **Clinical Significance:** 1. **Cancer**: YEATS4's role in regulating chromatin organization and transcription makes it a potential target for cancer therapy. 2. **Neurological disorders**: YEATS4's involvement in neuronal development and function suggests its potential involvement in neurological disorders, such as autism and schizophrenia. 3. **Developmental disorders**: YEATS4's expression in oogonial cells and other developmental cell types highlights its potential role in developmental disorders, such as anemia and blood disorders. 4. **Regenerative medicine**: YEATS4's involvement in cell cycle regulation and chromatin organization makes it a potential target for regenerative medicine applications. In conclusion, YEATS4 is a multifunctional gene that plays a crucial role in regulating chromatin organization, transcription, and cell cycle progression. Its involvement in various cellular processes, including DNA-templated transcription, double-strand break repair, and apoptosis, highlights its significance as a key node in cellular regulation. Further research is necessary to fully elucidate YEATS4's role in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1375578349

Symbol: YETS4_HUMAN

Name: NuMA-binding protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9302258

Title: Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I.

PubMed ID: 9302258

DOI: 10.1093/hmg/6.11.1817

PubMed ID: 10913114

Title: GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA.

PubMed ID: 10913114

DOI: 10.1074/jbc.m000994200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12963728

Title: Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.

PubMed ID: 12963728

DOI: 10.1074/jbc.c300389200

PubMed ID: 11903063

Title: Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells.

PubMed ID: 11903063

DOI: 10.1042/0264-6021:3630195

PubMed ID: 11756182

Title: The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex.

PubMed ID: 11756182

DOI: 10.1182/blood.v99.1.275

PubMed ID: 12620397

Title: Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2.

PubMed ID: 12620397

DOI: 10.1016/s0888-7543(02)00039-3

PubMed ID: 15196461

Title: The highly conserved and multifunctional NuA4 HAT complex.

PubMed ID: 15196461

DOI: 10.1016/j.gde.2004.02.009

PubMed ID: 14966270

Title: Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.

PubMed ID: 14966270

DOI: 10.1128/mcb.24.5.1884-1896.2004

PubMed ID: 18445686

Title: EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.

PubMed ID: 18445686

DOI: 10.1242/jcs.019174

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29437725

Title: Recognition of histone acetylation by the GAS41 YEATS domain promotes H2A.Z deposition in non-small cell lung cancer.

PubMed ID: 29437725

DOI: 10.1101/gad.303784.117

PubMed ID: 30071723

Title: GAS41 recognizes diacetylated histone H3 through a bivalent binding mode.

PubMed ID: 30071723

DOI: 10.1021/acschembio.8b00674

PubMed ID: 29900004

Title: Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity.

PubMed ID: 29900004

DOI: 10.1038/s41421-018-0027-0

PubMed ID: 29463709

Title: Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation.

PubMed ID: 29463709

DOI: 10.1073/pnas.1717664115

Sequence Information:

  • Length: 227
  • Mass: 26499
  • Checksum: 34C4692B227A7B85
  • Sequence:
  • MFKRMAEFGP DSGGRVKGVT IVKPIVYGNV ARYFGKKREE DGHTHQWTVY VKPYRNEDMS 
    AYVKKIQFKL HESYGNPLRV VTKPPYEITE TGWGEFEIII KIFFIDPNER PVTLYHLLKL 
    FQSDTNAMLG KKTVVSEFYD EMIFQDPTAM MQQLLTTSRQ LTLGAYKHET EFAELEVKTR 
    EKLEAAKKKT SFEIAELKER LKASRETINC LKNEIRKLEE DDQAKDI

Genular Protein ID: 279072809

Symbol: F8W0J4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 173
  • Mass: 20131
  • Checksum: 1E6954835FF324BE
  • Sequence:
  • MFKRMAEFGP DSGGRVKGVT IVKPIVYGNV ARYFGKKREE DGHTHQWTVY VKPYRNEVTL 
    YHLLKLFQSD TNAMLGKKTV VSEFYDEMIF QDPTAMMQQL LTTSRQLTLG AYKHETEFAE 
    LEVKTREKLE AAKKKTSFEI AELKERLKAS RETINCLKNE IRKLEEDDQA KDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.