Details for: CDK2AP1

Gene ID: 8099

Symbol: CDK2AP1

Ensembl ID: ENSG00000111328

Description: cyclin dependent kinase 2 associated protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.2755
    Cell Significance Index: -26.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 102.5455
    Cell Significance Index: -26.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.0668
    Cell Significance Index: -20.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.6102
    Cell Significance Index: -24.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.8802
    Cell Significance Index: -20.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.4606
    Cell Significance Index: -26.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9072
    Cell Significance Index: -26.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7257
    Cell Significance Index: -26.5400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 3.7354
    Cell Significance Index: 28.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.4615
    Cell Significance Index: 44.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.3827
    Cell Significance Index: 176.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4368
    Cell Significance Index: 168.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2359
    Cell Significance Index: 20.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2247
    Cell Significance Index: 60.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1929
    Cell Significance Index: 269.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9641
    Cell Significance Index: 102.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6473
    Cell Significance Index: 296.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0830
    Cell Significance Index: 31.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0207
    Cell Significance Index: 111.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8306
    Cell Significance Index: 19.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6441
    Cell Significance Index: 5.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6253
    Cell Significance Index: 15.6300
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.6005
    Cell Significance Index: 4.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5316
    Cell Significance Index: 86.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5167
    Cell Significance Index: 24.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5000
    Cell Significance Index: 5.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4038
    Cell Significance Index: 55.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3506
    Cell Significance Index: 15.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3337
    Cell Significance Index: 7.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2883
    Cell Significance Index: 36.9600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.2457
    Cell Significance Index: 1.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2280
    Cell Significance Index: 6.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1909
    Cell Significance Index: 84.3800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1670
    Cell Significance Index: 2.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1156
    Cell Significance Index: 3.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1023
    Cell Significance Index: 20.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1004
    Cell Significance Index: 90.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0807
    Cell Significance Index: 4.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0589
    Cell Significance Index: 5.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0427
    Cell Significance Index: 23.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0202
    Cell Significance Index: 3.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0162
    Cell Significance Index: 2.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0158
    Cell Significance Index: 1.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0109
    Cell Significance Index: 16.7700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0096
    Cell Significance Index: 0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0084
    Cell Significance Index: 15.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0049
    Cell Significance Index: 9.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0048
    Cell Significance Index: 0.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0045
    Cell Significance Index: 0.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0044
    Cell Significance Index: 0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0002
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0112
    Cell Significance Index: -7.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0149
    Cell Significance Index: -9.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0162
    Cell Significance Index: -12.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0165
    Cell Significance Index: -22.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0263
    Cell Significance Index: -19.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0283
    Cell Significance Index: -15.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0289
    Cell Significance Index: -21.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0320
    Cell Significance Index: -14.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0394
    Cell Significance Index: -7.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0470
    Cell Significance Index: -5.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0517
    Cell Significance Index: -0.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0520
    Cell Significance Index: -6.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0570
    Cell Significance Index: -12.0100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0573
    Cell Significance Index: -0.3600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0579
    Cell Significance Index: -0.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0701
    Cell Significance Index: -20.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0745
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0745
    Cell Significance Index: -8.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0906
    Cell Significance Index: -10.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1002
    Cell Significance Index: -14.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1005
    Cell Significance Index: -10.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1085
    Cell Significance Index: -1.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1109
    Cell Significance Index: -12.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1242
    Cell Significance Index: -5.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1636
    Cell Significance Index: -5.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1676
    Cell Significance Index: -5.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1715
    Cell Significance Index: -10.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1763
    Cell Significance Index: -13.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1849
    Cell Significance Index: -14.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2256
    Cell Significance Index: -3.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2306
    Cell Significance Index: -9.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2388
    Cell Significance Index: -24.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2404
    Cell Significance Index: -5.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2566
    Cell Significance Index: -15.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2916
    Cell Significance Index: -23.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3144
    Cell Significance Index: -21.1400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3243
    Cell Significance Index: -2.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3305
    Cell Significance Index: -21.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3609
    Cell Significance Index: -12.5400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.3616
    Cell Significance Index: -3.7300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4263
    Cell Significance Index: -2.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4301
    Cell Significance Index: -11.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4655
    Cell Significance Index: -13.0100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4896
    Cell Significance Index: -6.9700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.5346
    Cell Significance Index: -4.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5367
    Cell Significance Index: -9.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5381
    Cell Significance Index: -28.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5421
    Cell Significance Index: -14.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5434
    Cell Significance Index: -11.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDK2AP1 is a protein that belongs to the CDKAP family, which consists of proteins that interact with CDKs to regulate their activity. CDK2AP1 is specifically associated with CDK2, a key regulator of the cell cycle. The protein is characterized by its ability to interact with CDK2 and modulate its activity, thereby influencing the progression of the cell cycle. CDK2AP1 is also involved in the regulation of protein phosphorylation, a critical process that regulates various cellular functions, including cell growth, differentiation, and apoptosis. **Pathways and Functions:** CDK2AP1 is involved in several key pathways, including: 1. **Cell Cycle Regulation:** CDK2AP1 interacts with CDK2 to regulate the progression of the cell cycle. This interaction is critical for the proper progression of the cell cycle, as dysregulation of CDK2AP1 can lead to abnormal cell growth and proliferation. 2. **Protein Phosphorylation:** CDK2AP1 is involved in the regulation of protein phosphorylation, a critical process that regulates various cellular functions. CDK2AP1 interacts with CDK2 to phosphorylate proteins, thereby modulating their activity. 3. **Chromatin Remodeling:** CDK2AP1 is also involved in chromatin remodeling, a process that regulates gene expression. CDK2AP1 interacts with CDK2 to regulate the activity of chromatin remodeling complexes, thereby influencing gene expression. **Clinical Significance:** CDK2AP1 has significant clinical implications, particularly in the diagnosis and treatment of various diseases. Dysregulation of CDK2AP1 has been observed in several cancers, including lung cancer, breast cancer, and ovarian cancer. CDK2AP1 is also involved in the regulation of protein phosphorylation, a critical process that regulates various cellular functions. Dysregulation of CDK2AP1 can lead to abnormal protein phosphorylation, which can contribute to the development of various diseases. In addition, CDK2AP1 has been identified as a potential therapeutic target for the treatment of various diseases. Inhibition of CDK2AP1 has been shown to reduce the activity of CDK2, thereby inhibiting the progression of the cell cycle and reducing the risk of cancer. Furthermore, CDK2AP1 has been identified as a potential biomarker for the diagnosis of various diseases, including cancer. In conclusion, CDK2AP1 is a critical regulator of protein phosphorylation and cell cycle progression. Its involvement in various cellular pathways, including cell cycle regulation, protein phosphorylation, and chromatin remodeling, makes it a key player in the regulation of cellular functions. The clinical significance of CDK2AP1 is significant, particularly in the diagnosis and treatment of various diseases, including cancer.

Genular Protein ID: 2954080439

Symbol: CDKA1_HUMAN

Name: Cyclin-dependent kinase 2-associated protein 1

UniProtKB Accession Codes:

O14519 F5GYA4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9331572

Title: Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer.

PubMed ID: 9331572

DOI: 10.1002/(sici)1098-2264(199710)20:2<204::aid-gcc12>3.3.co;2-p

PubMed ID: 9506968

Title: Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1.

PubMed ID: 9506968

DOI: 10.1074/jbc.273.12.6704

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14985111

Title: Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R).

PubMed ID: 14985111

DOI: 10.1016/j.bbrc.2004.02.003

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 20523938

Title: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.

PubMed ID: 20523938

DOI: 10.1039/c004108d

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

PubMed ID: 22427660

Title: Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region.

PubMed ID: 22427660

DOI: 10.1074/jbc.m112.343863

Sequence Information:

  • Length: 115
  • Mass: 12365
  • Checksum: F3149F72467598C2
  • Sequence:
    • MSYKPNLAAH MPAAALNAAG SVHSPSTSMA TSSQYRQLLS DYGPPSLGYT QGTGNSQVPQ 
SKYAELLAII EELGKEIRPT YAGSKSAMER LKRGIIHARG LVRECLAETE RNARS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.