Details for: KDM5C
Gene ID: 8242
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: KDM5C
Ensembl ID: ENSG00000126012
Description: lysine demethylase 5C
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 10.28rCSI 18.11%PRS 68.04
-
CSI 8.35rCSI 6.91%PRS 74.42
-
CSI 7.65rCSI 12.15%PRS 81.95
-
CSI 6.51rCSI 10%PRS 81.2
-
CSI 5.31rCSI 12.04%PRS 73.97
-
CSI 4.77rCSI 3.86%PRS 74.03
-
CSI 4.66rCSI 4.03%PRS 76.67
-
CSI 4.13rCSI 6.64%PRS 61.41
-
CSI 4.11rCSI 12.2%PRS 81.34
-
CSI 3.6rCSI 6.36%PRS 52.27
-
CSI 3.54rCSI 3.48%PRS 74.66
-
CSI 3.39rCSI 8.76%PRS 66.84
-
CSI 3.33rCSI 2.62%PRS 78.44
-
CSI 3.08rCSI 19.23%PRS 63.36
-
CSI 3.05rCSI 2.12%PRS 83.42
-
CSI 2.91rCSI 7.12%PRS 64.99
-
CSI 2.91rCSI 2.09%PRS 85.31
-
CSI 2.84rCSI 2.11%PRS 64.77
-
CSI 2.81rCSI 1.66%PRS 88.09
-
CSI 2.77rCSI 3.52%PRS 77.65
-
CSI 2.75rCSI 4.5%PRS 60.93
-
CSI 2.72rCSI 4.89%PRS 65.14
-
CSI 2.71rCSI 2.06%PRS 84.72
-
CSI 2.69rCSI 1.87%PRS 86.32
-
CSI 2.69rCSI 2.34%PRS 82.39
-
CSI 2.66rCSI 4.98%PRS 59.77
-
CSI 2.64rCSI 5.03%PRS 83.86
-
CSI 2.62rCSI 7.58%PRS 61.09
-
CSI 2.58rCSI 5.9%PRS 72.64
-
CSI 2.52rCSI 1.95%PRS 75.29
-
CSI 2.51rCSI 3.78%PRS 77.22
-
CSI 2.5rCSI 1.87%PRS 85.84
-
CSI 2.46rCSI 2.63%PRS 72.63
-
CSI 2.42rCSI 2.13%PRS 77.4
-
CSI 2.38rCSI 2.11%PRS 69.87
-
CSI 2.37rCSI 6.18%PRS 72.48
-
CSI 2.32rCSI 1.93%PRS 72.24
-
CSI 2.32rCSI 1.94%PRS 75.41
-
CSI 2.32rCSI 2.99%PRS 54.55
-
CSI 2.31rCSI 2.15%PRS 72.81
-
CSI 2.31rCSI 2.1%PRS 85.13
-
CSI 2.25rCSI 2.47%PRS 74.93
-
CSI 2.19rCSI 1.92%PRS 80.31
-
CSI 2.19rCSI 1.64%PRS 77.93
-
CSI 2.19rCSI 2.28%PRS 71.81
-
CSI 2.18rCSI 2.97%PRS 77.48
-
CSI 2.13rCSI 2.56%PRS 70.02
-
CSI 2.1rCSI 1.66%PRS 59.38
-
CSI 2.1rCSI 1.59%PRS 85.1
-
CSI 2.09rCSI 2.45%PRS 86.78
-
CSI 2.07rCSI 2.96%PRS 74.02
-
CSI 2.02rCSI 8.21%PRS 64.65
-
CSI 2.01rCSI 2.4%PRS 53.04
-
CSI 1.99rCSI 2.46%PRS 69.25
-
CSI 1.98rCSI 2.07%PRS 69.06
-
CSI 1.97rCSI 1.73%PRS 60.21
-
CSI 1.97rCSI 1.81%PRS 73.59
-
CSI 1.95rCSI 3.42%PRS 64.57
-
CSI 1.93rCSI 7.21%PRS 63.85
-
CSI 1.92rCSI 1.77%PRS 80.93
-
CSI 1.9rCSI 10.64%PRS 75.77
-
CSI 1.88rCSI 3.36%PRS 71.41
-
CSI 1.88rCSI 1.81%PRS 63.97
-
CSI 1.85rCSI 3.19%PRS 62.51
-
CSI 1.85rCSI 1.78%PRS 71.6
-
CSI 1.82rCSI 2.6%PRS 73.54
-
CSI 1.8rCSI 2.56%PRS 68.12
-
CSI 1.74rCSI 2.66%PRS 68.49
-
CSI 1.72rCSI 1.63%PRS 71.25
-
CSI 1.69rCSI 3.43%PRS 50.06
-
CSI 1.68rCSI 3.92%PRS 86.03
-
CSI 1.68rCSI 1.94%PRS 77.72
-
CSI 1.67rCSI 1.29%PRS 74.03
-
CSI 1.64rCSI 3.61%PRS 76.21
-
CSI 1.64rCSI 3.67%PRS 53.79
-
CSI 1.63rCSI 1.66%PRS 83.07
-
CSI 1.58rCSI 3.76%PRS 73.93
-
CSI 1.58rCSI 1.97%PRS 51.23
-
CSI 1.58rCSI 2.41%PRS 76.24
-
CSI 1.58rCSI 2.55%PRS 67.64
-
CSI 1.57rCSI 4.09%PRS 72.77
-
CSI 1.56rCSI 2.48%PRS 64.54
-
CSI 1.54rCSI 2.35%PRS 72.48
-
CSI 1.49rCSI 5.78%PRS 73.93
-
CSI 1.46rCSI 2.26%PRS 70.95
-
CSI 1.41rCSI 1.88%PRS 78.21
-
CSI 1.38rCSI 1.65%PRS 88.81
-
CSI 1.37rCSI 1.87%PRS 72.84
-
CSI 1.33rCSI 1.2%PRS 69.38
-
CSI 1.31rCSI 2.1%PRS 55.03
-
CSI 1.3rCSI 1.51%PRS 63.15
-
CSI 1.3rCSI 1.78%PRS 63.24
-
CSI 1.26rCSI 2.29%PRS 63.11
-
CSI 1.25rCSI 3.1%PRS 70.93
-
CSI 1.21rCSI 1.2%PRS 65.59
-
CSI 1.18rCSI 2.02%PRS 79.69
-
CSI 1.16rCSI 3.06%PRS 80.12
-
CSI 1.09rCSI 2.9%PRS 62.86
-
CSI 0.98rCSI 3.08%PRS 57.46
-
CSI 0.97rCSI 2.46%PRS 61.66
-
CSI 0.2rCSI 1.5%PRS 59.1%
-
CSI 0.2rCSI 5.9%PRS 52.7%
-
CSI 0.3rCSI 7.6%PRS 52.0%
-
CSI 0.5rCSI 1.6%PRS 72.5%
-
CSI 0.5rCSI 2.8%PRS 54.3%
-
CSI 0.5rCSI 2.5%PRS 84.3%
-
CSI 0.5rCSI 1.6%PRS 55.0%
-
CSI 0.6rCSI 2.6%PRS 72.4%
-
CSI 0.6rCSI 2.3%PRS 53.7%
-
CSI 0.6rCSI 1.5%PRS 51.5%
-
CSI 0.7rCSI 5.8%PRS 65.5%
-
CSI 0.7rCSI 1.3%PRS 53.2%
-
CSI 1.0rCSI 2.1%PRS 57.7%
-
CSI 1.0rCSI 3.5%PRS 51.3%
-
CSI 1.0rCSI 2.5%PRS 61.7%
-
CSI 1.0rCSI 3.1%PRS 57.5%
-
CSI 1.1rCSI 2.9%PRS 62.9%
-
CSI 1.2rCSI 3.1%PRS 80.1%
-
CSI 1.2rCSI 2.0%PRS 79.7%
-
CSI 1.2rCSI 1.2%PRS 65.6%
-
CSI 1.3rCSI 3.1%PRS 70.9%
-
CSI 1.3rCSI 2.3%PRS 63.1%
-
CSI 1.3rCSI 1.8%PRS 63.2%
-
CSI 1.3rCSI 1.5%PRS 63.2%
-
CSI 1.3rCSI 2.1%PRS 55.0%
-
CSI 1.3rCSI 1.2%PRS 69.4%
-
CSI 1.4rCSI 1.9%PRS 72.8%
-
CSI 1.4rCSI 1.7%PRS 88.8%
-
CSI 1.4rCSI 1.9%PRS 78.2%
-
CSI 1.5rCSI 2.3%PRS 71.0%
-
CSI 1.5rCSI 5.8%PRS 73.9%
-
CSI 1.5rCSI 2.4%PRS 72.5%
-
CSI 1.6rCSI 2.5%PRS 64.5%
-
CSI 1.6rCSI 4.1%PRS 72.8%
-
CSI 1.6rCSI 2.6%PRS 67.6%
-
CSI 1.6rCSI 2.4%PRS 76.2%
-
CSI 1.6rCSI 2.0%PRS 51.2%
-
CSI 1.6rCSI 3.8%PRS 73.9%
-
CSI 1.6rCSI 1.7%PRS 83.1%
-
CSI 1.6rCSI 3.7%PRS 53.8%
-
CSI 1.6rCSI 3.6%PRS 76.2%
-
CSI 1.7rCSI 1.3%PRS 74.0%
-
CSI 1.7rCSI 1.9%PRS 77.7%
-
CSI 1.7rCSI 3.9%PRS 86.0%
-
CSI 1.7rCSI 3.4%PRS 50.1%
-
CSI 1.7rCSI 1.6%PRS 71.3%
-
CSI 1.7rCSI 2.7%PRS 68.5%
-
CSI 1.8rCSI 2.6%PRS 68.1%
-
CSI 1.8rCSI 2.6%PRS 73.5%
-
CSI 1.9rCSI 1.8%PRS 71.6%
-
CSI 1.9rCSI 3.2%PRS 62.5%
-
CSI 1.9rCSI 1.8%PRS 64.0%
-
CSI 1.9rCSI 3.4%PRS 71.4%
-
CSI 1.9rCSI 10.6%PRS 75.8%
-
CSI 1.9rCSI 1.8%PRS 80.9%
-
CSI 1.9rCSI 7.2%PRS 63.9%
-
CSI 2.0rCSI 3.4%PRS 64.6%
-
CSI 2.0rCSI 1.8%PRS 73.6%
-
CSI 2.0rCSI 1.7%PRS 60.2%
-
CSI 2.0rCSI 2.1%PRS 69.1%
-
CSI 2.0rCSI 2.5%PRS 69.3%
-
CSI 2.0rCSI 2.4%PRS 53.0%
-
CSI 2.0rCSI 8.2%PRS 64.7%
-
CSI 2.1rCSI 3.0%PRS 74.0%
-
CSI 2.1rCSI 2.5%PRS 86.8%
-
CSI 2.1rCSI 1.6%PRS 85.1%
-
CSI 2.1rCSI 1.7%PRS 59.4%
-
CSI 2.1rCSI 2.6%PRS 70.0%
-
CSI 2.2rCSI 3.0%PRS 77.5%
-
CSI 2.2rCSI 2.3%PRS 71.8%
-
CSI 2.2rCSI 1.6%PRS 77.9%
-
CSI 2.2rCSI 1.9%PRS 80.3%
-
CSI 2.3rCSI 2.5%PRS 74.9%
-
CSI 2.3rCSI 2.1%PRS 85.1%
-
CSI 2.3rCSI 2.2%PRS 72.8%
-
CSI 2.3rCSI 3.0%PRS 54.6%
-
CSI 2.3rCSI 1.9%PRS 75.4%
-
CSI 2.3rCSI 1.9%PRS 72.2%
-
CSI 2.4rCSI 6.2%PRS 72.5%
-
CSI 2.4rCSI 2.1%PRS 69.9%
-
CSI 2.4rCSI 2.1%PRS 77.4%
-
CSI 2.5rCSI 2.6%PRS 72.6%
-
CSI 2.5rCSI 1.9%PRS 85.8%
-
CSI 2.5rCSI 3.8%PRS 77.2%
-
CSI 2.5rCSI 2.0%PRS 75.3%
-
CSI 2.6rCSI 5.9%PRS 72.6%
-
CSI 2.6rCSI 7.6%PRS 61.1%
-
CSI 2.6rCSI 5.0%PRS 83.9%
-
CSI 2.7rCSI 5.0%PRS 59.8%
-
CSI 2.7rCSI 2.3%PRS 82.4%
-
CSI 2.7rCSI 1.9%PRS 86.3%
-
CSI 2.7rCSI 2.1%PRS 84.7%
-
CSI 2.7rCSI 4.9%PRS 65.1%
-
CSI 2.8rCSI 4.5%PRS 60.9%
-
CSI 2.8rCSI 3.5%PRS 77.7%
-
CSI 2.8rCSI 1.7%PRS 88.1%
-
CSI 2.8rCSI 2.1%PRS 64.8%
-
CSI 2.9rCSI 2.1%PRS 85.3%
-
CSI 2.9rCSI 7.1%PRS 65.0%
-
CSI 3.1rCSI 2.1%PRS 83.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2768432041
Symbol: KDM5C_HUMAN
Name: Lysine-specific demethylase 5C
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8162017
Title: Isolation and characterization of XE169, a novel human gene that escapes X-inactivation.
PubMed ID: 8162017
DOI: 10.1093/hmg/3.1.153
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7951230
Title: A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.
PubMed ID: 7951230
DOI: 10.1093/hmg/3.6.879
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17320161
Title: RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
PubMed ID: 17320161
PubMed ID: 17320160
Title: The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.
PubMed ID: 17320160
PubMed ID: 17468742
Title: The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation.
PubMed ID: 17468742
DOI: 10.1038/nature05823
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26645689
Title: Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
PubMed ID: 26645689
PubMed ID: 28262558
Title: Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
PubMed ID: 28262558
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 33323928
Title: Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.
PubMed ID: 33323928
PubMed ID: 19636912
Title: Backbone and sidechain 1H, 13C and 15N resonance assignments of the Bright/ARID domain from the human JARID1C (SMCX) protein.
PubMed ID: 19636912
PubMed ID: 27214403
Title: Structural analysis of human KDM5B guides histone demethylase inhibitor development.
PubMed ID: 27214403
PubMed ID: 15586325
Title: Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation.
PubMed ID: 15586325
DOI: 10.1086/427563
PubMed ID: 16538222
Title: A novel mutation in JARID1C gene associated with mental retardation.
PubMed ID: 16538222
PubMed ID: 16541399
Title: Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.
PubMed ID: 16541399
DOI: 10.1002/humu.9420
PubMed ID: 21076407
PubMed ID: 23356856
Title: Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C.
PubMed ID: 23356856
PubMed ID: 25666439
Title: Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity.
PubMed ID: 25666439
DOI: 10.1093/hmg/ddv046
Sequence Information:
- Length: 1560
- Mass: 175720
- Checksum: 5DC673D0091E7C87
- Sequence:
MEPGSDDFLP PPECPVFEPS WAEFRDPLGY IAKIRPIAEK SGICKIRPPA DWQPPFAVEV DNFRFTPRIQ RLNELEAQTR VKLNYLDQIA KFWEIQGSSL KIPNVERRIL DLYSLSKIVV EEGGYEAICK DRRWARVAQR LNYPPGKNIG SLLRSHYERI VYPYEMYQSG ANLVQCNTRP FDNEEKDKEY KPHSIPLRQS VQPSKFNSYG RRAKRLQPDP EPTEEDIEKN PELKKLQIYG AGPKMMGLGL MAKDKTLRKK DKEGPECPPT VVVKEELGGD VKVESTSPKT FLESKEELSH SPEPCTKMTM RLRRNHSNAQ FIESYVCRMC SRGDEDDKLL LCDGCDDNYH IFCLLPPLPE IPKGVWRCPK CVMAECKRPP EAFGFEQATR EYTLQSFGEM ADSFKADYFN MPVHMVPTEL VEKEFWRLVN SIEEDVTVEY GADIHSKEFG SGFPVSDSKR HLTPEEEEYA TSGWNLNVMP VLEQSVLCHI NADISGMKVP WLYVGMVFSA FCWHIEDHWS YSINYLHWGE PKTWYGVPSL AAEHLEEVMK KLTPELFDSQ PDLLHQLVTL MNPNTLMSHG VPVVRTNQCA GEFVITFPRA YHSGFNQGYN FAEAVNFCTA DWLPAGRQCI EHYRRLRRYC VFSHEELICK MAACPEKLDL NLAAAVHKEM FIMVQEERRL RKALLEKGIT EAEREAFELL PDDERQCIKC KTTCFLSALA CYDCPDGLVC LSHINDLCKC SSSRQYLRYR YTLDELPAML HKLKVRAESF DTWANKVRVA LEVEDGRKRS LEELRALESE ARERRFPNSE LLQQLKNCLS EAEACVSRAL GLVSGQEAGP HRVAGLQMTL TELRAFLDQM NNLPCAMHQI GDVKGVLEQV EAYQAEAREA LASLPSSPGL LQSLLERGRQ LGVEVPEAQQ LQRQVEQARW LDEVKRTLAP SARRGTLAVM RGLLVAGASV APSPAVDKAQ AELQELLTIA ERWEEKAHLC LEARQKHPPA TLEAIIREAE NIPVHLPNIQ ALKEALAKAR AWIADVDEIQ NGDHYPCLDD LEGLVAVGRD LPVGLEELRQ LELQVLTAHS WREKASKTFL KKNSCYTLLE VLCPCADAGS DSTKRSRWME KELGLYKSDT ELLGLSAQDL RDPGSVIVAF KEGEQKEKEG ILQLRRTNSA KPSPLASSST ASSTTSICVC GQVLAGAGAL QCDLCQDWFH GRCVSVPRLL SSPRPNPTSS PLLAWWEWDT KFLCPLCMRS RRPRLETILA LLVALQRLPV RLPEGEALQC LTERAISWQG RARQALASED VTALLGRLAE LRQRLQAEPR PEEPPNYPAA PASDPLREGS GKDMPKVQGL LENGDSVTSP EKVAPEEGSG KRDLELLSSL LPQLTGPVLE LPEATRAPLE ELMMEGDLLE VTLDENHSIW QLLQAGQPPD LERIRTLLEL EKAERHGSRA RGRALERRRR RKVDRGGEGD DPAREELEPK RVRSSGPEAE EVQEEEELEE ETGGEGPPAP IPTTGSPSTQ ENQNGLEPAE GTTSGPSAPF STLTPRLHLP CPQQPPQQQL
Genular Protein ID: 1426128277
Symbol: A0A6M4C8G8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1379
- Mass: 155119
- Checksum: 20A82456B8CF788E
- Sequence:
MEPGSDDFLP PPECPVFEPS WAEFRDPLGY IAKIRPIAEK SGICKIRPPA IVVEEGGYEA ICKDRRWARV AQRLNYPPGK NIGSLLRSHY ERIVYPYEMY QSGANLVQCN TRPFDNEEKD KEYKPHSIPL RQSVQPSKFN SYGRRAKRLQ PDPEPTEEDI EKNPELKKLQ IYGAGPKMMG LGLMAKDKTL RKKDKEGPEC PPTVVVKEEL GGDVKVESTS PKTFLESKEE LSHSPEPCTK MTMRLRRNHS NAQFIESYVC RMCSRGDEDD KLLLCDGCDD NYHIFCLLPP LPEIPKGVWR CPKCVMAECK RPPEAFGFEQ ATREYTLQSF GEMADSFKAD YFNMPVHMVP TELVEKEFWR LVNSIEEDVT VEYGADIHSK EFGSGFPVSD SKRHLTPEEE EYATSGWNLN VMPVLEQSVL CHINADISGM KVPWLYVGMV FSAFCWHIED HWSYSINYLH WGEPKTWYGV PSLAAEHLEE VMKKLTPELF DSQPDLLHQL VTLMNPNTLM SHGVPVVRTN QCAGEFVITF PRAYHSGFNQ GYNFAEAVNF CTADWLPAGR QCIEHYRRLR RYCVFSHEEL ICKMAACPEK LDLNLAAAVH KEMFIMVQEE RRLRKALLEK GITEAEREAF ELLPDDERQC IKCKTTCFLS ALACYDCPDG LVCLSHINDL CKCSSSRQYL RYRYTLDELP AMLHKLKVRA ESFDTWANKV RVALEVEDGR KRSLEELRAL ESEARERRFP NSELLQQLKN CLSEAEACVS RALGLVSGQE AGPHRVAGLQ MTLTELRAFL DQMNNLPCAM HQIGDVKGVL EQVEAYQAEA REALASLPSS PGLLQSLLER GRQLGVEVPE AQQLQRQVEQ ARWLDEVKRT LAPSARRGTL AVMRGLLVAG ASVAPSPAVD KAQAELQELL TIAERWEEKA HLCLEARQKH PPATLEAIIR EAENIPVHLP NIQALKEALA KARAWIADVD EIQNGDHYPC LDDLEGLVAV GRDLPVGLEE LRQLELQVLT AHSWREKASK TFLKKNSCYT LLEVLCPCAD AGSDSTKRSR WMEKELGLYK SDTELLGLSA QDLRDPGSVI VAFKEGEQKE KEGILQLRRT NSAKPSPLAS SSTASSTTSI CVCGQVLAGA GALQCDLCQD WFHGRCVSVP RLLSSPRPNP TSSPLLAWWE WDTKFLCPLC MRSRRPRLET ILALLVALQR LPVRLPEGEA LQCLTERAIS WQGRARQALA SEDVTALLGR LAELRQRLQA EPRPEEPPNY PAAPASDPLR EGSGKDMPKV QGLLENGDSV TSPEKVAPEE GSDLELLSSL LPQLTGPVLE LPEATRAPLE ELMMEGDLLE VTLDENHSIP ESLDFCILTP RYCSDLSSWG PAPGVFPPW