Details for: UBL4A

Gene ID: 8266

Symbol: UBL4A

Ensembl ID: ENSG00000102178

Description: ubiquitin like 4A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 69.2403
    Cell Significance Index: -10.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.4716
    Cell Significance Index: -14.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 40.3449
    Cell Significance Index: -16.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.5249
    Cell Significance Index: -16.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.6968
    Cell Significance Index: -15.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.3362
    Cell Significance Index: -15.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3041
    Cell Significance Index: -11.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2455
    Cell Significance Index: -13.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0040
    Cell Significance Index: -15.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3110
    Cell Significance Index: 78.7000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1416
    Cell Significance Index: 18.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1119
    Cell Significance Index: 120.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8637
    Cell Significance Index: 140.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8619
    Cell Significance Index: 7.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8133
    Cell Significance Index: 94.7800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.5869
    Cell Significance Index: 8.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5641
    Cell Significance Index: 39.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5021
    Cell Significance Index: 23.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4859
    Cell Significance Index: 6.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4592
    Cell Significance Index: 12.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3497
    Cell Significance Index: 10.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3399
    Cell Significance Index: 11.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3292
    Cell Significance Index: 45.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3084
    Cell Significance Index: 136.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3004
    Cell Significance Index: 15.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2772
    Cell Significance Index: 13.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2680
    Cell Significance Index: 241.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2587
    Cell Significance Index: 16.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2310
    Cell Significance Index: 46.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2102
    Cell Significance Index: 6.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1974
    Cell Significance Index: 107.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1938
    Cell Significance Index: 34.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1833
    Cell Significance Index: 11.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1776
    Cell Significance Index: 12.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1757
    Cell Significance Index: 22.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1482
    Cell Significance Index: 28.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1363
    Cell Significance Index: 7.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1323
    Cell Significance Index: 2.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1224
    Cell Significance Index: 14.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1050
    Cell Significance Index: 4.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1034
    Cell Significance Index: 10.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0904
    Cell Significance Index: 11.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0882
    Cell Significance Index: 10.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0641
    Cell Significance Index: 23.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0451
    Cell Significance Index: 3.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0275
    Cell Significance Index: 5.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0232
    Cell Significance Index: 0.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0221
    Cell Significance Index: 0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0136
    Cell Significance Index: 2.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0010
    Cell Significance Index: 0.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -8.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0109
    Cell Significance Index: -20.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0126
    Cell Significance Index: -19.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0137
    Cell Significance Index: -0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0143
    Cell Significance Index: -19.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0165
    Cell Significance Index: -0.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0185
    Cell Significance Index: -11.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0187
    Cell Significance Index: -13.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0202
    Cell Significance Index: -2.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0203
    Cell Significance Index: -2.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0235
    Cell Significance Index: -13.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0316
    Cell Significance Index: -14.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0400
    Cell Significance Index: -1.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0403
    Cell Significance Index: -0.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0673
    Cell Significance Index: -1.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0799
    Cell Significance Index: -11.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0827
    Cell Significance Index: -5.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0860
    Cell Significance Index: -18.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0962
    Cell Significance Index: -5.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1088
    Cell Significance Index: -1.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1191
    Cell Significance Index: -9.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1242
    Cell Significance Index: -1.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1245
    Cell Significance Index: -3.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1297
    Cell Significance Index: -3.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1350
    Cell Significance Index: -10.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1513
    Cell Significance Index: -15.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1685
    Cell Significance Index: -2.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2086
    Cell Significance Index: -12.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2123
    Cell Significance Index: -5.6800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2357
    Cell Significance Index: -2.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2392
    Cell Significance Index: -13.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2747
    Cell Significance Index: -7.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3063
    Cell Significance Index: -13.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3156
    Cell Significance Index: -5.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3168
    Cell Significance Index: -9.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3261
    Cell Significance Index: -11.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3408
    Cell Significance Index: -11.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3497
    Cell Significance Index: -3.2200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3522
    Cell Significance Index: -4.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3569
    Cell Significance Index: -4.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3615
    Cell Significance Index: -13.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3644
    Cell Significance Index: -4.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3687
    Cell Significance Index: -12.0700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3731
    Cell Significance Index: -3.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3757
    Cell Significance Index: -11.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3840
    Cell Significance Index: -12.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3904
    Cell Significance Index: -7.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3909
    Cell Significance Index: -9.0300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3971
    Cell Significance Index: -5.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UBL4A is a ubiquitin-like protein that belongs to the ubiquitin-like protein family. It is characterized by its ability to interact with other proteins, including tail-anchored membrane proteins, and regulate their localization and stability. UBL4A is also involved in the regulation of protein stability and regulation of protein stability, making it a potential regulator of various cellular processes. **Pathways and Functions:** UBL4A is involved in several cellular pathways, including: 1. **Bat3 complex**: UBL4A interacts with the Bat3 complex, which is a protein complex involved in the regulation of protein localization and stability. 2. **Protein localization**: UBL4A regulates the localization of tail-anchored membrane proteins to the endoplasmic reticulum membrane. 3. **Protein modification process**: UBL4A is involved in the modification of proteins, including the ubiquitination of proteins. 4. **Protein binding**: UBL4A interacts with other proteins, including protein-folding chaperones and protein-localization factors. 5. **Regulation of protein stability**: UBL4A regulates the stability of proteins, including the regulation of protein degradation and protein synthesis. **Clinical Significance:** UBL4A has been found to be significantly expressed in various human tissues, including the placenta, pancreas, and brain. Its expression has been observed in several disease states, including: 1. **Placental disorders**: UBL4A has been found to be overexpressed in placental disorders, such as preeclampsia and intrauterine growth restriction. 2. **Pancreatic disorders**: UBL4A has been found to be overexpressed in pancreatic disorders, such as type 2 diabetes and pancreatic cancer. 3. **Neurological disorders**: UBL4A has been found to be overexpressed in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, UBL4A is a ubiquitin-like protein that plays a crucial role in various cellular processes, including protein localization, modification, and stability. Its expression has been found to be significantly altered in various human diseases, highlighting its potential as a biomarker and therapeutic target. Further studies are needed to fully elucidate the functions and significance of UBL4A and its potential implications for human diseases. **Future Directions:** 1. **Investigation of UBL4A's role in human diseases**: Further studies are needed to investigate the role of UBL4A in human diseases, including its potential as a biomarker and therapeutic target. 2. **Elucidation of UBL4A's mechanisms**: The mechanisms by which UBL4A regulates protein localization, modification, and stability need to be elucidated to fully understand its functions. 3. **Development of therapeutic strategies**: Therapeutic strategies targeting UBL4A may be developed to treat various human diseases, including those mentioned above. In summary, UBL4A is a ubiquitin-like protein that plays a crucial role in various cellular processes. Its expression has been found to be significantly altered in various human diseases, highlighting its potential as a biomarker and therapeutic target. Further studies are needed to fully elucidate the functions and significance of UBL4A and its potential implications for human diseases.

Genular Protein ID: 1297848998

Symbol: UBL4A_HUMAN

Name: Ubiquitin-like protein GDX

UniProtKB Accession Codes:

P11441 Q5HY80

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2829204

Title: A 'housekeeping' gene on the X chromosome encodes a protein similar to ubiquitin.

PubMed ID: 2829204

DOI: 10.1073/pnas.85.3.851

PubMed ID: 8733135

Title: Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.

PubMed ID: 8733135

DOI: 10.1093/hmg/5.5.659

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20676083

Title: A ribosome-associating factor chaperones tail-anchored membrane proteins.

PubMed ID: 20676083

DOI: 10.1038/nature09296

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21636303

Title: A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.

PubMed ID: 21636303

DOI: 10.1016/j.molcel.2011.05.010

PubMed ID: 21743475

Title: Protein targeting and degradation are coupled for elimination of mislocalized proteins.

PubMed ID: 21743475

DOI: 10.1038/nature10181

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24424410

Title: USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

PubMed ID: 24424410

DOI: 10.7554/elife.01369

PubMed ID: 28104892

Title: Mechanistic basis for a molecular triage reaction.

PubMed ID: 28104892

DOI: 10.1126/science.aah6130

PubMed ID: 25713138

Title: Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis.

PubMed ID: 25713138

DOI: 10.1074/jbc.m114.631804

PubMed ID: 25535373

Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.

PubMed ID: 25535373

DOI: 10.1073/pnas.1402745112

Sequence Information:

  • Length: 157
  • Mass: 17777
  • Checksum: 9D6EE2D20D2C4C60
  • Sequence:
    • MQLTVKALQG RECSLQVPED ELVSTLKQLV SEKLNVPVRQ QRLLFKGKAL ADGKRLSDYS 
IGPNSKLNLV VKPLEKVLLE EGEAQRLADS PPPQVWQLIS KVLARHFSAA DASRVLEQLQ 
RDYERSLSRL TLDDIERLAS RFLHPEVTET MEKGFSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.