Details for: UBL4A

Gene ID: 8266

Symbol: UBL4A

Ensembl ID: ENSG00000102178

Description: ubiquitin like 4A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.01
    Marker Score: 1792
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.62
    Marker Score: 1297
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.3
    Marker Score: 1269
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.06
    Marker Score: 310
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.04
    Marker Score: 705
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71741
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47965
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.95
    Marker Score: 399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.93
    Marker Score: 1961.5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.93
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2710
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5145.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.9
    Marker Score: 674.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5248
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.84
    Marker Score: 3289
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.79
    Marker Score: 343
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.77
    Marker Score: 1761
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 638
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.7
    Marker Score: 390
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10913
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.68
    Marker Score: 498
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.67
    Marker Score: 957
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.66
    Marker Score: 5725
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2782
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.65
    Marker Score: 315
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.65
    Marker Score: 4138
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.64
    Marker Score: 366
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.64
    Marker Score: 802
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.64
    Marker Score: 664
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 403
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.6
    Marker Score: 2441
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6
    Marker Score: 2206
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.59
    Marker Score: 397
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.59
    Marker Score: 1120
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.58
    Marker Score: 317
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.57
    Marker Score: 260
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.57
    Marker Score: 240
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.57
    Marker Score: 1536.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.56
    Marker Score: 586
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.55
    Marker Score: 592
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.55
    Marker Score: 336
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.55
    Marker Score: 1156
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.55
    Marker Score: 4321
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.55
    Marker Score: 874
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.55
    Marker Score: 579
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.55
    Marker Score: 1112
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.54
    Marker Score: 308
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.54
    Marker Score: 268
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.53
    Marker Score: 500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.53
    Marker Score: 555
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.52
    Marker Score: 276
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.52
    Marker Score: 689
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.51
    Marker Score: 350
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.51
    Marker Score: 551
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.5
    Marker Score: 1170.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.49
    Marker Score: 493
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.48
    Marker Score: 3566
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.48
    Marker Score: 404
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.48
    Marker Score: 4819
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.47
    Marker Score: 447.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.47
    Marker Score: 302
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.47
    Marker Score: 1117
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.47
    Marker Score: 157
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.47
    Marker Score: 257
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.47
    Marker Score: 3101
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.46
    Marker Score: 561
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.46
    Marker Score: 2218
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.46
    Marker Score: 5205
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.46
    Marker Score: 228
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.46
    Marker Score: 291
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.46
    Marker Score: 264
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.46
    Marker Score: 138
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.46
    Marker Score: 163
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.46
    Marker Score: 224
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.46
    Marker Score: 1222
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.45
    Marker Score: 144
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.45
    Marker Score: 238
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 435
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.45
    Marker Score: 224
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.45
    Marker Score: 284
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.45
    Marker Score: 297
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.45
    Marker Score: 315
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.44
    Marker Score: 142
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.44
    Marker Score: 491
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.44
    Marker Score: 1377
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.44
    Marker Score: 1147
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.44
    Marker Score: 124
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.43
    Marker Score: 212

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Other Information

**Key Characteristics:** UBL4A is a ubiquitin-like protein that belongs to the ubiquitin-like protein family. It is characterized by its ability to interact with other proteins, including tail-anchored membrane proteins, and regulate their localization and stability. UBL4A is also involved in the regulation of protein stability and regulation of protein stability, making it a potential regulator of various cellular processes. **Pathways and Functions:** UBL4A is involved in several cellular pathways, including: 1. **Bat3 complex**: UBL4A interacts with the Bat3 complex, which is a protein complex involved in the regulation of protein localization and stability. 2. **Protein localization**: UBL4A regulates the localization of tail-anchored membrane proteins to the endoplasmic reticulum membrane. 3. **Protein modification process**: UBL4A is involved in the modification of proteins, including the ubiquitination of proteins. 4. **Protein binding**: UBL4A interacts with other proteins, including protein-folding chaperones and protein-localization factors. 5. **Regulation of protein stability**: UBL4A regulates the stability of proteins, including the regulation of protein degradation and protein synthesis. **Clinical Significance:** UBL4A has been found to be significantly expressed in various human tissues, including the placenta, pancreas, and brain. Its expression has been observed in several disease states, including: 1. **Placental disorders**: UBL4A has been found to be overexpressed in placental disorders, such as preeclampsia and intrauterine growth restriction. 2. **Pancreatic disorders**: UBL4A has been found to be overexpressed in pancreatic disorders, such as type 2 diabetes and pancreatic cancer. 3. **Neurological disorders**: UBL4A has been found to be overexpressed in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, UBL4A is a ubiquitin-like protein that plays a crucial role in various cellular processes, including protein localization, modification, and stability. Its expression has been found to be significantly altered in various human diseases, highlighting its potential as a biomarker and therapeutic target. Further studies are needed to fully elucidate the functions and significance of UBL4A and its potential implications for human diseases. **Future Directions:** 1. **Investigation of UBL4A's role in human diseases**: Further studies are needed to investigate the role of UBL4A in human diseases, including its potential as a biomarker and therapeutic target. 2. **Elucidation of UBL4A's mechanisms**: The mechanisms by which UBL4A regulates protein localization, modification, and stability need to be elucidated to fully understand its functions. 3. **Development of therapeutic strategies**: Therapeutic strategies targeting UBL4A may be developed to treat various human diseases, including those mentioned above. In summary, UBL4A is a ubiquitin-like protein that plays a crucial role in various cellular processes. Its expression has been found to be significantly altered in various human diseases, highlighting its potential as a biomarker and therapeutic target. Further studies are needed to fully elucidate the functions and significance of UBL4A and its potential implications for human diseases.

Genular Protein ID: 1297848998

Symbol: UBL4A_HUMAN

Name: Ubiquitin-like protein GDX

UniProtKB Accession Codes:

P11441 Q5HY80

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 3 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2829204

Title: A 'housekeeping' gene on the X chromosome encodes a protein similar to ubiquitin.

PubMed ID: 2829204

DOI: 10.1073/pnas.85.3.851

PubMed ID: 8733135

Title: Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.

PubMed ID: 8733135

DOI: 10.1093/hmg/5.5.659

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20676083

Title: A ribosome-associating factor chaperones tail-anchored membrane proteins.

PubMed ID: 20676083

DOI: 10.1038/nature09296

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21636303

Title: A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.

PubMed ID: 21636303

DOI: 10.1016/j.molcel.2011.05.010

PubMed ID: 21743475

Title: Protein targeting and degradation are coupled for elimination of mislocalized proteins.

PubMed ID: 21743475

DOI: 10.1038/nature10181

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24424410

Title: USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

PubMed ID: 24424410

DOI: 10.7554/elife.01369

PubMed ID: 28104892

Title: Mechanistic basis for a molecular triage reaction.

PubMed ID: 28104892

DOI: 10.1126/science.aah6130

PubMed ID: 25713138

Title: Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis.

PubMed ID: 25713138

DOI: 10.1074/jbc.m114.631804

PubMed ID: 25535373

Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.

PubMed ID: 25535373

DOI: 10.1073/pnas.1402745112

Sequence Information:

  • Length: 157
  • Mass: 17777
  • Checksum: 9D6EE2D20D2C4C60
  • Sequence:
    • MQLTVKALQG RECSLQVPED ELVSTLKQLV SEKLNVPVRQ QRLLFKGKAL ADGKRLSDYS 
IGPNSKLNLV VKPLEKVLLE EGEAQRLADS PPPQVWQLIS KVLARHFSAA DASRVLEQLQ 
RDYERSLSRL TLDDIERLAS RFLHPEVTET MEKGFSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.