Details for: TMEM187

Gene ID: 8269

Symbol: TMEM187

Ensembl ID: ENSG00000177854

Description: transmembrane protein 187

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.0825
    Cell Significance Index: -9.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.1424
    Cell Significance Index: -8.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 21.3658
    Cell Significance Index: -8.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.2067
    Cell Significance Index: -8.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.9322
    Cell Significance Index: -9.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.3522
    Cell Significance Index: -8.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.7218
    Cell Significance Index: -8.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5114
    Cell Significance Index: -9.9100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.4037
    Cell Significance Index: 22.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3239
    Cell Significance Index: 91.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8249
    Cell Significance Index: 49.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8234
    Cell Significance Index: 743.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7509
    Cell Significance Index: 81.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5969
    Cell Significance Index: 97.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5240
    Cell Significance Index: 51.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4585
    Cell Significance Index: 23.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3449
    Cell Significance Index: 16.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3342
    Cell Significance Index: 38.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2997
    Cell Significance Index: 18.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1984
    Cell Significance Index: 12.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1723
    Cell Significance Index: 7.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1715
    Cell Significance Index: 93.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1657
    Cell Significance Index: 3.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1564
    Cell Significance Index: 28.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1415
    Cell Significance Index: 1.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1214
    Cell Significance Index: 14.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1210
    Cell Significance Index: 16.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1060
    Cell Significance Index: 0.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1029
    Cell Significance Index: 19.5800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1008
    Cell Significance Index: 1.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0965
    Cell Significance Index: 3.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0963
    Cell Significance Index: 12.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0937
    Cell Significance Index: 2.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0932
    Cell Significance Index: 41.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0924
    Cell Significance Index: 2.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0848
    Cell Significance Index: 2.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0839
    Cell Significance Index: 16.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0625
    Cell Significance Index: 1.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0622
    Cell Significance Index: 12.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0476
    Cell Significance Index: 3.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0319
    Cell Significance Index: 1.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0246
    Cell Significance Index: 8.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0169
    Cell Significance Index: 2.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0166
    Cell Significance Index: 11.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0033
    Cell Significance Index: 0.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0032
    Cell Significance Index: 0.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0002
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0029
    Cell Significance Index: -2.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0066
    Cell Significance Index: -8.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0096
    Cell Significance Index: -6.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0116
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0116
    Cell Significance Index: -8.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0140
    Cell Significance Index: -1.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0150
    Cell Significance Index: -8.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0152
    Cell Significance Index: -1.9600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0161
    Cell Significance Index: -0.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0177
    Cell Significance Index: -8.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0242
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0278
    Cell Significance Index: -3.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0292
    Cell Significance Index: -0.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0323
    Cell Significance Index: -3.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0352
    Cell Significance Index: -10.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0388
    Cell Significance Index: -1.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0408
    Cell Significance Index: -1.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0453
    Cell Significance Index: -6.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0464
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0525
    Cell Significance Index: -11.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0530
    Cell Significance Index: -2.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0701
    Cell Significance Index: -2.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0754
    Cell Significance Index: -4.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0765
    Cell Significance Index: -4.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0892
    Cell Significance Index: -2.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0903
    Cell Significance Index: -4.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0947
    Cell Significance Index: -9.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1042
    Cell Significance Index: -1.5700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1065
    Cell Significance Index: -1.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1102
    Cell Significance Index: -8.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1143
    Cell Significance Index: -7.0300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1144
    Cell Significance Index: -1.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1216
    Cell Significance Index: -1.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1309
    Cell Significance Index: -8.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1312
    Cell Significance Index: -6.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1404
    Cell Significance Index: -2.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1470
    Cell Significance Index: -1.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1564
    Cell Significance Index: -5.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1615
    Cell Significance Index: -1.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1715
    Cell Significance Index: -5.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1871
    Cell Significance Index: -4.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1888
    Cell Significance Index: -8.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1983
    Cell Significance Index: -4.1500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2112
    Cell Significance Index: -3.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2134
    Cell Significance Index: -1.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2181
    Cell Significance Index: -8.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2305
    Cell Significance Index: -3.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2335
    Cell Significance Index: -8.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2348
    Cell Significance Index: -8.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Structure:** TMEM187 is a type II transmembrane protein, consisting of an extracellular N-terminal domain, a transmembrane domain, and an intracellular C-terminal domain. 2. **Wide Tissue Expression:** TMEM187 is expressed in various tissues, including the brain, colon, small intestine, cardiac muscle, and other organs. 3. **Neural Expression:** TMEM187 is predominantly found in GABAergic interneurons, forebrain radial glial cells, and other neural cells, suggesting a potential role in neural development and function. 4. **Cell Type-Specific Expression:** TMEM187 is expressed in specific cell types, including absorptive cells, tuft cells of the colon, intestinal crypt stem cells, and BEST4+ intestinal epithelial cells. **Pathways and Functions:** Despite the availability of expression data, the functional significance of TMEM187 remains unclear. However, its expression patterns suggest that it may be involved in various cellular processes, including: 1. **Cell Signaling:** TMEM187 may serve as a receptor or ligand for signaling molecules, influencing cellular responses to extracellular stimuli. 2. **Transport and Trafficking:** The transmembrane structure of TMEM187 suggests that it may be involved in the transport of molecules across cell membranes. 3. **Cell Adhesion:** TMEM187 may play a role in cell adhesion, influencing the interactions between cells and their microenvironment. **Clinical Significance:** TMEM187 has been identified as a significantly expressed gene in various human tissues and organs. While its functional significance remains unclear, its expression patterns suggest that it may be involved in the development and maintenance of tissue homeostasis. Future studies are needed to elucidate the functional role of TMEM187 and its potential involvement in human diseases. Potential applications of TMEM187 research include: 1. **Neurological Disorders:** TMEM187 may play a role in the development and progression of neurological disorders, such as epilepsy, schizophrenia, and Alzheimer's disease. 2. **Gastrointestinal Diseases:** The expression of TMEM187 in the colon and small intestine suggests that it may be involved in the development and maintenance of gastrointestinal homeostasis, potentially influencing the progression of diseases such as inflammatory bowel disease. 3. **Cancer:** TMEM187 may serve as a biomarker for cancer diagnosis or as a target for cancer therapy. In conclusion, TMEM187 is a transmembrane protein with a complex expression profile and potential functional significance in various tissues and organs. Further research is needed to elucidate the functional role of TMEM187 and its potential involvement in human diseases.

Genular Protein ID: 2147639174

Symbol: TM187_HUMAN

Name: Transmembrane protein 187

UniProtKB Accession Codes:

Q14656 B2RC47 Q6IAV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8786131

Title: Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach.

PubMed ID: 8786131

DOI: 10.1006/geno.1996.0293

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 261
  • Mass: 29148
  • Checksum: 736265D26A32C380
  • Sequence:
    • MNPEWGQAFV HVAVAGGLCA VAVFTGIFDS VSVQVGYEHY AEAPVAGLPA FLAMPFNSLV 
NMAYTLLGLS WLHRGGAMGL GPRYLKDVFA AMALLYGPVQ WLRLWTQWRR AAVLDQWLTL 
PIFAWPVAWC LYLDRGWRPW LFLSLECVSL ASYGLALLHP QGFEVALGAH VVAAVGQALR 
THRHYGSTTS ATYLALGVLS CLGFVVLKLC DHQLARWRLF QCLTGHFWSK VCDVLQFHFA 
FLFLTHFNTH PRFHPSGGKT R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.