Details for: ARID1A
Gene ID: 8289
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ARID1A
Ensembl ID: ENSG00000117713
Description: AT-rich interaction domain 1A
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 25.22rCSI 42.33%PRS 10.71
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CSI 12.61rCSI 39.41%PRS 11.42
-
CSI 12.16rCSI 27.8%PRS 17.62
-
CSI 11.69rCSI 18.8%PRS 11.66
-
CSI 10.97rCSI 26.65%PRS 10.51
-
CSI 9.69rCSI 17.1%PRS 10.67
-
CSI 9.4rCSI 24.94%PRS 29.24
-
CSI 8.72rCSI 35.16%PRS 16.36
-
CSI 7.73rCSI 12.33%PRS 15.57
-
CSI 7.04rCSI 7.48%PRS 31.45
-
CSI 6.59rCSI 18.16%PRS 16.81
-
CSI 6.5rCSI 8.86%PRS 42.39
-
CSI 6.39rCSI 23%PRS 10.07
-
CSI 6.35rCSI 24.71%PRS 29.87
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CSI 6.31rCSI 16.22%PRS 23.84
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CSI 5.69rCSI 31.08%PRS 28.98
-
CSI 5.55rCSI 5.24%PRS 19.03
-
CSI 5.41rCSI 8.72%PRS 28.18
-
CSI 5.38rCSI 5.28%PRS 28.34
-
CSI 5.29rCSI 17.71%PRS 12.73
-
CSI 5.2rCSI 30.6%PRS 11.25
-
CSI 4.97rCSI 7.64%PRS 25.07
-
CSI 4.94rCSI 10.87%PRS 20.43
-
CSI 4.72rCSI 17.84%PRS 11.03
-
CSI 4.44rCSI 22.28%PRS 24
-
CSI 4.43rCSI 13.87%PRS 12.3
-
CSI 4.19rCSI 7.85%PRS 13.06
-
CSI 4.08rCSI 9.04%PRS 16.84
-
CSI 4.06rCSI 5.05%PRS 19.27
-
CSI 4.03rCSI 4.22%PRS 16.95
-
CSI 3.95rCSI 5.81%PRS 16.68
-
CSI 3.7rCSI 6.4%PRS 13.83
-
CSI 3.7rCSI 6.33%PRS 24.67
-
CSI 3.64rCSI 5.78%PRS 15.36
-
CSI 3.56rCSI 4.33%PRS 22.83
-
CSI 3.54rCSI 16.55%PRS 36.41
-
CSI 3.48rCSI 4.21%PRS 21.71
-
CSI 3.47rCSI 10.29%PRS 25.66
-
CSI 3.46rCSI 3.56%PRS 29.46
-
CSI 3.43rCSI 9.05%PRS 21.69
-
CSI 3.35rCSI 5.52%PRS 21.44
-
CSI 3.31rCSI 2.45%PRS 15.87
-
CSI 3.28rCSI 2.65%PRS 28.52
-
CSI 3.17rCSI 2.44%PRS 16.77
-
CSI 3.16rCSI 3.04%PRS 18.83
-
CSI 3.15rCSI 75.44%PRS 9.02
-
CSI 3.12rCSI 2.5%PRS 32.46
-
CSI 3.1rCSI 19.88%PRS 27.63
-
CSI 3.09rCSI 74.57%PRS 9.96
-
CSI 3.07rCSI 12.53%PRS 18.54
-
CSI 2.98rCSI 4.4%PRS 28.38
-
CSI 2.98rCSI 6.8%PRS 15.62
-
CSI 2.9rCSI 19.05%PRS 53.41
-
CSI 2.88rCSI 2.84%PRS 19.74
-
CSI 2.87rCSI 4.65%PRS 18.39
-
CSI 2.86rCSI 3.9%PRS 16.12
-
CSI 2.86rCSI 7.45%PRS 16.7
-
CSI 2.83rCSI 2.49%PRS 20.82
-
CSI 2.82rCSI 2.1%PRS 26.86
-
CSI 2.78rCSI 3.46%PRS 25.68
-
CSI 2.75rCSI 40.66%PRS 43.64
-
CSI 2.7rCSI 16.34%PRS 40.06
-
CSI 2.69rCSI 1.59%PRS 25.26
-
CSI 2.68rCSI 3.73%PRS 18.63
-
CSI 2.65rCSI 3.79%PRS 20.4
-
CSI 2.62rCSI 5.88%PRS 11.24
-
CSI 2.6rCSI 4.55%PRS 13.65
-
CSI 2.55rCSI 3.28%PRS 17.7
-
CSI 2.54rCSI 3.48%PRS 20.56
-
CSI 2.54rCSI 4.53%PRS 30.33
-
CSI 2.53rCSI 18.62%PRS 10.35
-
CSI 2.53rCSI 1.76%PRS 21.63
-
CSI 2.49rCSI 3.84%PRS 17.02
-
CSI 2.47rCSI 5.63%PRS 18.75
-
CSI 2.39rCSI 11.46%PRS 13.68
-
CSI 2.35rCSI 4.83%PRS 18.03
-
CSI 2.25rCSI 1.62%PRS 24.89
-
CSI 2.25rCSI 3%PRS 23.8
-
CSI 2.24rCSI 1.88%PRS 21.68
-
CSI 2.23rCSI 3.2%PRS 24.79
-
CSI 2.23rCSI 7.4%PRS 20.54
-
CSI 2.21rCSI 6.33%PRS 26.84
-
CSI 2.18rCSI 4.16%PRS 28.78
-
CSI 2.16rCSI 2.72%PRS 27.96
-
CSI 2.16rCSI 1.61%PRS 30.54
-
CSI 2.15rCSI 9.56%PRS 17.76
-
CSI 2.08rCSI 1.68%PRS 18.18
-
CSI 2.04rCSI 2.62%PRS 17.57
-
CSI 2.02rCSI 1.54%PRS 23.92
-
CSI 2.01rCSI 1.69%PRS 28.89
-
CSI 2rCSI 3.62%PRS 45.98
-
CSI 2rCSI 2.31%PRS 15.92
-
CSI 1.99rCSI 2.82%PRS 25.11
-
CSI 1.98rCSI 10.25%PRS 35.27
-
CSI 1.98rCSI 5.8%PRS 52.8
-
CSI 1.98rCSI 10.12%PRS 18.2
-
CSI 1.97rCSI 2.83%PRS 28.79
-
CSI 1.93rCSI 5.01%PRS 23.44
-
CSI 1.91rCSI 7.43%PRS 24.62
-
CSI 1.89rCSI 3.44%PRS 15.07
-
CSI -1.8rCSI -9.6%PRS 32.3%
-
CSI -1.5rCSI -2.5%PRS 35.5%
-
CSI 0.1rCSI 0.6%PRS 35.1%
-
CSI 0.1rCSI 1.0%PRS 32.4%
-
CSI 0.2rCSI 0.4%PRS 13.9%
-
CSI 0.2rCSI 1.0%PRS 26.7%
-
CSI 0.2rCSI 1.0%PRS 27.6%
-
CSI 0.2rCSI 1.1%PRS 14.1%
-
CSI 0.2rCSI 0.3%PRS 23.4%
-
CSI 0.2rCSI 3.2%PRS 43.9%
-
CSI 0.3rCSI 1.1%PRS 29.3%
-
CSI 0.3rCSI 5.3%PRS 14.6%
-
CSI 0.3rCSI 2.5%PRS 33.1%
-
CSI 0.4rCSI 1.2%PRS 15.7%
-
CSI 0.4rCSI 3.7%PRS 24.0%
-
CSI 0.4rCSI 0.9%PRS 18.3%
-
CSI 0.4rCSI 1.4%PRS 31.4%
-
CSI 0.4rCSI 3.8%PRS 34.5%
-
CSI 0.4rCSI 1.2%PRS 19.1%
-
CSI 0.4rCSI 5.3%PRS 13.4%
-
CSI 0.4rCSI 0.9%PRS 11.3%
-
CSI 0.4rCSI 7.8%PRS 14.4%
-
CSI 0.4rCSI 2.5%PRS 45.5%
-
CSI 0.4rCSI 1.9%PRS 40.9%
-
CSI 0.4rCSI 3.6%PRS 29.2%
-
CSI 0.4rCSI 8.4%PRS 15.4%
-
CSI 0.4rCSI 0.8%PRS 22.9%
-
CSI 0.4rCSI 1.0%PRS 17.9%
-
CSI 0.4rCSI 2.3%PRS 31.2%
-
CSI 0.5rCSI 3.5%PRS 19.3%
-
CSI 0.5rCSI 2.2%PRS 15.6%
-
CSI 0.5rCSI 2.7%PRS 32.2%
-
CSI 0.5rCSI 1.3%PRS 35.2%
-
CSI 0.5rCSI 0.7%PRS 25.8%
-
CSI 0.5rCSI 1.4%PRS 28.1%
-
CSI 0.5rCSI 0.6%PRS 23.5%
-
CSI 0.5rCSI 2.8%PRS 42.4%
-
CSI 0.5rCSI 1.1%PRS 29.2%
-
CSI 0.6rCSI 3.2%PRS 53.8%
-
CSI 0.6rCSI 3.9%PRS 18.7%
-
CSI 0.6rCSI 1.1%PRS 18.6%
-
CSI 0.6rCSI 1.5%PRS 15.1%
-
CSI 0.6rCSI 0.9%PRS 16.8%
-
CSI 0.6rCSI 1.9%PRS 26.2%
-
CSI 0.6rCSI 2.3%PRS 24.7%
-
CSI 0.6rCSI 1.0%PRS 23.9%
-
CSI 0.6rCSI 0.8%PRS 27.4%
-
CSI 0.6rCSI 1.6%PRS 18.0%
-
CSI 0.6rCSI 1.5%PRS 28.8%
-
CSI 0.6rCSI 4.4%PRS 18.7%
-
CSI 0.6rCSI 1.8%PRS 20.5%
-
CSI 0.6rCSI 2.6%PRS 25.2%
-
CSI 0.6rCSI 2.8%PRS 33.6%
-
CSI 0.6rCSI 3.8%PRS 19.1%
-
CSI 0.6rCSI 1.0%PRS 29.4%
-
CSI 0.7rCSI 3.0%PRS 37.5%
-
CSI 0.7rCSI 0.9%PRS 34.5%
-
CSI 0.7rCSI 7.5%PRS 61.4%
-
CSI 0.7rCSI 2.3%PRS 29.5%
-
CSI 0.7rCSI 0.6%PRS 18.8%
-
CSI 0.7rCSI 0.4%PRS 22.1%
-
CSI 0.7rCSI 0.8%PRS 15.9%
-
CSI 0.7rCSI 2.4%PRS 31.1%
-
CSI 0.7rCSI 0.7%PRS 21.4%
-
CSI 0.7rCSI 5.9%PRS 8.4%
-
CSI 0.7rCSI 1.6%PRS 22.5%
-
CSI 0.7rCSI 2.0%PRS 31.0%
-
CSI 0.8rCSI 1.6%PRS 12.0%
-
CSI 0.8rCSI 1.1%PRS 19.2%
-
CSI 0.8rCSI 1.9%PRS 16.8%
-
CSI 0.8rCSI 0.8%PRS 33.5%
-
CSI 0.8rCSI 3.1%PRS 38.4%
-
CSI 0.8rCSI 0.9%PRS 31.4%
-
CSI 0.8rCSI 1.5%PRS 40.2%
-
CSI 0.8rCSI 1.2%PRS 20.8%
-
CSI 0.8rCSI 2.2%PRS 20.9%
-
CSI 0.8rCSI 5.0%PRS 40.1%
-
CSI 0.8rCSI 5.7%PRS 47.5%
-
CSI 0.8rCSI 0.9%PRS 20.6%
-
CSI 0.8rCSI 0.8%PRS 19.0%
-
CSI 0.8rCSI 4.2%PRS 21.1%
-
CSI 0.8rCSI 0.7%PRS 22.7%
-
CSI 0.8rCSI 1.8%PRS 13.0%
-
CSI 0.8rCSI 1.8%PRS 27.6%
-
CSI 0.8rCSI 1.8%PRS 24.3%
-
CSI 0.8rCSI 1.6%PRS 44.4%
-
CSI 0.8rCSI 1.1%PRS 19.9%
-
CSI 0.8rCSI 1.3%PRS 18.3%
-
CSI 0.8rCSI 2.1%PRS 13.8%
-
CSI 0.8rCSI 1.0%PRS 31.6%
-
CSI 0.8rCSI 1.2%PRS 18.1%
-
CSI 0.9rCSI 1.3%PRS 25.5%
-
CSI 0.9rCSI 1.3%PRS 21.6%
-
CSI 0.9rCSI 2.1%PRS 27.7%
-
CSI 0.9rCSI 7.7%PRS 11.6%
-
CSI 0.9rCSI 0.9%PRS 36.9%
-
CSI 0.9rCSI 1.9%PRS 35.5%
-
CSI 0.9rCSI 3.1%PRS 61.8%
-
CSI 0.9rCSI 1.9%PRS 36.3%
-
CSI 0.9rCSI 1.6%PRS 27.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1505880103
Symbol: ARI1A_HUMAN
Name: AT-rich interactive domain-containing protein 1A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11073988
Title: A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex.
PubMed ID: 11073988
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 12200431
Title: Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors.
PubMed ID: 12200431
PubMed ID: 11734557
Title: SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.
PubMed ID: 11734557
PubMed ID: 10757798
Title: The human SWI-SNF complex protein p270 is an ARID family member with non-sequence-specific DNA binding activity.
PubMed ID: 10757798
PubMed ID: 9434167
Title: Molecular cloning and expression of a novel human cDNA containing CAG repeats.
PubMed ID: 9434167
PubMed ID: 11318604
Title: Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex.
PubMed ID: 11318604
PubMed ID: 8804307
Title: Diversity and specialization of mammalian SWI/SNF complexes.
PubMed ID: 8804307
PubMed ID: 11780067
Title: Selectivity of chromatin-remodelling cofactors for ligand-activated transcription.
PubMed ID: 11780067
DOI: 10.1038/414924a
PubMed ID: 11988099
Title: Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein.
PubMed ID: 11988099
DOI: 10.1042/bj3640255
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22426308
Title: Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome.
PubMed ID: 22426308
DOI: 10.1038/ng.2219
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 12672490
Title: Recent advances in understanding chromatin remodeling by SWI/SNF complexes.
PubMed ID: 12672490
PubMed ID: 12665591
Title: Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.
PubMed ID: 12665591
PubMed ID: 15170388
Title: Two related ARID family proteins are alternative subunits of human SWI/SNF complexes.
PubMed ID: 15170388
DOI: 10.1042/bj20040524
PubMed ID: 18765789
Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.
PubMed ID: 18765789
DOI: 10.1101/gad.471408
PubMed ID: 22952240
Title: SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.
PubMed ID: 22952240
PubMed ID: 26601204
Title: Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.
PubMed ID: 26601204
PubMed ID: 26614907
Title: Identification and functional characterization of a novel bipartite nuclear localization sequence in ARID1A.
PubMed ID: 26614907
PubMed ID: 14722072
Title: Structure and DNA-binding sites of the SWI1 AT-rich interaction domain (ARID) suggest determinants for sequence-specific DNA recognition.
PubMed ID: 14722072
PubMed ID: 21248752
Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
PubMed ID: 21248752
DOI: 10.1038/nature09639
PubMed ID: 22009941
Title: Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types.
PubMed ID: 22009941
DOI: 10.1002/humu.21633
PubMed ID: 23906836
Title: A comprehensive molecular study on Coffin-Siris and Nicolaides-Baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling.
PubMed ID: 23906836
DOI: 10.1093/hmg/ddt366
Sequence Information:
- Length: 2285
- Mass: 242045
- Checksum: 85BC5B6061625D8E
- Sequence:
MAAQVAPAAA SSLGNPPPPP PSELKKAEQQ QREEAGGEAA AAAAAERGEM KAAAGQESEG PAVGPPQPLG KELQDGAESN GGGGGGGAGS GGGPGAEPDL KNSNGNAGPR PALNNNLTEP PGGGGGGSSD GVGAPPHSAA AALPPPAYGF GQPYGRSPSA VAAAAAAVFH QQHGGQQSPG LAALQSGGGG GLEPYAGPQQ NSHDHGFPNH QYNSYYPNRS AYPPPAPAYA LSSPRGGTPG SGAAAAAGSK PPPSSSASAS SSSSSFAQQR FGAMGGGGPS AAGGGTPQPT ATPTLNQLLT SPSSARGYQG YPGGDYSGGP QDGGAGKGPA DMASQCWGAA AAAAAAAAAS GGAQQRSHHA PMSPGSSGGG GQPLARTPQP SSPMDQMGKM RPQPYGGTNP YSQQQGPPSG PQQGHGYPGQ PYGSQTPQRY PMTMQGRAQS AMGGLSYTQQ IPPYGQQGPS GYGQQGQTPY YNQQSPHPQQ QQPPYSQQPP SQTPHAQPSY QQQPQSQPPQ LQSSQPPYSQ QPSQPPHQQS PAPYPSQQST TQQHPQSQPP YSQPQAQSPY QQQQPQQPAP STLSQQAAYP QPQSQQSQQT AYSQQRFPPP QELSQDSFGS QASSAPSMTS SKGGQEDMNL SLQSRPSSLP DLSGSIDDLP MGTEGALSPG VSTSGISSSQ GEQSNPAQSP FSPHTSPHLP GIRGPSPSPV GSPASVAQSR SGPLSPAAVP GNQMPPRPPS GQSDSIMHPS MNQSSIAQDR GYMQRNPQMP QYSSPQPGSA LSPRQPSGGQ IHTGMGSYQQ NSMGSYGPQG GQYGPQGGYP RQPNYNALPN ANYPSAGMAG GINPMGAGGQ MHGQPGIPPY GTLPPGRMSH ASMGNRPYGP NMANMPPQVG SGMCPPPGGM NRKTQETAVA MHVAANSIQN RPPGYPNMNQ GGMMGTGPPY GQGINSMAGM INPQGPPYSM GGTMANNSAG MAASPEMMGL GDVKLTPATK MNNKADGTPK TESKSKKSSS STTTNEKITK LYELGGEPER KMWVDRYLAF TEEKAMGMTN LPAVGRKPLD LYRLYVSVKE IGGLTQVNKN KKWRELATNL NVGTSSSAAS SLKKQYIQCL YAFECKIERG EDPPPDIFAA ADSKKSQPKI QPPSPAGSGS MQGPQTPQST SSSMAEGGDL KPPTPASTPH SQIPPLPGMS RSNSVGIQDA FNDGSDSTFQ KRNSMTPNPG YQPSMNTSDM MGRMSYEPNK DPYGSMRKAP GSDPFMSSGQ GPNGGMGDPY SRAAGPGLGN VAMGPRQHYP YGGPYDRVRT EPGIGPEGNM STGAPQPNLM PSNPDSGMYS PSRYPPQQQQ QQQQRHDSYG NQFSTQGTPS GSPFPSQQTT MYQQQQQNYK RPMDGTYGPP AKRHEGEMYS VPYSTGQGQP QQQQLPPAQP QPASQQQAAQ PSPQQDVYNQ YGNAYPATAT AATERRPAGG PQNQFPFQFG RDRVSAPPGT NAQQNMPPQM MGGPIQASAE VAQQGTMWQG RNDMTYNYAN RQSTGSAPQG PAYHGVNRTD EMLHTDQRAN HEGSWPSHGT RQPPYGPSAP VPPMTRPPPS NYQPPPSMQN HIPQVSSPAP LPRPMENRTS PSKSPFLHSG MKMQKAGPPV PASHIAPAPV QPPMIRRDIT FPPGSVEATQ PVLKQRRRLT MKDIGTPEAW RVMMSLKSGL LAESTWALDT INILLYDDNS IMTFNLSQLP GLLELLVEYF RRCLIEIFGI LKEYEVGDPG QRTLLDPGRF SKVSSPAPME GGEEEEELLG PKLEEEEEEE VVENDEEIAF SGKDKPASEN SEEKLISKFD KLPVKIVQKN DPFVVDCSDK LGRVQEFDSG LLHWRIGGGD TTEHIQTHFE SKTELLPSRP HAPCPPAPRK HVTTAEGTPG TTDQEGPPPD GPPEKRITAT MDDMLSTRSS TLTEDGAKSS EAIKESSKFP FGISPAQSHR NIKILEDEPH SKDETPLCTL LDWQDSLAKR CVCVSNTIRS LSFVPGNDFE MSKHPGLLLI LGKLILLHHK HPERKQAPLT YEKEEEQDQG VSCNKVEWWW DCLEMLRENT LVTLANISGQ LDLSPYPESI CLPVLDGLLH WAVCPSAEAQ DPFSTLGPNA VLSPQRLVLE TLSKLSIQDN NVDLILATPP FSRLEKLYST MVRFLSDRKN PVCREMAVVL LANLAQGDSL AARAIAVQKG SIGNLLGFLE DSLAATQFQQ SQASLLHMQN PPFEPTSVDM MRRAARALLA LAKVDENHSE FTLYESRLLD ISVSPLMNSL VSQVICDVLF LIGQS