H4C9 | ENSG00000276180 | NCBI 8294

Details for: H4C9

Gene ID: 8294

Symbol: H4C9

Ensembl ID: ENSG00000276180

Description: H4 clustered histone 9

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7175
Cell Significance Index: 136.5500
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.6883
Cell Significance Index: 9.6600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5110
Cell Significance Index: 50.5500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4843
Cell Significance Index: 21.9500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4258
Cell Significance Index: 25.5600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3892
Cell Significance Index: 42.3400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3852
Cell Significance Index: 10.3100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3226
Cell Significance Index: 291.2800
Cell Name: thymocyte (CL0000893)
Fold Change: 0.3158
Cell Significance Index: 3.9900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3066
Cell Significance Index: 49.8600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2794
Cell Significance Index: 5.8000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2478
Cell Significance Index: 7.1400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.2009
Cell Significance Index: 2.0800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1894
Cell Significance Index: 13.1000
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.1794
Cell Significance Index: 1.0200
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.1462
Cell Significance Index: 2.0500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1288
Cell Significance Index: 1.9300
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0990
Cell Significance Index: 2.4700
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.0975
Cell Significance Index: 0.9700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0973
Cell Significance Index: 11.4700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0827
Cell Significance Index: 2.6500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0701
Cell Significance Index: 3.6400
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0531
Cell Significance Index: 0.8000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0509
Cell Significance Index: 3.2900
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.0471
Cell Significance Index: 0.5100
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.0412
Cell Significance Index: 0.3600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0340
Cell Significance Index: 6.7400
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.0220
Cell Significance Index: 0.1200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0208
Cell Significance Index: 0.5200
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.0206
Cell Significance Index: 0.1600
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.0199
Cell Significance Index: 0.2300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0188
Cell Significance Index: 0.4000
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.0144
Cell Significance Index: 0.2000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0134
Cell Significance Index: 0.4700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0106
Cell Significance Index: 0.6500
Cell Name: surface ectodermal cell (CL0000114)
Fold Change: 0.0089
Cell Significance Index: 0.0700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0060
Cell Significance Index: 0.1300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0041
Cell Significance Index: 0.7400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0009
Cell Significance Index: 0.5000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0010
Cell Significance Index: -0.4600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0012
Cell Significance Index: -0.8600
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.0014
Cell Significance Index: -0.0100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0015
Cell Significance Index: -0.8500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0025
Cell Significance Index: -1.9100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0028
Cell Significance Index: -2.0500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0039
Cell Significance Index: -0.5400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0041
Cell Significance Index: -1.4900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0046
Cell Significance Index: -0.9600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0047
Cell Significance Index: -2.1200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0053
Cell Significance Index: -0.9000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0079
Cell Significance Index: -0.9100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0080
Cell Significance Index: -1.6100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0081
Cell Significance Index: -0.8300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0100
Cell Significance Index: -0.7100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0105
Cell Significance Index: -0.2200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0117
Cell Significance Index: -1.4400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0119
Cell Significance Index: -0.6700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0142
Cell Significance Index: -2.0600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0166
Cell Significance Index: -1.7300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0213
Cell Significance Index: -0.5800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0217
Cell Significance Index: -1.1400
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0230
Cell Significance Index: -0.3300
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0248
Cell Significance Index: -0.2700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0249
Cell Significance Index: -0.3400
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0253
Cell Significance Index: -0.1500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0260
Cell Significance Index: -1.2200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0262
Cell Significance Index: -2.0100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0287
Cell Significance Index: -0.5300
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0302
Cell Significance Index: -1.3200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0333
Cell Significance Index: -0.9300
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0338
Cell Significance Index: -0.3500
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0339
Cell Significance Index: -0.4900
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0340
Cell Significance Index: -1.3900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0372
Cell Significance Index: -1.7400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0380
Cell Significance Index: -1.6800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0394
Cell Significance Index: -0.6600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0394
Cell Significance Index: -1.1600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0395
Cell Significance Index: -1.0100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0423
Cell Significance Index: -1.1300
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0448
Cell Significance Index: -0.6200
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0450
Cell Significance Index: -0.5700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0451
Cell Significance Index: -1.1900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0454
Cell Significance Index: -1.7200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0455
Cell Significance Index: -0.6600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0462
Cell Significance Index: -1.6200
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.0472
Cell Significance Index: -0.4600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0475
Cell Significance Index: -1.6500
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0482
Cell Significance Index: -0.6300
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0487
Cell Significance Index: -1.1800
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0488
Cell Significance Index: -0.6300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0490
Cell Significance Index: -1.8000
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0495
Cell Significance Index: -0.5600
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0517
Cell Significance Index: -0.5000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0525
Cell Significance Index: -1.7200
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0547
Cell Significance Index: -0.7000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0553
Cell Significance Index: -1.7600
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.0561
Cell Significance Index: -0.7100
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.0629
Cell Significance Index: -0.3300
Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.0635
Cell Significance Index: -0.9500
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0655
Cell Significance Index: -1.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H4C9 is a histone protein that belongs to the H4 family, which is one of the five main histone proteins that make up chromatin. It is characterized by a unique structure, with a histone H4 N-terminal tail that is modified by acetylation, methylation, and phosphorylation. H4C9 is specifically localized to the centromere region of chromosomes, where it plays a role in the assembly of the pre-replicative complex and the regulation of DNA replication. **Pathways and Functions** H4C9 is involved in various cellular pathways, including: 1. **DNA Replication**: H4C9 is required for the assembly of the pre-replicative complex and the regulation of DNA replication. 2. **DNA Repair**: H4C9 plays a role in the recognition and association of DNA glycosylase with damaged sites, as well as the recruitment of ATM-mediated phosphorylation of repair and signaling proteins. 3. **Chromatin Organization**: H4C9 is involved in the regulation of chromatin structure and the assembly of nucleosomes. 4. **Gene Expression**: H4C9 is required for the regulation of gene expression, particularly in the context of DNA damage response. 5. **Cell Cycle**: H4C9 is involved in the regulation of the cell cycle, particularly in the G2/M checkpoint. **Clinical Significance** H4C9 has been implicated in various diseases, including: 1. **Cancer**: H4C9 has been shown to be overexpressed in various types of cancer, including breast cancer and colon cancer. 2. **Neurodegenerative Diseases**: H4C9 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Aging**: H4C9 has been shown to be involved in the regulation of cellular senescence and aging. 4. **Autoimmune Diseases**: H4C9 has been implicated in autoimmune diseases, including rheumatoid arthritis and lupus. In conclusion, H4C9 is a histone protein that plays a critical role in various cellular processes, including DNA replication, repair, and transcription. Its expression is significantly elevated in various cell types, and its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, aging, and autoimmune diseases. Further research is needed to fully understand the role of H4C9 in human disease and to develop therapeutic strategies to target this protein.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.