H2BC13 | ENSG00000185130 | NCBI 8340

Details for: H2BC13

Gene ID: 8340

Symbol: H2BC13

Ensembl ID: ENSG00000185130

Description: H2B clustered histone 13

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 6.5052
Cell Significance Index: -1.6500
Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 5.7218
Cell Significance Index: -0.8900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 1.3626
Cell Significance Index: -1.6800
Cell Name: thymocyte (CL0000893)
Fold Change: 0.7060
Cell Significance Index: 8.9200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5290
Cell Significance Index: 23.9800
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.5120
Cell Significance Index: 10.6200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4908
Cell Significance Index: 14.1400
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.4329
Cell Significance Index: 6.2000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4203
Cell Significance Index: 41.5800
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.3580
Cell Significance Index: 3.8800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3422
Cell Significance Index: 65.1200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3310
Cell Significance Index: 21.3600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3251
Cell Significance Index: 35.3700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2956
Cell Significance Index: 48.0800
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.2305
Cell Significance Index: 1.3100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2165
Cell Significance Index: 13.0000
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.2127
Cell Significance Index: 1.8600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1754
Cell Significance Index: 3.8000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1646
Cell Significance Index: 5.7900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1513
Cell Significance Index: 136.6100
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.1383
Cell Significance Index: 3.4500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1363
Cell Significance Index: 4.3700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1317
Cell Significance Index: 9.1100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1217
Cell Significance Index: 14.3500
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.1024
Cell Significance Index: 0.8700
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0876
Cell Significance Index: 1.2300
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.0748
Cell Significance Index: 0.7500
Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.0612
Cell Significance Index: 0.7600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0533
Cell Significance Index: 2.7700
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.0454
Cell Significance Index: 0.6300
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.0384
Cell Significance Index: 0.9800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0338
Cell Significance Index: 0.5100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0333
Cell Significance Index: 0.7100
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0294
Cell Significance Index: 0.7700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0241
Cell Significance Index: 0.6500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0144
Cell Significance Index: 0.3600
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.0140
Cell Significance Index: 0.2000
Cell Name: adipocyte (CL0000136)
Fold Change: 0.0118
Cell Significance Index: 0.1600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0050
Cell Significance Index: 1.0000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0036
Cell Significance Index: 1.9400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0009
Cell Significance Index: 0.0200
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0002
Cell Significance Index: -0.0100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0009
Cell Significance Index: -0.4200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0014
Cell Significance Index: -0.7800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0017
Cell Significance Index: -0.3100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0018
Cell Significance Index: -0.1100
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0020
Cell Significance Index: -0.0800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0023
Cell Significance Index: -1.7600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0023
Cell Significance Index: -0.3200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0023
Cell Significance Index: -0.1200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0030
Cell Significance Index: -0.5100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0038
Cell Significance Index: -1.3800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0039
Cell Significance Index: -1.7500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0044
Cell Significance Index: -1.2700
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0054
Cell Significance Index: -0.6900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0057
Cell Significance Index: -0.3200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0071
Cell Significance Index: -0.8200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0076
Cell Significance Index: -1.5300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0097
Cell Significance Index: -1.1900
Cell Name: germ cell (CL0000586)
Fold Change: -0.0119
Cell Significance Index: -0.0900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0126
Cell Significance Index: -0.8900
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.0127
Cell Significance Index: -0.1400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0130
Cell Significance Index: -1.3300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0138
Cell Significance Index: -1.7800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0219
Cell Significance Index: -1.0200
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0229
Cell Significance Index: -0.3900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0248
Cell Significance Index: -1.3000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0248
Cell Significance Index: -0.5200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0258
Cell Significance Index: -1.9200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0263
Cell Significance Index: -0.4400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0266
Cell Significance Index: -1.2500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0276
Cell Significance Index: -0.3000
Cell Name: DN4 thymocyte (CL0000808)
Fold Change: -0.0279
Cell Significance Index: -0.2100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0353
Cell Significance Index: -1.5600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0354
Cell Significance Index: -0.5300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0375
Cell Significance Index: -1.0000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0388
Cell Significance Index: -1.1400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0412
Cell Significance Index: -1.4300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0412
Cell Significance Index: -1.5600
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0424
Cell Significance Index: -0.4200
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0425
Cell Significance Index: -0.4400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0425
Cell Significance Index: -1.3900
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0434
Cell Significance Index: -0.6300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0434
Cell Significance Index: -1.1800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0435
Cell Significance Index: -1.2800
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0442
Cell Significance Index: -0.5000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0447
Cell Significance Index: -1.6400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0452
Cell Significance Index: -1.4400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0480
Cell Significance Index: -1.6800
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0506
Cell Significance Index: -0.3000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0512
Cell Significance Index: -1.2800
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0526
Cell Significance Index: -1.3400
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0623
Cell Significance Index: -0.7900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0640
Cell Significance Index: -0.8200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0644
Cell Significance Index: -1.5600
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.0647
Cell Significance Index: -0.8000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0649
Cell Significance Index: -1.8600
Cell Name: peg cell (CL4033014)
Fold Change: -0.0658
Cell Significance Index: -1.5200
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.0662
Cell Significance Index: -0.6500
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.0672
Cell Significance Index: -0.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** H2BC13 is a histone protein that is highly conserved across species, with high sequence similarity to other histone H2B variants. It is a component of nucleosomes, the basic units of chromatin, and is involved in the assembly of the pre-replicative complex and DNA replication. H2BC13 has been shown to interact with various proteins, including DNA repair enzymes, histone acetyltransferases, and histone deacetylases, which highlights its role in chromatin regulation and gene expression. **Pathways and Functions:** H2BC13 is involved in various cellular processes, including: 1. **DNA Repair:** H2BC13 interacts with DNA repair enzymes, such as ERCC6 and EHMT2, to regulate DNA repair and maintain genome stability. 2. **Immune Regulation:** H2BC13 has been shown to regulate immune responses by interacting with transcription factors, such as Notch and Wnt/β-catenin, which are involved in the development and differentiation of immune cells. 3. **Chromatin Regulation:** H2BC13 is involved in chromatin modification, including histone acetylation and deacetylation, which regulates gene expression and chromatin structure. 4. **Cell Cycle and Senescence:** H2BC13 is involved in the regulation of the cell cycle and senescence, including the assembly of the pre-replicative complex and DNA replication. **Clinical Significance:** H2BC13 has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** H2BC13 has been shown to regulate immune responses and has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** H2BC13 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma, and has been implicated in tumorigenesis and cancer progression. 3. **Neurological Disorders:** H2BC13 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, and has been shown to regulate gene expression and chromatin structure. **Significantly Expressed Cells:** H2BC13 is highly expressed in various cell types, including: 1. **Oligodendrocyte Precursor Cells:** H2BC13 is highly expressed in oligodendrocyte precursor cells, which are involved in the development and differentiation of the nervous system. 2. **Thymocytes:** H2BC13 is highly expressed in thymocytes, which are involved in the development and selection of T cells. 3. **Goblet Cells:** H2BC13 is highly expressed in goblet cells, which are involved in the production of mucus and are found in the epithelial lining of the gut. **Proteins:** H2BC13 interacts with various proteins, including: 1. **Histone Acetyltransferases:** H2BC13 interacts with histone acetyltransferases, such as HATs, to regulate chromatin modification and gene expression. 2. **Histone Deacetylases:** H2BC13 interacts with histone deacetylases, such as HDACs, to regulate chromatin modification and gene expression. 3. **DNA Repair Enzymes:** H2BC13 interacts with DNA repair enzymes, such as ERCC6 and EHMT2, to regulate DNA repair and maintain genome stability. In conclusion, H2BC13 is a multifunctional protein that plays a critical role in chromatin regulation, immune regulation, and disease. Further studies are needed to fully understand the mechanisms by which H2BC13 regulates cellular processes and its implications in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2B type 1-L

Genular Protein ID: 4015366565

Symbol: H2B1L_HUMAN

Name: Histone H2B type 1-L

UniProtKB Accession Codes:

Q99880 B2R5A3 Q52LW9

Database IDs:

Citations:

PubMed ID: 9439656

Title: The human histone gene cluster at the D6S105 locus.

PubMed ID: 9439656

DOI: 10.1007/s004390050630

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16627869

Title: Quantitative proteomic analysis of post-translational modifications of human histones.

PubMed ID: 16627869

DOI: 10.1074/mcp.m600007-mcp200

PubMed ID: 12757711

Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

PubMed ID: 12757711

DOI: 10.1016/s0092-8674(03)00355-6

PubMed ID: 16307923

Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

PubMed ID: 16307923

DOI: 10.1016/j.molcel.2005.09.025

PubMed ID: 16283522

Title: Inhibition of core histones acetylation by carcinogenic nickel(II).

PubMed ID: 16283522

DOI: 10.1007/s11010-005-8285-1

PubMed ID: 16713563

Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

PubMed ID: 16713563

DOI: 10.1016/j.cell.2006.04.029

PubMed ID: 16319397

Title: Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry.

PubMed ID: 16319397

DOI: 10.1074/mcp.m500288-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23824326

Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

PubMed ID: 23824326

DOI: 10.1101/gad.211037.112

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 27723750

Title: Serine is a new target residue for endogenous ADP-ribosylation on histones.

PubMed ID: 27723750

DOI: 10.1038/nchembio.2180

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27530147

Title: PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).

PubMed ID: 27530147

DOI: 10.1038/ncomms12404

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

Sequence Information:

Length: 126
Mass: 13952
Checksum: EAA150A983C8B03D
Sequence:

MPELAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM 
GIMNSFVNDI FERIASEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 
KYTSSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: H2BC13

Associated with

Cells (max top 100)

Other Information

The human histone gene cluster at the D6S105 locus. PubMed ID: 9439656

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Quantitative proteomic analysis of post-translational modifications of human histones. PubMed ID: 16627869

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. PubMed ID: 12757711

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. PubMed ID: 16307923

Inhibition of core histones acetylation by carcinogenic nickel(II). PubMed ID: 16283522

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. PubMed ID: 16713563

Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry. PubMed ID: 16319397

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. PubMed ID: 21726816

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. PubMed ID: 23824326

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters. PubMed ID: 27105113

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

Serine is a new target residue for endogenous ADP-ribosylation on histones. PubMed ID: 27723750

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). PubMed ID: 27530147

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297

Metabolic regulation of gene expression by histone lactylation. PubMed ID: 31645732

Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling. PubMed ID: 34874266