H2BC7 | ENSG00000277224 | NCBI 8343

Details for: H2BC7

Gene ID: 8343

Symbol: H2BC7

Ensembl ID: ENSG00000277224

Description: H2B clustered histone 7

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 2.3512
Cell Significance Index: 24.3400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.2641
Cell Significance Index: 430.8800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.4264
Cell Significance Index: 92.0300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.1916
Cell Significance Index: 117.8800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0606
Cell Significance Index: 172.5000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9354
Cell Significance Index: 844.6100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9308
Cell Significance Index: 42.1900
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.7207
Cell Significance Index: 10.0000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7048
Cell Significance Index: 42.3100
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.7022
Cell Significance Index: 7.6100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.4890
Cell Significance Index: 13.0800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.4500
Cell Significance Index: 6.1400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4192
Cell Significance Index: 28.9900
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.3529
Cell Significance Index: 2.7200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3481
Cell Significance Index: 10.0300
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.3411
Cell Significance Index: 3.4200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2864
Cell Significance Index: 33.7800
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2622
Cell Significance Index: 5.4400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2603
Cell Significance Index: 5.6400
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.1760
Cell Significance Index: 2.4700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1482
Cell Significance Index: 7.7000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1326
Cell Significance Index: 3.6100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1320
Cell Significance Index: 4.6400
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1314
Cell Significance Index: 1.9800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1196
Cell Significance Index: 3.8300
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.0570
Cell Significance Index: 0.5900
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.0527
Cell Significance Index: 0.3500
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0363
Cell Significance Index: 0.5200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0324
Cell Significance Index: 0.6900
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.0257
Cell Significance Index: 0.2000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0184
Cell Significance Index: 10.0300
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.0158
Cell Significance Index: 0.0900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0147
Cell Significance Index: 0.4100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0139
Cell Significance Index: 6.1600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0137
Cell Significance Index: 1.8800
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.0132
Cell Significance Index: 0.1400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0097
Cell Significance Index: 1.9200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0036
Cell Significance Index: 0.6600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0031
Cell Significance Index: 0.3500
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.0021
Cell Significance Index: 0.0200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0005
Cell Significance Index: -0.4000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0005
Cell Significance Index: -0.0200
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0014
Cell Significance Index: -0.0600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0024
Cell Significance Index: -0.5000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0028
Cell Significance Index: -5.2500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0048
Cell Significance Index: -7.3900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0062
Cell Significance Index: -0.7900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0074
Cell Significance Index: -4.7200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0075
Cell Significance Index: -5.6700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0082
Cell Significance Index: -0.2100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0087
Cell Significance Index: -4.9100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0093
Cell Significance Index: -3.3200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0122
Cell Significance Index: -5.5400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0123
Cell Significance Index: -0.5800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0185
Cell Significance Index: -3.1600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0225
Cell Significance Index: -2.7700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0234
Cell Significance Index: -2.3900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0242
Cell Significance Index: -4.8600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0260
Cell Significance Index: -1.4600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0316
Cell Significance Index: -1.9400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0349
Cell Significance Index: -5.0700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0356
Cell Significance Index: -4.6000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0359
Cell Significance Index: -2.5400
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0445
Cell Significance Index: -0.5600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0483
Cell Significance Index: -2.2500
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0521
Cell Significance Index: -0.7400
Cell Name: germ cell (CL0000586)
Fold Change: -0.0536
Cell Significance Index: -0.4000
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.0540
Cell Significance Index: -0.5600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0545
Cell Significance Index: -5.6800
Cell Name: PP cell (CL0000696)
Fold Change: -0.0561
Cell Significance Index: -0.5700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0600
Cell Significance Index: -1.5000
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0670
Cell Significance Index: -0.9400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0688
Cell Significance Index: -5.2800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0725
Cell Significance Index: -5.4000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0750
Cell Significance Index: -3.9400
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0772
Cell Significance Index: -2.0300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0812
Cell Significance Index: -1.7000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0984
Cell Significance Index: -1.2600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1081
Cell Significance Index: -1.6200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1120
Cell Significance Index: -1.2700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1168
Cell Significance Index: -3.1200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1297
Cell Significance Index: -2.1700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1301
Cell Significance Index: -4.5200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1320
Cell Significance Index: -5.8400
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.1352
Cell Significance Index: -1.5300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1511
Cell Significance Index: -4.4500
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1514
Cell Significance Index: -2.1700
Cell Name: thymocyte (CL0000893)
Fold Change: -0.1520
Cell Significance Index: -1.9200
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1539
Cell Significance Index: -1.9500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1540
Cell Significance Index: -5.8300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1546
Cell Significance Index: -5.0600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1596
Cell Significance Index: -5.5900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1621
Cell Significance Index: -5.9500
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1702
Cell Significance Index: -4.2500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1727
Cell Significance Index: -5.5000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1729
Cell Significance Index: -1.8800
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.1802
Cell Significance Index: -1.3100
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1860
Cell Significance Index: -4.7400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1941
Cell Significance Index: -5.5700
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: -0.2010
Cell Significance Index: -1.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Histone H2B family member**: H2BC7 is a member of the histone H2B family, which is essential for the structure and function of chromatin. 2. **Acetylation and deacetylation**: H2BC7 undergoes acetylation and deacetylation, which regulate its interactions with other proteins and influence gene expression. 3. **Pre-replicative complex assembly**: H2BC7 is involved in the assembly of the pre-replicative complex, a critical step in DNA replication. 4. **Chromatin modifications**: H2BC7 is involved in chromatin modifications during the maternal-to-zygotic transition, a process critical for the establishment of the germline. 5. **Lymphoid lineage restriction**: H2BC7 is specifically expressed in lymphoid lineage progenitor cells, suggesting its role in maintaining the integrity of the immune system. **Pathways and Functions** 1. **DNA replication**: H2BC7 is involved in the assembly of the pre-replicative complex, which is essential for DNA replication. 2. **Chromatin modifications**: H2BC7 is involved in chromatin modifications during the maternal-to-zygotic transition and in the regulation of gene expression through histone acetylation and deacetylation. 3. **Gene expression regulation**: H2BC7 regulates gene expression through its interactions with other proteins and histone modifications. 4. **Cell cycle regulation**: H2BC7 is involved in the regulation of the cell cycle, particularly in the G2/M checkpoint. 5. **DNA repair**: H2BC7 is involved in the recognition and association of DNA glycosylase with damaged DNA, which is essential for DNA repair. **Clinical Significance** 1. **Immune system disorders**: Abnormalities in H2BC7 expression have been linked to immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 2. **Cancer**: H2BC7 is involved in the regulation of gene expression and DNA replication, which makes it a potential target for cancer therapy. 3. **Neurological disorders**: H2BC7 is involved in the regulation of gene expression and chromatin modifications, which makes it a potential target for the treatment of neurological disorders. 4. **Reproductive disorders**: H2BC7 is involved in the regulation of gene expression and chromatin modifications during the maternal-to-zygotic transition, which makes it a potential target for the treatment of reproductive disorders. In conclusion, H2BC7 is a crucial gene involved in various cellular processes, including DNA replication, chromatin modifications, and gene expression regulation. Its expression is significantly restricted to lymphoid lineage progenitor cells, kidney proximal convoluted tubule epithelial cells, and intestinal epithelial cells, highlighting its potential role in maintaining tissue-specific gene expression. Further research is needed to fully understand the function and clinical significance of H2BC7.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.