H4C6 | ENSG00000274618 | NCBI 8361

Details for: H4C6

Gene ID: 8361

Symbol: H4C6

Ensembl ID: ENSG00000274618

Description: H4 clustered histone 6

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 5.5540
Cell Significance Index: 177.8900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.3805
Cell Significance Index: 59.5100
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.0897
Cell Significance Index: 5.3000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.9042
Cell Significance Index: 11.5800
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.8349
Cell Significance Index: 20.8200
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.7593
Cell Significance Index: 19.9700
Cell Name: germ cell (CL0000586)
Fold Change: 0.6271
Cell Significance Index: 4.7400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5642
Cell Significance Index: 107.3700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5075
Cell Significance Index: 23.0100
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.4696
Cell Significance Index: 2.9100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3578
Cell Significance Index: 35.3900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2929
Cell Significance Index: 264.4300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2722
Cell Significance Index: 29.6100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2705
Cell Significance Index: 31.9000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2371
Cell Significance Index: 38.5700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2332
Cell Significance Index: 15.0500
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.2332
Cell Significance Index: 3.3200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2267
Cell Significance Index: 13.6100
Cell Name: thymocyte (CL0000893)
Fold Change: 0.1622
Cell Significance Index: 2.0500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1376
Cell Significance Index: 9.5200
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.1302
Cell Significance Index: 0.7100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1256
Cell Significance Index: 3.6200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1214
Cell Significance Index: 2.6300
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.1081
Cell Significance Index: 1.3700
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.0716
Cell Significance Index: 1.8300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0695
Cell Significance Index: 1.8600
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.0423
Cell Significance Index: 0.4500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0359
Cell Significance Index: 1.2600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0284
Cell Significance Index: 0.6000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0255
Cell Significance Index: 0.5300
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0093
Cell Significance Index: 0.1300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0085
Cell Significance Index: 0.5200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0056
Cell Significance Index: 0.1200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0031
Cell Significance Index: 1.3800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0007
Cell Significance Index: 0.0100
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0008
Cell Significance Index: -0.0100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0010
Cell Significance Index: -0.5600
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0011
Cell Significance Index: -0.6200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0026
Cell Significance Index: -0.3600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0028
Cell Significance Index: -2.1400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0029
Cell Significance Index: -0.0300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0041
Cell Significance Index: -1.4700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0049
Cell Significance Index: -2.2300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0080
Cell Significance Index: -1.4500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0081
Cell Significance Index: -1.3900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0093
Cell Significance Index: -1.8600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0099
Cell Significance Index: -1.9600
Cell Name: sensory neuron (CL0000101)
Fold Change: -0.0106
Cell Significance Index: -0.0600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0110
Cell Significance Index: -0.7800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0146
Cell Significance Index: -1.8000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0205
Cell Significance Index: -1.1500
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0216
Cell Significance Index: -0.3100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0216
Cell Significance Index: -0.6000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0221
Cell Significance Index: -0.2400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0228
Cell Significance Index: -0.6100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0262
Cell Significance Index: -1.3600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0271
Cell Significance Index: -0.3700
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0320
Cell Significance Index: -0.4600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0328
Cell Significance Index: -1.5300
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0344
Cell Significance Index: -0.3400
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0360
Cell Significance Index: -0.4500
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.0371
Cell Significance Index: -0.2700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0387
Cell Significance Index: -1.8200
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.0400
Cell Significance Index: -0.3900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0412
Cell Significance Index: -0.6900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0422
Cell Significance Index: -1.5500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0432
Cell Significance Index: -1.9100
Cell Name: DN4 thymocyte (CL0000808)
Fold Change: -0.0465
Cell Significance Index: -0.3500
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0482
Cell Significance Index: -0.6900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0489
Cell Significance Index: -1.6000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0494
Cell Significance Index: -1.7300
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0504
Cell Significance Index: -1.2600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0530
Cell Significance Index: -1.8400
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0533
Cell Significance Index: -0.8100
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.0539
Cell Significance Index: -0.5400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0540
Cell Significance Index: -1.7200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0544
Cell Significance Index: -0.7900
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0550
Cell Significance Index: -2.3900
Cell Name: peg cell (CL4033014)
Fold Change: -0.0606
Cell Significance Index: -1.4000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0608
Cell Significance Index: -1.7900
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0610
Cell Significance Index: -0.8600
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0628
Cell Significance Index: -1.6000
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.0644
Cell Significance Index: -0.7700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0644
Cell Significance Index: -1.1900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0660
Cell Significance Index: -1.2900
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0663
Cell Significance Index: -0.7500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0665
Cell Significance Index: -1.8100
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0725
Cell Significance Index: -0.4300
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0726
Cell Significance Index: -0.9500
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: -0.0762
Cell Significance Index: -0.6300
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0808
Cell Significance Index: -0.8800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0815
Cell Significance Index: -0.9300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0837
Cell Significance Index: -2.4000
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0848
Cell Significance Index: -2.1200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0888
Cell Significance Index: -2.1500
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: -0.0890
Cell Significance Index: -0.8400
Cell Name: obsolete somatic cell (CL0002371)
Fold Change: -0.0904
Cell Significance Index: -0.6900
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0912
Cell Significance Index: -1.1800
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0918
Cell Significance Index: -2.0100
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0926
Cell Significance Index: -2.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H4C6 is a histone protein that belongs to the H4 family, which is one of the five main histone families. It is characterized by its ability to form nucleosomes with histone H3, which are the building blocks of chromatin. H4C6 is also known for its involvement in various chromatin-related processes, including DNA repair, transcriptional regulation, and cell cycle control. Its expression is tightly regulated and is often associated with specific cell types and developmental stages. **Pathways and Functions** H4C6 is involved in various cellular pathways, including: 1. **DNA Repair**: H4C6 plays a role in the assembly of nucleosomes at the origin of replication and the repair of DNA double-strand breaks. 2. **Transcriptional Regulation**: H4C6 is involved in the regulation of gene expression through the assembly of nucleosomes and the recruitment of transcriptional machinery. 3. **Cell Cycle Regulation**: H4C6 is involved in the regulation of the cell cycle, particularly in the G2/M phase, where it helps to maintain chromatin structure and facilitate DNA replication. 4. **Epigenetic Regulation**: H4C6 is involved in the regulation of epigenetic marks, such as DNA methylation and histone acetylation, which play a crucial role in gene expression and cellular differentiation. 5. **Immune Response**: H4C6 is expressed in immune cells and plays a role in the regulation of the immune response, particularly in the context of viral infections and inflammation. **Clinical Significance** Dysregulation of H4C6 has been implicated in various diseases, including: 1. **Cancer**: H4C6 is often overexpressed in cancer cells, where it contributes to the deregulation of gene expression and the promotion of tumorigenesis. 2. **Neurodegenerative Diseases**: H4C6 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it contributes to the disruption of chromatin structure and the regulation of gene expression. 3. **Immune Disorders**: H4C6 is involved in the regulation of the immune response, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, H4C6 is a crucial gene that plays a significant role in chromatin structure and function, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which H4C6 regulates cellular processes and to explore its potential as a therapeutic target for the treatment of diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.