Details for: NME5

Gene ID: 8382

Symbol: NME5

Ensembl ID: ENSG00000112981

Description: NME/NM23 family member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 151.1458
    Cell Significance Index: -23.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.7483
    Cell Significance Index: -23.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.1057
    Cell Significance Index: -22.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9743
    Cell Significance Index: -23.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.0406
    Cell Significance Index: 128.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9077
    Cell Significance Index: 382.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7254
    Cell Significance Index: 76.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5974
    Cell Significance Index: 60.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2249
    Cell Significance Index: 439.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9591
    Cell Significance Index: 64.4900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8464
    Cell Significance Index: 13.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8118
    Cell Significance Index: 443.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8016
    Cell Significance Index: 18.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7044
    Cell Significance Index: 20.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4213
    Cell Significance Index: 5.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2778
    Cell Significance Index: 16.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2324
    Cell Significance Index: 209.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2063
    Cell Significance Index: 22.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1850
    Cell Significance Index: 35.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1747
    Cell Significance Index: 28.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1707
    Cell Significance Index: 3.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1409
    Cell Significance Index: 97.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1226
    Cell Significance Index: 9.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1098
    Cell Significance Index: 19.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0819
    Cell Significance Index: 3.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0786
    Cell Significance Index: 147.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0784
    Cell Significance Index: 9.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0481
    Cell Significance Index: 4.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0425
    Cell Significance Index: 0.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0356
    Cell Significance Index: 2.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0340
    Cell Significance Index: 0.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0328
    Cell Significance Index: 6.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0302
    Cell Significance Index: 1.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0267
    Cell Significance Index: 3.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0210
    Cell Significance Index: 13.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0202
    Cell Significance Index: 37.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0179
    Cell Significance Index: 27.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0108
    Cell Significance Index: 1.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0078
    Cell Significance Index: 5.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0036
    Cell Significance Index: -0.2200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0050
    Cell Significance Index: -0.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0201
    Cell Significance Index: -0.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0225
    Cell Significance Index: -10.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0230
    Cell Significance Index: -17.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0266
    Cell Significance Index: -20.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0272
    Cell Significance Index: -12.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0329
    Cell Significance Index: -1.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0337
    Cell Significance Index: -19.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0400
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0412
    Cell Significance Index: -25.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0419
    Cell Significance Index: -4.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0431
    Cell Significance Index: -6.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0483
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0644
    Cell Significance Index: -11.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0649
    Cell Significance Index: -8.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0650
    Cell Significance Index: -1.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0652
    Cell Significance Index: -18.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0795
    Cell Significance Index: -5.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0898
    Cell Significance Index: -2.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0905
    Cell Significance Index: -9.2400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1025
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1033
    Cell Significance Index: -11.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1092
    Cell Significance Index: -2.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1122
    Cell Significance Index: -23.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1204
    Cell Significance Index: -1.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1225
    Cell Significance Index: -2.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1240
    Cell Significance Index: -7.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1284
    Cell Significance Index: -2.2000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1666
    Cell Significance Index: -1.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1889
    Cell Significance Index: -5.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2029
    Cell Significance Index: -16.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2055
    Cell Significance Index: -4.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2077
    Cell Significance Index: -21.6300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2093
    Cell Significance Index: -2.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2166
    Cell Significance Index: -15.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2171
    Cell Significance Index: -25.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2206
    Cell Significance Index: -7.0300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2316
    Cell Significance Index: -4.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2538
    Cell Significance Index: -8.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2646
    Cell Significance Index: -9.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2663
    Cell Significance Index: -8.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2678
    Cell Significance Index: -3.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2704
    Cell Significance Index: -5.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2706
    Cell Significance Index: -6.4900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2825
    Cell Significance Index: -3.9200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2999
    Cell Significance Index: -6.4800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3114
    Cell Significance Index: -3.9300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3289
    Cell Significance Index: -4.6100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3607
    Cell Significance Index: -3.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3611
    Cell Significance Index: -16.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3760
    Cell Significance Index: -9.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3788
    Cell Significance Index: -13.2700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4025
    Cell Significance Index: -6.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4043
    Cell Significance Index: -10.6300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.4137
    Cell Significance Index: -3.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4179
    Cell Significance Index: -21.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4646
    Cell Significance Index: -12.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4876
    Cell Significance Index: -17.9000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4980
    Cell Significance Index: -7.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NME5 is a gene that encodes a protein with nucleoside diphosphate kinase activity, which is essential for the regulation of nucleotide metabolism. The protein shares homology with NDK enzymes, suggesting a conserved mechanism of action. Additionally, NME5 is involved in the negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, indicating its role as a protective mechanism against cellular stress. The gene is also expressed in cells of the tracheobronchial tree, suggesting its involvement in the regulation of epithelial function and fluid movement. **Pathways and Functions** NME5 is involved in several cellular pathways, including: 1. **3'-5' exonuclease activity**: This pathway is involved in the degradation of nucleic acids, and NME5's exonuclease activity may play a role in regulating nucleotide metabolism. 2. **9+2 motile cilium**: NME5 is expressed in ciliated cells of the tracheobronchial tree, suggesting its involvement in the regulation of ciliary movement and fluid movement in the respiratory system. 3. **GTP biosynthetic process**: NME5 may be involved in the regulation of GTP metabolism, which is essential for various cellular processes, including cell signaling and movement. 4. **Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway**: NME5's protective role against cellular stress highlights its importance in maintaining cellular homeostasis. **Clinical Significance** The clinical significance of NME5 is still emerging, but its involvement in various cellular processes suggests its potential role in several diseases. For example: 1. **Respiratory diseases**: NME5's expression in ciliated cells of the tracheobronchial tree suggests its involvement in respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. 2. **Neurological disorders**: NME5's expression in neurons, including GABAergic cortical interneurons and corticothalamic-projecting glutamatergic neurons, suggests its potential role in neurological disorders, such as epilepsy and Alzheimer's disease. 3. **Cancer**: NME5's involvement in the regulation of oxidative stress-induced intrinsic apoptotic signaling pathway may suggest its potential role in cancer prevention and treatment. Overall, further research is needed to fully understand the clinical significance of NME5 and its role in various diseases.

Genular Protein ID: 3652373263

Symbol: NDK5_HUMAN

Name: Nucleoside diphosphate kinase homolog 5

UniProtKB Accession Codes:

P56597 B2R5G7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9742940

Title: A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells.

PubMed ID: 9742940

DOI: 10.1016/s0014-5793(98)00996-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16313181

Title: Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues.

PubMed ID: 16313181

DOI: 10.1021/bi0515974

PubMed ID: 32185794

Title: A nonsense variant in NME5 causes human primary ciliary dyskinesia with radial spoke defects.

PubMed ID: 32185794

DOI: 10.1111/cge.13742

PubMed ID: 32950024

Title: Generation of two hiPSC clones (MHHi019-A, MHHi019-B) from a primary ciliary dyskinesia patient carrying a homozygous deletion in the NME5 gene (c.415delA (p.Ile139Tyrfs*8)).

PubMed ID: 32950024

DOI: 10.1016/j.scr.2020.101988

Sequence Information:

  • Length: 212
  • Mass: 24236
  • Checksum: 9D37CD80338159A1
  • Sequence:
    • MEISMPPPQI YVEKTLAIIK PDIVDKEEEI QDIILRSGFT IVQRRKLRLS PEQCSNFYVE 
KYGKMFFPNL TAYMSSGPLV AMILARHKAI SYWLELLGPN NSLVAKETHP DSLRAIYGTD 
DLRNALHGSN DFAAAEREIR FMFPEVIVEP IPIGQAAKDY LNLHIMPTLL EGLTELCKQK 
PADPLIWLAD WLLKNNPNKP KLCHHPIVEE PY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.