Details for: UXT

Gene ID: 8409

Symbol: UXT

Ensembl ID: ENSG00000126756

Description: ubiquitously expressed prefoldin like chaperone

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 304.0273
    Cell Significance Index: -47.2900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 175.6534
    Cell Significance Index: -72.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 162.0525
    Cell Significance Index: -65.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 145.7460
    Cell Significance Index: -68.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 138.9620
    Cell Significance Index: -71.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 126.9893
    Cell Significance Index: -32.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 102.8431
    Cell Significance Index: -69.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 69.3695
    Cell Significance Index: -66.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.9102
    Cell Significance Index: -62.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.9296
    Cell Significance Index: -55.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.3389
    Cell Significance Index: -68.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.3353
    Cell Significance Index: -43.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3713
    Cell Significance Index: -20.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 6.2622
    Cell Significance Index: 167.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.9419
    Cell Significance Index: 183.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.2626
    Cell Significance Index: 210.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.7528
    Cell Significance Index: 129.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6821
    Cell Significance Index: 346.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.5943
    Cell Significance Index: 155.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.5897
    Cell Significance Index: 59.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5059
    Cell Significance Index: 344.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.4308
    Cell Significance Index: 71.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.3877
    Cell Significance Index: 281.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.3197
    Cell Significance Index: 164.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.2974
    Cell Significance Index: 60.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2763
    Cell Significance Index: 61.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1122
    Cell Significance Index: 259.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0178
    Cell Significance Index: 1101.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9563
    Cell Significance Index: 864.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8890
    Cell Significance Index: 340.5300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7306
    Cell Significance Index: 19.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7298
    Cell Significance Index: 128.9200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.2499
    Cell Significance Index: 13.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1608
    Cell Significance Index: 60.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1386
    Cell Significance Index: 32.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0818
    Cell Significance Index: 16.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0364
    Cell Significance Index: 18.3200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9971
    Cell Significance Index: 12.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8949
    Cell Significance Index: 152.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8792
    Cell Significance Index: 16.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8313
    Cell Significance Index: 750.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8189
    Cell Significance Index: 23.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7279
    Cell Significance Index: 93.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7149
    Cell Significance Index: 70.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6814
    Cell Significance Index: 6.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5738
    Cell Significance Index: 12.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3995
    Cell Significance Index: 18.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3843
    Cell Significance Index: 73.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3293
    Cell Significance Index: 3.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2322
    Cell Significance Index: 6.2000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2092
    Cell Significance Index: 1.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1353
    Cell Significance Index: 102.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1209
    Cell Significance Index: 4.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0347
    Cell Significance Index: 1.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0328
    Cell Significance Index: 24.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0134
    Cell Significance Index: -1.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0219
    Cell Significance Index: -41.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0368
    Cell Significance Index: -67.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0439
    Cell Significance Index: -27.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0439
    Cell Significance Index: -67.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0562
    Cell Significance Index: -76.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0757
    Cell Significance Index: -15.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0765
    Cell Significance Index: -43.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0872
    Cell Significance Index: -31.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0911
    Cell Significance Index: -57.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1336
    Cell Significance Index: -26.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1402
    Cell Significance Index: -63.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1440
    Cell Significance Index: -30.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1917
    Cell Significance Index: -21.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1938
    Cell Significance Index: -4.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2003
    Cell Significance Index: -57.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2755
    Cell Significance Index: -7.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3434
    Cell Significance Index: -40.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4121
    Cell Significance Index: -59.9100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4672
    Cell Significance Index: -2.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4838
    Cell Significance Index: -30.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5000
    Cell Significance Index: -57.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5358
    Cell Significance Index: -11.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5420
    Cell Significance Index: -9.0700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5580
    Cell Significance Index: -9.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5970
    Cell Significance Index: -6.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5979
    Cell Significance Index: -47.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6449
    Cell Significance Index: -67.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6689
    Cell Significance Index: -16.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6960
    Cell Significance Index: -42.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7213
    Cell Significance Index: -37.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7256
    Cell Significance Index: -9.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7526
    Cell Significance Index: -39.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7825
    Cell Significance Index: -60.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7910
    Cell Significance Index: -21.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7975
    Cell Significance Index: -44.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9491
    Cell Significance Index: -58.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9845
    Cell Significance Index: -66.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2066
    Cell Significance Index: -26.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.2936
    Cell Significance Index: -53.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2962
    Cell Significance Index: -38.1800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.3385
    Cell Significance Index: -6.1800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.3440
    Cell Significance Index: -8.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.4149
    Cell Significance Index: -71.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UXT is a prefoldin-like chaperone, which suggests its role in facilitating protein folding and stabilization. Its ubiquitously expressed nature indicates that it is a fundamental component of cellular homeostasis, present in all cell types. UXT's structural similarity to prefoldin, a chaperone involved in protein folding, supports its potential role in protein folding and quality control. **Pathways and Functions:** UXT's involvement in various cellular processes is mediated through multiple pathways and interactions. Notably, its binding to actin filaments, microtubules, and chromatin highlights its role in maintaining cytoskeletal organization and chromatin structure. UXT's interaction with transcriptional regulators, such as E2F6, suggests its involvement in transcriptional regulation, particularly in the context of cell cycle progression. Furthermore, its association with the Rpap3/R2TP/prefoldin-like complex implies a role in protein folding and quality control. **Key Functions:** 1. **Protein Folding and Stabilization:** UXT's prefoldin-like structure and interactions with other chaperones suggest its role in facilitating protein folding and stabilization. 2. **Transcriptional Regulation:** UXT's interaction with E2F6 and other transcriptional regulators indicates its involvement in regulating gene expression, particularly in the context of cell cycle progression. 3. **Cytoskeletal Organization:** UXT's binding to actin filaments and microtubules highlights its role in maintaining cytoskeletal organization and structure. 4. **Mitochondrial Transport:** UXT's association with the Rpap3/R2TP/prefoldin-like complex suggests its role in transporting mitochondria along microtubules. **Clinical Significance:** The identification of UXT as a multifaceted regulator of cellular processes has significant implications for our understanding of various diseases. Its involvement in protein folding, transcriptional regulation, and cytoskeletal organization makes it a potential target for therapeutic interventions in diseases characterized by aberrant protein folding, such as neurodegenerative disorders. Additionally, UXT's expression in malignant cells highlights its potential role in cancer progression and metastasis. Further studies are needed to elucidate the specific mechanisms by which UXT contributes to disease pathology and to explore its potential as a therapeutic target. In conclusion, UXT is a multifaceted regulator of cellular processes, with a wide range of functions that impact protein folding, transcriptional regulation, and cytoskeletal organization. Its ubiquitously expressed nature and involvement in various cellular processes make it a critical component of cellular homeostasis. Further studies are needed to fully elucidate the mechanisms by which UXT regulates cellular processes and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 4273698242

Symbol: UXT_HUMAN

Name: Protein UXT

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10087202

Title: Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue.

PubMed ID: 10087202

DOI: 10.1006/geno.1998.5712

PubMed ID: 11854421

Title: Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus.

PubMed ID: 11854421

DOI: 10.1091/mbc.01-10-0513

PubMed ID: 17635584

Title: UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation.

PubMed ID: 17635584

DOI: 10.1111/j.1742-4658.2007.05928.x

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 21307340

Title: UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.

PubMed ID: 21307340

DOI: 10.1091/mbc.e10-10-0827

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11827465

Title: Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity.

PubMed ID: 11827465

DOI: 10.1006/geno.2001.6679

PubMed ID: 16221885

Title: UXT is a novel centrosomal protein essential for cell viability.

PubMed ID: 16221885

DOI: 10.1091/mbc.e05-08-0705

PubMed ID: 17554592

Title: UXT (Ubiquitously Expressed Transcript) causes mitochondrial aggregation.

PubMed ID: 17554592

DOI: 10.1007/s11626-007-9016-6

PubMed ID: 17620405

Title: UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome.

PubMed ID: 17620405

DOI: 10.1083/jcb.200611081

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21730289

Title: Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP.

PubMed ID: 21730289

DOI: 10.1128/mcb.05429-11

PubMed ID: 28106301

Title: UXT is a LOX-PP interacting protein that modulates estrogen receptor alpha activity in breast cancer Cells.

PubMed ID: 28106301

DOI: 10.1002/jcb.25893

PubMed ID: 31738558

Title: Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.

PubMed ID: 31738558

DOI: 10.1021/acs.jproteome.9b00599

PubMed ID: 33010352

Title: The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-kappaB signaling pathway.

PubMed ID: 33010352

DOI: 10.1016/j.bbagen.2020.129754

Sequence Information:

  • Length: 157
  • Mass: 18246
  • Checksum: 94CE14C462DEE308
  • Sequence:
  • MATPPKRRAV EATGEKVLRY ETFISDVLQR DLRKVLDHRD KVYEQLAKYL QLRNVIERLQ 
    EAKHSELYMQ VDLGCNFFVD TVVPDTSRIY VALGYGFFLE LTLAEALKFI DRKSSLLTEL 
    SNSLTKDSMN IKAHIHMLLE GLRELQGLQN FPEKPHH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.