Details for: CUL4A

Gene ID: 8451

Symbol: CUL4A

Ensembl ID: ENSG00000139842

Description: cullin 4A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 230.1581
    Cell Significance Index: -35.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 165.5474
    Cell Significance Index: -41.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 110.4267
    Cell Significance Index: -45.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 96.3521
    Cell Significance Index: -45.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.0322
    Cell Significance Index: -37.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 83.7116
    Cell Significance Index: -43.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.1051
    Cell Significance Index: -45.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.1365
    Cell Significance Index: -38.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.4099
    Cell Significance Index: -39.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.5962
    Cell Significance Index: -41.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1962
    Cell Significance Index: -37.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.6011
    Cell Significance Index: -25.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.3227
    Cell Significance Index: -44.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.2432
    Cell Significance Index: 62.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.0478
    Cell Significance Index: 27.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9660
    Cell Significance Index: 390.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8724
    Cell Significance Index: 218.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.7623
    Cell Significance Index: 45.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6983
    Cell Significance Index: 130.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6895
    Cell Significance Index: 338.9200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 1.5712
    Cell Significance Index: 19.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4183
    Cell Significance Index: 37.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1250
    Cell Significance Index: 122.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0965
    Cell Significance Index: 178.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0411
    Cell Significance Index: 62.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9315
    Cell Significance Index: 334.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8493
    Cell Significance Index: 47.6600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.8205
    Cell Significance Index: 20.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7460
    Cell Significance Index: 14.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6184
    Cell Significance Index: 558.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5758
    Cell Significance Index: 398.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5124
    Cell Significance Index: 35.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5031
    Cell Significance Index: 14.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4757
    Cell Significance Index: 24.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4630
    Cell Significance Index: 56.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4519
    Cell Significance Index: 9.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4376
    Cell Significance Index: 20.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4099
    Cell Significance Index: 6.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4086
    Cell Significance Index: 73.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3675
    Cell Significance Index: 17.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3670
    Cell Significance Index: 9.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3402
    Cell Significance Index: 185.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3275
    Cell Significance Index: 8.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2652
    Cell Significance Index: 117.2500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2535
    Cell Significance Index: 2.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2494
    Cell Significance Index: 42.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2232
    Cell Significance Index: 30.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2022
    Cell Significance Index: 23.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1708
    Cell Significance Index: 8.8700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1682
    Cell Significance Index: 3.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1468
    Cell Significance Index: 14.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1389
    Cell Significance Index: 88.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1377
    Cell Significance Index: 259.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1371
    Cell Significance Index: 10.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1284
    Cell Significance Index: 1.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1250
    Cell Significance Index: 8.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1165
    Cell Significance Index: 7.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1163
    Cell Significance Index: 15.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0834
    Cell Significance Index: 37.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0783
    Cell Significance Index: 120.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0656
    Cell Significance Index: 120.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0381
    Cell Significance Index: 51.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0303
    Cell Significance Index: 1.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0039
    Cell Significance Index: 0.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0006
    Cell Significance Index: -0.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0058
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0148
    Cell Significance Index: -9.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0169
    Cell Significance Index: -2.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0193
    Cell Significance Index: -0.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0313
    Cell Significance Index: -22.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0356
    Cell Significance Index: -26.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0462
    Cell Significance Index: -26.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0695
    Cell Significance Index: -0.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0785
    Cell Significance Index: -3.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0960
    Cell Significance Index: -9.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1040
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1255
    Cell Significance Index: -26.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1321
    Cell Significance Index: -38.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1431
    Cell Significance Index: -20.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1483
    Cell Significance Index: -5.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1742
    Cell Significance Index: -12.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1957
    Cell Significance Index: -22.4200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2197
    Cell Significance Index: -3.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2624
    Cell Significance Index: -16.5400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3052
    Cell Significance Index: -4.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3235
    Cell Significance Index: -9.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3303
    Cell Significance Index: -34.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3902
    Cell Significance Index: -44.5400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.4016
    Cell Significance Index: -6.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4128
    Cell Significance Index: -13.2200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4329
    Cell Significance Index: -3.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4336
    Cell Significance Index: -10.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4341
    Cell Significance Index: -9.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4457
    Cell Significance Index: -7.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4687
    Cell Significance Index: -37.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4712
    Cell Significance Index: -16.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4736
    Cell Significance Index: -6.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4752
    Cell Significance Index: -12.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4864
    Cell Significance Index: -12.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** * CUL4A is a member of the cullin family of proteins, which are essential components of the SCF ubiquitin ligase complex. * The CUL4A protein is a scaffold for the assembly of the FBX7-SCF complex, which is responsible for the ubiquitination and degradation of target proteins. * CUL4A is highly expressed in multiple cell types, including cardiac myocytes, fibroblasts, epithelial cells, and germ cells. * The CUL4A protein has been shown to interact with various proteins, including FBX7, Skp1, and p53, which are involved in cell cycle regulation, DNA damage response, and protein degradation. **Pathways and Functions** * **Cell Cycle Regulation**: CUL4A plays a crucial role in the regulation of the cell cycle, particularly in the G1/S transition. The CUL4A-FBX7 complex ubiquitinates and degrades key cell cycle regulators, such as p27 and p21, to promote cell cycle progression. * **DNA Damage Response**: CUL4A is involved in the recognition and response to DNA damage. The CUL4A-FBX7 complex interacts with the PCNA-containing replication complex to recognize and bind to damaged DNA, leading to the activation of DNA repair pathways. * **Protein Degradation**: CUL4A is involved in the ubiquitination and degradation of target proteins, including cell cycle regulators, transcription factors, and oncogenes. The CUL4A-FBX7 complex ubiquitinates and degrades these proteins, leading to the regulation of cellular processes. * **Nucleotide Excision Repair (NER)**: CUL4A is involved in the regulation of NER, a DNA repair pathway that repairs damage to the genome. The CUL4A-FBX7 complex interacts with the NER complex to regulate the activity of NER enzymes. **Clinical Significance** * **Cancer**: CUL4A has been implicated in various cancers, including breast, lung, and colon cancer. Overexpression of CUL4A has been associated with tumor progression and poor prognosis. * **Neurodegenerative Diseases**: CUL4A has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Mutations in the CUL4A gene have been associated with an increased risk of developing these diseases. * **Cardiovascular Disease**: CUL4A has been implicated in cardiovascular disease, including heart failure and atherosclerosis. Overexpression of CUL4A has been associated with cardiac remodeling and increased risk of cardiovascular disease. * **Reproductive Health**: CUL4A has been implicated in reproductive health, including spermatogenesis and embryonic development. Mutations in the CUL4A gene have been associated with infertility and reproductive abnormalities. In conclusion, the CUL4A gene plays a crucial role in various cellular processes, including cell cycle regulation, DNA damage response, and protein degradation. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, cardiovascular disease, and reproductive health. Further research is needed to fully understand the role of CUL4A in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 3010890653

Symbol: CUL4A_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13619 A2A2W2 O75834 Q589T6 Q5TC62 Q6UP08 Q9UP17

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 20 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9721878

Title: The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers.

PubMed ID: 9721878

PubMed ID: 14578910

Title: Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.

PubMed ID: 14578910

DOI: 10.1038/ncb1061

PubMed ID: 15811626

Title: DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.

PubMed ID: 15811626

DOI: 10.1016/j.dnarep.2004.12.012

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9694792

Title: A new NEDD8-ligating system for cullin-4A.

PubMed ID: 9694792

DOI: 10.1101/gad.12.15.2263

PubMed ID: 8681378

Title: cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.

PubMed ID: 8681378

DOI: 10.1016/s0092-8674(00)81267-2

PubMed ID: 10597293

Title: Covalent modification of all members of human cullin family proteins by NEDD8.

PubMed ID: 10597293

DOI: 10.1038/sj.onc.1203093

PubMed ID: 10230407

Title: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.

PubMed ID: 10230407

DOI: 10.1016/s1097-2765(00)80482-7

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 14609952

Title: CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein.

PubMed ID: 14609952

DOI: 10.1093/emboj/cdg577

PubMed ID: 12609982

Title: TIP120A associates with cullins and modulates ubiquitin ligase activity.

PubMed ID: 12609982

DOI: 10.1074/jbc.m213070200

PubMed ID: 15548678

Title: Cul4A physically associates with MDM2 and participates in the proteolysis of p53.

PubMed ID: 15548678

DOI: 10.1158/0008-5472.can-04-2598

PubMed ID: 15448697

Title: Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.

PubMed ID: 15448697

DOI: 10.1038/ncb1172

PubMed ID: 14739464

Title: Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.

PubMed ID: 14739464

DOI: 10.1126/science.1093549

PubMed ID: 16482215

Title: Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

PubMed ID: 16482215

DOI: 10.1038/sj.emboj.7601002

PubMed ID: 17079684

Title: DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.

PubMed ID: 17079684

DOI: 10.1101/gad.1483206

PubMed ID: 16678110

Title: Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.

PubMed ID: 16678110

DOI: 10.1016/j.molcel.2006.03.035

PubMed ID: 16949367

Title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

PubMed ID: 16949367

DOI: 10.1016/j.molcel.2006.08.010

PubMed ID: 16537899

Title: Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome.

PubMed ID: 16537899

DOI: 10.1128/mcb.26.7.2531-2539.2006

PubMed ID: 17041588

Title: CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

PubMed ID: 17041588

DOI: 10.1038/ncb1490

PubMed ID: 17254749

Title: Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells -- evidence for cullin dimerization.

PubMed ID: 17254749

DOI: 10.1016/j.cellsig.2006.12.002

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20190741

Title: A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases.

PubMed ID: 20190741

DOI: 10.1038/ncb2035

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22935713

Title: Orc2 protects ORCA from ubiquitin-mediated degradation.

PubMed ID: 22935713

DOI: 10.4161/cc.21870

PubMed ID: 24209620

Title: A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.

PubMed ID: 24209620

DOI: 10.1016/j.cell.2013.10.014

PubMed ID: 24076655

Title: TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.

PubMed ID: 24076655

DOI: 10.1038/emboj.2013.209

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23478445

Title: CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.

PubMed ID: 23478445

DOI: 10.1016/j.molcel.2013.02.003

PubMed ID: 23201271

Title: Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.

PubMed ID: 23201271

DOI: 10.1016/j.str.2012.10.013

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26711351

Title: Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.

PubMed ID: 26711351

DOI: 10.1016/j.celrep.2015.11.061

PubMed ID: 26431207

Title: CUL4-DDB1-CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1.

PubMed ID: 26431207

DOI: 10.1371/journal.pone.0139725

PubMed ID: 26906416

Title: Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.

PubMed ID: 26906416

DOI: 10.1242/jcs.181784

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29779948

Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.

PubMed ID: 29779948

DOI: 10.1016/j.cell.2018.04.028

PubMed ID: 30166453

Title: CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.

PubMed ID: 30166453

DOI: 10.15252/embj.201797508

PubMed ID: 33854232

Title: AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.

PubMed ID: 33854232

DOI: 10.1038/s41586-021-03422-5

PubMed ID: 33854239

Title: The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.

PubMed ID: 33854239

DOI: 10.1038/s41586-021-03474-7

PubMed ID: 16964240

Title: Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

PubMed ID: 16964240

DOI: 10.1038/nature05175

PubMed ID: 22118460

Title: The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

PubMed ID: 22118460

DOI: 10.1016/j.cell.2011.10.035

Sequence Information:

  • Length: 759
  • Mass: 87680
  • Checksum: 3C4C6A1BBD94D51B
  • Sequence:
    • MADEAPRKGS FSALVGRTNG LTKPAALAAA PAKPGGAGGS KKLVIKNFRD RPRLPDNYTQ 
DTWRKLHEAV RAVQSSTSIR YNLEELYQAV ENLCSHKVSP MLYKQLRQAC EDHVQAQILP 
FREDSLDSVL FLKKINTCWQ DHCRQMIMIR SIFLFLDRTY VLQNSTLPSI WDMGLELFRT 
HIISDKMVQS KTIDGILLLI ERERSGEAVD RSLLRSLLGM LSDLQVYKDS FELKFLEETN 
CLYAAEGQRL MQEREVPEYL NHVSKRLEEE GDRVITYLDH STQKPLIACV EKQLLGEHLT 
AILQKGLDHL LDENRVPDLA QMYQLFSRVR GGQQALLQHW SEYIKTFGTA IVINPEKDKD 
MVQDLLDFKD KVDHVIEVCF QKNERFVNLM KESFETFINK RPNKPAELIA KHVDSKLRAG 
NKEATDEELE RTLDKIMILF RFIHGKDVFE AFYKKDLAKR LLVGKSASVD AEKSMLSKLK 
HECGAAFTSK LEGMFKDMEL SKDIMVHFKQ HMQNQSDSGP IDLTVNILTM GYWPTYTPME 
VHLTPEMIKL QEVFKAFYLG KHSGRKLQWQ TTLGHAVLKA EFKEGKKEFQ VSLFQTLVLL 
MFNEGDGFSF EEIKMATGIE DSELRRTLQS LACGKARVLI KSPKGKEVED GDKFIFNGEF 
KHKLFRIKIN QIQMKETVEE QVSTTERVFQ DRQYQIDAAI VRIMKMRKTL GHNLLVSELY 
NQLKFPVKPG DLKKRIESLI DRDYMERDKD NPNQYHYVA

Genular Protein ID: 683906486

Symbol: A0A0A0MR50_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MR50

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 9 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 3 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 667
  • Mass: 77720
  • Checksum: D9AD4FBD07BDB39E
  • Sequence:
    • MLYKQLRQAC EDHVQAQILP FREDSLDSVL FLKKINTCWQ DHCRQMIMIR SIFLFLDRTY 
VLQNSTLPSI CPVSYCLYRD MGLELFRTHI ISDKMVQSKT IDGILLLIER ERSGEAVDRS 
LLRSLLGMLS DLQVYKDSFE LKFLEETNCL YAAEGQRLMQ EREVPEYLNH VSKRLEEEGD 
RVITYLDHST QKPLIACVEK QLLGEHLTAI LQKGLDHLLD ENRVPDLAQM YQLFSRVRGG 
QQALLQHWSE YIKTFGTAIV INPEKDKDMV QDLLDFKDKV DHVIEVCFQK NERFVNLMKE 
SFETFINKRP NKPAELIAKH VDSKLRAGNK EATDEELERT LDKIMILFRF IHGKDVFEAF 
YKKDLAKRLL VGKSASVDAE KSMLSKLKHE CGAAFTSKLE GMFKDMELSK DIMVHFKQHM 
QNQSDSGPID LTVNILTMGY WPTYTPMEVH LTPEMIKLQE VFKAFYLGKH SGRKLQWQTT 
LGHAVLKAEF KEGKKEFQVS LFQTLVLLMF NEGDGFSFEE IKMATGIEDS ELRRTLQSLA 
CGKARVLIKS PKGKEVEDGD KFIFNGEFKH KLFRIKINQI QMKETVEEQV STTERVFQDR 
QYQIDAAIVR IMKMRKTLGH NLLVSELYNQ LKFPVKPGDL KKRIESLIDR DYMERDKDNP 
NQYHYVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.