Details for: GPR65

Gene ID: 8477

Symbol: GPR65

Ensembl ID: ENSG00000140030

Description: G protein-coupled receptor 65

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.1492
    Cell Significance Index: -14.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.9016
    Cell Significance Index: -14.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.3869
    Cell Significance Index: -17.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.0600
    Cell Significance Index: -19.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.0280
    Cell Significance Index: -14.8300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 6.9656
    Cell Significance Index: 18.6600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.8824
    Cell Significance Index: 91.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.3720
    Cell Significance Index: -16.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.0942
    Cell Significance Index: 102.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8215
    Cell Significance Index: -15.0800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 3.1346
    Cell Significance Index: 42.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0573
    Cell Significance Index: -8.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7708
    Cell Significance Index: 88.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9361
    Cell Significance Index: 41.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2176
    Cell Significance Index: 35.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1866
    Cell Significance Index: 17.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0490
    Cell Significance Index: 199.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8587
    Cell Significance Index: 84.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7975
    Cell Significance Index: 14.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6696
    Cell Significance Index: 604.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4255
    Cell Significance Index: 69.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2831
    Cell Significance Index: 30.7900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.2185
    Cell Significance Index: 2.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1842
    Cell Significance Index: 21.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1614
    Cell Significance Index: 10.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1019
    Cell Significance Index: 2.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0965
    Cell Significance Index: 2.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0646
    Cell Significance Index: 4.4700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0529
    Cell Significance Index: 0.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0348
    Cell Significance Index: 24.0500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0145
    Cell Significance Index: 0.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0079
    Cell Significance Index: -14.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0094
    Cell Significance Index: -0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0097
    Cell Significance Index: -17.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0115
    Cell Significance Index: -17.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0198
    Cell Significance Index: -0.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0252
    Cell Significance Index: -18.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0254
    Cell Significance Index: -18.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0282
    Cell Significance Index: -15.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0286
    Cell Significance Index: -18.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0336
    Cell Significance Index: -18.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0353
    Cell Significance Index: -1.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0365
    Cell Significance Index: -1.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0389
    Cell Significance Index: -17.6600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0415
    Cell Significance Index: -1.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0450
    Cell Significance Index: -16.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0484
    Cell Significance Index: -2.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0486
    Cell Significance Index: -13.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0678
    Cell Significance Index: -2.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0701
    Cell Significance Index: -4.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0706
    Cell Significance Index: -14.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0753
    Cell Significance Index: -15.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0777
    Cell Significance Index: -7.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0900
    Cell Significance Index: -16.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0902
    Cell Significance Index: -18.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1009
    Cell Significance Index: -17.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1027
    Cell Significance Index: -2.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1065
    Cell Significance Index: -14.6300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1105
    Cell Significance Index: -0.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1248
    Cell Significance Index: -18.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1293
    Cell Significance Index: -16.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1311
    Cell Significance Index: -16.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1371
    Cell Significance Index: -15.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1411
    Cell Significance Index: -18.2300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1419
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1563
    Cell Significance Index: -17.9100
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1570
    Cell Significance Index: -1.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1589
    Cell Significance Index: -4.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1704
    Cell Significance Index: -8.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2123
    Cell Significance Index: -16.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2168
    Cell Significance Index: -3.2700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2291
    Cell Significance Index: -3.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2473
    Cell Significance Index: -18.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2551
    Cell Significance Index: -17.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2863
    Cell Significance Index: -8.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2864
    Cell Significance Index: -14.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2867
    Cell Significance Index: -17.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3022
    Cell Significance Index: -15.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3067
    Cell Significance Index: -17.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3167
    Cell Significance Index: -19.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3285
    Cell Significance Index: -5.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3400
    Cell Significance Index: -8.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3687
    Cell Significance Index: -16.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3753
    Cell Significance Index: -17.5000
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.3847
    Cell Significance Index: -0.9800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4047
    Cell Significance Index: -5.6800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.4158
    Cell Significance Index: -4.9000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.4255
    Cell Significance Index: -2.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4297
    Cell Significance Index: -16.2700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.4369
    Cell Significance Index: -3.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4422
    Cell Significance Index: -15.4900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4611
    Cell Significance Index: -3.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4626
    Cell Significance Index: -16.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4922
    Cell Significance Index: -16.1200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4924
    Cell Significance Index: -4.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5109
    Cell Significance Index: -16.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5186
    Cell Significance Index: -10.1400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5713
    Cell Significance Index: -18.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR65 is a member of the class A/1 rhodopsin-like receptors, characterized by its ability to activate Gαq signaling events. Its expression is widespread, with significant presence in various immune cells, including natural killer (NK) cells, basophils, T cells, and myeloid leukocytes. The receptor is also expressed on enterocytes in the large intestine and on mucosal invariant T cells. Notably, GPR65 is activated by psychosine, a purine nucleoside that has been shown to have immunomodulatory effects. **Pathways and Functions:** GPR65 is involved in several signaling pathways, including the activation of GTPase activity, adenylate cyclase-activating GPCR signaling pathway, and apoptotic process. The receptor's activation leads to the stimulation of various downstream signaling pathways, including the positive regulation of Rho protein signal transduction and stress fiber assembly. Additionally, GPR65 plays a role in responding to acidic pH and has been implicated in the regulation of immune responses, including the activation of immune cells and the production of cytokines. **Clinical Significance:** GPR65 has been implicated in various diseases, including autoimmune disorders and cancer. Its involvement in immune responses makes it a potential target for the development of immunotherapies. For instance, GPR65 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential role as a tumor suppressor. Furthermore, the receptor's involvement in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, highlights its potential as a therapeutic target for the treatment of these conditions. In conclusion, GPR65 is a complex GPCR that plays a crucial role in various physiological and pathological processes. Its involvement in immune responses and its potential as a therapeutic target make it an area of significant research interest. Further studies are needed to fully elucidate the mechanisms by which GPR65 regulates immune responses and to explore its potential as a therapeutic agent. **Future Directions:** To further elucidate the function and significance of GPR65, future studies should focus on the following areas: 1. Elucidating the mechanisms by which GPR65 regulates immune responses, including its interaction with other immune cells and the production of cytokines. 2. Investigating the role of GPR65 in various diseases, including autoimmune disorders and cancer. 3. Developing therapeutic strategies that target GPR65, including the development of small molecule inhibitors and monoclonal antibodies. 4. Exploring the potential of GPR65 as a biomarker for disease diagnosis and prognosis. By advancing our understanding of GPR65, we can unlock new avenues for the treatment of various diseases and improve human health.

Genular Protein ID: 616454139

Symbol: PSYR_HUMAN

Name: Psychosine receptor

UniProtKB Accession Codes:

Q8IYL9 O75819

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9655242

Title: Cloning, characterization, and mapping of human homolog of mouse T-cell death-associated gene.

PubMed ID: 9655242

DOI: 10.1089/dna.1998.17.493

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11309421

Title: Identification of a molecular target of psychosine and its role in globoid cell formation.

PubMed ID: 11309421

DOI: 10.1083/jcb.153.2.429

PubMed ID: 27287411

Title: Genetic coding variant in GPR65 alters lysosomal pH and links lysosomal dysfunction with colitis risk.

PubMed ID: 27287411

DOI: 10.1016/j.immuni.2016.05.007

Sequence Information:

  • Length: 337
  • Mass: 39333
  • Checksum: CFDBF217291C0FA2
  • Sequence:
    • MNSTCIEEQH DLDHYLFPIV YIFVIIVSIP ANIGSLCVSF LQAKKESELG IYLFSLSLSD 
LLYALTLPLW IDYTWNKDNW TFSPALCKGS AFLMYMNFYS STAFLTCIAV DRYLAVVYPL 
KFFFLRTRRF ALMVSLSIWI LETIFNAVML WEDETVVEYC DAEKSNFTLC YDKYPLEKWQ 
INLNLFRTCT GYAIPLVTIL ICNRKVYQAV RHNKATENKE KKRIIKLLVS ITVTFVLCFT 
PFHVMLLIRC ILEHAVNFED HSNSGKRTYT MYRITVALTS LNCVADPILY CFVTETGRYD 
MWNILKFCTG RCNTSQRQRK RILSVSTKDT MELEVLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.