Details for: HIRIP3

Gene ID: 8479

Symbol: HIRIP3

Ensembl ID: ENSG00000149929

Description: HIRA interacting protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 73.8692
    Cell Significance Index: -11.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.4913
    Cell Significance Index: -14.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.7367
    Cell Significance Index: -16.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.8579
    Cell Significance Index: -13.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.4960
    Cell Significance Index: -13.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.4392
    Cell Significance Index: -16.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4310
    Cell Significance Index: -11.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3563
    Cell Significance Index: -17.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.3860
    Cell Significance Index: -10.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3463
    Cell Significance Index: 84.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0134
    Cell Significance Index: 100.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9260
    Cell Significance Index: 55.5900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8122
    Cell Significance Index: 6.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7742
    Cell Significance Index: 84.2100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7573
    Cell Significance Index: 12.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6801
    Cell Significance Index: 35.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6480
    Cell Significance Index: 585.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6086
    Cell Significance Index: 98.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5902
    Cell Significance Index: 68.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4881
    Cell Significance Index: 6.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4558
    Cell Significance Index: 15.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3763
    Cell Significance Index: 26.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3617
    Cell Significance Index: 42.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3204
    Cell Significance Index: 8.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3150
    Cell Significance Index: 14.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2608
    Cell Significance Index: 7.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2414
    Cell Significance Index: 6.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2379
    Cell Significance Index: 32.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2350
    Cell Significance Index: 10.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2292
    Cell Significance Index: 101.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2175
    Cell Significance Index: 11.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2079
    Cell Significance Index: 2.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2073
    Cell Significance Index: 25.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1961
    Cell Significance Index: 12.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1891
    Cell Significance Index: 24.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1560
    Cell Significance Index: 3.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1543
    Cell Significance Index: 27.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1505
    Cell Significance Index: 3.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1449
    Cell Significance Index: 4.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1398
    Cell Significance Index: 2.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1284
    Cell Significance Index: 9.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1150
    Cell Significance Index: 62.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0723
    Cell Significance Index: 14.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0716
    Cell Significance Index: 3.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0700
    Cell Significance Index: 13.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0475
    Cell Significance Index: 1.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0426
    Cell Significance Index: 15.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0340
    Cell Significance Index: 6.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0334
    Cell Significance Index: 0.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0155
    Cell Significance Index: 0.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0112
    Cell Significance Index: 7.7700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0011
    Cell Significance Index: 0.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0002
    Cell Significance Index: 0.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0034
    Cell Significance Index: -0.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0070
    Cell Significance Index: -13.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0092
    Cell Significance Index: -0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0095
    Cell Significance Index: -17.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0115
    Cell Significance Index: -17.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0124
    Cell Significance Index: -16.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0153
    Cell Significance Index: -1.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0161
    Cell Significance Index: -1.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0189
    Cell Significance Index: -14.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0194
    Cell Significance Index: -12.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0209
    Cell Significance Index: -6.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0236
    Cell Significance Index: -13.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0260
    Cell Significance Index: -0.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0296
    Cell Significance Index: -13.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0298
    Cell Significance Index: -18.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0334
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0446
    Cell Significance Index: -7.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0462
    Cell Significance Index: -5.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0568
    Cell Significance Index: -1.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0622
    Cell Significance Index: -1.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0630
    Cell Significance Index: -3.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0809
    Cell Significance Index: -3.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0849
    Cell Significance Index: -12.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0863
    Cell Significance Index: -18.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1226
    Cell Significance Index: -3.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1230
    Cell Significance Index: -3.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1417
    Cell Significance Index: -7.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1485
    Cell Significance Index: -11.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1503
    Cell Significance Index: -4.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1529
    Cell Significance Index: -12.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1670
    Cell Significance Index: -17.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1812
    Cell Significance Index: -11.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2110
    Cell Significance Index: -14.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2364
    Cell Significance Index: -6.3400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2470
    Cell Significance Index: -1.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2530
    Cell Significance Index: -7.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3104
    Cell Significance Index: -5.3200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3113
    Cell Significance Index: -2.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3256
    Cell Significance Index: -14.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3261
    Cell Significance Index: -7.1400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3271
    Cell Significance Index: -5.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3669
    Cell Significance Index: -9.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3792
    Cell Significance Index: -13.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3841
    Cell Significance Index: -11.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3842
    Cell Significance Index: -14.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HIRIP3 is a non-coding RNA gene that belongs to the HIRA family of genes, which are known for their involvement in chromatin organization and nucleolar development. The gene is specifically expressed in germ cells, extravillous trophoblasts, neural progenitor cells, oogonial cells, proerythroblasts, large pre-B-II cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and migratory enteric neural crest cells. This widespread expression suggests that HIRIP3 plays a crucial role in the development and maintenance of various cell types. **Pathways and Functions:** HIRIP3 is implicated in several key cellular pathways, including chromatin organization, nucleolus formation, and protein binding. The gene's involvement in chromatin organization is mediated through its interaction with HIRA proteins, which are essential for the formation and maintenance of nucleosomes. HIRIP3's role in nucleolus formation is also noteworthy, as it is involved in the regulation of ribosome biogenesis and nucleolar development. Additionally, HIRIP3's protein-binding capabilities suggest that it may play a role in regulating the activity of various proteins involved in cellular processes. One of the most significant functions of HIRIP3 is its involvement in the regulation of gene expression. Studies have shown that HIRIP3 can act as a microRNA (miRNA) sponge, binding to and regulating the expression of various mRNAs involved in cellular processes. This suggests that HIRIP3 may play a crucial role in the regulation of gene expression and the modulation of cellular responses to environmental stimuli. **Clinical Significance:** While the exact clinical significance of HIRIP3 is still unclear, its involvement in various cellular processes and pathways suggests that dysregulation of the gene may contribute to the development of various diseases. For example, alterations in chromatin organization and nucleolus formation have been implicated in the development of various cancers, including leukemia and lymphoma. Furthermore, HIRIP3's role in regulating gene expression and protein binding suggests that it may play a role in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's. Additionally, the gene's involvement in the regulation of ribosome biogenesis and nucleolar development may also contribute to its clinical significance in the context of hematological disorders, such as anemia and leukemia. In conclusion, HIRIP3 is a gene with a complex and multifaceted role in various cellular processes, including chromatin organization, nucleolus formation, and protein binding. While the exact clinical significance of the gene is still unclear, its involvement in various pathways and its potential role in the development of various diseases suggest that further research is warranted to fully elucidate its function and significance in human health and disease.

Genular Protein ID: 671088468

Symbol: HIRP3_HUMAN

Name: HIRA-interacting protein 3

UniProtKB Accession Codes:

Q9BW71 H3BSR3 O75707 O75708

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 6 Ensembl 2 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9710638

Title: Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA.

PubMed ID: 9710638

DOI: 10.1128/mcb.18.9.5546

PubMed ID: 17391060

Title: HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2.

PubMed ID: 17391060

DOI: 10.1515/bc.2007.045

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 38334665

Title: Identification and Characterization of HIRIP3 as a Histone H2A Chaperone.

PubMed ID: 38334665

DOI: 10.3390/cells13030273

Sequence Information:

  • Length: 556
  • Mass: 61957
  • Checksum: ACABE2E0032B8C13
  • Sequence:
    • MAREKEMQEF TRSFFRGRPD LSTLTHSIVR RRYLAHSGRS HLEPEEKQAL KRLVEEELLK 
MQVDEAASRE DKLDLTKKGK RPPTPCSDPE RKRFRFNSES ESGSEASSPD YFGPPAKNGV 
AAEVSPAKEE NPRRASKAVE ESSDEERQRD LPAQRGEESS EEEEKGYKGK TRKKPVVKKQ 
APGKASVSRK QAREESEESE AEPVQRTAKK VEGNKGTKSL KESEQESEEE ILAQKKEQRE 
EEVEEEEKEE DEEKGDWKPR TRSNGRRKSA REERSCKQKS QAKRLLGDSD SEEEQKEAAS 
SGDDSGRDRE PPVQRKSEDR TQLKGGKRLS GSSEDEEDSG KGEPTAKGSR KMARLGSTSG 
EESDLEREVS DSEAGGGPQG ERKNRSSKKS SRKGRTRSSS SSSDGSPEAK GGKAGSGRRG 
EDHPAVMRLK RYIRACGAHR NYKKLLGSCC SHKERLSILR AELEALGMKG TPSLGKCRAL 
KEQREEAAEV ASLDVANIIS GSGRPRRRTA WNPLGEAAPP GELYRRTLDS DEERPRPAPP 
DWSHMRGIIS SDGESN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.