RAE1 | ENSG00000101146 | NCBI 8480

Details for: RAE1

Gene ID: 8480

Symbol: RAE1

Ensembl ID: ENSG00000101146

Description: ribonucleic acid export 1

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective tpr may confer susceptibility towards thyroid papillary carcinoma (tpc)
(R-HSA-5619107)
Disease
(R-HSA-1643685)
Disorders of transmembrane transporters
(R-HSA-5619115)
Export of viral ribonucleoproteins from nucleus
(R-HSA-168274)
Gene expression (transcription)
(R-HSA-74160)
Gene silencing by rna
(R-HSA-211000)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Interactions of rev with host cellular proteins
(R-HSA-177243)
Interactions of vpr with host cellular proteins
(R-HSA-176033)
Interferon signaling
(R-HSA-913531)
Isg15 antiviral mechanism
(R-HSA-1169408)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of non-coding rna
(R-HSA-194441)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Nep/ns2 interacts with the cellular export machinery
(R-HSA-168333)
Ns1 mediated effects on host pathways
(R-HSA-168276)
Nuclear envelope breakdown
(R-HSA-2980766)
Nuclear import of rev protein
(R-HSA-180746)
Nuclear pore complex (npc) disassembly
(R-HSA-3301854)
Post-translational protein modification
(R-HSA-597592)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Regulation of glucokinase by glucokinase regulatory protein
(R-HSA-170822)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Rev-mediated nuclear export of hiv rna
(R-HSA-165054)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Slc transporter disorders
(R-HSA-5619102)
Snrnp assembly
(R-HSA-191859)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Sumoylation of dna replication proteins
(R-HSA-4615885)
Sumoylation of rna binding proteins
(R-HSA-4570464)
Sumoylation of sumoylation proteins
(R-HSA-4085377)
Sumoylation of ubiquitinylation proteins
(R-HSA-3232142)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transport of mature mrna derived from an intron-containing transcript
(R-HSA-159236)
Transport of mature mrna derived from an intronless transcript
(R-HSA-159231)
Transport of mature mrnas derived from intronless transcripts
(R-HSA-159234)
Transport of mature transcript to cytoplasm
(R-HSA-72202)
Transport of ribonucleoproteins into the host nucleus
(R-HSA-168271)
Transport of the slbp dependant mature mrna
(R-HSA-159230)
Transport of the slbp independent mature mrna
(R-HSA-159227)
Trna processing
(R-HSA-72306)
Trna processing in the nucleus
(R-HSA-6784531)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Vpr-mediated nuclear import of pics
(R-HSA-180910)
Cell division
(GO:0051301)
Cellular response to organic cyclic compound
(GO:0071407)
Cytoplasm
(GO:0005737)
Fibrillar center
(GO:0001650)
Microtubule binding
(GO:0008017)
Mitotic spindle pole
(GO:0097431)
Mrna export from nucleus
(GO:0006406)
Nuclear envelope
(GO:0005635)
Nuclear pore
(GO:0005643)
Nucleocytoplasmic transport
(GO:0006913)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of mitotic spindle organization
(GO:0060236)
Rna binding
(GO:0003723)
Rna export from nucleus
(GO:0006405)
Transcription-dependent tethering of rna polymerase ii gene dna at nuclear periphery
(GO:0000972)
Ubiquitin binding
(GO:0043130)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 123.6618
Cell Significance Index: -19.2400
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 80.8221
Cell Significance Index: -20.5000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 58.3812
Cell Significance Index: -24.0500
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 51.8509
Cell Significance Index: -24.4800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 51.0514
Cell Significance Index: -20.7400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 45.4912
Cell Significance Index: -23.4000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 21.8698
Cell Significance Index: -20.8800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.5124
Cell Significance Index: -22.8300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.7790
Cell Significance Index: -18.1600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.9933
Cell Significance Index: -23.6500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.5804
Cell Significance Index: -17.1400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.7913
Cell Significance Index: 276.1200
Cell Name: decidual cell (CL2000002)
Fold Change: 2.0575
Cell Significance Index: 33.0100
Cell Name: germ cell (CL0000586)
Fold Change: 1.7118
Cell Significance Index: 12.9300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.7099
Cell Significance Index: 199.2700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0060
Cell Significance Index: 60.4000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.9833
Cell Significance Index: 10.6900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.9177
Cell Significance Index: 31.8900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9018
Cell Significance Index: 146.6800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6763
Cell Significance Index: 134.2200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.6476
Cell Significance Index: 13.5600
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.5940
Cell Significance Index: 15.6200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5618
Cell Significance Index: 15.0000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5314
Cell Significance Index: 7.2500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5094
Cell Significance Index: 35.2300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4826
Cell Significance Index: 56.9100
Cell Name: kidney cell (CL1000497)
Fold Change: 0.4747
Cell Significance Index: 3.7900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4461
Cell Significance Index: 89.4800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4160
Cell Significance Index: 26.8400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3886
Cell Significance Index: 53.3600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3745
Cell Significance Index: 10.4700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3514
Cell Significance Index: 155.3600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3510
Cell Significance Index: 191.6700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3443
Cell Significance Index: 62.0600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3230
Cell Significance Index: 39.7100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3094
Cell Significance Index: 16.0800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2516
Cell Significance Index: 5.4500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2494
Cell Significance Index: 15.7200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2410
Cell Significance Index: 30.8900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2407
Cell Significance Index: 10.9100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2347
Cell Significance Index: 44.6700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2219
Cell Significance Index: 12.4500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2202
Cell Significance Index: 11.5600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1776
Cell Significance Index: 63.6900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1643
Cell Significance Index: 7.7200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.1522
Cell Significance Index: 4.4700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.1491
Cell Significance Index: 1.9100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1363
Cell Significance Index: 9.6400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1140
Cell Significance Index: 78.8300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0871
Cell Significance Index: 2.7900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0771
Cell Significance Index: 2.2200
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0761
Cell Significance Index: 9.8400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0691
Cell Significance Index: 3.2200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0593
Cell Significance Index: 3.0900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0445
Cell Significance Index: 3.3200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0430
Cell Significance Index: 1.5100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0201
Cell Significance Index: 1.5400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0168
Cell Significance Index: 0.4500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0011
Cell Significance Index: 2.1200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0063
Cell Significance Index: -0.3900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0064
Cell Significance Index: -11.8200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0082
Cell Significance Index: -12.6100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0121
Cell Significance Index: -16.4200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0125
Cell Significance Index: -7.9100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0146
Cell Significance Index: -0.3100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0178
Cell Significance Index: -13.0700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0179
Cell Significance Index: -13.5600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0206
Cell Significance Index: -9.3500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0215
Cell Significance Index: -0.3600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0223
Cell Significance Index: -16.5500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0298
Cell Significance Index: -3.0500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0323
Cell Significance Index: -0.6700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0381
Cell Significance Index: -21.5100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0432
Cell Significance Index: -26.9700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0601
Cell Significance Index: -1.5400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0619
Cell Significance Index: -4.1700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0648
Cell Significance Index: -18.6400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0762
Cell Significance Index: -2.0800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0798
Cell Significance Index: -13.6300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0955
Cell Significance Index: -13.8900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1088
Cell Significance Index: -2.9200
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1148
Cell Significance Index: -1.7200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1187
Cell Significance Index: -13.6000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1261
Cell Significance Index: -26.5700
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1292
Cell Significance Index: -1.5400
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1693
Cell Significance Index: -3.1300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2159
Cell Significance Index: -3.7000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2206
Cell Significance Index: -22.9700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2270
Cell Significance Index: -10.0400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2573
Cell Significance Index: -20.3800
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2735
Cell Significance Index: -2.2300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2979
Cell Significance Index: -11.2800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3200
Cell Significance Index: -9.1700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3324
Cell Significance Index: -20.3800
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.3800
Cell Significance Index: -5.3300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3833
Cell Significance Index: -11.2900
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4284
Cell Significance Index: -9.3800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4400
Cell Significance Index: -11.3100
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4577
Cell Significance Index: -13.0600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4998
Cell Significance Index: -3.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** RAE1 is an RNA-binding protein that regulates the export of viral RNA from the nucleus. It is a member of the exportin family, which is responsible for transporting RNAs and ribonucleoproteins across the nuclear envelope. RAE1 is highly expressed in cells that are susceptible to viral infections, such as oogonial cells, male germ cells, and neural progenitor cells. Its expression is also upregulated in response to viral infections, suggesting a role in antiviral defense. **Pathways and Functions:** RAE1 is involved in various cellular processes, including: 1. **Antiviral Mechanism:** RAE1 is a key player in the antiviral response, regulating the export of viral RNA from the nucleus. It interacts with viral proteins, such as Rev, to prevent their nuclear import and subsequent translation. 2. **Cell Cycle Regulation:** RAE1 is involved in the regulation of the cell cycle, particularly during the G2/M phase. It interacts with cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CKIs) to regulate cell cycle progression. 3. **Cytokine Signaling:** RAE1 is involved in the regulation of cytokine signaling, particularly in the context of immune responses. It interacts with cytokine receptors and signaling molecules to modulate immune responses. 4. **Heat Shock Response:** RAE1 is involved in the regulation of the heat shock response, particularly in the context of cellular stress. It interacts with heat shock proteins (HSPs) to regulate cellular stress responses. **Clinical Significance:** RAE1 has been implicated in various diseases, including: 1. **Thyroid Papillary Carcinoma (TPC):** Defects in RAE1 have been associated with an increased susceptibility to TPC, suggesting a role in cancer development. 2. **Infectious Diseases:** RAE1 is involved in the regulation of antiviral responses, making it a potential target for the treatment of viral infections, such as HIV and SARS-CoV-2. 3. **Immune System Disorders:** RAE1 is involved in the regulation of immune responses, making it a potential target for the treatment of immune system disorders, such as autoimmune diseases. **Conclusion:** RAE1 is a multifunctional gene that plays a crucial role in antiviral defense, cellular regulation, and immune response. Its dysregulation has been implicated in various diseases, including TPC, infectious diseases, and immune system disorders. Further research is needed to fully understand the functions and clinical significance of RAE1, but its potential as a therapeutic target is clear.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Rae1 protein homolog

Genular Protein ID: 2474784309

Symbol: RAE1L_HUMAN

Name: Rae1 protein homolog

UniProtKB Accession Codes:

P78406 A8K882 O15306 Q3SYL7 Q5TCH8 Q6V708 Q9H100 Q9NQM6

Database IDs:

Citations:

PubMed ID: 9370289

Title: The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of poly(A)+ RNA.

PubMed ID: 9370289

DOI: 10.1016/s0378-1119(97)00322-3

PubMed ID: 9256445

Title: mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm.

PubMed ID: 9256445

DOI: 10.1073/pnas.94.17.9119

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17172455

Title: Rae1 interaction with NuMA is required for bipolar spindle formation.

PubMed ID: 17172455

DOI: 10.1073/pnas.0609582104

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29293652

Title: USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.

PubMed ID: 29293652

DOI: 10.1371/journal.pone.0190513

PubMed ID: 22357847

Title: RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans.

PubMed ID: 22357847

DOI: 10.1523/jneurosci.2901-11.2012

PubMed ID: 33097660

Title: SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.

PubMed ID: 33097660

DOI: 10.1073/pnas.2016650117

PubMed ID: 33360543

Title: Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.

PubMed ID: 33360543

DOI: 10.1016/j.bbrc.2020.11.115

PubMed ID: 33849972

Title: SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98.

PubMed ID: 33849972

DOI: 10.1128/mbio.00065-21

PubMed ID: 20498086

Title: Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1.

PubMed ID: 20498086

DOI: 10.1073/pnas.1005389107

Sequence Information:

Length: 368
Mass: 40968
Checksum: 89A99C34BA668A97
Sequence:

MSLFGTTSGF GTSGTSMFGS ATTDNHNPMK DIEVTSSPDD SIGCLSFSPP TLPGNFLIAG 
SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLSSNQA 
IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD KTLKFWDTRS SNPMMVLQLP ERCYCADVIY 
PMAVVATAER GLIVYQLENQ PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV 
AIHYINPPNP AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW 
DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK NYIFLRNAAE 
ELKPRNKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RAE1

Associated with

Cells (max top 100)

Other Information

The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of poly(A)+ RNA. PubMed ID: 9370289

mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm. PubMed ID: 9256445

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Rae1 interaction with NuMA is required for bipolar spindle formation. PubMed ID: 17172455

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. PubMed ID: 29293652

RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans. PubMed ID: 22357847

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling. PubMed ID: 33097660

Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex. PubMed ID: 33360543

SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98. PubMed ID: 33849972

Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. PubMed ID: 20498086