Details for: PPFIBP2

Gene ID: 8495

Symbol: PPFIBP2

Ensembl ID: ENSG00000166387

Description: PPFIA binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 149.9242
    Cell Significance Index: -23.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.8613
    Cell Significance Index: -23.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.8815
    Cell Significance Index: -25.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.5161
    Cell Significance Index: -19.7100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 34.8722
    Cell Significance Index: -23.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.8538
    Cell Significance Index: -19.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.9058
    Cell Significance Index: -23.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7052
    Cell Significance Index: -23.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3237
    Cell Significance Index: -13.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.6053
    Cell Significance Index: 33.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5018
    Cell Significance Index: 129.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4781
    Cell Significance Index: 33.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2235
    Cell Significance Index: 400.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9452
    Cell Significance Index: 88.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5000
    Cell Significance Index: 184.4400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.4082
    Cell Significance Index: 12.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2300
    Cell Significance Index: 18.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1448
    Cell Significance Index: 32.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0441
    Cell Significance Index: 207.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9454
    Cell Significance Index: 24.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9306
    Cell Significance Index: 101.2200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.8817
    Cell Significance Index: 5.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8795
    Cell Significance Index: 52.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8437
    Cell Significance Index: 137.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7821
    Cell Significance Index: 16.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5053
    Cell Significance Index: 23.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4114
    Cell Significance Index: 6.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4006
    Cell Significance Index: 20.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3689
    Cell Significance Index: 10.3100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3639
    Cell Significance Index: 4.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3253
    Cell Significance Index: 11.4300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3122
    Cell Significance Index: 1.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3082
    Cell Significance Index: 21.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3060
    Cell Significance Index: 7.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2879
    Cell Significance Index: 22.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2822
    Cell Significance Index: 531.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2379
    Cell Significance Index: 85.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2179
    Cell Significance Index: 5.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2010
    Cell Significance Index: 181.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1933
    Cell Significance Index: 24.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1922
    Cell Significance Index: 354.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1875
    Cell Significance Index: 82.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1582
    Cell Significance Index: 3.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1546
    Cell Significance Index: 15.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1221
    Cell Significance Index: 24.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0751
    Cell Significance Index: 14.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0699
    Cell Significance Index: 44.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0589
    Cell Significance Index: 80.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0555
    Cell Significance Index: 30.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0543
    Cell Significance Index: 83.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0193
    Cell Significance Index: 13.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0158
    Cell Significance Index: 1.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0138
    Cell Significance Index: -2.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0144
    Cell Significance Index: -0.3900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0150
    Cell Significance Index: -0.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0158
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0187
    Cell Significance Index: -1.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0253
    Cell Significance Index: -19.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0256
    Cell Significance Index: -0.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0257
    Cell Significance Index: -18.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0275
    Cell Significance Index: -20.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0375
    Cell Significance Index: -21.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0418
    Cell Significance Index: -26.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0608
    Cell Significance Index: -17.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0737
    Cell Significance Index: -9.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0740
    Cell Significance Index: -10.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0897
    Cell Significance Index: -15.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0961
    Cell Significance Index: -2.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1019
    Cell Significance Index: -4.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1029
    Cell Significance Index: -11.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1238
    Cell Significance Index: -26.0900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1253
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1366
    Cell Significance Index: -15.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1403
    Cell Significance Index: -9.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1423
    Cell Significance Index: -2.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1601
    Cell Significance Index: -16.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1961
    Cell Significance Index: -12.3600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.2118
    Cell Significance Index: -2.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2171
    Cell Significance Index: -16.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2659
    Cell Significance Index: -21.0600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2838
    Cell Significance Index: -1.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2866
    Cell Significance Index: -17.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3007
    Cell Significance Index: -18.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3333
    Cell Significance Index: -21.5000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3385
    Cell Significance Index: -8.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3418
    Cell Significance Index: -22.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3558
    Cell Significance Index: -5.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3662
    Cell Significance Index: -19.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3663
    Cell Significance Index: -10.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4022
    Cell Significance Index: -22.5700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4031
    Cell Significance Index: -6.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4365
    Cell Significance Index: -7.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4584
    Cell Significance Index: -24.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4997
    Cell Significance Index: -16.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5211
    Cell Significance Index: -23.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5262
    Cell Significance Index: -7.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5307
    Cell Significance Index: -14.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5388
    Cell Significance Index: -19.7800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5407
    Cell Significance Index: -7.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PFPIB2 is a member of the liprin family, which consists of proteins that regulate cellular signaling and membrane trafficking. The gene is predominantly expressed in cells of the nervous system, immune cells, and epithelial tissues. Its expression is observed in various cell types, including anterior lens cells, renal alpha-intercalated cells, and taste receptor cells. PPFIBP2 is also involved in the regulation of protein-protein interactions, particularly at the synapses, where it interacts with receptor-type tyrosine-protein phosphatases. **Pathways and Functions:** PFPIB2 is involved in several cellular pathways, including: 1. **Neuronal system:** PPFIBP2 plays a crucial role in the development and maintenance of the neuronal system, particularly in the formation of synapses. It interacts with other proteins to regulate synaptic plasticity and neurotransmitter release. 2. **Protein-protein interactions:** PPFIBP2 is involved in the regulation of protein-protein interactions at synapses, which is essential for the proper functioning of the nervous system. 3. **Immune responses:** PPFIBP2 is expressed in immune cells, such as mononuclear cells and innate lymphoid cells, and is involved in the regulation of immune responses, particularly in the context of inflammation and tissue repair. 4. **Molecular_function:** PPFIBP2 is involved in the regulation of molecular functions, including protein binding, which is essential for the proper functioning of various cellular processes. **Clinical Significance:** PFPIB2 has been implicated in several disease pathways, including: 1. **Neurodegenerative diseases:** Alterations in PPFIBP2 expression have been observed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, suggesting its potential role in the pathogenesis of these diseases. 2. **Immune disorders:** PPFIBP2 is involved in the regulation of immune responses, and alterations in its expression have been observed in immune disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** PPFIBP2 has been implicated in cancer development and progression, particularly in the context of epithelial-to-mesenchymal transition. In conclusion, PPFIBP2 is a gene with multiple functions and implications in various cellular processes and disease pathways. Further research is necessary to fully elucidate its role in human health and disease, and to identify potential therapeutic targets for the treatment of neurodegenerative, immune, and cancer disorders.

Genular Protein ID: 2845465520

Symbol: LIPB2_HUMAN

Name: Liprin-beta-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9624153

Title: Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.

PubMed ID: 9624153

DOI: 10.1074/jbc.273.25.15611

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21462929

Title: Crystal structure of the central coiled-coil domain from human liprin-beta2.

PubMed ID: 21462929

DOI: 10.1021/bi200141e

Sequence Information:

  • Length: 876
  • Mass: 98544
  • Checksum: B01BF9286C6C1417
  • Sequence:
  • MASDASHALE AALEQMDGII AGTKTGADLS DGTCEPGLAS PASYMNPFPV LHLIEDLRLA 
    LEMLELPQER AALLSQIPGP TAAYIKEWFE ESLSQVNHHS AASNETYQER LARLEGDKES 
    LILQVSVLTD QVEAQGEKIR DLEVCLEGHQ VKLNAAEEML QQELLSRTSL ETQKLDLMTE 
    VSELKLKLVG MEKEQREQEE KQRKAEELLQ ELRHLKIKVE ELENERNQYE WKLKATKAEV 
    AQLQEQVALK DAEIERLHSQ LSRTAALHSE SHTERDQEIQ RLKMGMETLL LANEDKDRRI 
    EELTGLLNQY RKVKEIVMVT QGPSERTLSI NEEEPEGGFS KWNATNKDPE ELFKQEMPPR 
    CSSPTVGPPP LPQKSLETRA QKKLSCSLED LRSESVDKCM DGNQPFPVLE PKDSPFLAEH 
    KYPTLPGKLS GATPNGEAAK SPPTICQPDA TGSSLLRLRD TESGWDDTAV VNDLSSTSSG 
    TESGPQSPLT PDGKRNPKGI KKFWGKIRRT QSGNFYTDTL GMAEFRRGGL RATAGPRLSR 
    TRDSKGQKSD ANAPFAQWST ERVCAWLEDF GLAQYVIFAR QWVSSGHTLL TATPQDMEKE 
    LGIKHPLHRK KLVLAVKAIN TKQEEKSALL DHIWVTRWLD DIGLPQYKDQ FHESRVDRRM 
    LQYLTVNDLL FLKVTSQLHH LSIKCAIHVL HVNKFNPHCL HRRPADESNL SPSEVVQWSN 
    HRVMEWLRSV DLAEYAPNLR GSGVHGGLII LEPRFTGDTL AMLLNIPPQK TLLRRHLTTK 
    FNALIGPEAE QEKREKMASP AYTPLTTTAK VRPRKLGFSH FGNIRKKKFD ESTDYICPME 
    PSDGVSDSHR VYSGYRGLSP LDAPELDGLD QVGQIS

Genular Protein ID: 3959212599

Symbol: A0A804HKA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 927
  • Mass: 104102
  • Checksum: E4CCA729640ED206
  • Sequence:
  • MASDASHALE AALEQMDGII AGTKTGADLS DGTCEPGLAS PASYMNPFPV LHLIEDLRLA 
    LEMLELPQER AALLSQIPGP TAAYIKEWFE ESLSQVNHHS AASNETYQER LARLEGDKES 
    LILQVSVLTD QVEAQGEKIR DLEVCLEGHQ VKLNAAEEML QQELLSRTSL ETQKLDLMTE 
    VSELKLKLVG MEKEQREQEE KQRKAEELLQ ELRHLKIKVE ELENERNQYE WKLKATKAEV 
    AQLQEQVALK DAEIERLHSQ LSRTAALHSE SHTERDQEIQ RLKMGMETLL LANEDKDRRI 
    EELTGLLNQY RKVKEIVMVT QGPSERTLSI NEEEPEGGFS KWNATNKDPE ELFKQEMPPR 
    CSSPTVGPPP LPQKSLETRA QKKLSCSLED LRSESVDKCM DGNQPFPVLE PKDSPFLAEH 
    KYPTLPGKLS GATPNGEAAK SPPTICQPDA TGSSLLRLNR GRSVSAPVLG DTESGWDDTA 
    VVNDLSSTSS GTESGPQSPL TPDGKRNPKG IKKFWGKIRR TQSGNFYTDT LGMAEFRRGG 
    LRATAGPRLS RTRDSKGQKS DANAPFAQWS TERVCAWLED FGLAQYVIFA RQWVSSGHTL 
    LTATPQDMEK ELGIKHPLHR KKLVLAVKAI NTKQEEKSAL LDHIWVTRWL DDIGLPQYKD 
    QFHESRVDRR MLQYLTVNDL LFLKVTSQLH HLSIKCAIHV LHVNKFNPHC LHRRPADESN 
    LSPSEVVQWS NHRVMEWLRS VDLAEYAPNL RGSGVHGGLI ILEPRFTGDT LAMLLNIPPQ 
    KTLLRRHLTT KFNALIGPEA EQEKREKMAS PAYTPLTTTA KVRPRKLGFS HFGNIRKKKF 
    DESTDYICPM EPSDGVSDSH RVYSGYRGLS PLDAPELDGL DQMAPSEGTV TQIGLLSQDI 
    HRLTTMLSQD QLLNDSRLPA PNSDDWR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.