Details for: DGKD

Gene ID: 8527

Symbol: DGKD

Ensembl ID: ENSG00000077044

Description: diacylglycerol kinase delta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 195.7630
    Cell Significance Index: -30.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.9860
    Cell Significance Index: -30.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.5004
    Cell Significance Index: -26.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 59.8190
    Cell Significance Index: -30.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.0285
    Cell Significance Index: -26.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.8265
    Cell Significance Index: -30.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7508
    Cell Significance Index: -28.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.5204
    Cell Significance Index: -26.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8433
    Cell Significance Index: -30.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.9125
    Cell Significance Index: -12.9400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 5.0238
    Cell Significance Index: 81.0600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.6026
    Cell Significance Index: 112.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.3391
    Cell Significance Index: 85.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3440
    Cell Significance Index: 465.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2861
    Cell Significance Index: 147.4900
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.9660
    Cell Significance Index: 1.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9557
    Cell Significance Index: 150.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5721
    Cell Significance Index: 563.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3628
    Cell Significance Index: 39.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3324
    Cell Significance Index: 1203.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.2196
    Cell Significance Index: 20.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0620
    Cell Significance Index: 71.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0464
    Cell Significance Index: 64.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0377
    Cell Significance Index: 25.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0265
    Cell Significance Index: 27.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0050
    Cell Significance Index: 60.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9772
    Cell Significance Index: 43.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9531
    Cell Significance Index: 103.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8251
    Cell Significance Index: 134.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7814
    Cell Significance Index: 18.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7556
    Cell Significance Index: 34.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7505
    Cell Significance Index: 16.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7308
    Cell Significance Index: 85.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6592
    Cell Significance Index: 77.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6491
    Cell Significance Index: 24.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5973
    Cell Significance Index: 7.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5858
    Cell Significance Index: 901.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5807
    Cell Significance Index: 104.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5806
    Cell Significance Index: 32.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5391
    Cell Significance Index: 15.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4997
    Cell Significance Index: 34.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4786
    Cell Significance Index: 12.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4627
    Cell Significance Index: 853.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4056
    Cell Significance Index: 81.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3386
    Cell Significance Index: 637.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2782
    Cell Significance Index: 34.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2647
    Cell Significance Index: 16.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2636
    Cell Significance Index: 50.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2614
    Cell Significance Index: 166.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2421
    Cell Significance Index: 329.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2186
    Cell Significance Index: 6.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2177
    Cell Significance Index: 7.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2107
    Cell Significance Index: 20.8400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1971
    Cell Significance Index: 2.9100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1743
    Cell Significance Index: 2.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1463
    Cell Significance Index: 66.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0810
    Cell Significance Index: 11.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0782
    Cell Significance Index: 42.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0761
    Cell Significance Index: 1.6200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0662
    Cell Significance Index: 0.4000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0284
    Cell Significance Index: 0.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0269
    Cell Significance Index: 0.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0076
    Cell Significance Index: 3.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0101
    Cell Significance Index: -1.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0115
    Cell Significance Index: -8.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0116
    Cell Significance Index: -8.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0119
    Cell Significance Index: -7.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0357
    Cell Significance Index: -26.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0364
    Cell Significance Index: -20.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0406
    Cell Significance Index: -6.9300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0446
    Cell Significance Index: -0.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0504
    Cell Significance Index: -1.0700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0541
    Cell Significance Index: -0.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0751
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0839
    Cell Significance Index: -17.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0922
    Cell Significance Index: -26.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1002
    Cell Significance Index: -5.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1036
    Cell Significance Index: -4.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1128
    Cell Significance Index: -2.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1433
    Cell Significance Index: -18.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1445
    Cell Significance Index: -16.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1454
    Cell Significance Index: -18.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1599
    Cell Significance Index: -8.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1613
    Cell Significance Index: -3.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1739
    Cell Significance Index: -2.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1785
    Cell Significance Index: -18.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2033
    Cell Significance Index: -21.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2048
    Cell Significance Index: -9.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2304
    Cell Significance Index: -4.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2412
    Cell Significance Index: -17.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2545
    Cell Significance Index: -29.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2729
    Cell Significance Index: -14.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2809
    Cell Significance Index: -17.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3046
    Cell Significance Index: -5.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3232
    Cell Significance Index: -8.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3506
    Cell Significance Index: -11.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3616
    Cell Significance Index: -28.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3687
    Cell Significance Index: -7.2900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4033
    Cell Significance Index: -5.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4188
    Cell Significance Index: -7.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DGKD is a 130 kDa protein that belongs to the diacylglycerol kinase family, which is characterized by its ability to phosphorylate diacylglycerol (DAG) to produce phosphatidic acid (PA). DGKD is specifically expressed in various cell types, including GABAergic cortical interneurons, lens epithelial cells, and early pro-B cells. Notably, DGKD has been shown to interact with multiple proteins, including GPCRs, PKC, and clathrin, highlighting its role in complex signaling networks. **Pathways and Functions:** DGKD is involved in several key signaling pathways, including: 1. **GPCR signaling:** DGKD interacts with GPCRs to modulate their signaling output, influencing downstream effects such as platelet activation and signaling by GPCRs. 2. **DAG metabolism:** DGKD phosphorylates DAG to produce PA, which is a key regulator of cellular signaling pathways, including PKC activation and endocytosis. 3. **Endocytosis:** DGKD has been implicated in the regulation of clathrin-dependent endocytosis, highlighting its role in modulating cellular membrane dynamics. 4. **PKC signaling:** DGKD regulates PKC activity, influencing downstream effects on cell proliferation, differentiation, and survival. **Clinical Significance:** DGKD has been implicated in various diseases, including: 1. **Neurological disorders:** DGKD has been shown to play a role in the regulation of GABAergic signaling in cortical interneurons, which is critical for normal brain function. 2. **Cardiovascular disease:** DGKD has been implicated in platelet activation and aggregation, highlighting its potential role in the development of cardiovascular disease. 3. **Cancer:** DGKD has been shown to regulate PKC signaling, which is involved in cell proliferation and survival, making it a potential target for cancer therapy. In conclusion, DGKD is a critical enzyme involved in various cellular signaling pathways, including GPCR signaling, DAG metabolism, endocytosis, and PKC regulation. Further research is needed to fully elucidate the mechanisms of DGKD in these pathways and its clinical significance in various diseases. **Recommendations:** 1. **Further research:** Investigate the mechanisms of DGKD in GPCR signaling and DAG metabolism to better understand its role in cellular regulation. 2. **Disease modeling:** Use DGKD knockout or knockdown models to study its role in disease models, such as neurological disorders and cardiovascular disease. 3. **Therapeutic targeting:** Explore the potential of DGKD as a therapeutic target for the treatment of diseases, such as cancer and cardiovascular disease. By further elucidating the mechanisms of DGKD, we can gain a deeper understanding of its role in cellular regulation and its potential as a therapeutic target for various diseases.

Genular Protein ID: 2297965775

Symbol: DGKD_HUMAN

Name: 130 kDa diacylglycerol kinase

UniProtKB Accession Codes:

Q16760 Q14158 Q6PK55 Q8NG53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12200442

Title: Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions.

PubMed ID: 12200442

DOI: 10.1074/jbc.m206895200

PubMed ID: 8590280

Title: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8590280

DOI: 10.1093/dnares/2.4.167

PubMed ID: 8626538

Title: Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases.

PubMed ID: 8626538

DOI: 10.1074/jbc.271.14.8394

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12084710

Title: Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation.

PubMed ID: 12084710

DOI: 10.1074/jbc.m202035200

PubMed ID: 17880279

Title: Regulation of clathrin-dependent endocytosis by diacylglycerol kinase delta: importance of kinase activity and binding to AP2alpha.

PubMed ID: 17880279

DOI: 10.1042/bj20070755

PubMed ID: 23949095

Title: Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.

PubMed ID: 23949095

DOI: 10.1159/000351849

Sequence Information:

  • Length: 1214
  • Mass: 134525
  • Checksum: ED114429096D2112
  • Sequence:
    • MAAAAGAPPP GPPQPPPPPP PEESSDSEPE AEPGSPQKLI RKVSTSGQIR QKTIIKEGML 
TKQNNSFQRS KRRYFKLRGR TLYYAKTAKS IIFDEVDLTD ASVAESSTKN VNNSFTVITP 
CRKLILCADN RKEMEDWIAA LKTVQNREHF EPTQYSMDHF SGMHNWYACS HARPTYCNVC 
REALSGVTSH GLSCEVCKFK AHKRCAVRAT NNCKWTTLAS IGKDIIEDAD GIAMPHQWLE 
GNLPVSAKCT VCDKTCGSVL RLQDWRCLWC KAMVHTSCKE SLLTKCPLGL CKVSVIPPTA 
LNSIDSDGFW KASCPPSCTS PLLVFVNSKS GDNQGVKFLR RFKQLLNPAQ VFDLMNGGPH 
LGLRLFQKFD TFRILVCGGD GSVGWVLSEI DSLNLHKQCQ LGVLPLGTGN DLARVLGWGS 
ACDDDTQLPQ ILEKLERAST KMLDRWSVMA YEAKLPRQAS SSTVTEDFSE DSEVQQILFY 
EDSVAAHLSK ILTSDQHSVV ISSAKVLCET VKDFVARVGK AYEKTTESSE ESEVMAKKCS 
VLKEKLDSLL KTLDDESQAS SSLPNPPPTI AEEAEDGDGS GSICGSTGDR LVASACPARP 
QIFRPREQLM LRANSLKKAI RQIIEHTEKA VDEQNAQTQE QEGFVLGLSE SEEKMDHRVC 
PPLSHSESFG VPKGRSQRKV SKSPCEKLIS KGSLSLGSSA SLPPQPGSRD GLPALNTKIL 
YPNVRAGMSG SLPGGSVISR LLINADPFNS EPETLEYYTE KCVMNNYFGI GLDAKISLDF 
NNKRDEHPEK CRSRTKNMMW YGVLGTKELL HRTYKNLEQK VLLECDGRPI PLPSLQGIAV 
LNIPSYAGGT NFWGGTKEDD TFAAPSFDDK ILEVVAVFGS MQMAVSRVIR LQHHRIAQCR 
TVKISILGDE GVPVQVDGEA WVQPPGYIRI VHKNRAQTLT RDRAFESTLK SWEDKQKCEL 
PRPPSCSLHP EMLSEEEATQ MDQFGQAAGV LIHSIREIAQ SHRDMEQELA HAVNASSKSM 
DRVYGKPRTT EGLNCSFVLE MVNNFRALRS ETELLLSGKM ALQLDPPQKE QLGSALAEMD 
RQLRRLADTP WLCQSAEPGD EESVMLDLAK RSRSGKFRLV TKFKKEKNNK NKEAHSSLGA 
PVHLWGTEEV AAWLEHLSLC EYKDIFTRHD IRGSELLHLE RRDLKDLGVT KVGHMKRILC 
GIKELSRSAP AVEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.