Details for: CPZ

Gene ID: 8532

Symbol: CPZ

Ensembl ID: ENSG00000109625

Description: carboxypeptidase Z

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.5103
    Cell Significance Index: -10.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9456
    Cell Significance Index: 12.1100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.6524
    Cell Significance Index: 8.2600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1834
    Cell Significance Index: 2.9100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1087
    Cell Significance Index: 1.3700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0823
    Cell Significance Index: 1.3200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0443
    Cell Significance Index: 0.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0113
    Cell Significance Index: 0.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0037
    Cell Significance Index: -0.1600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0065
    Cell Significance Index: -1.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0072
    Cell Significance Index: -13.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0151
    Cell Significance Index: -11.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0162
    Cell Significance Index: -0.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0177
    Cell Significance Index: -13.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0181
    Cell Significance Index: -11.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0198
    Cell Significance Index: -11.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0200
    Cell Significance Index: -2.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0229
    Cell Significance Index: -12.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0427
    Cell Significance Index: -12.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0440
    Cell Significance Index: -0.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0497
    Cell Significance Index: -9.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0579
    Cell Significance Index: -10.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0680
    Cell Significance Index: -3.1700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0803
    Cell Significance Index: -1.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0874
    Cell Significance Index: -1.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0901
    Cell Significance Index: -0.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0940
    Cell Significance Index: -10.9500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0942
    Cell Significance Index: -1.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1034
    Cell Significance Index: -11.8500
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.1034
    Cell Significance Index: -0.9600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1080
    Cell Significance Index: -1.2700
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1099
    Cell Significance Index: -1.0800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1174
    Cell Significance Index: -1.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1231
    Cell Significance Index: -3.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1290
    Cell Significance Index: -13.1800
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.1295
    Cell Significance Index: -1.2900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1334
    Cell Significance Index: -1.3800
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1373
    Cell Significance Index: -1.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1419
    Cell Significance Index: -2.7700
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.1419
    Cell Significance Index: -1.3400
  • Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
    Fold Change: -0.1437
    Cell Significance Index: -1.2200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1480
    Cell Significance Index: -2.5300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1487
    Cell Significance Index: -2.0100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1507
    Cell Significance Index: -1.3600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1522
    Cell Significance Index: -1.0100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1560
    Cell Significance Index: -1.3100
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1605
    Cell Significance Index: -1.6600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1645
    Cell Significance Index: -2.1100
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.1748
    Cell Significance Index: -1.0900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1840
    Cell Significance Index: -1.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1991
    Cell Significance Index: -10.3700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2110
    Cell Significance Index: -2.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2137
    Cell Significance Index: -3.0600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2152
    Cell Significance Index: -1.3000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2196
    Cell Significance Index: -2.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2469
    Cell Significance Index: -11.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2530
    Cell Significance Index: -15.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2636
    Cell Significance Index: -8.4000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2645
    Cell Significance Index: -2.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2689
    Cell Significance Index: -7.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2951
    Cell Significance Index: -16.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3201
    Cell Significance Index: -11.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3268
    Cell Significance Index: -15.3600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.3345
    Cell Significance Index: -1.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3384
    Cell Significance Index: -11.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3445
    Cell Significance Index: -12.0700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.3588
    Cell Significance Index: -4.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3752
    Cell Significance Index: -11.0500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3830
    Cell Significance Index: -9.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3894
    Cell Significance Index: -10.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3921
    Cell Significance Index: -9.7800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3974
    Cell Significance Index: -6.7500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3983
    Cell Significance Index: -5.8300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3986
    Cell Significance Index: -4.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4262
    Cell Significance Index: -11.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4368
    Cell Significance Index: -11.6900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4426
    Cell Significance Index: -4.5900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.4582
    Cell Significance Index: -5.3200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4645
    Cell Significance Index: -11.8400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.5232
    Cell Significance Index: -8.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5261
    Cell Significance Index: -11.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5345
    Cell Significance Index: -19.6200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5421
    Cell Significance Index: -11.0300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5436
    Cell Significance Index: -11.6200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.5743
    Cell Significance Index: -9.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5799
    Cell Significance Index: -17.0300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5872
    Cell Significance Index: -6.9800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5872
    Cell Significance Index: -6.0000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.5887
    Cell Significance Index: -6.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5969
    Cell Significance Index: -9.9900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.6223
    Cell Significance Index: -12.4100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.6248
    Cell Significance Index: -10.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6654
    Cell Significance Index: -16.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6670
    Cell Significance Index: -19.1200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.6670
    Cell Significance Index: -10.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6711
    Cell Significance Index: -14.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6767
    Cell Significance Index: -16.2300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6798
    Cell Significance Index: -13.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6822
    Cell Significance Index: -14.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Metallocarboxypeptidase activity:** CPZ belongs to the metallocarboxypeptidase family, which is characterized by the presence of a zinc ion cofactor. This enzyme activity is essential for the cleavage of peptide bonds at the C-terminal end of protein substrates. 2. **Tissue-specific expression:** CPZ is highly expressed in various cell types, including microglial cells, dendritic cells, endothelial cells, and myoblasts. Its expression pattern suggests a role in immune cell function, angiogenesis, and muscle development. 3. **Zinc ion binding:** CPZ binds to zinc ions, which are essential for its catalytic activity. The zinc ion cofactor is also involved in the regulation of CPZ activity and its interaction with protein substrates. **Pathways and Functions:** 1. **Protein processing:** CPZ is involved in the processing of various protein substrates, including growth factors, cytokines, and neurotransmitters. Its activity is essential for the regulation of protein function and signaling pathways. 2. **Immune response:** CPZ is expressed in immune cells, including microglial cells and dendritic cells, and plays a role in the regulation of immune cell function, including antigen presentation and cytokine production. 3. **Wnt signaling pathway:** CPZ is involved in the regulation of the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and survival. Dysregulation of the Wnt pathway has been implicated in various diseases, including cancer and neurodegenerative disorders. 4. **Peptide metabolic process:** CPZ is involved in the degradation of peptide substrates, which is essential for the regulation of protein function and signaling pathways. **Clinical Significance:** 1. **Neurodegenerative disorders:** CPZ has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). Its dysregulation has been linked to the accumulation of toxic peptides and the disruption of protein processing pathways. 2. **Cancer:** CPZ has been shown to play a role in the regulation of cancer cell proliferation, invasion, and metastasis. Its dysregulation has been implicated in various types of cancer, including breast cancer, lung cancer, and colorectal cancer. 3. **Cardiovascular disease:** CPZ has been implicated in the regulation of cardiovascular function, including angiogenesis and endothelial cell function. Its dysregulation has been linked to the development of cardiovascular disease, including atherosclerosis and hypertension. In conclusion, CPZ is a multifaceted enzyme that plays a crucial role in various cellular processes, including immune response, protein processing, and cell signaling. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, cancer, and cardiovascular disease. Further research is needed to fully understand the role of CPZ in human health and disease.

Genular Protein ID: 2778986317

Symbol: CBPZ_HUMAN

Name: Carboxypeptidase Z

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9099699

Title: Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase.

PubMed ID: 9099699

DOI: 10.1074/jbc.272.16.10543

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10080937

Title: Purification and characterization of human metallocarboxypeptidase Z.

PubMed ID: 10080937

DOI: 10.1006/bbrc.1999.0378

PubMed ID: 10671522

Title: Carboxypeptidase Z is present in the regulated secretory pathway and extracellular matrix in cultured cells and in human tissues.

PubMed ID: 10671522

DOI: 10.1074/jbc.275.7.4865

PubMed ID: 11766880

Title: Carboxypeptidases from A to Z: implications in embryonic development and Wnt binding.

PubMed ID: 11766880

DOI: 10.1007/pl00000819

PubMed ID: 12417617

Title: Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary.

PubMed ID: 12417617

DOI: 10.1177/002215540205001111

Sequence Information:

  • Length: 652
  • Mass: 73655
  • Checksum: BFA1EA7753E63F98
  • Sequence:
  • MPPPLPLLLL TVLVVAAARP GCEFERNPAG ECHRPPAADS ATCVDLQLRT CSDAAYNHTT 
    FPNLLQHRSW EVVEASSEYI LLSVLHQLLE GQCNPDLRLL GCAVLAPRCE GGWVRRPCRH 
    ICEGLREVCQ PAFDAIDMAW PYFLDCHRYF TREDEGCYDP LEKLRGGLEA DEALPSGLPP 
    TFIRFSHHSY AQMVRVLRRT ASRCAHVART YSIGRSFDGR ELLVIEFSSR PGQHELMEPE 
    VKLIGNIHGN EVAGREMLIY LAQYLCSEYL LGNPRIQRLL NTTRIHLLPS MNPDGYEVAA 
    AEGAGYNGWT SGRQNAQNLD LNRNFPDLTS EYYRLAETRG ARSDHIPIPQ HYWWGKVAPE 
    TKAIMKWMQT IPFVLSASLH GGDLVVSYPF DFSKHPQEEK MFSPTPDEKM FKLLSRAYAD 
    VHPMMMDRSE NRCGGNFLKR GSIINGADWY SFTGGMSDFN YLHTNCFEIT VELGCVKFPP 
    EEALYILWQH NKESLLNFVE TVHRGIKGVV TDKFGKPVKN ARISVKGIRH DITTAPDGDY 
    WRLLPPGIHI VIAQAPGYAK VIKKVIIPAR MKRAGRVDFI LQPLGMGPKN FIHGLRRTGP 
    HDPLGGASSL GEATEPDPLR ARRQPSADGS KPWWWSYFTS LSTHRPRWLL KY

Genular Protein ID: 4229799546

Symbol: A0A384MDV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 652
  • Mass: 73627
  • Checksum: 666754B7A468EF7F
  • Sequence:
  • MPPPPPLLLL TVLVVAAARP GCEFERNPAG ECHRPPAADS ATCVDLQLRT CSDAAYNHTT 
    FPNLLQHRSW EVVEASSEYI LLSVLHQLLE GQCNPDLRLL GCAVLAPRCE GGWVRRPCRH 
    ICEGLREVCQ PAFDAIDMAW PYFLDCHRYF TREDEGCYDP LEKLRGGLEA DEALPSGLPP 
    TFIRFSHHSY AQMVRVLRRT ASRCAHVART YSIGRSFDGR ELLVIEFSSR PGQHELMEPE 
    VKLIGNIHGN EVAGREMLIY LAQYLCSEYL LGNPRIQRLL NTTRIHLLPS MNPDGYEVAA 
    AEGAGYNGWT SGRQNAQNLD LNRNFPDLTS EYYRLAETRG ARSDHIPIPQ HYWWGKVAPE 
    TKAIMKWMQT IPFVLSASLH GGDLVVSYPF DFSKHPQEEK MFSPTPDEKM FKLLSRAYAD 
    VHPMMMDRSE NRCGGNFLKR GSIINGADWY SFTGGMSDFN YLHTNCFEIT VELGCVKFPP 
    EEALYTLWQH NKESLLNFVE TVHRGIKGVV TDKFGKPVKN ARISVKGIRH DITTAPDGDY 
    WRLLPPGIHI VIAQAPGYAK VIKKVIIPAR MKRAGRVDFI LQPLGMGPKN FIHGLRRTGP 
    HDPLGGASSL GEATEPDPLR ARRQPSADGS KPWWWSYFTS LSTHRPRWLL KY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.