Details for: CAMK1

Gene ID: 8536

Symbol: CAMK1

Ensembl ID: ENSG00000134072

Description: calcium/calmodulin dependent protein kinase I

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.9873
    Cell Significance Index: -20.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.8472
    Cell Significance Index: -20.7600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 57.7743
    Cell Significance Index: -23.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.6207
    Cell Significance Index: -18.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.2319
    Cell Significance Index: -21.3600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.4390
    Cell Significance Index: -21.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.7321
    Cell Significance Index: -20.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6600
    Cell Significance Index: -20.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2534
    Cell Significance Index: -20.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9623
    Cell Significance Index: -12.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9882
    Cell Significance Index: -6.5400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.6608
    Cell Significance Index: 22.3500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.2897
    Cell Significance Index: 35.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0532
    Cell Significance Index: 124.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9708
    Cell Significance Index: 65.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7965
    Cell Significance Index: 159.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5352
    Cell Significance Index: 106.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5117
    Cell Significance Index: 31.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4691
    Cell Significance Index: 64.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4660
    Cell Significance Index: 75.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4635
    Cell Significance Index: 418.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4551
    Cell Significance Index: 49.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4520
    Cell Significance Index: 12.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4134
    Cell Significance Index: 24.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3324
    Cell Significance Index: 119.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2807
    Cell Significance Index: 10.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2637
    Cell Significance Index: 7.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2526
    Cell Significance Index: 13.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2387
    Cell Significance Index: 10.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2138
    Cell Significance Index: 40.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2105
    Cell Significance Index: 20.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1929
    Cell Significance Index: 5.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1836
    Cell Significance Index: 126.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1818
    Cell Significance Index: 4.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1716
    Cell Significance Index: 22.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1479
    Cell Significance Index: 3.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1423
    Cell Significance Index: 9.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1210
    Cell Significance Index: 3.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0688
    Cell Significance Index: 1.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0635
    Cell Significance Index: 7.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0451
    Cell Significance Index: 24.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0426
    Cell Significance Index: 0.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0166
    Cell Significance Index: 25.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0119
    Cell Significance Index: 21.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0111
    Cell Significance Index: 20.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0028
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0089
    Cell Significance Index: -5.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0093
    Cell Significance Index: -0.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0116
    Cell Significance Index: -7.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0185
    Cell Significance Index: -14.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0205
    Cell Significance Index: -9.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0207
    Cell Significance Index: -11.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0231
    Cell Significance Index: -2.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0236
    Cell Significance Index: -17.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0318
    Cell Significance Index: -5.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0404
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0422
    Cell Significance Index: -4.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0432
    Cell Significance Index: -1.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0434
    Cell Significance Index: -6.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0447
    Cell Significance Index: -7.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0466
    Cell Significance Index: -0.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0600
    Cell Significance Index: -17.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0601
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0605
    Cell Significance Index: -12.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0620
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0943
    Cell Significance Index: -10.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1066
    Cell Significance Index: -4.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1166
    Cell Significance Index: -15.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1339
    Cell Significance Index: -8.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1348
    Cell Significance Index: -10.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1350
    Cell Significance Index: -3.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1456
    Cell Significance Index: -4.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1523
    Cell Significance Index: -10.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1541
    Cell Significance Index: -8.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1587
    Cell Significance Index: -2.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1630
    Cell Significance Index: -3.5700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1633
    Cell Significance Index: -2.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1664
    Cell Significance Index: -8.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1722
    Cell Significance Index: -3.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1770
    Cell Significance Index: -13.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1878
    Cell Significance Index: -19.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1949
    Cell Significance Index: -9.1600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1987
    Cell Significance Index: -2.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2107
    Cell Significance Index: -6.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2124
    Cell Significance Index: -11.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2383
    Cell Significance Index: -8.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2523
    Cell Significance Index: -16.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2525
    Cell Significance Index: -20.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2644
    Cell Significance Index: -6.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2755
    Cell Significance Index: -8.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2794
    Cell Significance Index: -8.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2960
    Cell Significance Index: -18.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3186
    Cell Significance Index: -10.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3477
    Cell Significance Index: -7.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3586
    Cell Significance Index: -9.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3937
    Cell Significance Index: -10.5300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4189
    Cell Significance Index: -8.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4190
    Cell Significance Index: -4.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CAMK1 is a calcium/calmodulin-dependent serine/threonine kinase, which means it requires calcium/calmodulin as a cofactor to phosphorylate and activate its downstream targets. This enzyme is involved in numerous signaling pathways, including: 1. **Activation of NMDA receptors**: CAMK1 phosphorylates and regulates NMDA receptors, which are critical for synaptic plasticity and learning. 2. **Rac1 signaling**: CAMK1 interacts with Rac1, a small GTPase involved in cytoskeleton reorganization and cell migration. 3. **Cell cycle regulation**: CAMK1 phosphorylates and activates or inhibits proteins involved in cell cycle progression. 4. **Differentiation and development**: CAMK1 regulates the expression of genes involved in cell differentiation and development. **Pathways and Functions** CAMK1 is involved in various signaling pathways, including: 1. **Activation of NMDA receptors and postsynaptic events**: CAMK1 phosphorylates and regulates NMDA receptors, influencing synaptic plasticity and learning. 2. **Activation of Rac1 downstream of NMDARs**: CAMK1 interacts with Rac1, regulating cytoskeleton reorganization and cell migration. 3. **ATP binding and calmodulin-dependent protein kinase activity**: CAMK1 uses ATP as a phosphate donor and interacts with calmodulin to regulate its activity. 4. **Cell cycle regulation**: CAMK1 phosphorylates and activates or inhibits proteins involved in cell cycle progression. 5. **Negative regulation of NMDA receptor-mediated neuronal transmission**: CAMK1 inhibits NMDA receptor-mediated transmission, potentially regulating excitatory neurotransmission. 6. **Positive regulation of dendritic spine development**: CAMK1 promotes the development of dendritic spines, critical for synaptic plasticity. 7. **Regulation of muscle cell differentiation**: CAMK1 regulates the expression of genes involved in muscle cell differentiation. 8. **Regulation of protein export from nucleus**: CAMK1 phosphorylates and regulates proteins involved in nuclear export. **Clinical Significance** CAMK1 is implicated in various diseases and disorders, including: 1. **Neurological disorders**: CAMK1 is involved in the regulation of synaptic plasticity and learning, making it a potential target for the treatment of neurological disorders such as Alzheimer's disease and Parkinson's disease. 2. **Immune system dysregulation**: CAMK1 is expressed in immune cells, and dysregulation of its activity may contribute to immune system dysregulation and autoimmune diseases. 3. **Cancer**: CAMK1 is involved in cell cycle regulation and differentiation, making it a potential target for cancer therapy. 4. **Muscle disorders**: CAMK1 regulates muscle cell differentiation and function, making it a potential target for the treatment of muscle disorders such as muscular dystrophy. In conclusion, CAMK1 is a multifunctional protein kinase that plays a critical role in various cellular processes, including signal transduction, cell cycle regulation, and differentiation. Understanding its characteristics, pathways, and functions is essential for elucidating its role in various physiological and pathological processes, and for developing therapeutic strategies for diseases and disorders associated with CAMK1 dysregulation.

Genular Protein ID: 3094516828

Symbol: KCC1A_HUMAN

Name: Calcium/calmodulin-dependent protein kinase type 1

UniProtKB Accession Codes:

Q14012 Q3KPF6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7641687

Title: Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.

PubMed ID: 7641687

DOI: 10.1002/j.1460-2075.1995.tb00037.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9662074

Title: Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase.

PubMed ID: 9662074

DOI: 10.1007/bf02258368

PubMed ID: 11114197

Title: Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5.

PubMed ID: 11114197

DOI: 10.1073/pnas.260501497

PubMed ID: 11395482

Title: Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity.

PubMed ID: 11395482

DOI: 10.1074/jbc.m011720200

PubMed ID: 12193581

Title: Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase.

PubMed ID: 12193581

DOI: 10.1210/en.2001-211359

PubMed ID: 14507913

Title: Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I.

PubMed ID: 14507913

DOI: 10.1074/jbc.m308781200

PubMed ID: 14754892

Title: Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.

PubMed ID: 14754892

DOI: 10.1074/jbc.m312543200

PubMed ID: 17442826

Title: A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth.

PubMed ID: 17442826

DOI: 10.1523/jneurosci.0725-07.2007

PubMed ID: 17056143

Title: Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth.

PubMed ID: 17056143

DOI: 10.1016/j.neures.2006.09.013

PubMed ID: 18184567

Title: Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex.

PubMed ID: 18184567

DOI: 10.1016/j.neuron.2007.11.016

PubMed ID: 20181577

Title: CaMKK-CaMKI signaling pathways differentially control axon and dendrite elongation in cortical neurons.

PubMed ID: 20181577

DOI: 10.1523/jneurosci.5984-09.2010

PubMed ID: 11749376

Title: Structure and regulation of calcium/calmodulin-dependent protein kinases.

PubMed ID: 11749376

DOI: 10.1021/cr0002386

PubMed ID: 18817731

Title: Calmodulin-kinases: modulators of neuronal development and plasticity.

PubMed ID: 18817731

DOI: 10.1016/j.neuron.2008.08.021

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21301225

Title: Controlling the cell cycle: the role of calcium/calmodulin-stimulated protein kinases I and II.

PubMed ID: 21301225

DOI: 10.4161/cc.10.4.14798

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23707388

Title: Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.

PubMed ID: 23707388

DOI: 10.1016/j.cellsig.2013.05.012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23028635

Title: Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI.

PubMed ID: 23028635

DOI: 10.1371/journal.pone.0044828

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 370
  • Mass: 41337
  • Checksum: 57FA20ECE00FA76C
  • Sequence:
    • MLGAVEGPRW KQAEDIRDIY DFRDVLGTGA FSEVILAEDK RTQKLVAIKC IAKEALEGKE 
GSMENEIAVL HKIKHPNIVA LDDIYESGGH LYLIMQLVSG GELFDRIVEK GFYTERDASR 
LIFQVLDAVK YLHDLGIVHR DLKPENLLYY SLDEDSKIMI SDFGLSKMED PGSVLSTACG 
TPGYVAPEVL AQKPYSKAVD CWSIGVIAYI LLCGYPPFYD ENDAKLFEQI LKAEYEFDSP 
YWDDISDSAK DFIRHLMEKD PEKRFTCEQA LQHPWIAGDT ALDKNIHQSV SEQIKKNFAK 
SKWKQAFNAT AVVRHMRKLQ LGTSQEGQGQ TASHGELLTP VAGGPAAGCC CRDCCVEPGT 
ELSPTLPHQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.