Details for: APOL1

Gene ID: 8542

Symbol: APOL1

Ensembl ID: ENSG00000100342

Description: apolipoprotein L1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 97.5922
    Cell Significance Index: -15.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.5701
    Cell Significance Index: -14.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.4492
    Cell Significance Index: -15.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.5146
    Cell Significance Index: -15.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 6.2059
    Cell Significance Index: 322.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1011
    Cell Significance Index: -13.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8976
    Cell Significance Index: -15.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5450
    Cell Significance Index: -5.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9567
    Cell Significance Index: 228.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2790
    Cell Significance Index: 29.5500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.1849
    Cell Significance Index: 7.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0470
    Cell Significance Index: 14.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0083
    Cell Significance Index: 9.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9231
    Cell Significance Index: 25.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9049
    Cell Significance Index: 10.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7738
    Cell Significance Index: 13.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7694
    Cell Significance Index: 694.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6252
    Cell Significance Index: 13.3200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5746
    Cell Significance Index: 8.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5606
    Cell Significance Index: 68.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5492
    Cell Significance Index: 32.9700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5407
    Cell Significance Index: 7.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5384
    Cell Significance Index: 15.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5163
    Cell Significance Index: 56.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4715
    Cell Significance Index: 85.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4297
    Cell Significance Index: 69.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4297
    Cell Significance Index: 9.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3919
    Cell Significance Index: 44.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3773
    Cell Significance Index: 37.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3072
    Cell Significance Index: 21.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3046
    Cell Significance Index: 166.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2822
    Cell Significance Index: 38.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2332
    Cell Significance Index: 29.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1545
    Cell Significance Index: 96.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1276
    Cell Significance Index: 2.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0944
    Cell Significance Index: 2.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0718
    Cell Significance Index: 13.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0702
    Cell Significance Index: 1.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0657
    Cell Significance Index: 0.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0583
    Cell Significance Index: 1.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0133
    Cell Significance Index: 0.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0123
    Cell Significance Index: 2.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0060
    Cell Significance Index: 0.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0018
    Cell Significance Index: 0.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0013
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0078
    Cell Significance Index: -0.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0093
    Cell Significance Index: -17.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0117
    Cell Significance Index: -17.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0122
    Cell Significance Index: -6.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0129
    Cell Significance Index: -17.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0156
    Cell Significance Index: -11.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0192
    Cell Significance Index: -12.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0192
    Cell Significance Index: -1.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0204
    Cell Significance Index: -2.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0270
    Cell Significance Index: -0.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0272
    Cell Significance Index: -0.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0324
    Cell Significance Index: -14.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0337
    Cell Significance Index: -5.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0376
    Cell Significance Index: -7.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0386
    Cell Significance Index: -13.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0409
    Cell Significance Index: -1.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0442
    Cell Significance Index: -12.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0494
    Cell Significance Index: -1.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0539
    Cell Significance Index: -10.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0624
    Cell Significance Index: -0.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0787
    Cell Significance Index: -2.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0841
    Cell Significance Index: -3.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0854
    Cell Significance Index: -9.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1039
    Cell Significance Index: -1.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1128
    Cell Significance Index: -13.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1224
    Cell Significance Index: -8.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1488
    Cell Significance Index: -15.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1501
    Cell Significance Index: -6.1500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1600
    Cell Significance Index: -2.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1708
    Cell Significance Index: -11.0200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1725
    Cell Significance Index: -2.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1809
    Cell Significance Index: -11.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1862
    Cell Significance Index: -14.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1935
    Cell Significance Index: -2.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2026
    Cell Significance Index: -6.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2219
    Cell Significance Index: -5.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2278
    Cell Significance Index: -15.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2406
    Cell Significance Index: -15.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2560
    Cell Significance Index: -15.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2692
    Cell Significance Index: -7.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2901
    Cell Significance Index: -16.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2945
    Cell Significance Index: -15.4600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3440
    Cell Significance Index: -4.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3514
    Cell Significance Index: -10.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3714
    Cell Significance Index: -13.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3715
    Cell Significance Index: -9.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3943
    Cell Significance Index: -4.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3986
    Cell Significance Index: -17.6300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4019
    Cell Significance Index: -6.7600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.4053
    Cell Significance Index: -5.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4098
    Cell Significance Index: -14.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4146
    Cell Significance Index: -14.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** APOL1 is a small gene that encodes a protein of approximately 100 amino acids. The protein is a member of the lipocalin family and is characterized by a hydrophobic lipid-binding domain. APOL1 is primarily expressed in the liver, kidney, and other tissues, where it plays a critical role in lipid metabolism and innate immunity. The protein is also present in various cell types, including epithelial cells, endothelial cells, and immune cells, where it modulates the host's response to pathogens and other foreign substances. **Pathways and Functions:** APOL1 is involved in several key pathways and functions, including: 1. **Lipid Metabolism:** APOL1 regulates cholesterol and lipid metabolism by interacting with lipid-binding proteins and receptors, such as LDL receptors and scavenger receptors. 2. **Innate Immunity:** APOL1 modulates the innate immune response by interacting with pattern recognition receptors, such as Toll-like receptors and NOD-like receptors, and other immune molecules, such as cytokines and chemokines. 3. **Chloride Transport:** APOL1 is involved in chloride transport across cell membranes, which is essential for maintaining proper ion balance and cellular homeostasis. 4. **Protein Modification:** APOL1 is involved in post-translational protein modification, including phosphorylation and glycosylation, which regulates protein function and stability. 5. **Vesicle-Mediated Transport:** APOL1 is involved in vesicle-mediated transport, which regulates the movement of lipids and other molecules between cells and vesicles. **Clinical Significance:** The APOL1 gene has significant clinical implications, particularly in the context of African American patients with kidney disease. Variants of the APOL1 gene have been associated with an increased risk of diabetic nephropathy and other kidney-related complications. APOL1 has also been implicated in the pathogenesis of other diseases, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Further research is needed to fully understand the clinical significance of APOL1 and to develop targeted therapies for diseases associated with APOL1 dysfunction. In conclusion, the APOL1 gene is a critical component of the human genome that plays a vital role in lipid metabolism, innate immunity, and protein modification. Further research is needed to fully understand the clinical significance of APOL1 and to develop targeted therapies for diseases associated with APOL1 dysfunction.

Genular Protein ID: 2070373698

Symbol: APOL1_HUMAN

Name: Apolipoprotein L1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9325276

Title: Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L.

PubMed ID: 9325276

DOI: 10.1074/jbc.272.41.25576

PubMed ID: 11290834

Title: Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.

PubMed ID: 11290834

PubMed ID: 11374903

Title: The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.

PubMed ID: 11374903

DOI: 10.1006/geno.2001.6534

PubMed ID: 11944986

Title: The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.

PubMed ID: 11944986

DOI: 10.1006/geno.2002.6729

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 20635188

Title: Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene.

PubMed ID: 20635188

DOI: 10.1007/s00439-010-0861-0

PubMed ID: 20647424

Title: Association of trypanolytic ApoL1 variants with kidney disease in African Americans.

PubMed ID: 20647424

DOI: 10.1126/science.1193032

Sequence Information:

  • Length: 398
  • Mass: 43974
  • Checksum: BD1A8F1D7C5A889F
  • Sequence:
  • MEGAALLRVS VLCIWMSALF LGVGVRAEEA GARVQQNVPS GTDTGDPQSK PLGDWAAGTM 
    DPESSIFIED AIKYFKEKVS TQNLLLLLTD NEAWNGFVAA AELPRNEADE LRKALDNLAR 
    QMIMKDKNWH DKGQQYRNWF LKEFPRLKSE LEDNIRRLRA LADGVQKVHK GTTIANVVSG 
    SLSISSGILT LVGMGLAPFT EGGSLVLLEP GMELGITAAL TGITSSTMDY GKKWWTQAQA 
    HDLVIKSLDK LKEVREFLGE NISNFLSLAG NTYQLTRGIG KDIRALRRAR ANLQSVPHAS 
    ASRPRVTEPI SAESGEQVER VNEPSILEMS RGVKLTDVAP VSFFLVLDVV YLVYESKHLH 
    EGAKSETAEE LKKVAQELEE KLNILNNNYK ILQADQEL

Genular Protein ID: 2919159815

Symbol: B1AH95_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18477386

Title: Finishing the finished human chromosome 22 sequence.

PubMed ID: 18477386

DOI: 10.1186/gb-2008-9-5-r78

Sequence Information:

  • Length: 141
  • Mass: 14954
  • Checksum: 7E19BDB78F832AA0
  • Sequence:
  • MEGAALLRVS VLCIWMSALF LGVGVRAEEA GARVQQNVPS GTDTGDPQSK PLGDWAAGTM 
    DPGPAGSRGD SGEPCTLRPA CRGQRQHGGA SRISAEGPAP MPRRRTPSTA HLRVPKTSRR 
    NLLCMRAVSL LRMPLSISRK K

Genular Protein ID: 3139766536

Symbol: Q2KHQ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 398
  • Mass: 43927
  • Checksum: 6FDC5702C6C8EB36
  • Sequence:
  • MEGAALLRVS VLCIWMSALF LGVGVRAEEA GARVQQNVPS GTDTGDPQSK PLGDWAAGTM 
    DPESSIFIED AIKYFKEKVS TQNLLLLLTD NEAWNGFVAA AELPRNEADE LRKALDNLAR 
    QMIMKDKNWH DKGQQYRNWF LKEFPRLKSK LEDNIRRLRA LADGVQKVHK GTTIANVVSG 
    SLSISSGILT LVGMGLAPFT EGGSLVLLEP GMELGITAAL TGITSSTIDY GKKWWTQAQA 
    HDLVIKSLDK LKEVKEFLGE NISNFLSLAG NTYQLTRGIG KDIRALRRAR ANLQSVPHAS 
    ASRPRVTEPI SAESGEQVER VNEPSILEMS RGVKLTDVAP VSFFLVLDVV YLVYESKHLH 
    EGAKSETAEE LKKVAQELEE KLNILNNNYK ILQADQEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.