Details for: PIR

Gene ID: 8544

Symbol: PIR

Ensembl ID: ENSG00000087842

Description: pirin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 179.5619
    Cell Significance Index: -27.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.7925
    Cell Significance Index: -29.3700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.4960
    Cell Significance Index: -30.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.3318
    Cell Significance Index: -30.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.2157
    Cell Significance Index: -22.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3332
    Cell Significance Index: -30.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7191
    Cell Significance Index: -30.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.3582
    Cell Significance Index: 174.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.2372
    Cell Significance Index: 83.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.3060
    Cell Significance Index: 61.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1724
    Cell Significance Index: 29.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9706
    Cell Significance Index: 229.6500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.6361
    Cell Significance Index: 23.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5220
    Cell Significance Index: 40.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3812
    Cell Significance Index: 106.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.2853
    Cell Significance Index: 31.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1224
    Cell Significance Index: 111.0300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.6142
    Cell Significance Index: 9.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6072
    Cell Significance Index: 98.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5276
    Cell Significance Index: 189.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5188
    Cell Significance Index: 56.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4803
    Cell Significance Index: 59.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4714
    Cell Significance Index: 84.9800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4367
    Cell Significance Index: 9.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4357
    Cell Significance Index: 16.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4185
    Cell Significance Index: 18.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4128
    Cell Significance Index: 225.4200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3588
    Cell Significance Index: 5.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3473
    Cell Significance Index: 68.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3287
    Cell Significance Index: 227.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3217
    Cell Significance Index: 6.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3155
    Cell Significance Index: 2.9100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2889
    Cell Significance Index: 4.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2755
    Cell Significance Index: 7.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2635
    Cell Significance Index: 15.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2559
    Cell Significance Index: 17.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2266
    Cell Significance Index: 43.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1777
    Cell Significance Index: 80.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1263
    Cell Significance Index: 16.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1251
    Cell Significance Index: 235.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1225
    Cell Significance Index: 77.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1090
    Cell Significance Index: 7.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0982
    Cell Significance Index: 43.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0757
    Cell Significance Index: 2.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0745
    Cell Significance Index: 5.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0739
    Cell Significance Index: 113.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0504
    Cell Significance Index: 92.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0183
    Cell Significance Index: 24.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0157
    Cell Significance Index: 14.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0072
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0130
    Cell Significance Index: -9.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0140
    Cell Significance Index: -2.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0172
    Cell Significance Index: -9.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0238
    Cell Significance Index: -18.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0248
    Cell Significance Index: -0.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0317
    Cell Significance Index: -23.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0395
    Cell Significance Index: -7.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0609
    Cell Significance Index: -10.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0650
    Cell Significance Index: -13.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0780
    Cell Significance Index: -10.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0781
    Cell Significance Index: -22.4600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0810
    Cell Significance Index: -1.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0863
    Cell Significance Index: -3.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1098
    Cell Significance Index: -11.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1166
    Cell Significance Index: -3.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1279
    Cell Significance Index: -13.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1294
    Cell Significance Index: -14.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1364
    Cell Significance Index: -7.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1573
    Cell Significance Index: -4.4900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1925
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1984
    Cell Significance Index: -22.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2017
    Cell Significance Index: -6.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2033
    Cell Significance Index: -26.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2071
    Cell Significance Index: -4.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2346
    Cell Significance Index: -10.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2360
    Cell Significance Index: -5.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2372
    Cell Significance Index: -27.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2493
    Cell Significance Index: -3.6800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2686
    Cell Significance Index: -2.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2714
    Cell Significance Index: -1.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3162
    Cell Significance Index: -25.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3495
    Cell Significance Index: -21.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3544
    Cell Significance Index: -5.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3610
    Cell Significance Index: -22.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3752
    Cell Significance Index: -27.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3905
    Cell Significance Index: -18.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4390
    Cell Significance Index: -28.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4528
    Cell Significance Index: -23.7800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4599
    Cell Significance Index: -6.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4644
    Cell Significance Index: -26.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4795
    Cell Significance Index: -29.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4896
    Cell Significance Index: -8.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5016
    Cell Significance Index: -25.3500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5257
    Cell Significance Index: -9.2900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5467
    Cell Significance Index: -7.0100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.5503
    Cell Significance Index: -6.9300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5634
    Cell Significance Index: -8.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5663
    Cell Significance Index: -20.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6353
    Cell Significance Index: -12.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7023
    Cell Significance Index: -24.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Pirin is a 58-kDa protein that exhibits a unique structural composition, comprising three immunoglobulin-like domains and a C-terminal domain rich in proline and arginine residues. This unique structure allows Pirin to interact with a wide range of cellular partners, including transcription factors, signaling molecules, and other proteins. Notably, Pirin's ability to bind to various metal ions, such as zinc and calcium, is essential for its function in regulating immune responses. **Pathways and Functions:** Pirin's involvement in multiple cellular pathways underscores its significance in maintaining tissue homeostasis and immune regulation. Some of the key pathways and functions associated with Pirin include: 1. **Immune regulation:** Pirin interacts with various immune cells, including T-helper 17 cells, to modulate immune responses and prevent excessive inflammation. 2. **Monocyte differentiation:** Pirin plays a crucial role in the differentiation of monocytes into macrophages, a process essential for the clearance of pathogens and the maintenance of tissue homeostasis. 3. **Transcriptional regulation:** Pirin acts as a transcriptional coregulator, influencing the expression of genes involved in immune responses, cell differentiation, and tissue development. 4. **Cell signaling:** Pirin interacts with signaling molecules, such as NF-κB, to regulate the activation of immune cells and the production of pro-inflammatory cytokines. **Clinical Significance:** Pirin's dysregulation has been implicated in various diseases, including autoimmune disorders, inflammatory bowel disease, and cancer. Some of the clinical implications of Pirin's dysfunction include: 1. **Autoimmune diseases:** Alterations in Pirin expression or function have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, characterized by excessive immune activation and tissue damage. 2. **Inflammatory bowel disease:** Dysregulation of Pirin has been implicated in the pathogenesis of inflammatory bowel disease, including Crohn's disease and ulcerative colitis, through its impact on immune cell function and tissue homeostasis. 3. **Cancer:** Pirin's role in regulating immune responses and cell differentiation makes it a potential target for cancer therapy, particularly in the context of immunotherapies aimed at enhancing anti-tumor immune responses. In conclusion, Pirin is a complex protein with far-reaching implications in immune regulation, cell differentiation, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying Pirin's function and its potential therapeutic applications.

Genular Protein ID: 2634569938

Symbol: PIR_HUMAN

Name: Pirin

UniProtKB Accession Codes:

O00625 Q5U0G0 Q6FHD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9079676

Title: Identification of pirin, a novel highly conserved nuclear protein.

PubMed ID: 9079676

DOI: 10.1074/jbc.272.13.8482

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10362352

Title: The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.

PubMed ID: 10362352

DOI: 10.1038/sj.onc.1202717

PubMed ID: 15951572

Title: Structural and biochemical analysis reveal pirins to possess quercetinase activity.

PubMed ID: 15951572

DOI: 10.1074/jbc.m501034200

PubMed ID: 17288615

Title: Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis.

PubMed ID: 17288615

DOI: 10.1186/1465-9921-8-10

PubMed ID: 20089166

Title: Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches.

PubMed ID: 20089166

DOI: 10.1186/1471-2121-11-5

PubMed ID: 19766747

Title: Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese.

PubMed ID: 19766747

DOI: 10.1016/j.bone.2009.09.012

PubMed ID: 20010624

Title: Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation.

PubMed ID: 20010624

DOI: 10.1038/leu.2009.247

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 14573596

Title: Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor.

PubMed ID: 14573596

DOI: 10.1074/jbc.m310022200

PubMed ID: 20711196

Title: A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.

PubMed ID: 20711196

DOI: 10.1038/nchembio.423

PubMed ID: 23716661

Title: Pirin is an iron-dependent redox regulator of NF-kappaB.

PubMed ID: 23716661

DOI: 10.1073/pnas.1221743110

Sequence Information:

  • Length: 290
  • Mass: 32113
  • Checksum: D06AC100F356496D
  • Sequence:
    • MGSSKKVTLS VLSREQSEGV GARVRRSIGR PELKNLDPFL LFDEFKGGRP GGFPDHPHRG 
FETVSYLLEG GSMAHEDFCG HTGKMNPGDL QWMTAGRGIL HAEMPCSEEP AHGLQLWVNL 
RSSEKMVEPQ YQELKSEEIP KPSKDGVTVA VISGEALGIK SKVYTRTPTL YLDFKLDPGA 
KHSQPIPKGW TSFIYTISGD VYIGPDDAQQ KIEPHHTAVL GEGDSVQVEN KDPKRSHFVL 
IAGEPLREPV IQHGPFVMNT NEEISQAILD FRNAKNGFER AKTWKSKIGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.