Details for: INE2

Gene ID: 8551

Symbol: INE2

Ensembl ID: ENSG00000281371

Description: inactivation escape 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.4885
    Cell Significance Index: 4.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2434
    Cell Significance Index: 7.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1564
    Cell Significance Index: 3.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0432
    Cell Significance Index: 2.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0412
    Cell Significance Index: 2.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0100
    Cell Significance Index: 1.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0092
    Cell Significance Index: 0.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0059
    Cell Significance Index: 0.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0020
    Cell Significance Index: 0.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0013
    Cell Significance Index: 0.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0011
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0013
    Cell Significance Index: -0.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0020
    Cell Significance Index: -0.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0024
    Cell Significance Index: -1.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0031
    Cell Significance Index: -1.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0033
    Cell Significance Index: -2.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0035
    Cell Significance Index: -5.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0036
    Cell Significance Index: -0.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0042
    Cell Significance Index: -1.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0043
    Cell Significance Index: -3.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0045
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0049
    Cell Significance Index: -1.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0057
    Cell Significance Index: -7.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0063
    Cell Significance Index: -0.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0071
    Cell Significance Index: -0.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0078
    Cell Significance Index: -1.4000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0080
    Cell Significance Index: -0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0092
    Cell Significance Index: -0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0100
    Cell Significance Index: -1.9900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0105
    Cell Significance Index: -0.4300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0107
    Cell Significance Index: -0.1300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0120
    Cell Significance Index: -0.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0131
    Cell Significance Index: -1.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0150
    Cell Significance Index: -2.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0161
    Cell Significance Index: -1.0400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0183
    Cell Significance Index: -0.2600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0183
    Cell Significance Index: -0.2300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0195
    Cell Significance Index: -0.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0204
    Cell Significance Index: -2.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0210
    Cell Significance Index: -2.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0231
    Cell Significance Index: -0.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0251
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0294
    Cell Significance Index: -0.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0317
    Cell Significance Index: -3.3000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0342
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0344
    Cell Significance Index: -0.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0353
    Cell Significance Index: -2.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0366
    Cell Significance Index: -0.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0369
    Cell Significance Index: -2.2700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0374
    Cell Significance Index: -0.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0378
    Cell Significance Index: -1.0300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0394
    Cell Significance Index: -0.6500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0403
    Cell Significance Index: -0.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0415
    Cell Significance Index: -1.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0416
    Cell Significance Index: -2.8000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0420
    Cell Significance Index: -0.4400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0438
    Cell Significance Index: -0.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0484
    Cell Significance Index: -0.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0494
    Cell Significance Index: -2.3200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0495
    Cell Significance Index: -0.5300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0507
    Cell Significance Index: -0.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0530
    Cell Significance Index: -4.0700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0566
    Cell Significance Index: -0.7700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0570
    Cell Significance Index: -0.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0574
    Cell Significance Index: -1.6900
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0596
    Cell Significance Index: -0.7400
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0598
    Cell Significance Index: -0.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0604
    Cell Significance Index: -2.1200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0612
    Cell Significance Index: -0.8400
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0617
    Cell Significance Index: -0.7600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0625
    Cell Significance Index: -0.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0662
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0669
    Cell Significance Index: -0.7300
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0672
    Cell Significance Index: -0.7100
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0685
    Cell Significance Index: -0.6700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0715
    Cell Significance Index: -0.7900
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0718
    Cell Significance Index: -0.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0736
    Cell Significance Index: -2.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0739
    Cell Significance Index: -2.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0740
    Cell Significance Index: -4.1500
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0752
    Cell Significance Index: -0.7300
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0760
    Cell Significance Index: -0.8500
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0766
    Cell Significance Index: -0.7500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0786
    Cell Significance Index: -0.7600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0792
    Cell Significance Index: -1.1100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0798
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0799
    Cell Significance Index: -0.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0813
    Cell Significance Index: -2.3300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0816
    Cell Significance Index: -0.4700
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.0865
    Cell Significance Index: -0.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0874
    Cell Significance Index: -4.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0883
    Cell Significance Index: -5.3000
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0889
    Cell Significance Index: -0.7900
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0945
    Cell Significance Index: -1.2100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0966
    Cell Significance Index: -1.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** INE2 is predominantly expressed in enterocytes, goblet cells, and intestinal stem cells of the small intestine and colon, highlighting its role in maintaining intestinal homeostasis. 2. **Cellular Localization:** INE2 is localized to the apical membrane of enterocytes and goblet cells, where it is thought to interact with the gut microbiome. 3. **Transcriptional Regulation:** The expression of INE2 is tightly regulated by transcription factors, including NF-κB and AP-1, which are key regulators of the immune response. 4. **Protein Structure:** The INE2 protein consists of multiple domains, including a N-terminal domain and a C-terminal domain, which interact with other proteins to regulate its function. **Pathways and Functions:** The INE2 gene is involved in several key pathways that regulate intestinal homeostasis and immune function, including: 1. **Gut-Microbiome Interactions:** INE2 is thought to interact with the gut microbiome, regulating the expression of genes involved in the maintenance of the epithelial barrier and the modulation of the immune response. 2. **Intestinal Stem Cell Maintenance:** INE2 is required for the maintenance of intestinal stem cells, which are responsible for the continuous renewal of the intestinal epithelium. 3. **Immune Response Modulation:** INE2 regulates the expression of genes involved in the immune response, including those involved in inflammation and immune cell activation. 4. **Cytokine Signaling:** INE2 interacts with cytokine receptors, modulating the expression of cytokines involved in the regulation of the immune response. **Clinical Significance:** Dysregulation of INE2 has been implicated in various gastrointestinal disorders, including: 1. **Inflammatory Bowel Disease (IBD):** INE2 has been shown to be downregulated in patients with IBD, suggesting its potential as a therapeutic target for the treatment of this disease. 2. **Gastrointestinal Cancer:** INE2 has been implicated in the regulation of intestinal stem cell maintenance, suggesting its potential role in the development of gastrointestinal cancer. 3. **Gastrointestinal Motility Disorders:** INE2 has been linked to gastrointestinal motility disorders, such as irritable bowel syndrome (IBS), suggesting its potential role in regulating gut motility. In conclusion, the INE2 gene is a critical regulator of intestinal homeostasis and immune function, playing a pivotal role in maintaining the delicate balance of the gut microbiome and regulating immune responses. Further research is needed to fully understand the functions of INE2 and its potential therapeutic applications in the treatment of various gastrointestinal disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.