Details for: BHLHE40

Gene ID: 8553

Symbol: BHLHE40

Ensembl ID: ENSG00000134107

Description: basic helix-loop-helix family member e40

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 290.7193
    Cell Significance Index: -45.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 168.4254
    Cell Significance Index: -42.7200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 118.0490
    Cell Significance Index: -48.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 70.7279
    Cell Significance Index: -47.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.7085
    Cell Significance Index: -45.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.8724
    Cell Significance Index: -42.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4925
    Cell Significance Index: -45.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.4072
    Cell Significance Index: -18.4000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.3946
    Cell Significance Index: 27.0500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.3276
    Cell Significance Index: 20.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.0858
    Cell Significance Index: 160.3000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.3662
    Cell Significance Index: 9.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.3127
    Cell Significance Index: 66.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8972
    Cell Significance Index: 51.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7700
    Cell Significance Index: 131.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.7628
    Cell Significance Index: 51.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6331
    Cell Significance Index: 45.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.3407
    Cell Significance Index: 2524.3900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.3386
    Cell Significance Index: 23.6600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.0779
    Cell Significance Index: 2.4300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.8929
    Cell Significance Index: 21.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8104
    Cell Significance Index: 38.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8008
    Cell Significance Index: 14.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7773
    Cell Significance Index: 701.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.7280
    Cell Significance Index: 1120.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6716
    Cell Significance Index: 19.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6046
    Cell Significance Index: 65.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6035
    Cell Significance Index: 121.0600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6021
    Cell Significance Index: 8.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.5899
    Cell Significance Index: 1087.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5382
    Cell Significance Index: 14.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5227
    Cell Significance Index: 85.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5203
    Cell Significance Index: 230.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5172
    Cell Significance Index: 11.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4737
    Cell Significance Index: 258.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4334
    Cell Significance Index: 275.2600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3814
    Cell Significance Index: 6.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3592
    Cell Significance Index: 16.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3306
    Cell Significance Index: 19.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2805
    Cell Significance Index: 38.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2372
    Cell Significance Index: 107.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2362
    Cell Significance Index: 16.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2360
    Cell Significance Index: 30.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2227
    Cell Significance Index: 27.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.2223
    Cell Significance Index: 23.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2176
    Cell Significance Index: 5.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2152
    Cell Significance Index: 292.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1763
    Cell Significance Index: 8.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1663
    Cell Significance Index: 29.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1636
    Cell Significance Index: 31.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1164
    Cell Significance Index: 4.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1122
    Cell Significance Index: 14.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1055
    Cell Significance Index: 18.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1045
    Cell Significance Index: 10.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0582
    Cell Significance Index: 1.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0530
    Cell Significance Index: 40.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0321
    Cell Significance Index: 6.3800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0281
    Cell Significance Index: 0.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0219
    Cell Significance Index: 2.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0156
    Cell Significance Index: 0.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0092
    Cell Significance Index: 0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0160
    Cell Significance Index: -10.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0220
    Cell Significance Index: -2.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0227
    Cell Significance Index: -16.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0429
    Cell Significance Index: -29.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0504
    Cell Significance Index: -2.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0530
    Cell Significance Index: -29.9100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0688
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0881
    Cell Significance Index: -18.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0991
    Cell Significance Index: -35.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1041
    Cell Significance Index: -1.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1086
    Cell Significance Index: -15.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1188
    Cell Significance Index: -34.1700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1228
    Cell Significance Index: -1.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1509
    Cell Significance Index: -1.3900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1532
    Cell Significance Index: -2.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1654
    Cell Significance Index: -12.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1866
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2033
    Cell Significance Index: -23.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2284
    Cell Significance Index: -9.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2333
    Cell Significance Index: -4.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2546
    Cell Significance Index: -29.6700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2750
    Cell Significance Index: -2.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2763
    Cell Significance Index: -19.5400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3112
    Cell Significance Index: -4.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3148
    Cell Significance Index: -19.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3226
    Cell Significance Index: -6.8700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3327
    Cell Significance Index: -4.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3344
    Cell Significance Index: -39.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5133
    Cell Significance Index: -40.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5151
    Cell Significance Index: -33.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5579
    Cell Significance Index: -17.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6675
    Cell Significance Index: -44.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6716
    Cell Significance Index: -29.7100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.7066
    Cell Significance Index: -9.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7512
    Cell Significance Index: -46.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7622
    Cell Significance Index: -48.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7922
    Cell Significance Index: -11.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7950
    Cell Significance Index: -8.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BHLHE40 is a member of the basic helix-loop-helix (bHLH) family of transcription factors, which are known for their role in regulating gene expression. This particular bHLH protein contains a unique E-box binding motif, which allows it to interact with other transcription factors to regulate gene expression. BHLHE40 is also known to interact with other proteins, such as Bmal1 and MRF, to form heterodimers that regulate circadian gene expression. **Pathways and Functions:** BHLHE40 is involved in several key pathways, including: 1. **Circadian Rhythm Regulation:** BHLHE40 plays a crucial role in regulating the circadian rhythm by interacting with other transcription factors to regulate the expression of genes involved in this process. 2. **Anterior/Posterior Pattern Specification:** BHLHE40 is involved in regulating the specification of anterior and posterior tissues during embryonic development. 3. **Neurogenesis:** BHLHE40 is also involved in regulating neurogenesis, the process by which new neurons are generated in the brain. 4. **DNA-Binding Transcription Factor Activity:** BHLHE40 has been shown to interact with other transcription factors to regulate gene expression, including the regulation of transcription by RNA polymerase II. **Clinical Significance:** BHLHE40 has been implicated in several diseases, including: 1. **Circadian Rhythm Disorders:** Dysregulation of the circadian rhythm has been linked to various diseases, including insomnia, depression, and metabolic disorders. BHLHE40 may play a role in these disorders by regulating the expression of genes involved in the circadian rhythm. 2. **Cancer:** BHLHE40 has been shown to be involved in regulating the expression of genes involved in cancer, including the regulation of neurogenesis and the suppression of tumor growth. 3. **Neurological Disorders:** BHLHE40 may also play a role in regulating neurogenesis and the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, BHLHE40 is a complex transcription factor that plays a crucial role in regulating the circadian rhythm, as well as other cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of BHLHE40 in human health and disease. **Recommendations for Further Research:** 1. **Investigate the role of BHLHE40 in circadian rhythm disorders:** Further research is needed to understand the role of BHLHE40 in regulating the circadian rhythm and its potential involvement in circadian rhythm disorders. 2. **Explore the therapeutic potential of BHLHE40:** BHLHE40 may have therapeutic potential in treating diseases related to its dysregulation, including circadian rhythm disorders and cancer. 3. **Investigate the interaction between BHLHE40 and other transcription factors:** Further research is needed to understand the interaction between BHLHE40 and other transcription factors to fully elucidate its role in regulating gene expression. By continuing to investigate the role of BHLHE40 in regulating the circadian rhythm and other cellular processes, we can gain a deeper understanding of this complex transcription factor and its potential therapeutic applications.

Genular Protein ID: 4191221606

Symbol: BHE40_HUMAN

Name: Class E basic helix-loop-helix protein 40

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9240428

Title: Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes.

PubMed ID: 9240428

DOI: 10.1006/bbrc.1997.6960

PubMed ID: 11226878

Title: Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2.

PubMed ID: 11226878

DOI: 10.1093/oxfordjournals.jbchem.a002869

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11278694

Title: Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway.

PubMed ID: 11278694

DOI: 10.1074/jbc.m010516200

PubMed ID: 12397359

Title: Dec1 and Dec2 are regulators of the mammalian molecular clock.

PubMed ID: 12397359

DOI: 10.1038/nature01123

PubMed ID: 14672706

Title: A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.

PubMed ID: 14672706

DOI: 10.1016/j.bbrc.2003.11.099

PubMed ID: 15193144

Title: DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1.

PubMed ID: 15193144

DOI: 10.1042/bj20040592

PubMed ID: 15560782

Title: Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1.

PubMed ID: 15560782

DOI: 10.1111/j.1432-1033.2004.04379.x

PubMed ID: 18411297

Title: DEC1 modulates the circadian phase of clock gene expression.

PubMed ID: 18411297

DOI: 10.1128/mcb.02168-07

PubMed ID: 19786558

Title: The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.

PubMed ID: 19786558

DOI: 10.1124/mol.109.057000

PubMed ID: 21829689

Title: SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.

PubMed ID: 21829689

DOI: 10.1371/journal.pone.0023046

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28797635

Title: Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP).

PubMed ID: 28797635

DOI: 10.1016/j.abb.2017.08.004

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30012868

Title: Dec1 and CLOCK regulate Na+/K+-ATPase beta1 subunit expression and blood pressure.

PubMed ID: 30012868

DOI: 10.1161/hypertensionaha.118.11075

Sequence Information:

  • Length: 412
  • Mass: 45510
  • Checksum: 2D73A3D4980793E5
  • Sequence:
  • MERIPSAQPP PACLPKAPGL EHGDLPGMYP AHMYQVYKSR RGIKRSEDSK ETYKLPHRLI 
    EKKRRDRINE CIAQLKDLLP EHLKLTTLGH LEKAVVLELT LKHVKALTNL IDQQQQKIIA 
    LQSGLQAGEL SGRNVETGQE MFCSGFQTCA REVLQYLAKH ENTRDLKSSQ LVTHLHRVVS 
    ELLQGGTSRK PSDPAPKVMD FKEKPSSPAK GSEGPGKNCV PVIQRTFAHS SGEQSGSDTD 
    TDSGYGGESE KGDLRSEQPC FKSDHGRRFT MGERIGAIKQ ESEEPPTKKN RMQLSDDEGH 
    FTSSDLISSP FLGPHPHQPP FCLPFYLIPP SATAYLPMLE KCWYPTSVPV LYPGLNASAA 
    ALSSFMNPDK ISAPLLMPQR LPSPLPAHPS VDSSVLLQAL KPIPPLNLET KD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.