Details for: BHLHE40
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 290.7193
Cell Significance Index: -45.2200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 168.4254
Cell Significance Index: -42.7200 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 118.0490
Cell Significance Index: -48.6300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 70.7279
Cell Significance Index: -47.4600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 36.7085
Cell Significance Index: -45.2600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.8724
Cell Significance Index: -42.5200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.4925
Cell Significance Index: -45.3500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.4072
Cell Significance Index: -18.4000 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 4.3946
Cell Significance Index: 27.0500 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 3.3276
Cell Significance Index: 20.5300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 3.0858
Cell Significance Index: 160.3000 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 2.3662
Cell Significance Index: 9.0600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.3127
Cell Significance Index: 66.3000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.8972
Cell Significance Index: 51.6400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.7700
Cell Significance Index: 131.9200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.7628
Cell Significance Index: 51.7700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6331
Cell Significance Index: 45.6400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.3407
Cell Significance Index: 2524.3900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.3386
Cell Significance Index: 23.6600 - Cell Name: epidermal cell (CL0000362)
Fold Change: 1.0779
Cell Significance Index: 2.4300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.8929
Cell Significance Index: 21.7900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8104
Cell Significance Index: 38.0900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.8008
Cell Significance Index: 14.8000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7773
Cell Significance Index: 701.8400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.7280
Cell Significance Index: 1120.7700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6716
Cell Significance Index: 19.3500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6046
Cell Significance Index: 65.7600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6035
Cell Significance Index: 121.0600 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.6021
Cell Significance Index: 8.6600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.5899
Cell Significance Index: 1087.8700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5382
Cell Significance Index: 14.3700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5227
Cell Significance Index: 85.0200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5203
Cell Significance Index: 230.0300 - Cell Name: peg cell (CL4033014)
Fold Change: 0.5172
Cell Significance Index: 11.9500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4737
Cell Significance Index: 258.7200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.4334
Cell Significance Index: 275.2600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.3814
Cell Significance Index: 6.4300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3592
Cell Significance Index: 16.2800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3306
Cell Significance Index: 19.8500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2805
Cell Significance Index: 38.5200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2372
Cell Significance Index: 107.6600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2362
Cell Significance Index: 16.3400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.2360
Cell Significance Index: 30.4900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2227
Cell Significance Index: 27.3900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.2223
Cell Significance Index: 23.1500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2176
Cell Significance Index: 5.8200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2152
Cell Significance Index: 292.6100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1763
Cell Significance Index: 8.2200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1663
Cell Significance Index: 29.9800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1636
Cell Significance Index: 31.1400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1164
Cell Significance Index: 4.0900 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1122
Cell Significance Index: 14.3800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1055
Cell Significance Index: 18.0100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1045
Cell Significance Index: 10.3400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0582
Cell Significance Index: 1.2600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0530
Cell Significance Index: 40.1500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0321
Cell Significance Index: 6.3800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0281
Cell Significance Index: 0.1700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0219
Cell Significance Index: 2.5000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0156
Cell Significance Index: 0.8200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0092
Cell Significance Index: 0.2300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0040
Cell Significance Index: -2.9300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0160
Cell Significance Index: -10.0100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0220
Cell Significance Index: -2.2500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0227
Cell Significance Index: -16.6100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0429
Cell Significance Index: -29.6700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0504
Cell Significance Index: -2.5500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0530
Cell Significance Index: -29.9100 - Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.0688
Cell Significance Index: -1.1100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0881
Cell Significance Index: -18.5500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0991
Cell Significance Index: -35.5300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1041
Cell Significance Index: -1.4200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1086
Cell Significance Index: -15.7800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1188
Cell Significance Index: -34.1700 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.1228
Cell Significance Index: -1.0900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1509
Cell Significance Index: -1.3900 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1532
Cell Significance Index: -2.3700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1654
Cell Significance Index: -12.6900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1866
Cell Significance Index: -2.1200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2033
Cell Significance Index: -23.3000 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2284
Cell Significance Index: -9.3600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2333
Cell Significance Index: -4.8400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2546
Cell Significance Index: -29.6700 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.2750
Cell Significance Index: -2.1200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2763
Cell Significance Index: -19.5400 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.3112
Cell Significance Index: -4.4300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3148
Cell Significance Index: -19.3000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3226
Cell Significance Index: -6.8700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3327
Cell Significance Index: -4.9100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3344
Cell Significance Index: -39.4400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5133
Cell Significance Index: -40.6600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5151
Cell Significance Index: -33.2300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5579
Cell Significance Index: -17.8700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6675
Cell Significance Index: -44.8900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6716
Cell Significance Index: -29.7100 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.7066
Cell Significance Index: -9.1000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.7512
Cell Significance Index: -46.1700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7622
Cell Significance Index: -48.0400 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.7922
Cell Significance Index: -11.8700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.7950
Cell Significance Index: -8.2300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4191221606
Symbol: BHE40_HUMAN
Name: Class E basic helix-loop-helix protein 40
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9240428
Title: Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes.
PubMed ID: 9240428
PubMed ID: 11226878
Title: Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2.
PubMed ID: 11226878
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11278694
Title: Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway.
PubMed ID: 11278694
PubMed ID: 12397359
Title: Dec1 and Dec2 are regulators of the mammalian molecular clock.
PubMed ID: 12397359
DOI: 10.1038/nature01123
PubMed ID: 14672706
Title: A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.
PubMed ID: 14672706
PubMed ID: 15193144
Title: DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1.
PubMed ID: 15193144
DOI: 10.1042/bj20040592
PubMed ID: 15560782
Title: Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1.
PubMed ID: 15560782
PubMed ID: 18411297
Title: DEC1 modulates the circadian phase of clock gene expression.
PubMed ID: 18411297
DOI: 10.1128/mcb.02168-07
PubMed ID: 19786558
Title: The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.
PubMed ID: 19786558
PubMed ID: 21829689
Title: SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.
PubMed ID: 21829689
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28797635
Title: Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP).
PubMed ID: 28797635
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30012868
Title: Dec1 and CLOCK regulate Na+/K+-ATPase beta1 subunit expression and blood pressure.
PubMed ID: 30012868
Sequence Information:
- Length: 412
- Mass: 45510
- Checksum: 2D73A3D4980793E5
- Sequence:
MERIPSAQPP PACLPKAPGL EHGDLPGMYP AHMYQVYKSR RGIKRSEDSK ETYKLPHRLI EKKRRDRINE CIAQLKDLLP EHLKLTTLGH LEKAVVLELT LKHVKALTNL IDQQQQKIIA LQSGLQAGEL SGRNVETGQE MFCSGFQTCA REVLQYLAKH ENTRDLKSSQ LVTHLHRVVS ELLQGGTSRK PSDPAPKVMD FKEKPSSPAK GSEGPGKNCV PVIQRTFAHS SGEQSGSDTD TDSGYGGESE KGDLRSEQPC FKSDHGRRFT MGERIGAIKQ ESEEPPTKKN RMQLSDDEGH FTSSDLISSP FLGPHPHQPP FCLPFYLIPP SATAYLPMLE KCWYPTSVPV LYPGLNASAA ALSSFMNPDK ISAPLLMPQR LPSPLPAHPS VDSSVLLQAL KPIPPLNLET KD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.