Details for: PRPF18

Gene ID: 8559

Symbol: PRPF18

Ensembl ID: ENSG00000165630

Description: pre-mRNA processing factor 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 138.9307
    Cell Significance Index: -21.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 88.3721
    Cell Significance Index: -22.4200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 63.0177
    Cell Significance Index: -25.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.5242
    Cell Significance Index: -25.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.3560
    Cell Significance Index: -21.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.6491
    Cell Significance Index: -24.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 37.7037
    Cell Significance Index: -25.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.4825
    Cell Significance Index: -21.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.9926
    Cell Significance Index: -24.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5368
    Cell Significance Index: -20.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2083
    Cell Significance Index: -22.1400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7235
    Cell Significance Index: -14.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5534
    Cell Significance Index: -25.8600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 6.3576
    Cell Significance Index: 104.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.1825
    Cell Significance Index: 150.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1231
    Cell Significance Index: 130.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0866
    Cell Significance Index: 14.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0546
    Cell Significance Index: 211.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8369
    Cell Significance Index: 136.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7721
    Cell Significance Index: 22.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7667
    Cell Significance Index: 220.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6219
    Cell Significance Index: 76.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5746
    Cell Significance Index: 15.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5216
    Cell Significance Index: 19.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5211
    Cell Significance Index: 93.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4727
    Cell Significance Index: 20.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4725
    Cell Significance Index: 93.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4580
    Cell Significance Index: 20.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4427
    Cell Significance Index: 24.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4412
    Cell Significance Index: 11.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4264
    Cell Significance Index: 152.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4197
    Cell Significance Index: 21.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4086
    Cell Significance Index: 6.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3987
    Cell Significance Index: 176.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3831
    Cell Significance Index: 8.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3548
    Cell Significance Index: 48.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3542
    Cell Significance Index: 16.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3497
    Cell Significance Index: 22.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3344
    Cell Significance Index: 182.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3147
    Cell Significance Index: 8.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2711
    Cell Significance Index: 12.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2397
    Cell Significance Index: 30.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2252
    Cell Significance Index: 17.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2009
    Cell Significance Index: 12.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1962
    Cell Significance Index: 23.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1926
    Cell Significance Index: 11.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1798
    Cell Significance Index: 17.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1751
    Cell Significance Index: 158.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1689
    Cell Significance Index: 4.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1632
    Cell Significance Index: 11.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1626
    Cell Significance Index: 12.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1250
    Cell Significance Index: 21.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1109
    Cell Significance Index: 5.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1107
    Cell Significance Index: 21.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0909
    Cell Significance Index: 11.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0902
    Cell Significance Index: 10.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0749
    Cell Significance Index: 0.6900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0579
    Cell Significance Index: 0.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0178
    Cell Significance Index: 0.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0011
    Cell Significance Index: -1.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0071
    Cell Significance Index: -9.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0126
    Cell Significance Index: -9.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0144
    Cell Significance Index: -9.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0153
    Cell Significance Index: -11.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0167
    Cell Significance Index: -10.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0220
    Cell Significance Index: -12.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0230
    Cell Significance Index: -10.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0276
    Cell Significance Index: -0.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0284
    Cell Significance Index: -0.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0449
    Cell Significance Index: -6.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0481
    Cell Significance Index: -4.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0494
    Cell Significance Index: -2.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0609
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0618
    Cell Significance Index: -13.0100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0688
    Cell Significance Index: -0.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0834
    Cell Significance Index: -2.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1044
    Cell Significance Index: -3.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1071
    Cell Significance Index: -7.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1476
    Cell Significance Index: -2.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1553
    Cell Significance Index: -4.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1574
    Cell Significance Index: -17.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1750
    Cell Significance Index: -6.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1863
    Cell Significance Index: -3.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1864
    Cell Significance Index: -4.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1973
    Cell Significance Index: -4.3200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2160
    Cell Significance Index: -3.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2265
    Cell Significance Index: -11.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2363
    Cell Significance Index: -6.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2420
    Cell Significance Index: -25.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2568
    Cell Significance Index: -20.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2653
    Cell Significance Index: -6.9700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2685
    Cell Significance Index: -3.3300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2833
    Cell Significance Index: -2.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3033
    Cell Significance Index: -3.1400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3466
    Cell Significance Index: -2.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3570
    Cell Significance Index: -7.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3950
    Cell Significance Index: -11.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRPF18 is a member of the pre-mRNA splicing factor family, which is responsible for the removal of introns and the joining of exons during RNA processing. The protein is characterized by its high degree of sequence conservation across species, suggesting its essential role in the spliceosome machinery. PRPF18 is specifically associated with the U2-type post-spliceosomal complex, a subset of the spliceosome complex that is involved in the final stages of pre-mRNA processing. The protein's ability to interact with other spliceosomal components and RNA molecules underscores its central role in regulating the splicing process. **Pathways and Functions:** PRPF18 is integral to the generation of catalytic spliceosomes, which are essential for the second transesterification step in the splicing reaction. This step involves the formation of the phosphodiester bond between the 5' splice site and the 3' splice site, resulting in the mature mRNA. PRPF18's involvement in this process highlights its importance in regulating the accuracy and efficiency of pre-mRNA splicing. Additionally, PRPF18 is implicated in various other cellular pathways, including metabolism of RNA, nuclear speck formation, and protein binding. Its role in these processes underscores its broader impact on cellular function and regulation. **Clinical Significance:** While PRPF18's role in pre-mRNA splicing is well-established, its clinical significance remains poorly understood. However, alterations in PRPF18 expression or function have been implicated in various neurological disorders, including schizophrenia, autism spectrum disorder, and frontotemporal dementia. These conditions often involve disruptions in pre-mRNA splicing, which can lead to aberrant protein expression and cellular dysfunction. Furthermore, PRPF18 has been identified as a potential therapeutic target in the treatment of these disorders, highlighting the need for further research into its mechanisms and clinical applications. Significantly expressed cells including germ cell, L2/3-6 intratelencephalic projecting glutamatergic neuron, corticothalamic-projecting glutamatergic cortical neuron, L5 extratelencephalic projecting glutamatergic cortical neuron, L6b glutamatergic cortical neuron, pvalb GABAergic cortical interneuron, choroid plexus epithelial cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, absorptive cell, suggest its involvement in neurological functions and development. In conclusion, PRPF18 is a crucial component of the pre-mRNA splicing machinery, playing a pivotal role in regulating the accuracy and efficiency of RNA processing. While its clinical significance remains poorly understood, alterations in PRPF18 expression or function have been implicated in various neurological disorders. Further research into the mechanisms and clinical applications of PRPF18 is necessary to fully elucidate its role in human health and disease.

Genular Protein ID: 1076702080

Symbol: PRP18_HUMAN

Name: Pre-mRNA-splicing factor 18

UniProtKB Accession Codes:

Q99633 Q5T9P9 Q9BUI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9000057

Title: A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor.

PubMed ID: 9000057

DOI: 10.1101/gad.11.1.139

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11823439

Title: A cyclophilin functions in pre-mRNA splicing.

PubMed ID: 11823439

DOI: 10.1093/emboj/21.3.470

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 342
  • Mass: 39860
  • Checksum: 269D79E1E733CF6D
  • Sequence:
    • MDILKSEILR KRQLVEDRNL LVENKKYFKR SELAKKEEEA YFERCGYKIQ PKEEDQKPLT 
SSNPVLELEL AEEKLPMTLS RQEVIRRLRE RGEPIRLFGE TDYDAFQRLR KIEILTPEVN 
KGLRNDLKAA LDKIDQQYLN EIVGGQEPGE EDTQNDLKVH EENTTIEELE ALGESLGKGD 
DHKDMDIITK FLKFLLGVWA KELNAREDYV KRSVQGKLNS ATQKQTESYL RPLFRKLRKR 
NLPADIKESI TDIIKFMLQR EYVKANDAYL QMAIGNAPWP IGVTMVGIHA RTGREKIFSK 
HVAHVLNDET QRKYIQGLKR LMTICQKHFP TDPSKCVEYN AL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.