Details for: AKR7A2

Gene ID: 8574

Symbol: AKR7A2

Ensembl ID: ENSG00000053371

Description: aldo-keto reductase family 7 member A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 207.5281
    Cell Significance Index: -32.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.6706
    Cell Significance Index: -30.1000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 88.1666
    Cell Significance Index: -36.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.5432
    Cell Significance Index: -33.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.4876
    Cell Significance Index: -38.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 72.9026
    Cell Significance Index: -37.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 57.4348
    Cell Significance Index: -38.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.6850
    Cell Significance Index: -34.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.7983
    Cell Significance Index: -36.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5817
    Cell Significance Index: -37.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8582
    Cell Significance Index: -23.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.5757
    Cell Significance Index: -26.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7731
    Cell Significance Index: 968.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6363
    Cell Significance Index: 34.2500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.5429
    Cell Significance Index: 19.7600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.5191
    Cell Significance Index: 12.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5184
    Cell Significance Index: 70.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5000
    Cell Significance Index: 52.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4994
    Cell Significance Index: 16.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4272
    Cell Significance Index: 13.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2684
    Cell Significance Index: 174.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2191
    Cell Significance Index: 149.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1789
    Cell Significance Index: 61.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1595
    Cell Significance Index: 86.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1242
    Cell Significance Index: 30.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1172
    Cell Significance Index: 16.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0852
    Cell Significance Index: 75.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0751
    Cell Significance Index: 48.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0474
    Cell Significance Index: 14.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0352
    Cell Significance Index: 66.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0316
    Cell Significance Index: 22.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8527
    Cell Significance Index: 19.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8426
    Cell Significance Index: 22.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8098
    Cell Significance Index: 95.5000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8041
    Cell Significance Index: 6.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7936
    Cell Significance Index: 143.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6248
    Cell Significance Index: 80.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6096
    Cell Significance Index: 550.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5287
    Cell Significance Index: 68.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4674
    Cell Significance Index: 206.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4436
    Cell Significance Index: 43.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4074
    Cell Significance Index: 28.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3985
    Cell Significance Index: 68.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3813
    Cell Significance Index: 10.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3594
    Cell Significance Index: 10.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3089
    Cell Significance Index: 14.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3032
    Cell Significance Index: 57.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2955
    Cell Significance Index: 58.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2721
    Cell Significance Index: 14.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2489
    Cell Significance Index: 49.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2221
    Cell Significance Index: 4.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2051
    Cell Significance Index: 2.3300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.1124
    Cell Significance Index: 0.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0934
    Cell Significance Index: 2.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0850
    Cell Significance Index: 30.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0811
    Cell Significance Index: 2.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0580
    Cell Significance Index: 42.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0244
    Cell Significance Index: 46.0100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0210
    Cell Significance Index: 0.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0125
    Cell Significance Index: 0.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0017
    Cell Significance Index: 1.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0000
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0129
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0165
    Cell Significance Index: -10.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0170
    Cell Significance Index: -31.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0187
    Cell Significance Index: -1.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0187
    Cell Significance Index: -28.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0208
    Cell Significance Index: -1.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0241
    Cell Significance Index: -32.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0276
    Cell Significance Index: -17.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0448
    Cell Significance Index: -25.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0590
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0617
    Cell Significance Index: -13.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0645
    Cell Significance Index: -29.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0884
    Cell Significance Index: -12.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0895
    Cell Significance Index: -2.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0899
    Cell Significance Index: -10.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0972
    Cell Significance Index: -7.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1105
    Cell Significance Index: -2.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1133
    Cell Significance Index: -32.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1699
    Cell Significance Index: -19.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2336
    Cell Significance Index: -26.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3417
    Cell Significance Index: -35.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3473
    Cell Significance Index: -19.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3605
    Cell Significance Index: -22.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3818
    Cell Significance Index: -19.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4056
    Cell Significance Index: -27.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4062
    Cell Significance Index: -4.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4132
    Cell Significance Index: -12.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4497
    Cell Significance Index: -27.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4561
    Cell Significance Index: -12.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4629
    Cell Significance Index: -13.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4694
    Cell Significance Index: -36.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5055
    Cell Significance Index: -14.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5705
    Cell Significance Index: -14.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5862
    Cell Significance Index: -4.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7088
    Cell Significance Index: -13.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7371
    Cell Significance Index: -32.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7547
    Cell Significance Index: -19.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** AKR7A2 is a NADPH-dependent enzyme that exhibits aldose reductase activity. This enzyme is characterized by its ability to reduce aldoses to alditols, as well as its capacity to activate and detoxify certain xenobiotics, such as aflatoxin B1. AKR7A2 has been shown to be a bifunctional enzyme, meaning that it can perform both reducing and oxidizing reactions. This unique property allows AKR7A2 to participate in both metabolic pathways and detoxification processes. **Pathways and Functions** AKR7A2 is involved in various cellular pathways, including: 1. **Aflatoxin activation and detoxification**: AKR7A2 is responsible for the reduction of aflatoxin B1 aldehyde to aflatoxin B1, a more water-soluble and less toxic compound. This reaction is crucial for the detoxification of aflatoxin B1, which is a known carcinogen produced by certain fungi. 2. **Carbohydrate metabolic process**: AKR7A2 plays a role in the metabolism of carbohydrates, including the reduction of aldoses to alditols. 3. **Lipid metabolic process**: AKR7A2 is involved in the metabolism of lipids, including the reduction of aldehydes to alcohols. 4. **Electron transfer activity**: AKR7A2 exhibits electron transfer activity, which is essential for the functioning of various cellular pathways. **Clinical Significance** The AKR7A2 gene has several clinical implications: 1. **Cancer risk**: The ability of AKR7A2 to activate and detoxify aflatoxin B1 makes it a potential risk factor for cancer, particularly in individuals exposed to aflatoxin B1-contaminated foods or environments. 2. **Aflatoxin B1 poisoning**: AKR7A2 can play a role in the detoxification of aflatoxin B1, which is a known cause of liver damage and cancer. 3. **Genetic variation**: Variations in the AKR7A2 gene have been associated with an increased risk of certain cancers, such as liver and breast cancer. 4. **Drug metabolism**: AKR7A2 is involved in the metabolism of certain drugs, including daunorubicin and doxorubicin, which are used to treat cancer. In conclusion, the AKR7A2 gene plays a crucial role in various cellular processes, including the activation and detoxification of aflatoxin B1, the metabolism of carbohydrates and lipids, and the functioning of electron transfer pathways. Its clinical significance lies in its potential role in cancer risk, aflatoxin B1 poisoning, genetic variation, and drug metabolism. Further research is needed to fully understand the functions and clinical implications of the AKR7A2 gene.

Genular Protein ID: 3567624142

Symbol: ARK72_HUMAN

Name: Aflatoxin B1 aldehyde reductase member 2

UniProtKB Accession Codes:

O43488 O75749 Q5TG63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9576847

Title: Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.

PubMed ID: 9576847

DOI: 10.1042/bj3320021

PubMed ID: 9823300

Title: Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells.

PubMed ID: 9823300

PubMed ID: 10510318

Title: Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.

PubMed ID: 10510318

DOI: 10.1042/bj3430487

PubMed ID: 12071861

Title: Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.

PubMed ID: 12071861

DOI: 10.1042/bj20020342

PubMed ID: 17591773

Title: Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2.

PubMed ID: 17591773

DOI: 10.1074/jbc.m702465200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18752886

Title: Genetic variation of aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells.

PubMed ID: 18752886

DOI: 10.1016/j.canlet.2008.07.013

Sequence Information:

  • Length: 359
  • Mass: 39589
  • Checksum: 2C9775FE4B977D2A
  • Sequence:
    • MLSAASRVVS RAAVHCALRS PPPEARALAM SRPPPPRVAS VLGTMEMGRR MDAPASAAAV 
RAFLERGHTE LDTAFMYSDG QSETILGGLG LGLGGGDCRV KIATKANPWD GKSLKPDSVR 
SQLETSLKRL QCPQVDLFYL HAPDHGTPVE ETLHACQRLH QEGKFVELGL SNYASWEVAE 
ICTLCKSNGW ILPTVYQGMY NATTRQVETE LFPCLRHFGL RFYAYNPLAG GLLTGKYKYE 
DKDGKQPVGR FFGNSWAETY RNRFWKEHHF EAIALVEKAL QAAYGASAPS VTSAALRWMY 
HHSQLQGAHG DAVILGMSSL EQLEQNLAAT EEGPLEPAVV DAFNQAWHLV AHECPNYFR

Genular Protein ID: 22062562

Symbol: B4DZX4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DZX4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 168
  • Mass: 18256
  • Checksum: 2C7081F9468A9E15
  • Sequence:
    • MSRPPPPRVA SVLGTMEMGR RMDAPASAAA VRAFLERGHT ELDTAFMYSD GQSETILGGL 
GLGLGGGDCR VKIATKANPW DGKSLKPDSV RSQLETSLKR LQCPQVDLFY LRAPDHGTPV 
EETLHACQRL HQEGKFVELG LTNYASWEVA EICTLCKSRP HMAPAPPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.