Details for: USO1

Gene ID: 8615

Symbol: USO1

Ensembl ID: ENSG00000138768

Description: USO1 vesicle transport factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 403.9340
    Cell Significance Index: -62.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 232.4918
    Cell Significance Index: -58.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 137.0195
    Cell Significance Index: -64.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 127.5916
    Cell Significance Index: -51.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 116.3330
    Cell Significance Index: -59.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 96.4648
    Cell Significance Index: -64.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.5068
    Cell Significance Index: -52.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.7050
    Cell Significance Index: -63.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.9534
    Cell Significance Index: -58.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.2770
    Cell Significance Index: -64.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.5399
    Cell Significance Index: -47.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.3191
    Cell Significance Index: -29.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.9384
    Cell Significance Index: 78.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.5707
    Cell Significance Index: 66.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.0705
    Cell Significance Index: 158.8900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.7513
    Cell Significance Index: 42.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7131
    Cell Significance Index: 343.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6015
    Cell Significance Index: 317.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5941
    Cell Significance Index: 21.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5634
    Cell Significance Index: 170.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4823
    Cell Significance Index: 28.9300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2277
    Cell Significance Index: 20.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1602
    Cell Significance Index: 209.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1455
    Cell Significance Index: 140.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0850
    Cell Significance Index: 176.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0651
    Cell Significance Index: 49.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9965
    Cell Significance Index: 27.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8190
    Cell Significance Index: 293.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8004
    Cell Significance Index: 109.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7703
    Cell Significance Index: 695.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7415
    Cell Significance Index: 404.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5931
    Cell Significance Index: 101.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5586
    Cell Significance Index: 386.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5493
    Cell Significance Index: 15.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5035
    Cell Significance Index: 222.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4972
    Cell Significance Index: 22.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4954
    Cell Significance Index: 224.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4330
    Cell Significance Index: 11.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4147
    Cell Significance Index: 23.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3953
    Cell Significance Index: 26.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3911
    Cell Significance Index: 10.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3070
    Cell Significance Index: 15.9500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2005
    Cell Significance Index: 2.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1892
    Cell Significance Index: 36.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1771
    Cell Significance Index: 112.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1770
    Cell Significance Index: 8.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1761
    Cell Significance Index: 331.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1520
    Cell Significance Index: 19.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1130
    Cell Significance Index: 8.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1124
    Cell Significance Index: 4.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0945
    Cell Significance Index: 5.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0933
    Cell Significance Index: 172.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0877
    Cell Significance Index: 134.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0633
    Cell Significance Index: 3.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0630
    Cell Significance Index: 2.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0373
    Cell Significance Index: 4.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0324
    Cell Significance Index: 44.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0043
    Cell Significance Index: -0.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0047
    Cell Significance Index: -0.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0116
    Cell Significance Index: -8.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0147
    Cell Significance Index: -0.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0164
    Cell Significance Index: -12.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0250
    Cell Significance Index: -2.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0346
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0363
    Cell Significance Index: -26.8600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0475
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0552
    Cell Significance Index: -34.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0691
    Cell Significance Index: -38.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0812
    Cell Significance Index: -4.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0957
    Cell Significance Index: -9.7800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1004
    Cell Significance Index: -1.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1342
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1441
    Cell Significance Index: -30.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1483
    Cell Significance Index: -9.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1524
    Cell Significance Index: -11.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1723
    Cell Significance Index: -20.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1754
    Cell Significance Index: -25.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1848
    Cell Significance Index: -53.1800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1992
    Cell Significance Index: -2.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2324
    Cell Significance Index: -2.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2662
    Cell Significance Index: -5.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2666
    Cell Significance Index: -30.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4069
    Cell Significance Index: -6.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4485
    Cell Significance Index: -46.7000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4672
    Cell Significance Index: -53.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5211
    Cell Significance Index: -11.2900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5264
    Cell Significance Index: -7.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5898
    Cell Significance Index: -46.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6062
    Cell Significance Index: -31.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7206
    Cell Significance Index: -36.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7733
    Cell Significance Index: -47.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7737
    Cell Significance Index: -22.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8793
    Cell Significance Index: -7.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8822
    Cell Significance Index: -25.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9304
    Cell Significance Index: -29.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9399
    Cell Significance Index: -32.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9890
    Cell Significance Index: -28.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0014
    Cell Significance Index: -6.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0587
    Cell Significance Index: -22.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0611
    Cell Significance Index: -26.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Vesicle Transport Function:** USO1 is a general vesicular transport factor that regulates the movement of transport vesicles between the ER and the Golgi apparatus, facilitating the proper localization and modification of proteins. 2. **Protein Modification:** USO1 is involved in the regulation of post-translational protein modification, including glycosylation and protein binding. 3. **Cell Cycle Regulation:** USO1 plays a role in regulating the cell cycle, particularly during mitosis, ensuring proper protein localization and function. 4. **Cell Type-Specific Expression:** USO1 is highly expressed in various cell types, including cardiac myocytes, skeletal muscle fibers, and immune cells. **Pathways and Functions:** 1. **Asparagine N-Linked Glycosylation:** USO1 regulates the formation and movement of transport vesicles involved in asparagine N-linked glycosylation, ensuring proper protein modification. 2. **Copii-Mediated Anterograde Transport:** USO1 is involved in copii-mediated anterograde transport, regulating the movement of transport vesicles from the ER to the Golgi apparatus. 3. **Endoplasmic Reticulum to Golgi Vesicle-Mediated Transport:** USO1 regulates the formation and movement of transport vesicles involved in ER-to-Golgi transport, ensuring proper protein localization and modification. 4. **Golgi Apparatus Function:** USO1 regulates the function of the Golgi apparatus, including Golgi cisternae pericentriolar stack reorganization and Golgi vesicle docking. **Clinical Significance:** 1. **Cardiac Dysfunctions:** Alterations in USO1 expression have been linked to cardiac dysfunctions, including heart failure and arrhythmias. 2. **Muscular Dystrophy:** USO1 mutations have been associated with muscular dystrophy, highlighting the importance of USO1 in maintaining muscle function. 3. **Immune System Disorders:** USO1 is involved in regulating immune cell function, and alterations in USO1 expression have been linked to immune system disorders, including autoimmune diseases. 4. **Cancer:** USO1 is overexpressed in various types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumorigenesis. In conclusion, the USO1 gene plays a crucial role in regulating various cellular processes, including vesicle transport, protein modification, and cell cycle progression. Its dysregulation has been linked to various diseases, highlighting the importance of further research into the functions and clinical significance of the USO1 gene.

Genular Protein ID: 3872211330

Symbol: USO1_HUMAN

Name: General vesicular transport factor p115

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9478999

Title: Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane.

PubMed ID: 9478999

DOI: 10.1074/jbc.273.9.5385

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19454686

Title: The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor.

PubMed ID: 19454686

DOI: 10.4049/jimmunol.0803710

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19247479

Title: Unusual armadillo fold in the human general vesicular transport factor p115.

PubMed ID: 19247479

DOI: 10.1371/journal.pone.0004656

Sequence Information:

  • Length: 962
  • Mass: 107895
  • Checksum: C963652209031008
  • Sequence:
  • MNFLRGVMGG QSAGPQHTEA ETIQKLCDRV ASSTLLDDRR NAVRALKSLS KKYRLEVGIQ 
    AMEHLIHVLQ TDRSDSEIIG YALDTLYNII SNEEEEEVEE NSTRQSEDLG SQFTEIFIKQ 
    QENVTLLLSL LEEFDFHVRW PGVKLLTSLL KQLGPQVQQI ILVSPMGVSR LMDLLADSRE 
    VIRNDGVLLL QALTRSNGAI QKIVAFENAF ERLLDIISEE GNSDGGIVVE DCLILLQNLL 
    KNNNSNQNFF KEGSYIQRMK PWFEVGDENS GWSAQKVTNL HLMLQLVRVL VSPTNPPGAT 
    SSCQKAMFQC GLLQQLCTIL MATGVPADIL TETINTVSEV IRGCQVNQDY FASVNAPSNP 
    PRPAIVVLLM SMVNERQPFV LRCAVLYCFQ CFLYKNQKGQ GEIVSTLLPS TIDATGNSVS 
    AGQLLCGGLF STDSLSNWCA AVALAHALQE NATQKEQLLR VQLATSIGNP PVSLLQQCTN 
    ILSQGSKIQT RVGLLMLLCT WLSNCPIAVT HFLHNSANVP FLTGQIAENL GEEEQLVQGL 
    CALLLGISIY FNDNSLESYM KEKLKQLIEK RIGKENFIEK LGFISKHELY SRASQKPQPN 
    FPSPEYMIFD HEFTKLVKEL EGVITKAIYK SSEEDKKEEE VKKTLEQHDN IVTHYKNMIR 
    EQDLQLEELR QQVSTLKCQN EQLQTAVTQQ VSQIQQHKDQ YNLLKIQLGK DNQHQGSYSE 
    GAQMNGIQPE EIGRLREEIE ELKRNQELLQ SQLTEKDSMI ENMKSSQTSG TNEQSSAIVS 
    ARDSEQVAEL KQELATLKSQ LNSQSVEITK LQTEKQELLQ KTEAFAKSVE VQGETETIIA 
    TKTTDVEGRL SALLQETKEL KNEIKALSEE RTAIKEQLDS SNSTIAILQT EKDKLELEIT 
    DSKKEQDDLL VLLADQDQKI LSLKNKLKDL GHPVEEEDEL ESGDQEDEDD ESEDPGKDLD 
    HI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.