Details for: PSMG1

Gene ID: 8624

Symbol: PSMG1

Ensembl ID: ENSG00000183527

Description: proteasome assembly chaperone 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.3338
    Cell Significance Index: -12.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.3677
    Cell Significance Index: -13.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.3971
    Cell Significance Index: -25.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.7376
    Cell Significance Index: -19.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.1104
    Cell Significance Index: -20.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1353
    Cell Significance Index: -22.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.0104
    Cell Significance Index: -18.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1809
    Cell Significance Index: -24.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3041
    Cell Significance Index: -13.2200
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 3.9964
    Cell Significance Index: 1.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7826
    Cell Significance Index: -6.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.7271
    Cell Significance Index: 443.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3498
    Cell Significance Index: 141.0700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.3263
    Cell Significance Index: 17.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0213
    Cell Significance Index: 27.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0166
    Cell Significance Index: 13.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9748
    Cell Significance Index: 67.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9734
    Cell Significance Index: 20.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8984
    Cell Significance Index: 811.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7648
    Cell Significance Index: 17.6700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7633
    Cell Significance Index: 8.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6972
    Cell Significance Index: 7.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6426
    Cell Significance Index: 33.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6003
    Cell Significance Index: 73.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5885
    Cell Significance Index: 80.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5751
    Cell Significance Index: 314.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5651
    Cell Significance Index: 249.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5608
    Cell Significance Index: 39.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5453
    Cell Significance Index: 34.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5218
    Cell Significance Index: 94.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4701
    Cell Significance Index: 21.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4584
    Cell Significance Index: 21.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4076
    Cell Significance Index: 11.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3794
    Cell Significance Index: 10.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3674
    Cell Significance Index: 47.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3530
    Cell Significance Index: 4.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3518
    Cell Significance Index: 9.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3295
    Cell Significance Index: 66.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3251
    Cell Significance Index: 16.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3217
    Cell Significance Index: 11.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2806
    Cell Significance Index: 6.0800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2750
    Cell Significance Index: 2.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2673
    Cell Significance Index: 7.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2433
    Cell Significance Index: 11.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2371
    Cell Significance Index: 7.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2345
    Cell Significance Index: 17.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2264
    Cell Significance Index: 11.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2215
    Cell Significance Index: 14.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2147
    Cell Significance Index: 40.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2067
    Cell Significance Index: 41.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1894
    Cell Significance Index: 67.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1892
    Cell Significance Index: 22.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1607
    Cell Significance Index: 20.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1536
    Cell Significance Index: 15.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1367
    Cell Significance Index: 94.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0930
    Cell Significance Index: 2.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0839
    Cell Significance Index: 2.4700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0538
    Cell Significance Index: 0.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0232
    Cell Significance Index: 17.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0110
    Cell Significance Index: 0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0049
    Cell Significance Index: 9.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0045
    Cell Significance Index: 0.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0033
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0095
    Cell Significance Index: -17.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0122
    Cell Significance Index: -18.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0141
    Cell Significance Index: -8.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0222
    Cell Significance Index: -2.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0231
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0243
    Cell Significance Index: -18.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0367
    Cell Significance Index: -20.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0370
    Cell Significance Index: -1.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0380
    Cell Significance Index: -17.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0476
    Cell Significance Index: -29.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0670
    Cell Significance Index: -19.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0712
    Cell Significance Index: -1.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0791
    Cell Significance Index: -9.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0840
    Cell Significance Index: -1.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0871
    Cell Significance Index: -1.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0910
    Cell Significance Index: -1.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1033
    Cell Significance Index: -15.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1163
    Cell Significance Index: -13.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1271
    Cell Significance Index: -26.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1631
    Cell Significance Index: -10.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1694
    Cell Significance Index: -4.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1833
    Cell Significance Index: -14.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2130
    Cell Significance Index: -16.8700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2188
    Cell Significance Index: -1.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2304
    Cell Significance Index: -23.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2460
    Cell Significance Index: -6.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2463
    Cell Significance Index: -3.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2870
    Cell Significance Index: -17.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2887
    Cell Significance Index: -14.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3154
    Cell Significance Index: -3.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3374
    Cell Significance Index: -13.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3548
    Cell Significance Index: -19.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3618
    Cell Significance Index: -2.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3731
    Cell Significance Index: -9.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3963
    Cell Significance Index: -17.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PSMG1 is a member of the HSP90 family of molecular chaperones, which are known for their ability to assist in the folding and assembly of proteins. PSMG1 is specifically involved in the assembly of the proteasome core complex, a crucial step in the degradation of proteins. Its expression is tightly regulated, with significant levels detected in cells undergoing rapid proliferation, such as erythroid progenitor cells and extravillous trophoblasts. PSMG1 is also expressed in cells of the immune system, including immature innate lymphoid cells, suggesting its potential role in modulating immune responses. **Pathways and Functions:** PSMG1 is involved in various cellular processes, including: 1. **Proteasome assembly and function**: PSMG1 plays a crucial role in the assembly of the proteasome core complex, ensuring its proper functioning and degradation of damaged or misfolded proteins. 2. **Protein folding and quality control**: PSMG1 assists in the folding of proteins, preventing the accumulation of misfolded proteins that can lead to cellular stress and disease. 3. **Cell proliferation and differentiation**: PSMG1 is highly expressed in cells undergoing rapid proliferation, suggesting its involvement in regulating cellular growth and differentiation. 4. **Immune system regulation**: PSMG1 is expressed in cells of the immune system, suggesting its potential role in modulating immune responses and preventing autoimmune diseases. **Clinical Significance:** Dysregulation of PSMG1 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of PSMG1 has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis. 2. **Immunological disorders**: PSMG1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where its dysregulation can lead to immune system dysfunction. 3. **Neurodegenerative diseases**: PSMG1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where its dysregulation can contribute to protein misfolding and aggregation. In conclusion, PSMG1 is a critical gene involved in maintaining protein homeostasis and regulating cellular processes. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 3222972872

Symbol: PSMG1_HUMAN

Name: Chromosome 21 leucine-rich protein

UniProtKB Accession Codes:

O95456 B5BUN2 Q6FHA3 Q6FHD3 Q6S713

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 13 EMDB 6 Ensembl 2 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9784380

Title: Identification and characterization of a new gene from human chromosome 21 between markers D21S343 and D21S268 encoding a leucine-rich protein.

PubMed ID: 9784380

DOI: 10.1006/bbrc.1998.9352

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10872820

Title: Down syndrome critical region gene 2: expression during mouse development and in human cell lines indicates a function related to cell proliferation.

PubMed ID: 10872820

DOI: 10.1006/bbrc.2000.2726

PubMed ID: 15590417

Title: DSCR2, a Down syndrome critical region protein, is localized to the endoplasmic reticulum of mammalian cells.

PubMed ID: 15590417

PubMed ID: 15670775

Title: Molecular and cellular characterization of the Down syndrome critical region protein 2.

PubMed ID: 15670775

DOI: 10.1016/j.bbrc.2004.09.226

PubMed ID: 16251969

Title: A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.

PubMed ID: 16251969

DOI: 10.1038/nature04106

PubMed ID: 17707236

Title: 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals.

PubMed ID: 17707236

DOI: 10.1016/j.molcel.2007.06.025

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 288
  • Mass: 32854
  • Checksum: 2D4A84485C290839
  • Sequence:
    • MAATFFGEVV KAPCRAGTED EEEEEEGRRE TPEDREVRLQ LARKREVRLL RRQTKTSLEV 
SLLEKYPCSK FIIAIGNNAV AFLSSFVMNS GVWEEVGCAK LWNEWCRTTD TTHLSSTEAF 
CVFYHLKSNP SVFLCQCSCY VAEDQQYQWL EKVFGSCPRK NMQITILTCR HVTDYKTSES 
TGSLPSPFLR ALKTQNFKDS ACCPLLEQPN IVHDLPAAVL SYCQVWKIPA ILYLCYTDVM 
KLDLITVEAF KPILSTRSLK GLVKNIPQST EILKKLMTTN EIQSNIYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.