Details for: EIF4G3

Gene ID: 8672

Symbol: EIF4G3

Ensembl ID: ENSG00000075151

Description: eukaryotic translation initiation factor 4 gamma 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 680.5416
    Cell Significance Index: -105.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 405.6483
    Cell Significance Index: -102.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 225.8735
    Cell Significance Index: -106.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 210.3348
    Cell Significance Index: -85.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 192.5211
    Cell Significance Index: -99.0300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 158.9217
    Cell Significance Index: -106.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 89.6053
    Cell Significance Index: -85.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 86.2724
    Cell Significance Index: -106.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 38.0862
    Cell Significance Index: -116.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 37.0493
    Cell Significance Index: -99.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 36.7954
    Cell Significance Index: -80.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 26.9890
    Cell Significance Index: -106.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 8.4430
    Cell Significance Index: 217.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.9610
    Cell Significance Index: 334.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.1033
    Cell Significance Index: 1471.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.4881
    Cell Significance Index: 97.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2838
    Cell Significance Index: 658.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.2815
    Cell Significance Index: 2269.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.2378
    Cell Significance Index: 217.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.6617
    Cell Significance Index: 117.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.6540
    Cell Significance Index: 100.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6046
    Cell Significance Index: 516.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3616
    Cell Significance Index: 181.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.1274
    Cell Significance Index: 60.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1206
    Cell Significance Index: 130.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.0617
    Cell Significance Index: 1309.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.8292
    Cell Significance Index: 35.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.5036
    Cell Significance Index: 36.0600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2404
    Cell Significance Index: 17.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1729
    Cell Significance Index: 211.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1494
    Cell Significance Index: 59.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9663
    Cell Significance Index: 118.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.9179
    Cell Significance Index: 1728.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.7626
    Cell Significance Index: 346.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.7625
    Cell Significance Index: 1406.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6975
    Cell Significance Index: 380.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.6840
    Cell Significance Index: 1052.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6200
    Cell Significance Index: 67.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.5521
    Cell Significance Index: 13.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4884
    Cell Significance Index: 8.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3230
    Cell Significance Index: 9.3100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2287
    Cell Significance Index: 2.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2221
    Cell Significance Index: 30.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2024
    Cell Significance Index: 275.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2002
    Cell Significance Index: 88.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1973
    Cell Significance Index: 8.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1600
    Cell Significance Index: 15.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0045
    Cell Significance Index: 0.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0268
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0402
    Cell Significance Index: -25.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0765
    Cell Significance Index: -56.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0941
    Cell Significance Index: -69.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1385
    Cell Significance Index: -104.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1522
    Cell Significance Index: -85.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2814
    Cell Significance Index: -48.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2996
    Cell Significance Index: -1.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3059
    Cell Significance Index: -49.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3141
    Cell Significance Index: -37.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3266
    Cell Significance Index: -93.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3381
    Cell Significance Index: -71.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3723
    Cell Significance Index: -19.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3974
    Cell Significance Index: -8.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4071
    Cell Significance Index: -26.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4244
    Cell Significance Index: -44.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5350
    Cell Significance Index: -68.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5703
    Cell Significance Index: -12.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5918
    Cell Significance Index: -68.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5943
    Cell Significance Index: -60.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6385
    Cell Significance Index: -13.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.6387
    Cell Significance Index: -82.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6679
    Cell Significance Index: -23.4700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7458
    Cell Significance Index: -10.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7703
    Cell Significance Index: -48.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7925
    Cell Significance Index: -90.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8186
    Cell Significance Index: -38.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8761
    Cell Significance Index: -23.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8828
    Cell Significance Index: -100.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.9926
    Cell Significance Index: -73.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1277
    Cell Significance Index: -28.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1567
    Cell Significance Index: -91.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.2388
    Cell Significance Index: -57.7600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.2615
    Cell Significance Index: -15.7300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -1.2631
    Cell Significance Index: -20.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.2723
    Cell Significance Index: -89.9800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.3133
    Cell Significance Index: -13.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.3496
    Cell Significance Index: -36.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3503
    Cell Significance Index: -26.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.3826
    Cell Significance Index: -72.5900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.4078
    Cell Significance Index: -11.4800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.4093
    Cell Significance Index: -18.8000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.4906
    Cell Significance Index: -16.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4957
    Cell Significance Index: -48.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.5685
    Cell Significance Index: -21.4000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.5868
    Cell Significance Index: -24.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.6051
    Cell Significance Index: -51.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.6521
    Cell Significance Index: -35.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7027
    Cell Significance Index: -104.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.7321
    Cell Significance Index: -15.9500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.7430
    Cell Significance Index: -29.3600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.7629
    Cell Significance Index: -22.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF4G3 is a gene that encodes a protein, IF4G3, which is a subunit of the eukaryotic translation initiation factor 4f complex. This complex is responsible for initiating protein synthesis in response to specific sequences on messenger RNA (mRNA). EIF4G3 is characterized by its ability to bind to the 5' cap of mRNA and regulate translational initiation. Its expression is widespread, with significant levels detected in various immune cells, including mature microglial cells, oligodendrocytes, and cortical cells of the adrenal gland. **Pathways and Functions:** EIF4G3 is involved in several key pathways, including: 1. **Antiviral Mechanism by IFN-Stimulated Genes:** EIF4G3 plays a crucial role in the regulation of antiviral genes induced by interferons (IFNs). IFNs stimulate the expression of genes involved in antiviral defense, and EIF4G3 is necessary for the efficient translation of these genes. 2. **Cytokine Signaling in the Immune System:** EIF4G3 is involved in the regulation of cytokine signaling, which is essential for the proper functioning of the immune system. Cytokines are signaling molecules that facilitate communication between immune cells, and EIF4G3 helps to regulate their translation. 3. **Regulation of Translational Initiation:** EIF4G3 regulates the initiation of protein synthesis by binding to the 5' cap of mRNA and recruiting the eIF4A protein, which unwinds the mRNA secondary structure. This process is essential for the efficient translation of mRNAs. 4. **Negative Regulation of Autophagy:** EIF4G3 has been shown to negatively regulate autophagy, a process by which cells recycle damaged or dysfunctional components. Autophagy is essential for maintaining cellular homeostasis, and dysregulation of EIF4G3 may contribute to autophagy-related diseases. **Clinical Significance:** Dysregulation of EIF4G3 has been implicated in various diseases, including: 1. **Viral Infections:** EIF4G3 plays a crucial role in the regulation of antiviral genes, and dysregulation of this gene may contribute to the development of viral infections. 2. **Autoimmune Diseases:** EIF4G3 is involved in the regulation of cytokine signaling, which is essential for the proper functioning of the immune system. Dysregulation of EIF4G3 may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** EIF4G3 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. Overexpression of EIF4G3 may contribute to the development and progression of cancer. In conclusion, EIF4G3 is a crucial gene that plays a pivotal role in regulating translational initiation and modulating the immune response. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and therapeutic applications.

Genular Protein ID: 1655575332

Symbol: IF4G3_HUMAN

Name: Eukaryotic translation initiation factor 4 gamma 3

UniProtKB Accession Codes:

O43432 B9EGQ7 Q15597 Q504Z1 Q5SWC3 Q8NEN1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9418880

Title: A novel functional human eukaryotic translation initiation factor 4G.

PubMed ID: 9418880

DOI: 10.1128/mcb.18.1.334

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9857202

Title: A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.

PubMed ID: 9857202

DOI: 10.1093/emboj/17.24.7480

PubMed ID: 14507913

Title: Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I.

PubMed ID: 14507913

DOI: 10.1074/jbc.m308781200

PubMed ID: 12663812

Title: Human rhin4ovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different.

PubMed ID: 12663812

DOI: 10.1128/jvi.77.8.5026-5029.2003

PubMed ID: 15016848

Title: Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro.

PubMed ID: 15016848

DOI: 10.1128/jvi.78.7.3271-3278.2004

PubMed ID: 10872469

Title: eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.

PubMed ID: 10872469

DOI: 10.1146/annurev.biochem.68.1.913

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12975586

Title: Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII.

PubMed ID: 12975586

DOI: 10.1023/a:1025442322316

PubMed ID: 11172724

Title: A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery.

PubMed ID: 11172724

DOI: 10.1016/s1097-2765(01)00167-8

Sequence Information:

  • Length: 1585
  • Mass: 176652
  • Checksum: EA483139373DCA5C
  • Sequence:
    • MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM VNHLPMPYPV 
PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFPNAYGT PFYPSQPVYQ 
SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPTSTPTP 
PQQLPSQVPE HSPVVYGTVE SAHLAASTPV TAASDQKQEE KPKPDPVLKS PSPVLRLVLS 
GEKKEQEGQT SETTAIVSIA ELPLPPSPTT VSSVARSTIA APTSSALSSQ PIFTTAIDDR 
CELSSPREDT IPIPSLTSCT ETSDPLPTNE NDDDICKKPC SVAPNDIPLV SSTNLINEIN 
GVSEKLSATE SIVEIVKQEV LPLTLELEIL ENPPEEMKLE CIPAPITPST VPSFPPTPPT 
PPASPPHTPV IVPAAATTVS SPSAAITVQR VLEEDESIRT CLSEDAKEIQ NKIEVEADGQ 
TEEILDSQNL NSRRSPVPAQ IAITVPKTWK KPKDRTRTTE EMLEAELELK AEEELSIDKV 
LESEQDKMSQ GFHPERDPSD LKKVKAVEEN GEEAEPVRNG AESVSEGEGI DANSGSTDSS 
GDGVTFPFKP ESWKPTDTEG KKQYDREFLL DFQFMPACIQ KPEGLPPISD VVLDKINQPK 
LPMRTLDPRI LPRGPDFTPA FADFGRQTPG GRGVPLLNVG SRRSQPGQRR EPRKIITVSV 
KEDVHLKKAE NAWKPSQKRD SQADDPENIK TQELFRKVRS ILNKLTPQMF NQLMKQVSGL 
TVDTEERLKG VIDLVFEKAI DEPSFSVAYA NMCRCLVTLK VPMADKPGNT VNFRKLLLNR 
CQKEFEKDKA DDDVFEKKQK ELEAASAPEE RTRLHDELEE AKDKARRRSI GNIKFIGELF 
KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD QYFNQMEKIV 
KERKTSSRIR FMLQDVIDLR LCNWVSRRAD QGPKTIEQIH KEAKIEEQEE QRKVQQLMTK 
EKRRPGVQRV DEGGWNTVQG AKNSRVLDPS KFLKITKPTI DEKIQLVPKA QLGSWGKGSS 
GGAKASETDA LRSSASSLNR FSALQPPAPS GSTPSTPVEF DSRRTLTSRG SMGREKNDKP 
LPSATARPNT FMRGGSSKDL LDNQSQEEQR REMLETVKQL TGGVDVERNS TEAERNKTRE 
SAKPEISAMS AHDKAALSEE ELERKSKSII DEFLHINDFK EAMQCVEELN AQGLLHVFVR 
VGVESTLERS QITRDHMGQL LYQLVQSEKL SKQDFFKGFS ETLELADDMA IDIPHIWLYL 
AELVTPMLKE GGISMRELTI EFSKPLLPVG RAGVLLSEIL HLLCKQMSHK KVGALWREAD 
LSWKDFLPEG EDVHNFLLEQ KLDFIESDSP CSSEALSKKE LSAEELYKRL EKLIIEDKAN 
DEQIFDWVEA NLDEIQMSSP TFLRALMTAV CKAAIIADSS TFRVDTAVIK QRVPILLKYL 
DSDTEKELQA LYALQASIVK LDQPANLLRM FFDCLYDEEV ISEDAFYKWE SSKDPAEQNG 
KGVALKSVTA FFTWLREAEE ESEDN

Genular Protein ID: 1800604341

Symbol: A0A0A0MSA7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSA7

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.M700120-MCP200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1621
  • Mass: 180498
  • Checksum: E338E703B94164C3
  • Sequence:
    • MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM VNHLPMPYPV 
PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFPNAYGT PFYPSQPVYQ 
SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPTSTPTP 
PQLPSQVPEH SPVVYGTVES AHLAASTPVT AASDQKQEEK PKPDPVLKSP SPVLRLVLSG 
EKKEQEGQTS ETTAIVSIAE LPLPPSPTTV SSVARSTIAA PTSSALSSQP IFTTAIDDRC 
ELSSPREDTI PIPSLTSCTE TSDPLPTNEN DDDICKKPCS VAPNDIPLVS STNLINEING 
VSEKLSATES IVEIVKQEVL PLTLELEILE NPPEEMKLEC IPAPITPSTV PSFPPTPPTP 
PASPPHTPVI VPAAATTVSS PSAAITVQRV LEEDESIRTC LSEDAKEIQN KIEVEADGQT 
EEILDSQNLN SRRSPVPAQI AITVPKTWKK PKDRTRTTEE MLEAELELKA EEELSIDKVL 
ESEQDKMSQG FHPERDPSDL KKVKAVEENG EEAEPVRNGA ESVSEGEGID ANSGSTDSSG 
DGVTFPFKPE SWKPTDTEGK KQYDREFLLD FQFMPACIQK PEGLPPISDV VLDKINQPKL 
PMRTLDPRIL PRGPDFTPAF ADFGRQTPGG RGVPICKVQS RHGLPILEQS KAPTCPPLVM 
SHPPMKSLPL GLLNVGSRRS QPGQRREPRK IITVSVKEDV HLKKAENAWK PSQKRDSQAD 
DPENIKTQEL FRKVRSILNK LTPQMFNQLM KQVSGLTVDT EERLKGVIDL VFEKAIDEPS 
FSVAYANMCR CLVTLKVPMA DKPGNTVNFR KLLLNRCQKE FEKDKADDDV FEKKQKELEA 
ASAPEERTRL HDELEEAKDK ARRRSIGNIK FIGELFKLKM LTEAIMHDCV VKLLKNHDEE 
SLECLCRLLT TIGKDLDFEK AKPRMDQYFN QMEKIVKERK TSSRIRFMLQ DVIDLRLCNW 
VSRRADQGPK TIEQIHKEAK IEEQEEQRKV QQLMTKEKRR PGVQRVDEGG WNTVQGAKNS 
RVLDPSKFLK ITKPTIDEKI QLVPKAQLGS WGKGSSGGAK ASETDALRSS ASSLNRFSAL 
QPPAPSGSTP STPVEFDSRR TLTSRGSMGR EKNDKPLPSA TARPNTFMRG GSSKDLLDNQ 
SQEEQRREML ETVKQLTGGV DVERNSTEAE RNKTRESAKP EISAMSAHDK AALSEEELER 
KSKSIIDEFL HINDFKEAMQ CVEELNAQGL LHVFVRVGVE STLERSQITR DHMGQLLYQL 
VQSEKLSKQD FFKGFSETLE LADDMAIDIP HIWLYLAELV TPMLKEGGIS MRELTIEFSK 
PLLPVGRAGV LLSEILHLLC KQMSHKKVGA LWREADLSWK DFLPEGEDVH NFLLEQKLDF 
IESDSPCSSE ALSKKELSAE ELYKRLEKLI IEDKANDEQI FDWVEANLDE IQMSSPTFLR 
ALMTAVCKAA IIADSSTFRV DTAVIKQRVP ILLKYLDSDT EKELQALYAL QASIVKLDQP 
ANLLRMFFDC LYDEEVISED AFYKWESSKD PAEQNGKGVA LKSVTAFFTW LREAEEESED 
N

Genular Protein ID: 2082075673

Symbol: Q59GJ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GJ0

Database IDs:

ARBA 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 3 SAM 1 SMART 3 SUPFAM 1

Sequence Information:

  • Length: 1780
  • Mass: 195958
  • Checksum: 65102752AEE27684
  • Sequence:
    • VKKIHRHRLS PATEKGAASS GEGDKDPPPP AHEDIAVKGT ATAAGTGPGT GAAAAAAAAV 
PPPHPAAAAA AAAAAAAAAA AVPPPHPNIR ALQTQAPQQI PRGPVQQPLE DRIFTPAVSA 
VYSTVTQVAR QPGTPTPSPY SAHEINKGHP NLAATPPGHA SSPGLSQTPY PSGQNAGPTT 
LVYPQTPQTM NSQPQTRSPG GFRPIQFFQR PQIQPPRATI PNSSPSIRPG AQTPTAVYQA 
NQHIMMVNHL PMPYPVPQGP QYCIPQYRHS GPPYVGPPQQ YPVQPPGPGP FYPGPGPGDF 
PNAYGTPFYP SQPVYQSAPI IVPTQQQPPP AKREKKTIRI RDPNQGGKDI TEEIMSGGGS 
RNPTPPIGRP TSTPTPPQLP SQVPEHSPVV YGTVESAHLA ASTPVTAASD QKQEEKPKPD 
PVLKSPSPVL RLVLSGEKKE QEGQTSETTA IVSIAELPLP PSPTTVSSVA RSTIAAPTSS 
ALSSQPIFTT AIDDRCELSS PREDTIPIPS LTSCTETSDP LPTNENDDDI CKKPCSVAPN 
DIPLVSSTNL INEINGVSEK LSATESIVEI VKQEVLPLTL ELEILENPPE EMKLECIPAP 
ITPSTVPSFP PTPPTPPASP PHTPVIVPAA ATTVSSPSAA ITVQRVLEED ESIRTCLSED 
AKEIQNKIEV EADGQTEEIL DSQNLNSRRS PVPAQIAITV PKTWKKPKDR TRTTEEMLEA 
ELELKAEEEL SIDKVLESEQ DKMSQGFHPE RDPSDLKKVK AVEENGEEAE PVRNGAESVS 
EGEGIDANSG STDSSGDGVT FPFKPESWKP TDTEGKKQYD REFLLDFQFM PACIQKPEGL 
PPISDVVLDK INQPKLPMRT LDPRILPRGP DFTPAFADFG RQTPGGRGVP LLNVGSRRSQ 
PGQRREPRKI ITVSVKEDVH LKKAENAWKP SQKRDSQADD PENIKTQELF RKVRSILNKL 
TPQMFNQLMK QVSGLTVDTE ERLKGVIDLV FEKAIDEPSF SVAYANMCRC LVTLKVPMAD 
KPGNTVNFRK LLLNRCQKEF EKDKADDDVF EKKQKELEAA SAPEERTRLH DELEEAKDKA 
RRRSIGNIKF IGELFKLKML TEAIMHDCVV KLLKNHDEES LECLCRLLTT IGKDLDFEKA 
KPRMDQYFNQ MEKIVKERKT SSRIRFMLQD VIDLRLCNWV SRRADQGPKT IEQIHKEAKI 
EEQEEQRKVQ QLMTKEKRRP GVQRVDEGGW NTVQGAKNSR VLDPSKFLKI TKPTIDEKIQ 
LVPKAQLGSW GKGSSGGAKA SETDALRSSA SSLNRFSALQ PPAPSGSTPS TPVEFDSRRT 
LTSRGSMGRE KNDKPLPSAT ARPNTFMRGG SSKDLLDNQS QEEQRREMLE TVKQLTGGVD 
VERNSTEAER NKTRESAKPE ISAMSAHDKA ALSEEELERK SKSIIDEFLH INDFKEAMQC 
VEELNAQGLL HVFVRVGVES TLERSQITRD HMGQLLYQLV QSEKLSKQDF FKGFSETLEL 
ADDMAIDIPH IWLYLAELVT PMLKEGGISM RELTIEFSKP LLPVGRAGVL LSEILHLLCK 
QMSHKKVGAL WREADLSWKD FLPEGEDVHN FLLEQKLDFI ESDSPCSSEA LSKKELSAEE 
LYKRLEKLII EDKANDEQIF DWVEANLDEI QMSSPTFLRA LMTAVCKAAI IADSSTFRVD 
TAVIKQRVPI LLKYLDSDTE KELQALYALQ ASIVKLDQPA NLLRMFFDCL YDEEVISEDA 
FYKWESSKDP AEQNGKGVAL KSVTAFFTWL REAEEESEDN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.