Details for: EIF4G3

Gene ID: 8672

Symbol: EIF4G3

Ensembl ID: ENSG00000075151

Description: eukaryotic translation initiation factor 4 gamma 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.12
    Marker Score: 139,296
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.12
    Marker Score: 73,150
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.1
    Marker Score: 22,044
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.89
    Marker Score: 9,729
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.87
    Marker Score: 9,264
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 3.83
    Marker Score: 1,385
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.78
    Marker Score: 12,677
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.77
    Marker Score: 5,076
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.77
    Marker Score: 17,456
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.73
    Marker Score: 3,222
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.52
    Marker Score: 18,491
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.48
    Marker Score: 4,211
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.38
    Marker Score: 3,827
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.37
    Marker Score: 7,395
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.31
    Marker Score: 24,946
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.31
    Marker Score: 7,600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.3
    Marker Score: 2,931
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.15
    Marker Score: 13,173
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.12
    Marker Score: 6,004
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.1
    Marker Score: 2,150
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.07
    Marker Score: 2,367
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.07
    Marker Score: 3,533
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.06
    Marker Score: 1,521
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.05
    Marker Score: 2,298
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3
    Marker Score: 878
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.92
    Marker Score: 62,273
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.88
    Marker Score: 4,049
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.84
    Marker Score: 1,655
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.79
    Marker Score: 55,580
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.77
    Marker Score: 41,350
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.72
    Marker Score: 7,774
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.72
    Marker Score: 20,848
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.67
    Marker Score: 101,352
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.66
    Marker Score: 845
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.54
    Marker Score: 1,515
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.54
    Marker Score: 10,510
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.52
    Marker Score: 1,366
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.52
    Marker Score: 4,230
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.5
    Marker Score: 10,436
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.43
    Marker Score: 804
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.42
    Marker Score: 2,309
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.42
    Marker Score: 89,221
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.39
    Marker Score: 754
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.35
    Marker Score: 985
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.31
    Marker Score: 1,344
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.3
    Marker Score: 1,343
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.28
    Marker Score: 8,815
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.28
    Marker Score: 1,276
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.27
    Marker Score: 2,508
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.27
    Marker Score: 653
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.27
    Marker Score: 2,443
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.25
    Marker Score: 1,478
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.23
    Marker Score: 2,761
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.21
    Marker Score: 3,210
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.2
    Marker Score: 2,744
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.2
    Marker Score: 1,448
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.2
    Marker Score: 1,137
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.16
    Marker Score: 20,304
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.15
    Marker Score: 548
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.14
    Marker Score: 2,589
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.14
    Marker Score: 7,009
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.12
    Marker Score: 2,273
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.1
    Marker Score: 1,169
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.09
    Marker Score: 1,170
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.07
    Marker Score: 46,315
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127,361
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.07
    Marker Score: 1,088
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.06
    Marker Score: 749
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.02
    Marker Score: 2,525
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.02
    Marker Score: 8,215
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.01
    Marker Score: 20,767
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.99
    Marker Score: 517
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.98
    Marker Score: 1,717
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.97
    Marker Score: 975
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.91
    Marker Score: 966
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18,098
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.89
    Marker Score: 725
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.86
    Marker Score: 29,822
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15,939
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.84
    Marker Score: 680
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.84
    Marker Score: 882
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.8
    Marker Score: 6,203
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.79
    Marker Score: 488
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.78
    Marker Score: 652
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.77
    Marker Score: 15,541
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.77
    Marker Score: 925
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.73
    Marker Score: 2,452
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.72
    Marker Score: 972
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.71
    Marker Score: 1,805
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.71
    Marker Score: 582
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.7
    Marker Score: 1,138
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.68
    Marker Score: 5,975
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.66
    Marker Score: 621
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.61
    Marker Score: 5,736
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.61
    Marker Score: 489
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.59
    Marker Score: 2,457
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.56
    Marker Score: 3,169
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.55
    Marker Score: 585
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.52
    Marker Score: 738
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.5
    Marker Score: 412

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF4G3 is a gene that encodes a protein, IF4G3, which is a subunit of the eukaryotic translation initiation factor 4f complex. This complex is responsible for initiating protein synthesis in response to specific sequences on messenger RNA (mRNA). EIF4G3 is characterized by its ability to bind to the 5' cap of mRNA and regulate translational initiation. Its expression is widespread, with significant levels detected in various immune cells, including mature microglial cells, oligodendrocytes, and cortical cells of the adrenal gland. **Pathways and Functions:** EIF4G3 is involved in several key pathways, including: 1. **Antiviral Mechanism by IFN-Stimulated Genes:** EIF4G3 plays a crucial role in the regulation of antiviral genes induced by interferons (IFNs). IFNs stimulate the expression of genes involved in antiviral defense, and EIF4G3 is necessary for the efficient translation of these genes. 2. **Cytokine Signaling in the Immune System:** EIF4G3 is involved in the regulation of cytokine signaling, which is essential for the proper functioning of the immune system. Cytokines are signaling molecules that facilitate communication between immune cells, and EIF4G3 helps to regulate their translation. 3. **Regulation of Translational Initiation:** EIF4G3 regulates the initiation of protein synthesis by binding to the 5' cap of mRNA and recruiting the eIF4A protein, which unwinds the mRNA secondary structure. This process is essential for the efficient translation of mRNAs. 4. **Negative Regulation of Autophagy:** EIF4G3 has been shown to negatively regulate autophagy, a process by which cells recycle damaged or dysfunctional components. Autophagy is essential for maintaining cellular homeostasis, and dysregulation of EIF4G3 may contribute to autophagy-related diseases. **Clinical Significance:** Dysregulation of EIF4G3 has been implicated in various diseases, including: 1. **Viral Infections:** EIF4G3 plays a crucial role in the regulation of antiviral genes, and dysregulation of this gene may contribute to the development of viral infections. 2. **Autoimmune Diseases:** EIF4G3 is involved in the regulation of cytokine signaling, which is essential for the proper functioning of the immune system. Dysregulation of EIF4G3 may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** EIF4G3 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. Overexpression of EIF4G3 may contribute to the development and progression of cancer. In conclusion, EIF4G3 is a crucial gene that plays a pivotal role in regulating translational initiation and modulating the immune response. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and therapeutic applications.

Genular Protein ID: 1655575332

Symbol: IF4G3_HUMAN

Name: Eukaryotic translation initiation factor 4 gamma 3

UniProtKB Accession Codes:

O43432 B9EGQ7 Q15597 Q504Z1 Q5SWC3 Q8NEN1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9418880

Title: A novel functional human eukaryotic translation initiation factor 4G.

PubMed ID: 9418880

DOI: 10.1128/mcb.18.1.334

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9857202

Title: A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.

PubMed ID: 9857202

DOI: 10.1093/emboj/17.24.7480

PubMed ID: 14507913

Title: Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I.

PubMed ID: 14507913

DOI: 10.1074/jbc.m308781200

PubMed ID: 12663812

Title: Human rhin4ovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different.

PubMed ID: 12663812

DOI: 10.1128/jvi.77.8.5026-5029.2003

PubMed ID: 15016848

Title: Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro.

PubMed ID: 15016848

DOI: 10.1128/jvi.78.7.3271-3278.2004

PubMed ID: 10872469

Title: eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.

PubMed ID: 10872469

DOI: 10.1146/annurev.biochem.68.1.913

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12975586

Title: Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII.

PubMed ID: 12975586

DOI: 10.1023/a:1025442322316

PubMed ID: 11172724

Title: A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery.

PubMed ID: 11172724

DOI: 10.1016/s1097-2765(01)00167-8

Sequence Information:

  • Length: 1585
  • Mass: 176652
  • Checksum: EA483139373DCA5C
  • Sequence:
    • MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM VNHLPMPYPV 
PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFPNAYGT PFYPSQPVYQ 
SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPTSTPTP 
PQQLPSQVPE HSPVVYGTVE SAHLAASTPV TAASDQKQEE KPKPDPVLKS PSPVLRLVLS 
GEKKEQEGQT SETTAIVSIA ELPLPPSPTT VSSVARSTIA APTSSALSSQ PIFTTAIDDR 
CELSSPREDT IPIPSLTSCT ETSDPLPTNE NDDDICKKPC SVAPNDIPLV SSTNLINEIN 
GVSEKLSATE SIVEIVKQEV LPLTLELEIL ENPPEEMKLE CIPAPITPST VPSFPPTPPT 
PPASPPHTPV IVPAAATTVS SPSAAITVQR VLEEDESIRT CLSEDAKEIQ NKIEVEADGQ 
TEEILDSQNL NSRRSPVPAQ IAITVPKTWK KPKDRTRTTE EMLEAELELK AEEELSIDKV 
LESEQDKMSQ GFHPERDPSD LKKVKAVEEN GEEAEPVRNG AESVSEGEGI DANSGSTDSS 
GDGVTFPFKP ESWKPTDTEG KKQYDREFLL DFQFMPACIQ KPEGLPPISD VVLDKINQPK 
LPMRTLDPRI LPRGPDFTPA FADFGRQTPG GRGVPLLNVG SRRSQPGQRR EPRKIITVSV 
KEDVHLKKAE NAWKPSQKRD SQADDPENIK TQELFRKVRS ILNKLTPQMF NQLMKQVSGL 
TVDTEERLKG VIDLVFEKAI DEPSFSVAYA NMCRCLVTLK VPMADKPGNT VNFRKLLLNR 
CQKEFEKDKA DDDVFEKKQK ELEAASAPEE RTRLHDELEE AKDKARRRSI GNIKFIGELF 
KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD QYFNQMEKIV 
KERKTSSRIR FMLQDVIDLR LCNWVSRRAD QGPKTIEQIH KEAKIEEQEE QRKVQQLMTK 
EKRRPGVQRV DEGGWNTVQG AKNSRVLDPS KFLKITKPTI DEKIQLVPKA QLGSWGKGSS 
GGAKASETDA LRSSASSLNR FSALQPPAPS GSTPSTPVEF DSRRTLTSRG SMGREKNDKP 
LPSATARPNT FMRGGSSKDL LDNQSQEEQR REMLETVKQL TGGVDVERNS TEAERNKTRE 
SAKPEISAMS AHDKAALSEE ELERKSKSII DEFLHINDFK EAMQCVEELN AQGLLHVFVR 
VGVESTLERS QITRDHMGQL LYQLVQSEKL SKQDFFKGFS ETLELADDMA IDIPHIWLYL 
AELVTPMLKE GGISMRELTI EFSKPLLPVG RAGVLLSEIL HLLCKQMSHK KVGALWREAD 
LSWKDFLPEG EDVHNFLLEQ KLDFIESDSP CSSEALSKKE LSAEELYKRL EKLIIEDKAN 
DEQIFDWVEA NLDEIQMSSP TFLRALMTAV CKAAIIADSS TFRVDTAVIK QRVPILLKYL 
DSDTEKELQA LYALQASIVK LDQPANLLRM FFDCLYDEEV ISEDAFYKWE SSKDPAEQNG 
KGVALKSVTA FFTWLREAEE ESEDN

Genular Protein ID: 1800604341

Symbol: A0A0A0MSA7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSA7

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.M700120-MCP200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1621
  • Mass: 180498
  • Checksum: E338E703B94164C3
  • Sequence:
    • MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM VNHLPMPYPV 
PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFPNAYGT PFYPSQPVYQ 
SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPTSTPTP 
PQLPSQVPEH SPVVYGTVES AHLAASTPVT AASDQKQEEK PKPDPVLKSP SPVLRLVLSG 
EKKEQEGQTS ETTAIVSIAE LPLPPSPTTV SSVARSTIAA PTSSALSSQP IFTTAIDDRC 
ELSSPREDTI PIPSLTSCTE TSDPLPTNEN DDDICKKPCS VAPNDIPLVS STNLINEING 
VSEKLSATES IVEIVKQEVL PLTLELEILE NPPEEMKLEC IPAPITPSTV PSFPPTPPTP 
PASPPHTPVI VPAAATTVSS PSAAITVQRV LEEDESIRTC LSEDAKEIQN KIEVEADGQT 
EEILDSQNLN SRRSPVPAQI AITVPKTWKK PKDRTRTTEE MLEAELELKA EEELSIDKVL 
ESEQDKMSQG FHPERDPSDL KKVKAVEENG EEAEPVRNGA ESVSEGEGID ANSGSTDSSG 
DGVTFPFKPE SWKPTDTEGK KQYDREFLLD FQFMPACIQK PEGLPPISDV VLDKINQPKL 
PMRTLDPRIL PRGPDFTPAF ADFGRQTPGG RGVPICKVQS RHGLPILEQS KAPTCPPLVM 
SHPPMKSLPL GLLNVGSRRS QPGQRREPRK IITVSVKEDV HLKKAENAWK PSQKRDSQAD 
DPENIKTQEL FRKVRSILNK LTPQMFNQLM KQVSGLTVDT EERLKGVIDL VFEKAIDEPS 
FSVAYANMCR CLVTLKVPMA DKPGNTVNFR KLLLNRCQKE FEKDKADDDV FEKKQKELEA 
ASAPEERTRL HDELEEAKDK ARRRSIGNIK FIGELFKLKM LTEAIMHDCV VKLLKNHDEE 
SLECLCRLLT TIGKDLDFEK AKPRMDQYFN QMEKIVKERK TSSRIRFMLQ DVIDLRLCNW 
VSRRADQGPK TIEQIHKEAK IEEQEEQRKV QQLMTKEKRR PGVQRVDEGG WNTVQGAKNS 
RVLDPSKFLK ITKPTIDEKI QLVPKAQLGS WGKGSSGGAK ASETDALRSS ASSLNRFSAL 
QPPAPSGSTP STPVEFDSRR TLTSRGSMGR EKNDKPLPSA TARPNTFMRG GSSKDLLDNQ 
SQEEQRREML ETVKQLTGGV DVERNSTEAE RNKTRESAKP EISAMSAHDK AALSEEELER 
KSKSIIDEFL HINDFKEAMQ CVEELNAQGL LHVFVRVGVE STLERSQITR DHMGQLLYQL 
VQSEKLSKQD FFKGFSETLE LADDMAIDIP HIWLYLAELV TPMLKEGGIS MRELTIEFSK 
PLLPVGRAGV LLSEILHLLC KQMSHKKVGA LWREADLSWK DFLPEGEDVH NFLLEQKLDF 
IESDSPCSSE ALSKKELSAE ELYKRLEKLI IEDKANDEQI FDWVEANLDE IQMSSPTFLR 
ALMTAVCKAA IIADSSTFRV DTAVIKQRVP ILLKYLDSDT EKELQALYAL QASIVKLDQP 
ANLLRMFFDC LYDEEVISED AFYKWESSKD PAEQNGKGVA LKSVTAFFTW LREAEEESED 
N

Genular Protein ID: 2082075673

Symbol: Q59GJ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GJ0

Database IDs:

ARBA 3 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 3 SAM 1 SMART 3 SUPFAM 1

Sequence Information:

  • Length: 1780
  • Mass: 195958
  • Checksum: 65102752AEE27684
  • Sequence:
    • VKKIHRHRLS PATEKGAASS GEGDKDPPPP AHEDIAVKGT ATAAGTGPGT GAAAAAAAAV 
PPPHPAAAAA AAAAAAAAAA AVPPPHPNIR ALQTQAPQQI PRGPVQQPLE DRIFTPAVSA 
VYSTVTQVAR QPGTPTPSPY SAHEINKGHP NLAATPPGHA SSPGLSQTPY PSGQNAGPTT 
LVYPQTPQTM NSQPQTRSPG GFRPIQFFQR PQIQPPRATI PNSSPSIRPG AQTPTAVYQA 
NQHIMMVNHL PMPYPVPQGP QYCIPQYRHS GPPYVGPPQQ YPVQPPGPGP FYPGPGPGDF 
PNAYGTPFYP SQPVYQSAPI IVPTQQQPPP AKREKKTIRI RDPNQGGKDI TEEIMSGGGS 
RNPTPPIGRP TSTPTPPQLP SQVPEHSPVV YGTVESAHLA ASTPVTAASD QKQEEKPKPD 
PVLKSPSPVL RLVLSGEKKE QEGQTSETTA IVSIAELPLP PSPTTVSSVA RSTIAAPTSS 
ALSSQPIFTT AIDDRCELSS PREDTIPIPS LTSCTETSDP LPTNENDDDI CKKPCSVAPN 
DIPLVSSTNL INEINGVSEK LSATESIVEI VKQEVLPLTL ELEILENPPE EMKLECIPAP 
ITPSTVPSFP PTPPTPPASP PHTPVIVPAA ATTVSSPSAA ITVQRVLEED ESIRTCLSED 
AKEIQNKIEV EADGQTEEIL DSQNLNSRRS PVPAQIAITV PKTWKKPKDR TRTTEEMLEA 
ELELKAEEEL SIDKVLESEQ DKMSQGFHPE RDPSDLKKVK AVEENGEEAE PVRNGAESVS 
EGEGIDANSG STDSSGDGVT FPFKPESWKP TDTEGKKQYD REFLLDFQFM PACIQKPEGL 
PPISDVVLDK INQPKLPMRT LDPRILPRGP DFTPAFADFG RQTPGGRGVP LLNVGSRRSQ 
PGQRREPRKI ITVSVKEDVH LKKAENAWKP SQKRDSQADD PENIKTQELF RKVRSILNKL 
TPQMFNQLMK QVSGLTVDTE ERLKGVIDLV FEKAIDEPSF SVAYANMCRC LVTLKVPMAD 
KPGNTVNFRK LLLNRCQKEF EKDKADDDVF EKKQKELEAA SAPEERTRLH DELEEAKDKA 
RRRSIGNIKF IGELFKLKML TEAIMHDCVV KLLKNHDEES LECLCRLLTT IGKDLDFEKA 
KPRMDQYFNQ MEKIVKERKT SSRIRFMLQD VIDLRLCNWV SRRADQGPKT IEQIHKEAKI 
EEQEEQRKVQ QLMTKEKRRP GVQRVDEGGW NTVQGAKNSR VLDPSKFLKI TKPTIDEKIQ 
LVPKAQLGSW GKGSSGGAKA SETDALRSSA SSLNRFSALQ PPAPSGSTPS TPVEFDSRRT 
LTSRGSMGRE KNDKPLPSAT ARPNTFMRGG SSKDLLDNQS QEEQRREMLE TVKQLTGGVD 
VERNSTEAER NKTRESAKPE ISAMSAHDKA ALSEEELERK SKSIIDEFLH INDFKEAMQC 
VEELNAQGLL HVFVRVGVES TLERSQITRD HMGQLLYQLV QSEKLSKQDF FKGFSETLEL 
ADDMAIDIPH IWLYLAELVT PMLKEGGISM RELTIEFSKP LLPVGRAGVL LSEILHLLCK 
QMSHKKVGAL WREADLSWKD FLPEGEDVHN FLLEQKLDFI ESDSPCSSEA LSKKELSAEE 
LYKRLEKLII EDKANDEQIF DWVEANLDEI QMSSPTFLRA LMTAVCKAAI IADSSTFRVD 
TAVIKQRVPI LLKYLDSDTE KELQALYALQ ASIVKLDQPA NLLRMFFDCL YDEEVISEDA 
FYKWESSKDP AEQNGKGVAL KSVTAFFTWL REAEEESEDN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.